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Employment (1)

Université Laval: Québec, Quebec, CA

2019-08 to 2024-02 | Postdoctoral fellow (Département de Biologie)
Employment
Source: Self-asserted source
David Bradley

Education and qualifications (4)

University of Cambridge: Cambridge, Cambridgeshire, GB

2015-06 to 2018-11 | PhD (EMBL-EBI)
Education
Source: Self-asserted source
David Bradley

University of Cambridge: Cambridge, Cambridgeshire, GB

2014-10 to 2015-05 | Master of Research (Department of Veterinary Medicine & EMBL-EBI)
Education
Source: Self-asserted source
David Bradley

University of Cambridge: Cambridge, Cambridgeshire, GB

2013-10 to 2014-06 | Master of Natural Sciences (Department of Biochemistry)
Education
Source: Self-asserted source
David Bradley

University of Cambridge: Cambridge, Cambridgeshire, GB

2010-10 to 2013-06 | Bachelor of Arts (Department of Genetics)
Education
Source: Self-asserted source
David Bradley

Funding (1)

Exploring evolutionary mechanisms to buffer spurious crosstalk in signalling networks

2020-08 to 2022-08 | Grant
EMBO (Heidelberg, DE)
Source: Self-asserted source
David Bradley

Works (16)

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

Nature Communications
2025-02-11 | Journal article
DOI: 10.1038/s41467-025-56597-0
Contributors: Soham Dibyachintan; Alexandre K. Dubé; David Bradley; Pascale Lemieux; Ugo Dionne; Christian R. Landry
Source: check_circle
Crossref

The fitness cost of spurious phosphorylation

The EMBO Journal
2024-09-10 | Journal article
DOI: 10.1038/s44318-024-00200-7
Contributors: David Bradley; Alexander Hogrebe; Rohan Dandage; Alexandre K Dubé; Mario Leutert; Ugo Dionne; Alexis Chang; Judit Villén; Christian R Landry
Source: check_circle
Crossref

The substrate quality of CK2 target sites has a determinant role on their function and evolution

Cell Systems
2024-06 | Journal article
DOI: 10.1016/j.cels.2024.05.005
Part of ISSN: 2405-4712
Contributors: David Bradley; Chantal Garand; Hugo Belda; Isabelle Gagnon-Arsenault; Moritz Treeck; Sabine Elowe; Christian R. Landry
Source: Self-asserted source
David Bradley

Residues Neighboring an SH3-Binding Motif Participate in the InteractionIn Vivo

2024-05-14 | Preprint
DOI: 10.1101/2024.05.13.593936
Contributors: David F. Jordan; Alexandre K. Dubé; Ugo Dionne; David Bradley; Christian R. Landry
Source: check_circle
Crossref

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network

2024-02-24 | Preprint
DOI: 10.1101/2024.02.23.581840
Contributors: Soham Dibyachintan; Alexandre K Dube; David Bradley; Pascale Lemieux; Ugo Dionne; Christian R Landry
Source: check_circle
Crossref

Evolution and inhibition of the FIKK effector kinase family inP. falciparum

2024-02-23 | Preprint
DOI: 10.1101/2024.02.22.581535
Contributors: Hugo Belda; David Bradley; Evangelos Christodoulou; Stephanie D. Nofal; Malgorzata Broncel; David Jones; Heledd Davies; M. Teresa Bertran; Andrew G. Purkiss; Roksana W. Ogrodowicz et al.
Source: check_circle
Crossref

Dissection of the role of a Src homology 3 domain in the evolution of binding preference of paralogous proteins

GENETICS
2024-01-03 | Journal article
DOI: 10.1093/genetics/iyad175
Part of ISSN: 1943-2631
Contributors: Pascale Lemieux; David Bradley; Alexandre K Dubé; Ugo Dionne; Christian R Landry
Source: Self-asserted source
David Bradley

Parallel Nonfunctionalization of CK1δ/ε Kinase Ohnologs Following a Whole-Genome Duplication Event

Molecular Biology and Evolution
2023-12-01 | Journal article
DOI: 10.1093/molbev/msad246
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Contributors: Daniel Evans-Yamamoto; Alexandre K Dubé; Gourav Saha; Samuel Plante; David Bradley; Isabelle Gagnon-Arsenault; Christian R Landry
Source: Self-asserted source
David Bradley

The evolution of post-translational modifications

Current Opinion in Genetics and Development
2022-10 | Journal article
DOI: 10.1016/j.gde.2022.101956
Part of ISSN: 0959-437X
Contributors: David Bradley
Source: Self-asserted source
David Bradley

Protein context shapes the specificity of SH3 domain-mediated interactions in vivo.

Nature communications
2021-03-12 | Journal article
DOI: 10.1038/s41467-021-21873-2
PMID: 33712617
PMC: PMC7954794
Source: Self-asserted source
David Bradley

Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases

Cell Reports
2021-01 | Journal article
DOI: 10.1016/j.celrep.2020.108602
Part of ISSN: 2211-1247
Source: Self-asserted source
David Bradley

Prediction of Signed Protein Kinase Regulatory Circuits

Cell Systems
2020-05 | Journal article
DOI: 10.1016/j.cels.2020.04.005
Part of ISSN: 2405-4712
Source: Self-asserted source
David Bradley

Selective deployment of transcription factor paralogs with submaximal strength facilitates gene regulation in the immune system.

Nature immunology
2019-08-26 | Journal article
DOI: 10.1038/s41590-019-0471-5
PMID: 31451789
Source: Self-asserted source
David Bradley

Evolution of protein kinase substrate recognition at the active site

PLOS Biology
2019-06-24 | Journal article
DOI: 10.1371/journal.pbio.3000341
Contributors: David Bradley; Benjamin E. Turk; Pedro Beltrao
Source: check_circle
Crossref

The evolution of protein kinase specificity

Apollo - University of Cambridge Repository
2019-03-12 | Journal article
DOI: 10.17863/cam.37729
Source: Self-asserted source
David Bradley

Evolution, dynamics and dysregulation of kinase signalling

Current Opinion in Structural Biology
2018-02 | Journal article
DOI: 10.1016/j.sbi.2017.12.008
Contributors: David Ochoa; David Bradley; Pedro Beltrao
Source: check_circle
Crossref

Peer review (3 reviews for 3 publications/grants)

Review activity for Nature communications (1)
Review activity for PLOS genetics. (1)
Review activity for Review Commons (1)
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