Personal information

Biography

David M. Klyne PhD, MSc (MolBiol), DPhty, BAppSc) is a NHMRC Emerging Leadership Fellow and Fulbright Scholar within the Centre for Clinical Research Excellence in Spinal Pain, Injury and Health. There he leads an international team that probe the bio-psycho-social mechanisms that underlie physiological and pathological pain. His niche is in understanding the neuro-immune pathways involved and how they can be targeted with interventions using a blend of basic and clinical sciences and his skills and knowledge gained through his four degrees – neuro-immunology (PhD), molecular biology (Master), physiotherapy (Doctorate) and applied sciences (Bachelor).

David has received numerous national and international research awards that span basic and clinical sciences. These include the premier international award for spine research (ISSLS Prize) on two occasions – in Basic Science (2019) and Clinical Science (2018). In 2019, he was awarded a postdoctoral Fulbright Fellowship to continue his work elucidating the role of sleep in chronic pain at the Lewis Katz School of Medicine (Temple University), in the USA. He was also one of ten Australian scientists to attend the Lindau Nobel Laureate Meeting in 2019 and again in 2023, and has received more than $100K in research prize money and $17.5M in research funding.

Impact
Klyne's research has attracted 17.5M ($8.5M as CIA/PI) from local, national and international funding bodies, been adopted by the world’s leading forum on pain (IASP) in the form of an online Fact Sheet (2021; >50K online visits), informed clinical guidelines and policies relating to the management of pain (e.g., American Academy of Orthopaedic Manual Physical Therapists), and formed the basis of a chapter in one of the world’s leading physiotherapy textbooks – Grieve's (2024). His reputation is exemplified by his >40 national/international presentations (>20 funded invited and/or Keynote) and invitations to provide expertise on global matters such as at the 2019 Opioid Epidemic Consortium in Kentucky, USA. The significance of Klyne's program of research to the broader public is evidenced by features in the media, including 9 News Australia (interview), the Sydney Morning Herald and Australian Academy of Science. In 2021, 9 News released a mini-documentary about Klyne's work on sleep and pain, which ranked in the top 5 stories nationally on NineMSN. From this program of work, Klyne is consistently ranked in the top 1% of experts globally in back pain (Expertscape).

Activities

Employment (4)

University of Queensland: Brisbane, AU

2024-01-24 to present | NHMRC Emerging Leadership Fellow (NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health)
Employment
Source: Self-asserted source
David Klyne

University of Queensland: Brisbane, AU

2023-01-01 to present | Senior Research Fellow (NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health)
Employment
Source: Self-asserted source
David Klyne

Temple University: Philadelphia, US

2016-01-01 to present | Research Affiliate
Employment
Source: Self-asserted source
David Klyne

The University of Queensland: Brisbane, QLD, AU

2018-01-01 to 2022-12-22 | Research Fellow (NHMRC Centre of Clinical Research Excellence in Spinal Pain, Injury and Health)
Employment
Source: Self-asserted source
David Klyne

Education and qualifications (4)

University of Queensland: Brisbane, QLD, AU

2013-01-01 to 2018-06-30 | MSc (MolBiol)
Education
Source: Self-asserted source
David Klyne

University of Queensland: Brisbane, QLD, AU

2013-03-01 to 2018-06-15 | PhD (Immunology and Neurosciences)
Education
Source: Self-asserted source
David Klyne

Bond University: Gold Coast, QLD, AU

2009-01-01 to 2011-12-01 | DPhty
Education
Source: Self-asserted source
David Klyne

Queensland University of Technology: Brisbane, QLD, AU

2006-01-01 to 2008-12-01 | BAppSc
Education
Source: Self-asserted source
David Klyne

Professional activities (2)

Australian Pain Society: North Sydney, AU

2024-01-01 to present | Full Member
Membership
Source: Self-asserted source
David Klyne

International Association for the Study of Pain: Seattle, WA, US

2019 to present | Full Member
Membership
Source: Self-asserted source
David Klyne

Funding (7)

The role of sleep, physical activity and central sensitisation in chronic back pain development

2023-12-15 to present | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER:

2027008

Source: Self-asserted source
David Klyne via DimensionsWizard

PRioRTI: PReventing chronic pain after whiplash Road Traffic Injury

2023-01 to 2027-12 | Grant
National Health and Medical Research Council (Canberra, Australian Capital Territory, AU)
Source: Self-asserted source
David Klyne

What causes low back pain to flare: Has a major opportunity to understand back pain been missed?

2022-09-22 to 2027-08-31 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Bethesda, US)
GRANT_NUMBER: R01AR080354
Source: Self-asserted source
David Klyne via DimensionsWizard

A machine learning approach for detecting stress using wearable devices

2022-06 to 2022-12 | Grant
University of Queensland (Brisbane, AU)
Source: Self-asserted source
David Klyne

Biomarkers of tissue tolerance and behavior in a rat model

2022-04 to 2026-03 | Grant
National Institute of Arthritis and Musculoskeletal and Skin Diseases (Md., Md., US)
Source: Self-asserted source
David Klyne

Understanding Acute to Chronic Back Pain Pathways and Testing New Solutions

2020-09-30 to 2023-09-29 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-20-1-0909

Source: Self-asserted source
David Klyne via DimensionsWizard

Sleep, Pain and Advanced Pain Management

2019-07-01 to 2020-01-31 | Grant
Council for International Exchange of Scholars (Washington D.C., US)
GRANT_NUMBER: grant.8714509
Source: Self-asserted source
David Klyne via DimensionsWizard

Works (50 of 58)

Items per page:
Page 1 of 2

Characterization of pain-related behaviors in a rat model of acute-to-chronic low back pain: single vs. multi-level disc injury

Frontiers in Pain Research
2024 | Journal article
Contributors: Barbe, Mary F; Chen, Frank Liu; Loomis, Regina H; Harris, Michele Y; Kim, Brandon M; Xie, Kevin; Hilliard, Brendan A; McGonagle, Elizabeth R; Bailey, Taylor D; Gares, Ryan P et al.
Source: Self-asserted source
David Klyne

Coordination of hip and spine in individuals with acute low back pain during unstable sitting

The Spine Journal
2024 | Journal article
Contributors: Alshehri, Mansour Abdullah; van den Hoorn, Wolbert; Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Is sleep the new treatment for pain? Two issues need resolving before deciding

Sleep
2024 | Other
Contributors: Klyne, David M; Hall, Michelle
Source: Self-asserted source
David Klyne

Poor lumbar spine coordination in acute low back pain predicts persistent long-term pain and disability

European Spine Journal
2024 | Journal article
Contributors: Alshehri, Mansour Abdullah; van den Hoorn, Wolbert; Klyne, David M; van Dieën, Jaap H; Cholewicki, Jacek; Hodges, Paul W
Source: Self-asserted source
David Klyne

Poor sleep versus exercise: A duel to decide whether pain resolves or persists after injury

Brain, Behavior, & Immunity-Health
2024 | Journal article
Contributors: Klyne, David M; Hilliard, Brendan A; Harris, Michele Y; Amin, Mamta; Hall, Michelle; Besomi, Manuela; Mustafa, Sanam; Farrell, Scott F; Rawashdeh, Oliver; Han, Felicity Y et al.
Source: Self-asserted source
David Klyne

TaggedH1TABLE OF CONTENTSTaggedEnd

2024 | Journal article
Contributors: Schoenfeld, Andrew J; Chen, Mingda; Baumann, Anthony N; Cheng, Christina W; Furey, Christopher G; Xiong, Grace X; Nguyen, Andrew; Hering, Kalei; Alshehri, Mansour Abdullah; van den Hoorn, Wolbert et al.
Source: Self-asserted source
David Klyne

THE ADDITIVE EFFECTS OF AEROBIC ACTIVITY TO STRENGTHENING EXERCISE FOR HIP OSTEOARTHRITIS: A RANDOMIZED CONTROLLED TRIAL

Osteoarthritis and Cartilage
2024 | Journal article
Contributors: Hall, Michelle; Allison, Kim; Knox, Gabrielle; Hinman, Rana S; Bennell, Kim; Spiers, Libby; Plinsinga, Melanie; Klyne, David; McManus, Fiona; De Silva, Anurika et al.
Source: Self-asserted source
David Klyne

Trunk postural control during unstable sitting among individuals with and without low back pain: A systematic review with an individual participant data meta-analysis

Plos one
2024 | Journal article
Contributors: Alshehri, Mansour Abdullah; Alzahrani, Hosam; van den Hoorn, Wolbert; Klyne, David M; Vette, Albert H; Hendershot, Brad D; Roberts, Brad WR; Larivière, Christian; Barbado, David; Vera-Garcia, Francisco J et al.
Source: Self-asserted source
David Klyne

Genetic impact of blood C-reactive protein levels on chronic spinal & widespread pain

European Spine Journal
2023 | Journal article
Contributors: Farrell, Scott F; Sterling, Michele; Klyne, David M; Mustafa, Sanam; Campos, Adrián I; Kho, Pik-Fang; Lundberg, Mischa; Renteŕıa, Miguel E; Ngo, Trung Thanh; Cuéllar-Partida, Gabriel
Source: Self-asserted source
David Klyne

How do nonsurgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies

Arthritis Care & Research
2023 | Journal article
Contributors: Lima, Yuri Lopes; Lee, Hopin; Klyne, David M; Dobson, Fiona L; Hinman, Rana S; Bennell, Kim L; Hall, Michelle
Source: Self-asserted source
David Klyne

Low back pain and osteoarthritis pain: a perspective of estrogen

Bone research
2023 | Journal article
Contributors: Pang, Huiwen; Chen, Shihui; Klyne, David M; Harrich, David; Ding, Wenyuan; Yang, Sidong; Han, Felicity Y
Source: Self-asserted source
David Klyne

Neurobiology of osteoarthritis: a systematic review and activation likelihood estimation meta-analysis

Scientific reports
2023 | Journal article
Contributors: Hall, Michelle; Dobson, Fiona; Klyne, David Murray; Zheng, Carmen Jiamin; Lima, Yuri Lopes; Egorova-Brumley, Natalia
Source: Self-asserted source
David Klyne

Pain-related cognitions and emotional distress are not associated with conditioned pain modulation: an explorative analysis of 1142 participants with acute, subacute, and chronic pain

Pain
2023 | Journal article
Contributors: Plinsinga, Melanie Louise; Vuvan, Viana; Maclachlan, Liam; Klyne, David; Graven-Nielsen, Thomas; Vicenzino, Bill; Hodges, Paul; Vaegter, Henrik Bjarke
Source: Self-asserted source
David Klyne

Balance control in unstable sitting in individuals with an acute episode of low back pain

Gait & posture
2022 | Journal article
Contributors: van den Hoorn, Wolbert; Meroni, Roberto; Klyne, David M; Alshehri, Mansour Abdullah; Hodges, Paul W
Source: Self-asserted source
David Klyne

Effects of adding aerobic physical activity to strengthening exercise on hip osteoarthritis symptoms: protocol for the PHOENIX randomised controlled trial

BMC musculoskeletal disorders
2022 | Journal article
Contributors: Hall, Michelle; Allison, Kim; Hinman, Rana S; Bennell, Kim L; Spiers, Libby; Knox, Gabrielle; Plinsinga, Melanie; Klyne, David M; McManus, Fiona; Lamb, Karen E et al.
Source: Self-asserted source
David Klyne

Postural control of the trunk in individuals with and without low back pain during unstable sitting: A protocol for a systematic review with an individual participant data meta-analysis

Plos one
2022 | Journal article
Contributors: Alshehri, Mansour Abdullah; van den Hoorn, Wolbert; Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Relationship between systemic inflammation and recovery over 12 months after an acute episode of low back pain

The Spine Journal
2022 | Journal article
Contributors: Klyne, David M; Barbe, Mary F; Hodges, Paul W
Source: Self-asserted source
David Klyne

Risk factors for low back pain outcome: Does it matter when they are measured?

European Journal of Pain
2022 | Journal article
Contributors: Klyne, David Murray; Hall, Leanne Marie; Nicholas, Michael K; Hodges, Paul William
Source: Self-asserted source
David Klyne

Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis

Journal of Neurophysiology
2021 | Journal article
Contributors: Alshehri, Mansour Abdullah; van den Hoorn, Wolbert; Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Does the interaction between local and systemic inflammation provide a link from psychology and lifestyle to tissue health in musculoskeletal conditions?

International Journal of Molecular Sciences
2021 | Journal article
Contributors: Klyne, David M; Barbe, Mary F; James, Greg; Hodges, Paul W
Source: Self-asserted source
David Klyne

Supplemental Data for" Coordination of hip and spine to maintain equilibrium in unstable sitting revealed by spectral analysis" paper

2021 | Journal article
Contributors: Alshehri, Mansour Abdullah; van den Hoorn, Wolbert; Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Uncovering the role of sleep and exercise in the transition from acute to persistent pain

Brain, Behavior, and Immunity
2021 | Journal article
Contributors: Klyne, DM; Hilliard, B; Harris, M; Amin, M; Testa, C; Hobson, L; Cruz, G; Hodges, PW; Barbe, MF
Source: Self-asserted source
David Klyne

Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?

International Journal of Molecular Sciences
2021-07 | Journal article | Author
Contributors: David Klyne; Mary F. Barbe; Greg James; Paul W. Hodges
Source: check_circle
Multidisciplinary Digital Publishing Institute

Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy

Journal of Orthopaedic Research®
2020 | Journal article
Contributors: Barbe, Mary F; Hilliard, Brendan A; Amin, Mamta; Harris, Michele Y; Hobson, Lucas J; Cruz, Geneva E; Dorotan, Jocelynne T; Paul, Ryan W; Klyne, David M; Popoff, Steven N
Source: Self-asserted source
David Klyne

Circulating adipokines in predicting the transition from acute to persistent low back pain

Pain Medicine
2020 | Journal article
Contributors: Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Cohort profile: why do people keep hurting their back?

BMC research notes
2020 | Journal article
Contributors: Klyne, David M; van den Hoorn, Wolbert; Barbe, Mary F; Cholewicki, Jacek; M. Hall, Leanne; Khan, Asaduzzaman; Meroni, Roberto; Moseley, G Lorimer; Nicholas, Michael; O’Sullivan, Lee et al.
Source: Self-asserted source
David Klyne

Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders

BMC musculoskeletal disorders
2020 | Journal article
Contributors: Smith, Tianqi Tenchi Gao; Barr-Gillespie, Ann E; Klyne, David M; Harris, Michelle Y; Amin, Mamta; Paul, Ryan W; Cruz, Geneva E; Zhao, Huaqing; Gallagher, Sean; Barbe, Mary F
Source: Self-asserted source
David Klyne

Forced treadmill running reduces systemic inflammation yet worsens upper limb discomfort in a rat model of work-related musculoskeletal disorders

BMC musculoskeletal disorders
2020 | Journal article
EID:

2-s2.0-85078713093

Contributors: Smith, T.T.G.; Barr-Gillespie, A.E.; Klyne, D.M.; Harris, M.Y.; Amin, M.; Paul, R.W.; Cruz, G.E.; Zhao, H.; Gallagher, S.; Barbe, M.F.
Source: Self-asserted source
David Klyne via Scopus - Elsevier

Trunk stiffness decreases and trunk damping increases with experimental low back pain

Journal of Biomechanics
2020 | Journal article
Contributors: van den Hoorn, Wolbert; Cholewicki, Jacek; Coppieters, Michel W; Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Why do people keep hurting their back?

2020 | Journal article
Contributors: Klyne, David M; den Hoorn, Wolbert Van; Barbe, Mary F; Cholewicki, Jacek; Hall, Leanne M; Khan, Asaduzzaman; Meroni, Roberto; Moseley, G Lorimer; Nicholas, Michael; O'Sullivan, Lee et al.
Source: Self-asserted source
David Klyne

Circulating Adipokines in Predicting the Transition from Acute to Persistent Low Back Pain

Pain Medicine
2020-03 | Journal article
Part of ISSN: 1526-2375
Contributors: David M Klyne; Paul W Hodges
Source: Self-asserted source
David Klyne via Crossref Metadata Search

Blocking CTGF/CCN2 reduces established tissue fibrosis and sensorimotor declines in a rat model of overuse injury

Orthopaedic Research Society Annual Meeting
2020-02 | Conference paper
Source: Self-asserted source
David Klyne

Abstract # 3121 Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

Brain, Behavior, and Immunity
2019 | Journal article
Source: Self-asserted source
David Klyne

Abstract# 3121 Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

Brain, Behavior, and Immunity
2019 | Journal article
Contributors: Klyne, DM
Source: Self-asserted source
David Klyne

Are signs of central sensitization in acute low back pain a precursor to poor outcome?

The journal of pain
2019 | Journal article
Contributors: Klyne, David M; Moseley, G Lorimer; Sterling, Michele; Barbe, Mary F; Hodges, Paul W
Source: Self-asserted source
David Klyne

Are Signs of Central Sensitization in Acute Low Back Pain a Precursor to Poor Outcome?

Journal of Pain
2019 | Journal article
EID:

2-s2.0-85064461460

Contributors: Klyne, D.M.; Moseley, G.L.; Sterling, M.; Barbe, M.F.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier

ISSLS prize in basic science 2019: physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration

European Spine Journal
2019 | Journal article
Contributors: James, G; Klyne, DM; Millecamps, M; Stone, LS; Hodges, PW
Source: Self-asserted source
David Klyne

ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration

European Spine Journal
2019 | Journal article
EID:

2-s2.0-85061278865

Contributors: James, G.; Klyne, D.M.; Millecamps, M.; Stone, L.S.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier
grade
Preferred source (of 2)‎

Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al.

The Spine Journal
2019 | Journal article
Contributors: Klyne, David M; Hodges, Paul W
Source: Self-asserted source
David Klyne

Letter to the editor concerning “Multiple confounders influence the association between low-grade systemic inflammation and musculoskeletal pain. A call for a prudent interpretation of the literature” by Schipholt et al.

Spine Journal
2019 | Journal article
EID:

2-s2.0-85073773297

Contributors: Klyne, D.M.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier
grade
Preferred source (of 2)‎

Biological factors in the transition from acute to persistent low back pain

2018 | Journal article
Contributors: Klyne, David Murray
Source: Self-asserted source
David Klyne

Individual variation in pain sensitivity and conditioned pain modulation in acute low back pain: effect of stimulus type, sleep, and psychological and lifestyle factors

The Journal of Pain
2018 | Journal article
Contributors: Klyne, David M; Moseley, G Lorimer; Sterling, Michele; Barbe, Mary F; Hodges, Paul W
Source: Self-asserted source
David Klyne

Individual Variation in Pain Sensitivity and Conditioned Pain Modulation in Acute Low Back Pain: Effect of Stimulus Type, Sleep, and Psychological and Lifestyle Factors

Journal of Pain
2018 | Journal article
EID:

2-s2.0-85046629736

Contributors: Klyne, D.M.; Moseley, G.L.; Sterling, M.; Barbe, M.F.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier
grade
Preferred source (of 2)‎

ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

European Spine Journal
2018 | Journal article
Contributors: Klyne, David M; Barbe, Mary F; van den Hoorn, Wolbert; Hodges, Paul W
Source: Self-asserted source
David Klyne

ISSLS PRIZE IN CLINICAL SCIENCE 2018: longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode—the good, the bad, and the ugly

European Spine Journal
2018 | Journal article
EID:

2-s2.0-85042199421

Contributors: Klyne, D.M.; Barbe, M.F.; van den Hoorn, W.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier
grade
Preferred source (of 2)‎

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: A potential factor in tissue effects in low back pain

Journal of Bodywork and Movement Therapies
2018 | Journal article
Contributors: Klyne, David; Barbe, Mary; Van Den Hoorn, Wolbert; Hodges, Paul
Source: Self-asserted source
David Klyne

Longitudinal analysis of inflammatory, psychological, and sleep-related factors following an acute low back pain episode: A potential factor in tissue effects in low back pain

Journal of Bodywork and Movement Therapies
2018-10 | Journal article
Part of ISSN: 1360-8592
Contributors: David Klyne; Mary Barbe; Wolbert Van Den Hoorn; Paul Hodges
Source: Self-asserted source
David Klyne via Crossref Metadata Search
grade
Preferred source (of 2)‎

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Brain, behavior, and immunity
2017 | Journal article
Contributors: Klyne, David M; Barbe, Mary F; Hodges, Paul W
Source: Self-asserted source
David Klyne

Systemic inflammatory profiles and their relationships with demographic, behavioural and clinical features in acute low back pain

Brain, Behavior, and Immunity
2017 | Journal article
EID:

2-s2.0-85007453210

Contributors: Klyne, D.M.; Barbe, M.F.; Hodges, P.W.
Source: Self-asserted source
David Klyne via Scopus - Elsevier
grade
Preferred source (of 2)‎

Effect of types and anatomic arrangement of painful stimuli on conditioned pain modulation

The Journal of Pain
2015 | Journal article
Contributors: Klyne, David M; Schmid, Annina B; Moseley, G Lorimer; Sterling, Michele; Hodges, Paul W
Source: Self-asserted source
David Klyne
Items per page:
Page 1 of 2