Manu Lopus (0000-0002-4829-3960)

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Dr Manu Lopus PhD, FRSC is an Associate Professor at the School of Biological Sciences, UM-DAE Centre for Excellence in Basic Sciences where he is also the Principal Investigator of Cellular Nanomedicine and Chemical Biology Laboratory. Dr Lopus obtained his PhD in Biotechnology from the Indian Institute of Technology Bombay and postdoctoral training at the University of California, Santa Barbara. His current research areas are designer nanomedicines, non-apoptotic cell death mechanisms, and nano-herbal therapeutics

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University of California Santa Barbara: Santa Barbara, CA, US

Associate Specialist II (Molecular, Cellular, and Developmental Biology)

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Manu Lopus

https://orcid.org/0000-0002-4829-3960

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Biography

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Employment (3)

University of California Santa Barbara: Santa Barbara, CA, US

University of California Santa Barbara: Santa Barbara, CA, US

Centre for Excellence in Basic Science: Mumbai, Maharashtra, IN

Education and qualifications (1)

Indian Institute of Technology Bombay: Mumbai, MH, IN

Professional activities (9)

Molecular Medicine Reports: Athina, GR

Oncology Letters : Athina, GR

National Academy of Sciences India: Allahabad, IN

Material Research Society of India: Mumbai, IN

Society of Biological Chemists, India: Mumbai, IN

Indian Association for Cancer Research: Mumbai, IN

Maharashtra Academy of Sciences : Mumbai, Maharahstra, IN

Royal Society of Chemistry: London, GB

The Royal Society of Biology: London, London, GB

Works (50 of 67)

Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging

From Self-Assembly to Drug Delivery: Understanding and Exploring Protein Fibrils

Induction of autophagy-dependent and caspase- and microtubule-acetylation-independent cell death by phytochemical-stabilized gold nanopolygons in colorectal adenocarcinoma cells

The mode of action of sorafenib in MDA-MB-231 breast carcinoma cells involves components of apoptotic, necroptotic and autophagy-dependent cell death pathways

Antiproliferative efficacy and mechanism of action of aggregation-resistant, polymorphous nanosilver functionalized with asparagus phytochemicals (Ar-AgNPs) in the breast adenocarcinoma MDA-MB-231 cells

Antiproliferative efficacy and mechanism of action of garlic phytochemicals-functionalized gold nanoparticles in triple-negative breast cancer cells

Exploring the efficacy of tryptone-stabilized silver nanoparticles against respiratory tract infection-causing bacteria: a study on planktonic and biofilm forms

Biochemical and in silico analysis of the binding mode of erastin with tubulin

The Advent of Nano-herbal Medicine

Smart Delivery Systems Responsive to Cathepsin B Activity for Cancer Treatment

Ashwagandha: A potential source for cancer therapeutics

Proteomic and metabolomic profiling combined with in vitro studies reveal the antiproliferative mechanism of silver nanoparticles in MDA-MB-231 breast carcinoma cells

Nano-ayurvedic medicine and its potential in cancer treatment.

Tryptone-stabilized silver nanoparticles' potential to mitigate planktonic and biofilm growth forms of Serratia marcescens.

Editorial: Non-apoptotic cell death mechanisms and their therapeutic significance.

In vitro characterization and molecular dynamic simulation of shikonin as a tubulin-targeted anticancer agent

Ashwagandha-polyphenols-functionalized gold nanoparticles facilitate apoptosis by perturbing microtubule assembly dynamics in breast cancer cells

Targeting disorders in unstructured and structured proteins in various diseases

Mechanistic insights into encapsulation and release of drugs in colloidal niosomal systems: biophysical aspects

Induction of microtubule hyper stabilization and robust G2/M arrest by N‐4‐CN in human breast carcinoma MDA‐MB‐231 cells

The spontaneous remission of cancer: Current insights and therapeutic significance.

Triphala polyphenols-functionalized gold nanoparticles impair cancer cell survival through induction of tubulin dysfunction

9-PAN promotes tubulin- and ROS-mediated cell death in human triple-negative breast cancer cells

Tubulin- and ROS-dependent antiproliferative mechanism of a potent analogue of noscapine, N-propargyl noscapine.

Cell death mechanisms in eukaryotes

Tryptone-stabilized gold nanoparticles induce unipolar clustering of supernumerary centrosomes and G1 arrest in triple-negative breast cancer cells

Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability.

Insights into the structure and tubulin-targeted anticancer potential of N-(3-bromobenzyl) noscapine

Chemical characteristics, antioxidant and anticancer potential of sulfated polysaccharides from Chlamydomonas reinhardtii

Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics

Synthesis, photophysical studies of positional isomers of heteroaryl BODIPYs, and biological evaluation of Di-pyrrolyl BODIPY on human pancreatic cancer cells

Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules

Tryptone-stabilized gold nanoparticles target tubulin and inhibit cell viability by inducing an unusual form of cell cycle arrest.

Editorial:Tubulin-targeted Cancer Chemotherapeutics: Advances and Challenges.

Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.

From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics.

Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

Subtle Alterations in Microtubule Assembly Dynamics by Br-TMB-Noscapine Strongly Suppress Triple-Negative Breast Cancer Cell Viability Without Mitotic Arrest

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics

Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype.

Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype.

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents.

Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents.

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation.

Rational Design, Synthesis, and Biological Evaluation of Third Generation α-Noscapine Analogues as Potent Tubulin Binding Anti-Cancer Agents

Mechanism of mitotic arrest induced by dolastatin 15 involves loss of tension across kinetochore pairs.

Peer review (87 reviews for 36 publications/grants)