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Researchgate Profile

Other IDs

Scopus Author ID: 56992839400
SciProfiles: 982483

Keywords

stem cells, molecular biology, neuronal differentiation, brain spheres, sensory neurons, motor neurons, RT-qPCR, alternatives to animal experiments, intestinal organoids, host pathogen interaction, Botulinum toxins, toxicology, in vitro, risk assessment

Countries

Germany

Activities

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Employment (3)

University of Veterinary Medicine Hannover, Foundation: Hannover, Niedersachsen, DE

2018-07 to present | Junior Professor for Alternative/Complementary Methods to Animal Experiments (Institute for Food Quality and Food Safety)
Employment
Source: Self-asserted source
Bettina Seeger

University of Veterinary Medicine Hannover, Foundation: Hannover, DE

2016-05 to 2018-06 | Postdoctoral Researcher (Institute for Food Toxicology)
Employment
Source: Self-asserted source
Bettina Seeger

University of Veterinary Medicine Hannover, Foundation: Hannover, DE

2013-04 to 2016-04 | Ph.D. student (Institute for Food Toxicology and Analytical Chemistry)
Employment
Source: Self-asserted source
Bettina Seeger

Education and qualifications (5)

EUROTOX: Brussels, Brussels, BE

2021-03 to present | European Registered Toxicologist, ERT
Qualification
Source: Self-asserted source
Bettina Seeger

Veterinary Chamber of Lower Saxony: Hannover, Lower Saxony, DE

2020-11 to present | Authorization for further training of Veterinary specialists for Pharmacology and Toxicology
Qualification
Source: Self-asserted source
Bettina Seeger

Veterinary Chamber of Lower Saxony: Hannover, Lower Saxony, DE

2020-10 | Veterinary Specialist for Pharmacology and Toxicology
Qualification
Source: Self-asserted source
Bettina Seeger

University of Veterinary Medicine Hannover, Foundation: Hanover, Lower Saxony, DE

2013-04 to 2016-04 | PhD of toxicology (Institute for Food Toxicology)
Education
Source: Self-asserted source
Bettina Seeger

University of Veterinary Medicine Hannover, Foundation: Hannover, DE

2007-10-01 to 2013-03-31 | most comparable to DVM
Education
Source: Self-asserted source
Bettina Seeger

Professional activities (3)

European Socitey for Alternatives to Animal Testing, EUSAAT: Vienna, AT

2022 to present
Membership
Source: Self-asserted source
Bettina Seeger

German Toxicology Society (GT): -, DE

2016 to present
Membership
Source: Self-asserted source
Bettina Seeger

European Society of Toxicology In Vitro (ESTIV): -, NL

2014 to present
Membership
Source: Self-asserted source
Bettina Seeger

Funding (7)

3Rs concepts to improve the quality of biomedical science (IMPROVE)

2022-10 to 2026-10 | Grant
COST Association (Brussels, BE)
URL: https://www.cost.eu/actions/CA21139/
GRANT_NUMBER: CA21139
Source: Self-asserted source
Bettina Seeger

European Network for Skin Engineering and Modeling (NETSKINMODELS)

2022-09 to 2026-09 | Grant
COST Association (Brussels, BE)
URL: https://www.cost.eu/actions/CA21108/
GRANT_NUMBER: CA21108
Source: Self-asserted source
Bettina Seeger

PARC - Partnership for Risk Assessment of Chemicals

2022-05 to 2029-04 | Grant
European Commission (Brussels, BE)
URL: https://www.eu-parc.eu/
Source: Self-asserted source
Bettina Seeger

Studies on the occurrence and toxicity of molds in cheese

2021-06 to 2023-05 | Grant
Brigitte und Wolfram Gedek Stiftung (München, DE)
Source: Self-asserted source
Bettina Seeger

Self-assembly and crypt formation ("budding") in intestinal organoids differentiated from porcine induced pluripotent stem cells - Development of a complex intestinal model for the pig

2020-01 to 2021-12 | Grant
H. Wilhelm Schaumann Stiftung (Hamburg, DE)
Source: Self-asserted source
Bettina Seeger

R2N - Development of an in vitro-model for the investigation of pathogenicity mechanisms of gut diseases caused by zoonotic pathogens

2017-08 to 2022-12 | Grant
Ministry for Science and Culture of Lower Saxony (Hannover, Lower Saxony, DE)
Part of GRANT_NUMBER: A2
Source: Self-asserted source
Bettina Seeger

MoNLightBoNT-Assay - Development of an assay for the evaluation of Botulinum toxin activity based on transgenic human stem cells differentiated to motor neurons

2017-04 to 2020-09 | Grant
German Federal Ministry of Education and Research (PTJ, Jülich, DE)
GRANT_NUMBER:

031L0132B
Source: Self-asserted source
Bettina Seeger

Works (19)

β-Hydroxybutyrate affects cell physiological parameters, inflammatory markers and hormone receptor expression in bovine endometrial gland cells in vitro

Placenta
2023-10 | Journal article
DOI: 10.1016/j.placenta.2023.08.071
Part of ISSN: 0143-4004
Contributors: Kim Kraushaar; Julia Hollenbach; Niklas Schmauch; Bettina Seeger; Christiane Pfarrer
Source: Self-asserted source
Bettina Seeger

β-Hydroxybutyrate Effects on Bovine Caruncular Epithelial Cells: A Model for Investigating the Peri-Implantation Period Disruption in Ketotic Dairy Cows

Animals
2023-09-18 | Journal article
DOI: 10.3390/ani13182950
Contributors: Carolin Hildebrand; Julia Hollenbach; Bettina Seeger; Christiane Pfarrer
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS

Frontiers in Cell and Developmental Biology
2023-02-14 | Journal article
DOI: 10.3389/fcell.2023.996952
Part of ISSN: 2296-634X
Contributors: Bita Massih; Alexander Veh; Maren Schenke; Simon Mungwa; Bettina Seeger; Bhuvaneish T. Selvaraj; Siddharthan Chandran; Peter Reinhardt; Jared Sterneckert; Andreas Hermann et al.
Source: Self-asserted source
Bettina Seeger

The Current Status and Work of Three Rs Centres and Platforms in Europe*

Alternatives to Laboratory Animals
2022-11 | Journal article | Author
DOI: 10.1177/02611929221140909
Part of ISSN: 0261-1929
Part of ISSN: 2632-3559
Contributors: Winfried Neuhaus; Birgit Reininger-Gutmann; Beate Rinner; Roberto Plasenzotti; Doris Wilflingseder; Joery De Kock; Tamara Vanhaecke; Vera Rogiers; Dagmar Jírová; Kristina Kejlová et al.
Source: Self-asserted source
Bettina Seeger

Investigation of the pathophysiology of bacterial mastitis using precision-cut bovine udder slices

Journal of Dairy Science
2022-09 | Journal article
DOI: 10.3168/jds.2021-21533
Contributors: V. Filor; B. Seeger; N. de Buhr; M. von Köckritz-Blickwede; M. Kietzmann; H. Oltmanns; J. Meißner
Source: check_circle
Crossref

Validation of a Novel Double Control Quantitative Copy Number PCR Method to Quantify Off-Target Transgene Integration after CRISPR-Induced DNA Modification

Methods and Protocols
2022-05-25 | Journal article
DOI: 10.3390/mps5030043
Contributors: Brit-Maren Michaud Schjeide; Maren Schenke; Bettina Seeger; Gerhard Paul Püschel
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

The Rise of Three Rs Centres and Platforms in Europe*

Alternatives to Laboratory Animals
2022-05-16 | Journal article
DOI: 10.1177/02611929221099165
Part of ISSN: 0261-1929
Part of ISSN: 2632-3559
Source: Self-asserted source
Bettina Seeger
grade
Preferred source (of 2)‎

Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells

PLOS ONE
2021-10-07 | Journal article
DOI: 10.1371/journal.pone.0257824
Contributors: Pascal Hoffmann; Mária A. Deli; Marion Burmester; Marion Langeheine; Ralph Brehm; Michael T. Empl; Bettina Seeger; Gerhard Breves
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig intestine

PLOS ONE
2021-08-23 | Journal article
DOI: 10.1371/journal.pone.0256143
Contributors: Pascal Hoffmann; Gianfranco D. Alpini; Nadine Schnepel; Marion Langeheine; Katrin Künnemann; Guntram A. Grassl; Ralph Brehm; Bettina Seeger; Gemma Mazzuoli-Weber; Gerhard Breves
Source: check_circle
Crossref

Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1

Toxins
2021-08-22 | Journal article
DOI: 10.3390/toxins13080585
Contributors: Maren Schenke; Hélène-Christine Prause; Wiebke Bergforth; Adina Przykopanski; Andreas Rummel; Frank Klawonn; Bettina Seeger
Source: check_circle
Crossref

Repair of O6-carboxymethylguanine adducts by O6-methylguanine-DNA methyltransferase in human colon epithelial cells

Carcinogenesis
2021-08-19 | Journal article
DOI: 10.1093/carcin/bgab049
Contributors: Tina Kostka; Michael T Empl; Nina Seiwert; Susanne M Geisen; Pascal Hoffmann; Janine Adam; Bettina Seeger; Jerry W Shay; Markus Christmann; Shana J Sturla et al.
Source: check_circle
Crossref

Connexin43 in Germ Cells Seems to Be Dispensable for Murine Spermatogenesis

International Journal of Molecular Sciences
2021-07-25 | Journal article
DOI: 10.3390/ijms22157924
Contributors: Kristina Rode; Marion Langeheine; Bettina Seeger; Ralph Brehm
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Farm Animal-derived Models of the Intestinal Epithelium: Recent Advances and Future Applications of Intestinal Organoids

Alternatives to Laboratory Animals
2020-09 | Journal article
DOI: 10.1177/0261192920974026
Contributors: Bettina Seeger
Source: check_circle
Crossref

Analysis of Motor Neurons Differentiated from Human Induced Pluripotent Stem Cells for the Use in Cell-Based Botulinum Neurotoxin Activity Assays

Toxins
2020-04-25 | Journal article
DOI: 10.3390/toxins12050276
Contributors: Maren Schenke; Brit-Maren Schjeide; Gerhard P. Püschel; Bettina Seeger
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Implementing data - The future of alternative methods - VZET symposium 2019

Altex
2019 | Journal article
DOI: 10.14573/ALTEX.1906211
EID:

2-s2.0-85077222761

Part of ISSN: 18688551 1868596X
Contributors: Seeger, B.
Source: Self-asserted source
Bettina Seeger via Scopus - Elsevier

Assessment of mixture toxicity of (tri)azoles and their hepatotoxic effects in vitro by means of omics technologies

Archives of Toxicology
2019-08-28 | Journal article
DOI: 10.1007/s00204-019-02502-w
Contributors: Bettina Seeger; Almut Mentz; Constanze Knebel; Flavia Schmidt; Hanna Bednarz; Karsten Niehaus; Stephan Albaum; Jörn Kalinowski; Thomas Noll; Pablo Steinberg et al.
Source: check_circle
Crossref

Importance of alternative methods for animal testing in the context of conformity assessment of medical devices

Berliner und Münchener Tierärztliche Wochenschrift
2018-06-28 | Journal article
DOI: 10.2376/0005-9366-17107
Source: Self-asserted source
Bettina Seeger

Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor α and β.

2016 | Journal article
DOI: 10.1371/journal.pone.0147490
PMID: 26812056
PMC: PMC4728068
Contributors: Seeger B; Klawonn F; Nguema Bekale B; Steinberg P
Source: Self-asserted source
Bettina Seeger via Europe PubMed Central

The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures

Toxicology Letters
2016-01 | Journal article
DOI: 10.1016/j.toxlet.2015.11.015
Contributors: Bettina Seeger; Frank Klawonn; Boris Nguema Bekale; Pablo Steinberg
Source: check_circle
Crossref

Peer review (22 reviews for 14 publications/grants)

Review activity for Animals. (2)
Review activity for Archiv für Lebensmittelhygiene (1)
Review activity for Archives of toxicology. (2)
Review activity for Archives of toxicology. (4)
Review activity for ATLA : (1)
Review activity for Chemical research in toxicology. (1)
Review activity for Environmental pollution. (2)
Review activity for Pest management science. (2)
Review activity for Reproductive toxicology. (1)
Review activity for Science of the total environment. (1)
Review activity for Toxicology letters. (1)
Review activity for Toxicology. (1)
Review activity for Toxins. (1)
Review activity for Veterinary research. (2)
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