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Other IDs

Scopus Author ID: 6701444736

Keywords

X-ray Crystallography, Structural Biology, Signal Recognition Particle, SRP, Trypanosome, VSG

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Employment (1)

Northwestern University: Chicago, IL, US

Associate Professor (Biochemistry and Molecular Genetics)
Employment
Source: Self-asserted source
Douglas Freymann

Education and qualifications (2)

Harvard University: Cambridge, MA, US

1981 to 1989 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
Douglas Freymann

Massachusetts Institute of Technology: Cambridge, Massachusetts, US

1975 to 1979 | B.S. (Biology)
Education
Source: Self-asserted source
Douglas Freymann

Works (40)

A marine sponge-derived lectin reveals hidden pathway for thrombopoietin receptor activation

Nature Communications
2022-11-25 | Journal article
DOI: 10.1038/s41467-022-34921-2
Contributors: Hiromi Watari; Hiromu Kageyama; Nami Masubuchi; Hiroya Nakajima; Kako Onodera; Pamela J. Focia; Takumi Oshiro; Takashi Matsui; Yoshio Kodera; Tomohisa Ogawa et al.
Source: Self-asserted source
Douglas Freymann

Insight into human Miro1/2 domain organization based on the structure of its N-terminal GTPase

Journal of Structural Biology
2020-12 | Journal article
DOI: 10.1016/j.jsb.2020.107656
Part of ISSN: 1047-8477
Contributors: Kyle P. Smith; Pamela J. Focia; Srinivas Chakravarthy; Eric C. Landahl; Julian L. Klosowiak; Sarah E. Rice; Douglas Freymann
Source: Self-asserted source
Douglas Freymann

Structural assembly of the human Miro1/2 GTPases based on the crystal structure of the N-terminal GTPase domain

BioRxiv
2019-08-08 | Preprint
DOI: 10.1101/729251
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann

Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1718373115
EID:

2-s2.0-85047905835
Contributors: Yeung, P.S.-W.; Yamashita, M.; Ing, C.E.; Pomès, R.; Freymann, D.M.; Prakriya, M.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Structural insights into Parkin substrate lysine targeting from minimal Miro substrates

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep33019
EID:

2-s2.0-84986252317
Contributors: Klosowiak, J.L.; Park, S.; Smith, K.P.; French, M.E.; Focia, P.J.; Freymann, D.M.; Rice, S.E.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Miro: A Driver of the Kinesin Motor

2013 | Conference abstract
DOI: 10.1016/j.bpj.2012.11.259
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann

Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

EMBO Reports
2013 | Journal article
DOI: 10.1038/embor.2013.151
EID:

2-s2.0-84887126428
Contributors: Klosowiak, J.L.; Focia, P.J.; Chakravarthy, S.; Landahl, E.C.; Freymann, D.M.; Rice, S.E.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Structure of a tetrameric galectin fromCinachyrellasp. (ball sponge)

2012 | Journal article
DOI: 10.1107/S0907444912022834
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Nucleotide-binding flexibility in ultrahigh-resolution structures of the SRP GTPase Ffh

2008 | Journal article
DOI: 10.1107/S090744490802444X
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Structure of the GMPPNP-stabilized NG domain complex of the SRP GTPases Ffh and FtsY

2007 | Journal article
DOI: 10.1016/j.jsb.2006.10.025
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

X-ray structure of the T. Aquaticus Ftsy:GDP complex suggests functional roles for the C-terminal helix of the SRP GTPases

2007 | Journal article
DOI: 10.1002/prot.21200
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Analysis of protein hydration in ultrahigh-resolution structures of the SRP GTPase Ffh

2006 | Journal article
DOI: 10.1107/S0907444906040807
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Structure of a GDP:AlF4 Complex of the SRP GTPases Ffh and FtsY, and Identification of a Peripheral Nucleotide Interaction Site

2006 | Journal article
DOI: 10.1016/j.jmb.2006.05.031
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Heterodimeric GTPase Core of the SRP Targeting Complex

Science
2004 | Journal article
DOI: 10.1126/science.1090827
EID:

2-s2.0-0346373753
Contributors: Focia, P.J.; Shepotinovskaya, I.V.; Seidler, J.A.; Freymann, D.M.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh

2004 | Journal article
DOI: 10.1002/prot.10598
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Purification of RanGDP, RanGTP, and RanGMPPNP by ion exchange chromatography

2004 | Journal article
DOI: 10.1016/j.ab.2004.06.017
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Crystallization of the GMPPCP complex of the NG domains ofThermus aquaticusFfh and FtsY

2003 | Journal article
DOI: 10.1107/S0907444903016573
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology
2002 | Journal article
DOI: 10.1016/S0167-4838(02)00287-X
EID:

2-s2.0-0037140924
Contributors: Shepotinovskaya, I.V.; Freymann, D.M.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity

Proceedings of the National Academy of Sciences of the United States of America
2002 | Journal article
DOI: 10.1073/pnas.052715799
EID:

2-s2.0-0037022557
Contributors: Prasanna Murthy, S.N.; Iismaa, S.; Begg, G.; Freymann, D.M.; Graham, R.M.; Lorand, L.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Structural Basis for Mobility in the 1.1Å Crystal Structure of the NG Domain of Thermus aquaticus Ffh

2002 | Journal article
DOI: 10.1016/S0022-2836(02)00476-X
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

The Conformation of Bound GMPPNP Suggests a Mechanism for Gating the Active Site of the SRP GTPase

2001 | Journal article
DOI: 10.1016/S0969-2126(01)00641-4
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

THE SIGNAL RECOGNITION PARTICLE

2001 | Journal article
DOI: 10.1146/annurev.biochem.70.1.755
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi

Chemistry and Biology
2000 | Journal article
DOI: 10.1016/S1074-5521(00)00045-4
EID:

2-s2.0-0034521429
Contributors: Freymann, D.M.; Wenck, M.A.; Engel, J.C.; Feng, J.; Focia, P.J.; Eakin, A.E.; Craig, S.P.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor

Science
2000 | Journal article
DOI: 10.1126/science.288.5471.1640
EID:

2-s2.0-0034596007
Contributors: Peluso, P.; Herschlag, D.; Nock, S.; Freymann, D.M.; Johnson, A.E.; Walter, P.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design

2000 | Journal article
DOI: 10.1006/jmbi.2000.3544
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP

Nat Struct Biol
1999 | Journal article
DOI: 10.1038/11572
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Structure of the phylogenetically most conserved domain of SRP RNA

RNA
1999 | Journal article
DOI: 10.1017/S1355838299991458
EID:

2-s2.0-0032709518
Contributors: Schmitz, U.; Behrens, S.; Freymann, D.M.; Keenan, R.J.; Lukavsky, P.; Walter, P.; James, T.L.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Crystal Structure of the Signal Sequence Binding Subunit of the Signal Recognition Particle

1998 | Journal article
DOI: 10.1016/S0092-8674(00)81418-X
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Ion-channel-forming colicins

1998 | Journal article
DOI: 10.1016/S0959-440X(98)80132-2
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Crystal structure of colicin Ia

1997 | Journal article
DOI: 10.1038/385461a0
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

Crystallographic studies of parasite hgprtases pamela

FASEB Journal
1997 | Journal article
EID:

2-s2.0-33750100469
Contributors: Focia, J.; Somoza, J.R.; Freymann, D.M.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Structure of the conserved GTPase domain of the signal recognition particle

Nature
1997 | Journal article
DOI: 10.1038/385361a0
EID:

2-s2.0-0031017523
Contributors: Freymann, D.M.; Keenan, R.J.; Stroud, R.M.; Walter, P.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structure of the signal sequence recognition protein, Ffh

FASEB Journal
1997 | Journal article
EID:

2-s2.0-33750150526
Contributors: Keenan, R.; Freymann, D.; Walter, P.; Stroud, R.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP)

RNA
1996 | Journal article
EID:

2-s2.0-0029856954
Contributors: Schmitz, U.; Freymann, D.M.; James, T.L.; Keenan, R.J.; Vinayak, R.; Walter, P.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog

Proceedings of the National Academy of Sciences of the United States of America
1993 | Journal article
DOI: 10.1073/pnas.90.11.5229
EID:

2-s2.0-0027288333
Contributors: Bernstein, H.D.; Zopf, D.; Freymann, D.M.; Walter, P.
Source: Self-asserted source
Douglas Freymann via Scopus - Elsevier

2·9 Å resolution structure of the N-terminal domain of a variant surface glycoprotein from Trypanosoma brucei

1990 | Journal article
DOI: 10.1016/S0022-2836(05)80066-X
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
grade
Preferred source (of 2)‎

The partial crystal structure of a VSG from Trypanosoma brucei

1988 | Dissertation or Thesis
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann

Two variant surface glycoproteins of Trypanosoma Brucei of different sequence classes have similar 6 Å resolution X-ray structures

Nature
1987-01 | Journal article
DOI: 10.1038/325084a0
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann

Protein, DNA, and Virus Crystallography with a Focused Imaging Proportional Counter

Science
1986-05-30 | Journal article
DOI: 10.1126/science.3704639
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann

6 Å-Resolution X-ray structure of a variable surface glycoprotein from Trypanosoma brucei

Nature
1984-09-13 | Journal article
DOI: 10.1038/311167a0
Contributors: Douglas Freymann
Source: Self-asserted source
Douglas Freymann
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