Personal information

stem cells, iPS, RPE, retinal pigment epithelium, disease modelling, bestrophinopathies, AMD, The London Project to Cure Blindness
United Kingdom

Activities

Employment (5)

University College London: London, London, GB

2020-08-01 to present | Lecturer and Principal Investigator (Institute of Ophthalmology)
Employment
Source: Self-asserted source
Amanda-Jayne Carr

University College London: London, GB

2007-09-14 to 2020-07-31 | Senior Research Fellow (Institute of Opthalmology)
Employment
Source: Self-asserted source
Amanda-Jayne Carr

University College London: London, GB

2006-04-10 to 2007-09-14 | Research Associate (Institute of Ophthalmology)
Employment
Source: Self-asserted source
Amanda-Jayne Carr

University College London: London, GB

2005-06-13 to 2006-04-07 | Wellcome Trust VIP Fellowship (Anatomy and Developmental Biology)
Employment
Source: Self-asserted source
Amanda-Jayne Carr

University College London: London, GB

2002-06-10 to 2005-06-06 | Research Associate (Anatomy and Developmental Biology)
Employment
Source: Self-asserted source
Amanda-Jayne Carr

Education and qualifications (2)

University of Manchester Faculty of Life Sciences: Manchester, Manchester, GB

1998-09-21 to 2002-06-07 | PhD Neuroscience (Plants, microbes and Animal Biology)
Education
Source: Self-asserted source
Amanda-Jayne Carr

Keele University: Keele, Staffordshire, GB

1995-09-18 to 1998-06-06 | BSc Biology and Biochemistry (Double First Class Honours) (Life Science)
Education
Source: Self-asserted source
Amanda-Jayne Carr

Funding (3)

Using induced pluripotent stem cells to investigate Bestrophin- associated macular degeneration

2015-01 to 2018-01 | Grant
Macular Society (Andover, Hampshire, GB)
Source: Self-asserted source
Amanda-Jayne Carr

UK Department for Business Innovation and Skills Travel Grant (Japan)

2013-03 to present | Award
UK Department for Business Innovation and Skills (Japan) (Tokyo, JP)
Source: Self-asserted source
Amanda-Jayne Carr

Single cell circadian oscillators

2004-06 to present | Award
Royal Society (London, GB)
Source: Self-asserted source
Amanda-Jayne Carr

Works (35)

A revolution in sight: using induced pluripotent stem cells to investigate diseases of the retinal pigment epithelium

The Biochemist
2023-12-20 | Journal article
Part of ISSN: 0954-982X
Part of ISSN: 1740-1194
Contributors: Ana Alonso-Carriazo Fernandez; Zaynab Butt; Evangeline Foster; Amanda-Jayne Carr
Source: Self-asserted source
Amanda-Jayne Carr

Establishment and characterization of an iPSC line (UCLi023-A) derived from a Late-Onset Retinal Degeneration patient carrying a founder mutation in C1QTNF5

Stem Cell Research
2023-06 | Journal article
Part of ISSN: 1873-5061
Contributors: Ana Alonso-Carriazo Fernández; Phoebe Ashley-Norman; Zaynab Butt; Mariya Moosajee; Amanda-Jayne Francis Carr
Source: Self-asserted source
Amanda-Jayne Carr

Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model

2021-12-18 | Preprint
Contributors: Amy Leung; Almudena Sacristan-Reviriego; Pedro R. L. Perdigão; Hali Sai; Michalis Georgiou; Angelos Kalitzeos; Amanda-Jayne F. Carr; Peter J. Coffey; Michel Michaelides; James Bainbridge et al.
Source: check_circle
Crossref

Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies

Therapeutic Advances in Ophthalmology
2021-01 | Journal article
Contributors: Simranjeet Singh Grewal; Joseph J. Smith; Amanda-Jayne F. Carr
Source: check_circle
Crossref

Annexin A8 regulates Wnt signaling to maintain the phenotypic plasticity of retinal pigment epithelial cells

Scientific Reports
2020-01-27 | Journal article
Contributors: Katharina Lueck; Amanda-Jayne F. Carr; Lu Yu; John Greenwood; Stephen E. Moss
Source: check_circle
Crossref

Bestrophin1: A Gene that Causes Many Diseases

Retinal Degenerative Diseases
2019 | Book chapter
Part of ISBN: 9783030273774
Part of ISBN: 9783030273781
Part of ISSN: 0065-2598
Part of ISSN: 2214-8019
Source: Self-asserted source
Amanda-Jayne Carr

Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell‐Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation

2019-04-29 | Journal article
Part of ISSN: 2157-6564
Part of ISSN: 2157-6580
Source: Self-asserted source
Amanda-Jayne Carr

Phase 1 clinical study of an embryonic stem cell–derived retinal pigment epithelium patch in age-related macular degeneration

2018-03-19 | Journal article
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Amanda-Jayne Carr

Regulation of retinal pigment epithelial cell phenotype by Annexin A8

Scientific Reports
2017-07-05 | Journal article
Contributors: Katharina Lueck; Amanda-Jayne F. Carr; Dimitrios Stampoulis; Volker Gerke; Ursula Rescher; John Greenwood; Stephen E. Moss
Source: check_circle
Crossref

Rescue of the MERTK phagocytic defect in a human iPSC disease model using translational read-through inducing drugs

Scientific Reports
2017-03-03 | Journal article
Contributors: Conor M. Ramsden; Britta Nommiste; Amelia R. Lane; Amanda-Jayne F. Carr; Michael B. Powner; Matthew J. K. Smart; Li Li Chen; Manickam N. Muthiah; Andrew R. Webster; Anthony T. Moore et al.
Source: check_circle
Crossref

Mislocalisation of BEST1 in iPSC-derived retinal pigment epithelial cells from a family with autosomal dominant vitreoretinochoroidopathy (ADVIRC).

2016 | Journal article
Contributors: Carter DA; Smart MJ; Letton WV; Ramsden CM; Nommiste B; Chen LL; Fynes K; Muthiah MN; Goh P; Lane A et al.
Source: Self-asserted source
Amanda-Jayne Carr via Europe PubMed Central

Spontaneous Generation of Patient-Specific Retinal Pigment Epithelial Cells Using Induced Pluripotent Stem Cell Technology

Working with Stem Cells
2016-08-20 | Book chapter
Part of ISBN: 978-3319305806
Source: Self-asserted source
Amanda-Jayne Carr

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.

2016-06 | Journal article
Contributors: Parfitt DA; Lane A; Ramsden CM; Carr AJ; Munro PM; Jovanovic K; Schwarz N; Kanuga N; Muthiah MN; Hull S et al.
Source: Self-asserted source
Amanda-Jayne Carr via Europe PubMed Central

Using Stem Cells to Model Diseases of the Outer Retina.

2015 | Journal article
Contributors: Yvon C; Ramsden CM; Lane A; Powner MB; da Cruz L; Coffey PJ; Carr AJ
Source: Self-asserted source
Amanda-Jayne Carr via Europe PubMed Central

Translational read-through of the RP2 Arg120stop mutation in patient iPSC-derived retinal pigment epithelium cells.

2015-02 | Journal article
Contributors: Schwarz N; Carr AJ; Lane A; Moeller F; Chen LL; Aguilà M; Nommiste B; Muthiah MN; Kanuga N; Wolfrum U et al.
Source: Self-asserted source
Amanda-Jayne Carr via Europe PubMed Central

Engineering efficient retinal pigment epithelium differentiation from human pluripotent stem cells.

2014-11-01 | Journal article
Source: Self-asserted source
Amanda-Jayne Carr

Neural retinal regeneration with pluripotent stem cells.

2014-04 | Book chapter
PMID:

24732764

Source: Self-asserted source
Amanda-Jayne Carr

Development of human embryonic stem cell therapies for age-related macular degeneration

Trends in Neurosciences
2013-07 | Journal article
DOI:

10.1016/j.tins.2013.03.006

Part of ISSN:

0166-2236

Contributors: Amanda-Jayne F. Carr; Matthew J.K. Smart; Conor M. Ramsden; Michael B. Powner; Lyndon da Cruz; Peter J. Coffey
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Stem cells in retinal regeneration: past, present and future

Development
2013-05 | Journal article
DOI:

10.1242/dev.092270

Part of ISSN:

0950-1991

Contributors: C. M. Ramsden; M. B. Powner; A.-J. F. Carr; M. J. K. Smart; L. da Cruz; P. J. Coffey
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Degeneration of cortical function in the Royal College of Surgeons rat

Vision Research
2011-10 | Journal article
DOI:

10.1016/j.visres.2011.08.012

Part of ISSN:

0042-6989

Contributors: Carlos Gias; Anthony Vugler; Jean Lawrence; Amanda Jayne Carr; Li Li Chen; Ahmed Ahmado; Ma’ayan Semo; Peter J. Coffey
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

iPS cells - an alternative source of RPE?

Acta Ophthalmologica
2011-09 | Journal article
DOI:

10.1111/j.1755-3768.2011.2231.x

Part of ISSN:

1755-375X

Contributors: A CARR
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Induction of Differentiation by Pyruvate and DMEM in the Human Retinal Pigment Epithelium Cell Line ARPE-19

Investigative Ophthalmology & Visual Science
2011-07-08 | Journal article
DOI:

10.1167/iovs.10-6374

Part of ISSN:

0146-0404

Contributors: A. Ahmado; A.-J. Carr; A. A. Vugler; M. Semo; C. Gias; J. M. Lawrence; L. L. Chen; F. K. Chen; P. Turowski; L. da Cruz et al.
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.

2011-06 | Journal article
PMID:

21738400

Source: Self-asserted source
Amanda-Jayne Carr

Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat.

2009-12 | Journal article
PMID:

19997644

Source: Self-asserted source
Amanda-Jayne Carr

Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay.

2009-02 | Journal article
PMID:

19204785

Source: Self-asserted source
Amanda-Jayne Carr

Elucidating the phenomenon of HESC-derived RPE: Anatomy of cell genesis, expansion and retinal transplantation

Experimental Neurology
2008 | Journal article
DOI:

10.1016/j.expneurol.2008.09.007

Part of ISSN:

0014-4886

Contributors: Anthony Vugler; Amanda-Jayne Carr; Jean Lawrence; Li Li Chen; Kelly Burrell; Andrew Wright; Peter Lundh; Ma'ayan Semo; Ahmad Ahmado; Carlos Gias et al.
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Embryonic stem cells and retinal repair

Mechanisms of Development
2007-11 | Journal article
DOI:

10.1016/j.mod.2007.08.002

Part of ISSN:

0925-4773

Contributors: Anthony Vugler; Jean Lawrence; James Walsh; Amanda Carr; Carlos Gias; Ma’ayan Semo; Ahmad Ahmado; Lyndon da Cruz; Peter Andrews; Peter Coffey
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Light Reaches the Very Heart of the Zebrafish Clock

Chronobiol Int
2006-01 | Journal article
DOI:

10.1080/07420520500464395

Part of ISSN:

0742-0528

Contributors: Amanda‐Jayne F. Carr; T. Katherine Tamai; Lucy C. Young; Veronica Ferrer; Marcus P. Dekens; David Whitmore
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

The fish watch - zebrafish: a clock in every cell

2005-12 | Magazine article
Source: Self-asserted source
Amanda-Jayne Carr

Zebrafish circadian clocks: cells that see light

Biochem. Soc. Trans
2005-10-01 | Journal article
DOI:

10.1042/bst20050962

Part of ISSN:

0300-5127

Contributors: T.K. Tamai; A.J. Carr; D. Whitmore
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

The tau mutation in the Syrian hamster differentially reprograms the circadian clock in the SCN and peripheral tissues.

2005-04 | Journal article
PMID:

15834107

Source: Self-asserted source
Amanda-Jayne Carr

Imaging of single light-responsive clock cells reveals fluctuating free-running periods

Nat Cell Biol
2005-03 | Journal article
DOI:

10.1038/ncb1232

Part of ISSN:

1465-7392

Contributors: Amanda-Jayne F. Carr; David Whitmore
Source: Self-asserted source
Amanda-Jayne Carr via Crossref Metadata Search

Photoperiod differentially regulates circadian oscillators in central and peripheral tissues of the Syrian hamster.

2003-09 | Journal article
Contributors: Carr AJ; Johnston JD; Semikhodskii AG; Nolan T; Cagampang FR; Stirland JA; Loudon AS
Source: Self-asserted source
Amanda-Jayne Carr via Europe PubMed Central

Photoperiod Differentially Regulates Circadian Oscillators in Central and Peripheral Tissues of the Syrian Hamster

Current Biology
2003-09-02 | Journal article
Source: Self-asserted source
Amanda-Jayne Carr
grade
Preferred source (of 2)‎

Evidence for an endogenous per1- and ICER-independent seasonal timer in the hamster pituitary gland.

2003-05-01 | Journal article
PMID:

12724339

Source: Self-asserted source
Amanda-Jayne Carr