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ResearcherID: H-3277-2013
SciProfiles: 2865290

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Employment (1)

Infex Therapeutics: Alderley Park, Cheshire, GB

2018-11 to present | Head of Biology (Biology)
Employment
Source: Self-asserted source
Victoria Savage

Professional activities (2)

British Society for Antimicrobial Chemotherapy: Birmingham, GB

Service
Source: Self-asserted source
Victoria Savage

European Society of Clinical Microbiology and Infectious Diseases: Basel, CH

2018 to present
Membership
Source: Self-asserted source
Victoria Savage

Works (15)

Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial

Cells
2023-06-21 | Journal article
DOI: 10.3390/cells12131683
Contributors: Nicola Ooi; Ian R. Cooper; Brendan Norman; James A. Gallagher; Nick Sireau; George Bou-Gharios; Lakshminarayan R. Ranganath; Victoria J. Savage
Source: check_circle
Crossref
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Preferred source (of 2)‎

Discovery and structure-activity relationships of a novel oxazolidinone class of bacterial type II topoisomerase inhibitors.

Bioorganic & medicinal chemistry letters
2022-02 | Journal article
DOI: 10.1016/j.bmcl.2022.128648
PMID: 35231579
Contributors: Lyons A; Kirkham J; Blades K; Orr D; Dauncey E; Smith O; Dick E; Walker R; Matthews T; Bunt A et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Restoring carbapenem efficacy: a novel carbapenem companion targeting metallo-β-lactamases in carbapenem-resistant Enterobacterales

Journal of Antimicrobial Chemotherapy
2021-01-19 | Journal article
DOI: 10.1093/jac/dkaa455
Contributors: Nicola Ooi; Victoria E Lee; Nathan Chalam-Judge; Rebecca Newman; Andrew J Wilkinson; Ian R Cooper; David Orr; Sally Lee; Victoria J Savage
Source: check_circle
Crossref

Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 1.

RSC medicinal chemistry
2020-09 | Journal article
DOI: 10.1039/d0md00174k
PMID: 34095844
PMC: PMC8126884
Contributors: Kirk R; Kirk R; Ratcliffe A; Noonan G; Uosis-Martin M; Lyth D; Bardell-Cox O; Massam J; Schofield P; Hindley S et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2.

RSC medicinal chemistry
2020-09 | Journal article
DOI: 10.1039/d0md00175a
PMID: 34095845
PMC: PMC8126889
Contributors: Kirk R; Kirk R; Ratcliffe A; Noonan G; Uosis-Martin M; Lyth D; Bardell-Cox O; Massam J; Schofield P; Lyons A et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Design, synthesis and antibacterial properties of pyrimido[4,5-b]indol-8-amine inhibitors of DNA gyrase.

Bioorganic & medicinal chemistry letters
2018-05 | Journal article
DOI: 10.1016/j.bmcl.2018.05.049
PMID: 30122228
Contributors: McGarry DH; Cooper IR; Walker R; Warrilow CE; Pichowicz M; Ratcliffe AJ; Salisbury AM; Savage VJ; Moyo E; Maclean J et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.

Antimicrobial agents and chemotherapy
2017-04 | Journal article
DOI: 10.1128/aac.02100-16
PMID: 28223393
PMC: PMC5404544
Contributors: Charrier C; Salisbury AM; Savage VJ; Duffy T; Moyo E; Chaffer-Malam N; Ooi N; Newman R; Cheung J; Metzger R et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Efficacy of a Novel Tricyclic Topoisomerase Inhibitor in a Murine Model of Neisseria gonorrhoeae Infection.

Antimicrobial agents and chemotherapy
2016-08 | Journal article
DOI: 10.1128/aac.00913-16
PMID: 27324777
PMC: PMC4997832
Contributors: Savage VJ; Charrier C; Salisbury AM; Box H; Chaffer-Malam N; Huxley A; Kirk R; Noonan GM; Mohmed S; Craighead MW et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Discovery and structure-activity relationships of a novel isothiazolone class of bacterial type II topoisomerase inhibitors.

Bioorganic & medicinal chemistry letters
2016-07 | Journal article
DOI: 10.1016/j.bmcl.2016.07.061
PMID: 27499455
Contributors: Cooper IR; McCarroll AJ; McGarry D; Kirkham J; Pichowicz M; Walker R; Warrilow C; Salisbury AM; Savage VJ; Moyo E et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

In vitro biological evaluation of novel broad-spectrum isothiazolone inhibitors of bacterial type II topoisomerases.

The Journal of antimicrobial chemotherapy
2016-06 | Journal article
DOI: 10.1093/jac/dkw228
PMID: 27353465
Contributors: Charrier C; Salisbury AM; Savage VJ; Moyo E; Forward H; Ooi N; Cheung J; Metzger R; McGarry D; Walker R et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Biological profiling of novel tricyclic inhibitors of bacterial DNA gyrase and topoisomerase IV.

The Journal of antimicrobial chemotherapy
2016-03 | Journal article
DOI: 10.1093/jac/dkw061
PMID: 27032669
Contributors: Savage VJ; Charrier C; Salisbury AM; Moyo E; Forward H; Chaffer-Malam N; Metzger R; Huxley A; Kirk R; Uosis-Martin M et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

European journal of medicinal chemistry
2013-06 | Journal article
DOI: 10.1016/j.ejmech.2013.06.017
PMID: 23867605
Contributors: Škedelj V; Perdih A; Brvar M; Kroflič A; Dubbée V; Savage V; O'Neill AJ; Solmajer T; Bešter-Rogač M; Blanot D et al.
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Population diversification in Staphylococcus aureus biofilms may promote dissemination and persistence.

PloS one
2013-04 | Journal article
DOI: 10.1371/journal.pone.0062513
PMID: 23646129
PMC: PMC3640034
Contributors: Savage VJ; Chopra I; O'Neill AJ
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Staphylococcus aureus biofilms promote horizontal transfer of antibiotic resistance.

Antimicrobial agents and chemotherapy
2013-01 | Journal article
DOI: 10.1128/aac.02008-12
PMID: 23357771
PMC: PMC3623343
Contributors: Savage VJ; Chopra I; O'Neill AJ
Source: Self-asserted source
Victoria Savage via Europe PubMed Central

Increased mutability of Staphylococci in biofilms as a consequence of oxidative stress.

PloS one
2012-10 | Journal article
DOI: 10.1371/journal.pone.0047695
PMID: 23110091
PMC: PMC3480535
Contributors: Ryder VJ; Chopra I; O'Neill AJ
Source: Self-asserted source
Victoria Savage via Europe PubMed Central
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