Personal information

Heart development, Cardiomyocytes, Left ventricle, Cardiomyocyte maturation, Cardiomyocyte ageing, Heart failure

Biography

Dr Andreia Bernardo trained as a Molecular Biologist at the University of Aberdeen (2004-2008) before moving to the University of Cambridge for her Postdoc (2008-2012), where she specialised on early cell fate decisions and human pluripotent stem cell biology. She then secured a British Heart Foundation Intermediate fellowship (2012-2018) to study heart development. After, Andreia moved to the Francis Crick Institute (2018-2022) and under a Wellcome Trust Career re-entry fellowship she developed an interest in heart chamber specification. She is now a group leader at Imperial College London (2023-Present) working on heart development, maturation and ageing and using human pluripotent stem cells to understand the perturbations leading to cardiovascular disease. Andreia is also interested in the development of novel therapies for left ventricle diseases.

Activities

Employment (5)

Imperial College London: London, GB

2023-01-01 to present | Research Fellow (National Heart and Lung Institute)
Employment
Source: Self-asserted source
Andreia Sofia Bernardo

The Francis Crick Institute: London, GB

2019-03-11 to 2022-12-31 | Wellcome Trust Career re-entry fellow (Developmental Biology)
Employment
Source: Self-asserted source
Andreia Sofia Bernardo

The Francis Crick Institute: London, GB

2018-08-01 to 2019-03-10 | Postdoctoral Training Fellow (Developmental Biology)
Employment
Source: Self-asserted source
Andreia Sofia Bernardo

University of Cambridge: Cambridge, Cambridgeshire, GB

2012-10-01 to 2018-07-31 | BHF Intermediate Basic Science Research Fellow (Surgery)
Employment
Source: Self-asserted source
Andreia Sofia Bernardo

University of Cambridge: Cambridge, Cambridgeshire, GB

2007-11 to 2012-09 | Research Associate (Surgery)
Employment
Source: Self-asserted source
Andreia Sofia Bernardo

Education and qualifications (3)

University of Aberdeen: Aberdeen, Aberdeen, GB

2004-09 to 2008-09 | PhD in Molecular Biology; Foundation for Science and Technology Scholarship (Medical Sciences)
Education
Source: Self-asserted source
Andreia Sofia Bernardo

University of Aberdeen: Aberdeen, Aberdeen, GB

2003-09 to 2004-08 | Masters equivalent traneeship; Leonardo da Vinci Scolarship (Medical Sciencies)
Education
Source: Self-asserted source
Andreia Sofia Bernardo

University of Lisbon : Lisbon, Lisbon, PT

1999-09 to 2003-07 | Degree of Biology (Faculty of Sciences)
Education
Source: Self-asserted source
Andreia Sofia Bernardo

Funding (11)

Optimising best hPSLV-CM delivery method into the heart: bio-distribution and safety study

2024-04 to 2024-10 | Grant
Imperial College London (London, GB)
Source: Self-asserted source
Andreia Sofia Bernardo

Examining the mechanisms behind cardiomyocyte integration in the heart

2023-08 to 2026-08 | Grant
British Heart Foundation (London, GB)
GRANT_NUMBER:

PG/23/11464

Source: Self-asserted source
Andreia Sofia Bernardo

Electrophysiology study of hPSC-derived left ventricle cardiomyocytes

2022-10 to 2023-06 | Grant
The Francis Crick Institute (London, GB)
Source: Self-asserted source
Andreia Sofia Bernardo

Envelhecimento cardiovascular através da lente do Síndrome de Hutchinson-Gilford Progeria

2022-01-22 to 2023-12-21 | Grant
Fundação para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

173045PRJ

Source: Self-asserted source
Andreia Sofia Bernardo via DimensionsWizard

Validating human pluripotent stem cell derived left ventricle-like cardiomyocytes as a bespoke model for toxicology and drug discovery

2021-09 to 2023-12 | Grant
LifeArc (London, GB)
Source: Self-asserted source
Andreia Sofia Bernardo

Maturation of hPSC-derived left ventricle cardiomyocytes for cell therapy

2020-09 to 2021-09 | Grant
The Francis Crick Institute (London, GB)
Source: Self-asserted source
Andreia Sofia Bernardo

Left ventricle cardiomyocytes: their emergence, identity and maturation

2019-03-11 to 2024-03-11 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

210987/Z/18/Z

Source: Self-asserted source
Andreia Sofia Bernardo via DimensionsWizard
grade
Preferred source (of 2)‎

Molecular determinants underpinning development of human pluripotent stem cells into cardiomyocytes

Source: Self-asserted source
Andreia Sofia Bernardo
grade
Preferred source (of 3)‎

Study the new role Ccbe1 growth factor in creating heart tissue starting ES cell

Source: Self-asserted source
Andreia Sofia Bernardo via DimensionsWizard
grade
Preferred source (of 2)‎

Modelling endocrine pancreas development in mouse embryonic stem cells by activation of Pdx1 gene

2004-09 to 2007-12 | Award
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, PT)
GRANT_NUMBER:

SFRH/BD/17341/2004

Source: Self-asserted source
Andreia Sofia Bernardo

Characterisation of pancreatic Nestin expressing cells, possible progenitors of the islets of Langerhans

2003-09 to 2004-06 | Award
Leonardo da Vinci (Lisbon, PT)
Source: Self-asserted source
Andreia Sofia Bernardo

Works (23)

Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes.

Cell reports
2024-01-09 | Journal article
Contributors: Benjamin B Johnson; Cosson MV; Tsansizi LI; Holmes TL; Gilmore T; Katherine Hampton; Song OR; Vo NTN; Nasir A; Chabronova A et al.
Source: Self-asserted source
Andreia Sofia Bernardo

Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells.

Cell reports methods
2023-04-24 | Journal article
Contributors: Nicola Dark; Cosson MV; Tsansizi LI; Owen TJ; Ferraro E; Francis AJ; Selina Tsai; Bouissou C; Weston A; Collinson L et al.
Source: Self-asserted source
Andreia Sofia Bernardo

3D human induced pluripotent stem cell-derived bioengineered skeletal muscles for tissue, disease and therapy modeling.

Nature protocols
2023-02-15 | Journal article | Author
Contributors: Pinton L; Khedr M; Lionello VM; Sarcar S; Maffioletti SM; SUMITAVA DASTIDAR; Elisa Negroni; Choi S; Khokhar N; Bigot A et al.
Source: Self-asserted source
Andreia Sofia Bernardo

In vitro cellular reprogramming to model gonad development and its disorders

Science Advances
2023-01-06 | Journal article
Contributors: Nitzan Gonen; Caroline Eozenou; Richard Mitter; Maëva Elzaiat; Isabelle Stévant; Rona Aviram; Andreia Sofia Bernardo; Almira Chervova; Somboon Wankanit; Emmanuel Frachon et al.
Source: check_circle
Crossref

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture

Cells
2022-10-17 | Journal article
Contributors: Maria Faleeva; Ivan Diakonov; Prashant Srivastava; Masoud Ramuz; Gaia Calamera; Kjetil Andressen; Nadja Bork; Lorenza Tsansizi; Marie-Victoire Cosson; Andreia Bernardo et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro.

Stem cell reports
2022-03-24 | Journal article
Contributors: Fay Cooper; Gentsch GE; Mitter R; Bouissou C; Lyn Healy; Rodriguez AH; Smith JC; Bernardo AS
Source: Self-asserted source
Andreia Sofia Bernardo

Modelling Metabolic Shifts during Cardiomyocyte Differentiation, Iron Deficiency and Transferrin Rescue Using Human Pluripotent Stem Cells.

Metabolites
2021-12-22 | Journal article
Contributors: Benjamin B Johnson; Johannes Reinhold; Terri L Holmes; Moore JA; Cowell V; Bernardo AS; Rushworth SA; Vassilios Vassiliou; James Smith
Source: Self-asserted source
Andreia Sofia Bernardo

Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13.

Nature communications
2020-08 | Journal article
Contributors: Pitrez PR; Estronca L; Monteiro LM; Colell G; Vazão H; Santinha D; Harhouri K; Thornton D; Navarro C; Egesipe AL et al.
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central

Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states.

Epigenetics & Chromatin
2019-02-15 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo
grade
Preferred source (of 3)‎

Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

Biology Open
2018-01-01 | Journal article
Contributors: Andreia S. Bernardo; Alice Jouneau; Hendrik Marks; Philip Kensche; Julianna Kobolak; Kristine Freude; Vanessa Hall; Anita Feher; Zsuzsanna Polgar; Chiara Sartori et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development.

Stem cell reports
2016-10 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells.

Development (Cambridge, England)
2015-06 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Stable methylation at promoters distinguishes epiblast stem cells from embryonic stem cells and the in vivo epiblasts.

Stem cells and development
2014-09 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Differentiation of trophoblast cells from human embryonic stem cells: to be or not to be?

Reproduction (Cambridge, England)
2014-05 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Directed differentiation of embryonic origin-specific vascular smooth muscle subtypes from human pluripotent stem cells.

Nature protocols
2014-04 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.

Nature biotechnology
2012-01 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

BRACHYURY and CDX2 mediate BMP-induced differentiation of human and mouse pluripotent stem cells into embryonic and extraembryonic lineages.

Cell stem cell
2011-08 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells.

Stem cells (Dayton, Ohio)
2009-02 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Pancreatic transcription factors and their role in the birth, life and survival of the pancreatic beta cell.

Molecular and cellular endocrinology
2008-11 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Stem cells and metabolic diseases.

Biochemical Society transactions
2008-06 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Embryonic stem cell therapy for diabetes mellitus.

Seminars in cell & developmental biology
2007-12 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Presence of endocrine and exocrine markers in EGFP-positive cells from the developing pancreas of a nestin/EGFP mouse.

Molecular and cellular endocrinology
2006-07 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Purification and Characterization of a Population of EGFP-Expressing Cells from the Developing Pancreas of a Neurogenin3/EGFP Transgenic Mouse.

Organogenesis
2005-01 | Journal article
Source: Self-asserted source
Andreia Sofia Bernardo via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (6 reviews for 3 publications/grants)

Review activity for Cell reports. (1)
Review activity for Communications biology. (1)
Review activity for Stem cell reports. (4)