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Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science

Cancer Discovery
2023-10-05 | Journal article
DOI: 10.1158/2159-8290.CD-23-0280
Contributors: Darrin D. Stuart; Angel Guzman-Perez; Natasja Brooijmans; Erica L. Jackson; Gregory V. Kryukov; Adam A. Friedman; Axel Hoos
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Data from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.c.6544943
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Data from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.c.6544943.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S1 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525877.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S1 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525877
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S2 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525874.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S2 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525874
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S3 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525871.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S3 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525871
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S4 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525868.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S4 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525868
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S5 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525865.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S5 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525865
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S6 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525862.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplemental Figure S6 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525862
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplementary Legends from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525859.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplementary Legends from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525859
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplementary Tables 1-3 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525856.v1
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Supplementary Tables 1-3 from RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

2023-04-03 | Preprint
DOI: 10.1158/1541-7786.22525856
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

Molecular Cancer Research
2021-06-01 | Journal article
DOI: 10.1158/1541-7786.MCR-20-1022
Contributors: Matthew S. Crowe; Tatiana Zavorotinskaya; Charles F. Voliva; Matthew D. Shirley; Yanqun Wang; David A. Ruddy; Daniel P. Rakiec; Jeffery A. Engelman; Darrin D. Stuart; Alyson K. Freeman
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Peer review (1 review for 1 publication/grant)

Review activity for Nature chemical biology. (1)
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