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Other IDs

Scopus Author ID: 35884406600

Keywords

RNA products, Research and Development, Equity advocate, Immunology, Vaccines, Biopharmaceuticals

Countries

Brazil

Biography

She holds a PhD in Cellular and Molecular Biology from the Oswaldo Cruz Foundation (2013), with an internship at the AIDS Vaccine Research Lab (UW-Madison-USA), a Master's degree in Parasite Biology from the Oswaldo Cruz Foundation (2005), and a degree in Biomedicine from the Federal University of the State of Rio de Janeiro (2002). She is currently the Head of the Implementation of a Regional Hub for the Development and Production of RNA Products for the Pan American Health Organization (PAHO/WHO), at the Vice-Directorate for Innovation (Bio-Manguinhos-FIOCRUZ), where she works on the development of RNA-based vaccines and therapies entirely developed in Brazil, with patents filled. This initiative seeks regional self-sufficiency in the production of vaccines and medicines, as well as the democratization of the RNA platform for the countries of Latin America and the Caribbean. In 2021, she was awarded by Women in Science of PDA Brazil, and in 2022, by SIBEN-Argentina with the Altruism Award for the Improvement of Global Health, for her important role in the development of the RNA platform in Brazil. In 2024, together with Bio-Manguinhos quality team, she received the Oswaldo Cruz Award granted at the 8th Internation Symposyum on Immunobiologicals for the work of developing the control strategy for RNA vaccines at FIOCRUZ. Also in 2024, she became member of Advisory Board for Chanjo Imperial Hub Initiative- Imperial College London. She is now Visiting Fellow at the University of New South Wales - Australia. She has 19 years of experience in the areas of Immunology and in the Development of Vaccines and Biopharmaceuticals, as well as have been actively advocating for Public Health and Equity in the Distribution of Vaccines and Health Products in Low and Middle Income Countries.

Activities

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Employment (3)

Fundação Oswaldo Cruz: Rio de Janeiro, BR

2021-09-21 to present | Head of RNA Products Development (Technological Development Projects Office)
Employment
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Fundação Oswaldo Cruz: Rio de Janeiro, BR

2017-09-17 to 2021-09-21 | Head of LATAM Group (Monoclonal Antibodies Technology Laboratory (LATAM)- Technological Development Vice Directory- Bio-Manguinhos)
Employment
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Fundação Oswaldo Cruz: Rio de Janeiro, BR

2006-10-26 to 2017-09-27 | Tecnologist (Tecnological Immunology Laboratory)
Employment
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Education and qualifications (4)

Fundação Oswaldo Cruz: Rio de Janeiro, BR

2009-07-01 to 2013-07-01 | PhD (Cellular and Molecular Biology- Instituto Oswaldo Cruz)
Education
Source: Self-asserted source
Patrícia Cristina da Costa Neves

University of Wisconsin Health: Madison, US

2010-01-05 to 2010-03-06 | Internship- PhD (AIDS Vaccine Research Laboratory)
Qualification
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Fundação Oswaldo Cruz: Rio de Janeiro, BR

2003-01-31 to 2005-10-05 | Master (Parasitary Biology- Instituto Oswaldo Cruz)
Education
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Universidade Federal do Estado do Rio de Janeiro: Rio de Janeiro, BR

1997-07-01 to 2001-12-01 | Bachelor (Biomedicin)
Education
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Professional activities (2)

University of New South Wales: Sydney, AU

2025-01-31 to present | Visiting Fellow (School of Biotechnology and Biomolecular Sciences)
Invited position
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Imperial College London: London, GB

2024-12-01 to present | Scientific Advisory Board Member (Chanjo Imperial Hub)
Membership
Source: Self-asserted source
Patrícia Cristina da Costa Neves

Works (32)

Immunogenicity of PvCyRPA, PvCelTOS and Pvs25 chimeric recombinant protein of Plasmodium vivax in murine model

Frontiers in Immunology
2024 | Journal article
DOI: 10.3389/fimmu.2024.1392043
EID:

2-s2.0-85197368375

Part of ISSN: 16643224
Contributors: Matos, A.D.S.; Soares, I.F.; Rodrigues-da-Silva, R.N.; Rodolphi, C.M.; Albrecht, L.; Donassolo, R.A.; Lopez-Camacho, C.; Ano Bom, A.P.D.; Neves, P.C.D.C.; Conte, F.D.P. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Unleashing Fungicidal Forces: Exploring the Synergistic Power of Amphotericin B-Loaded Nanoparticles and Monoclonal Antibodies

Journal of Fungi
2024 | Journal article
DOI: 10.3390/jof10050344
EID:

2-s2.0-85194381660

Part of ISSN: 2309608X
Contributors: Souza, C.S.D.; Lopes, V.R.D.C.; Barcellos, G.; Alexandrino-Junior, F.; Neves, P.C.D.C.; Patricio, B.F.D.C.; Rocha, H.V.A.; Ano Bom, A.P.D.; Figueiredo, A.B.C.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 3)‎

Evaluation of Two Adjuvant Formulations for an Inactivated Yellow Fever 17DD Vaccine Candidate in Mice

Vaccines
2023 | Journal article
DOI: 10.3390/vaccines11010073
EID:

2-s2.0-85146819367

Part of ISSN: 2076393X
Contributors: Cajaraville, A.C.D.R.A.; Gomes, M.P.D.B.; Azamor, T.; Pereira, R.C.; Neves, P.C.D.C.; De Luca, P.M.; Lima, S.M.B.D.; Gaspar, L.P.; Caride, E.; Freire, M.D.S. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

Inactivated and Immunogenic SARS-CoV-2 for Safe Use in Immunoassays and as an Immunization Control for Non-Clinical Trials

Viruses
2023 | Journal article
DOI: 10.3390/v15071486
EID:

2-s2.0-85165970260

Part of ISSN: 19994915
Contributors: Gomes, M.P.D.B.; Linhares, J.H.R.; dos Santos, T.P.; Pereira, R.C.; Santos, R.T.; da Silva, S.A.; Souza, M.C.D.O.; da Silva, J.F.A.; Trindade, G.F.; Gomes, V.S. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

The role of immune subtyping in glioma mRNA vaccine development

Immunotherapy
2023 | Journal article
DOI: 10.2217/imt-2023-0027
EID:

2-s2.0-85168221361

Part of ISSN: 17507448 1750743X
Contributors: Guterres, A.; Abrahim, M.; Da Costa Neves, P.C.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

Animal models and SARS-CoV-2-induced pulmonary and neurological injuries

Memorias do Instituto Oswaldo Cruz
2022 | Journal article
DOI: 10.1590/0074-02760220239
EID:

2-s2.0-85146877144

Part of ISSN: 16788060 00740276
Contributors: Pinto, M.A.; da Silva, A.S.; Flores Rodrigues, D.D.R.; Müller, R.; de Vasconcelos, G.A.L.B.M.; da Costa Neves, P.C.; de Oliveira, J.M.; Marchevsky, R.S.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Biotechnological Evolution of siRNA Molecules: From Bench Tool to the Refined Drug

Pharmaceuticals
2022 | Journal article
DOI: 10.3390/ph15050575
EID:

2-s2.0-85131018009

Part of ISSN: 14248247
Contributors: de Brito e Cunha, D.; Frederico, A.B.T.; Azamor, T.; Melgaço, J.G.; da Costa Neves, P.C.; Bom, A.P.D.A.; Tilli, T.M.; Missailidis, S.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 3)‎

The emergence of new lineages of the Mpox virus could affect the 2022 outbreak

bioRxiv
2022 | Other
DOI: 10.1101/2022.07.07.498743
EID:

2-s2.0-85160877985

Part of ISSN: 26928205
Contributors: Abrahim, M.; Guterres, A.; da Costa Neves, P.C.; Bom, A.P.D.A.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

Activation of an effective immune response after yellow fever vaccination is associated with the genetic background and early response of ifn-γ and clec5a

Viruses
2021 | Journal article
DOI: 10.3390/v13010096
EID:

2-s2.0-85100121800

Part of ISSN: 19994915
Contributors: Azamor, T.; da Silva, A.M.V.; Melgaço, J.G.; Dos Santos, A.P.; Xavier-Carvalho, C.; Alvarado-Arnez, L.E.; Batista-Silva, L.R.; de Souza Matos, D.C.; Bayma, C.; Missailidis, S. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1

Frontiers in Immunology
2021 | Journal article
DOI: 10.3389/fimmu.2021.764746
EID:

2-s2.0-85120952983

Part of ISSN: 16643224
Contributors: Azamor, T.; Cunha, D.P.; da Silva, A.M.V.; Bezerra, O.C.D.L.; Ribeiro-Alves, M.; Calvo, T.L.; Kehdy, F.D.S.G.; Manta, F.D.N.; Pinto, T.G.D.T.; Ferreira, L.P. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha

Frontiers in Cellular and Infection Microbiology
2021 | Journal article
DOI: 10.3389/fcimb.2021.656393
EID:

2-s2.0-85111009499

Part of ISSN: 22352988
Contributors: Silva, A.M.V.D.; Alvarado-Arnez, L.E.; Azamor, T.; Batista-Silva, L.R.; Leal-Calvo, T.; Bezerra, O.C.D.L.; Ribeiro-Alves, M.; Kehdy, F.D.S.G.; Neves, P.C.D.C.; Bayma, C. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Safety and immunogenicity of 17DD attenuated yellow fever vaccine in howler monkeys (Alouatta spp.)

Journal of Medical Primatology
2021 | Journal article
DOI: 10.1111/jmp.12501
EID:

2-s2.0-85096645408

Part of ISSN: 16000684 00472565
Contributors: Tavares da Silva Fernandes, A.; Moreira, S.B.; Gaspar, L.P.; Simões, M.; Cajaraville, A.C.D.R.A.; Pereira, R.C.; Gomes, M.P.D.B.; Linhares, J.H.R.; Santos, V.D.O.; Santos, R.T. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Two-step in vitro model to evaluate the cellular immune response to SARS-CoV-2

Cells
2021 | Journal article
DOI: 10.3390/cells10092206
EID:

2-s2.0-85115895944

Part of ISSN: 20734409
Contributors: Melgaço, J.G.; Azamor, T.; Silva, A.M.V.; Linhares, J.H.R.; Dos Santos, T.P.; Mendes, Y.S.; de Lima, S.M.B.; Fernandes, C.B.; da Silva, J.; de Souza, A.F. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

Cellular and Molecular Immunology Approaches for the Development of Immunotherapies against the New Coronavirus (SARS-CoV-2): Challenges to Near-Future Breakthroughs

Journal of Immunology Research
2020 | Journal article
DOI: 10.1155/2020/8827670
EID:

2-s2.0-85098715166

Part of ISSN: 23147156 23148861
Contributors: Melgaço, J.G.; Brito E Cunha, D.; Azamor, T.; Da Silva, A.M.V.; Tubarão, L.N.; Gonçalves, R.B.; Monteiro, R.Q.; Missailidis, S.; Da Costa Neves, P.C.; Ano Bom, A.P.D.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
grade
Preferred source (of 2)‎

In vitro inhibition of SARS-CoV-2 infection by bovine lactoferrin

bioRxiv
2020 | Other
DOI: 10.1101/2020.05.13.093781
EID:

2-s2.0-85098909876

Part of ISSN: 26928205
Contributors: de Carvalho, C.A.M.; da Rocha Matos, A.; Caetano, B.C.; de Sousa, I.P.; da Costa Campos, S.P.; Geraldino, B.R.; Barros, C.A.; de Almeida, M.A.P.; Rocha, V.P.; da Silva, A.M.V. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Initial development of biosimilar immune checkpoint blockers using HEK293 cells

Protein Expression and Purification
2020 | Journal article
DOI: 10.1016/j.pep.2020.105596
EID:

2-s2.0-85079215638

Part of ISSN: 10960279 10465928
Contributors: Ramos, M.B.; Araújo, A.E.V.D.; Pestana, C.P.; Ano Bom, A.P.D.; Bastos, R.C.; de Almeida Oliveira, A.; da Costa Neves, P.C.; da Silva Junior, H.C.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Aptamers as delivery agents of siRNA and chimeric formulations for the treatment of cancer

Pharmaceutics
2019 | Journal article
DOI: 10.3390/pharmaceutics11120684
EID:

2-s2.0-85076775741

Part of ISSN: 19994923
Contributors: Bom, A.P.D.A.; Neves, P.C.C.; de Almeida, C.E.B.; Silva, D.; Missailidis, S.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Congenital Zika Syndrome is associated with maternal genetic background

bioRxiv
2019 | Other
DOI: 10.1101/715862
EID:

2-s2.0-85095630491

Part of ISSN: 26928205
Contributors: Azamor, T.; Cunha, D.P.; da Silva, A.M.V.; de Lima Bezerra, O.C.; Ribeiro-Alves, M.; Calvo, T.L.; de Souza Gomes Kehdy, F.; de Neves Manta, F.S.; Pinto, T.G.; Ferreira, L.P. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Different aspects of platelet evaluation in dengue: Measurement of circulating mediators, ability to interact with the virus, the degree of activation and quantification of intraplatelet protein content

Virus Research
2019 | Journal article
DOI: 10.1016/j.virusres.2018.09.013
EID:

2-s2.0-85056635418

Part of ISSN: 18727492 01681702
Contributors: Barros, T.A.D.C.; Batista, D.D.O.; Torrentes de Carvalho, A.; Costa Faria, N.R.D.; Barreto-Vieira, D.F.; Jácome, F.C.; Barth, O.M.; Nogueira, R.M.R.; Neves, P.C.D.C.; Matos, D.C.D.S. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Identification and validation of specific B-cell epitopes of hantaviruses associated to hemorrhagic fever and renal syndrome

PLoS Neglected Tropical Diseases
2019 | Journal article
DOI: 10.1371/JOURNAL.PNTD.0007915
EID:

2-s2.0-85076687336

Part of ISSN: 19352735 19352727
Contributors: De Paiva Conte, F.; Tinoco, B.C.; Chaves, T.S.; De Oliveira, R.C.; Mansur, J.F.; Mohana-Borges, R.; De Lemos, E.R.S.; Da Costa Neves, P.C.; Rodrigues-Da-Silva, R.N.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Plant-produced subunit vaccine candidates against yellow fever induce virus neutralizing antibodies and confer protection against viral challenge in animal models

American Journal of Tropical Medicine and Hygiene
2018 | Journal article
DOI: 10.4269/ajtmh.16-0293
EID:

2-s2.0-85041516091

Part of ISSN: 00029637
Contributors: Tottey, S.; Shoji, Y.; Jones, R.M.; Chichester, J.A.; Green, B.J.; Musiychuk, K.; Si, H.; Manceva, S.D.; Rhee, A.; Shamloul, M. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures

Vaccine
2015 | Journal article
DOI: 10.1016/j.vaccine.2015.03.077
EID:

2-s2.0-84939567661

Part of ISSN: 18732518 0264410X
Contributors: Pereira, R.C.; Silva, A.N.M.R.; Souza, M.C.O.; Silva, M.V.; Neves, P.P.C.C.; Silva, A.A.M.V.; Matos, D.D.C.S.; Herrera, M.A.O.; Yamamura, A.M.Y.; Freire, M.S. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Improved genetic stability of recombinant yellow fever 17d virus expressing a lentiviral gag gene fragment

Virology
2014 | Journal article
DOI: 10.1016/j.virol.2014.01.017
EID:

2-s2.0-84893592979

Part of ISSN: 00426822 10960341
Contributors: Santana, M.G.V.D.; Neves, P.C.C.; Santos, J.R.D.; Lima, N.S.; Santos, A.A.C.D.; Watkins, D.I.; Galler, R.; Bonaldo, M.C.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Early IFN-gamma production after YF 17D vaccine virus immunization in mice and its association with adaptive immune responses

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0081953
EID:

2-s2.0-84891949728

Part of ISSN: 19326203
Contributors: Neves, P.C.C.; Santos, J.R.; Tubarão, L.N.; Bonaldo, M.C.; Galler, R.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Recombinant Yellow Fever Viruses Elicit CD8<sup>+</sup> T Cell Responses and Protective Immunity against Trypanosoma cruzi

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0059347
EID:

2-s2.0-84875122482

Part of ISSN: 19326203
Contributors: Nogueira, R.T.; Nogueira, A.R.; Pereira, M.C.S.; Rodrigues, M.M.; Neves, P.C.C.; Galler, R.; Bonaldo, M.C.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Activated lymphocytes and high liver expression of IFN-γ are associated with fulminant hepatic failure in patients

Liver International
2012 | Journal article
DOI: 10.1111/j.1478-3231.2011.02654.x
EID:

2-s2.0-83255162070

Part of ISSN: 14783223 14783231
Contributors: dos Santos, D.C.M.; Neves, P.C.C.; Azeredo, E.L.; Pelajo-Machado, M.; Martinho, J.M.S.G.; Pacheco-Moreira, L.F.; Araújo, C.C.V.; Cruz, O.G.; de Oliveira, J.M.; Pinto, M.A.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

GagCM9-specific CD8 <sup>+</sup> T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivo

PLoS ONE
2011 | Journal article
DOI: 10.1371/journal.pone.0023515
EID:

2-s2.0-80052065199

Part of ISSN: 19326203
Contributors: Vojnov, L.; Martins, M.A.; Almeida, J.R.; Ende, Z.; Rakasz, E.G.; Reynolds, M.R.; Leon, E.J.; Weisgrau, K.L.; Burwitz, B.J.; Folkvord, J.M. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

CD8<sup>+</sup> gamma-delta TCR<sup>+</sup> and CD4<sup>+</sup> T cells produce IFN-γ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses

Vaccine
2010 | Journal article
DOI: 10.1016/j.vaccine.2010.09.090
EID:

2-s2.0-78649680321

Part of ISSN: 0264410X
Contributors: Neves, P.C.C.; Rudersdorf, R.A.; Galler, R.; Bonaldo, M.C.; Santana, M.G.V.D.; Mudd, P.A.; Martins, M.A.; Rakasz, E.G.; Wilson, N.A.; Watkins, D.I.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

The live-attenuated yellow fever vaccine 17D induces broad and potent T cell responses against several viral proteins in Indian rhesus macaques-implications for recombinant vaccine design

Immunogenetics
2010 | Journal article
DOI: 10.1007/s00251-010-0461-0
EID:

2-s2.0-77957576725

Part of ISSN: 00937711 14321211
Contributors: Mudd, P.A.; Piaskowski, S.M.; Neves, P.C.C.; Rudersdorf, R.; Kolar, H.L.; Eernisse, C.M.; Weisgrau, K.L.; De Santana, M.G.V.; Wilson, N.A.; Bonaldo, M.C. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Eosinophils involved in fulminant hepatic failure are associated with high interleukin-6 expression and absence of interleukin-5 in liver and peripheral blood

Liver International
2009 | Journal article
DOI: 10.1111/j.1478-3231.2008.01872.x
EID:

2-s2.0-62749160837

Part of ISSN: 14783223 14783231
Contributors: Dos Santos, D.C.M.; da Silva Gomes Martinho, J.M.; Pacheco-Moreira, L.F.; de Araújo, C.C.V.; Caroli-Bottino, A.; Pannain, V.L.; Trinta, K.S.; Gandini, M.; da Costa Neves, P.C.; de Souza Matos, D.C. et al.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

Pattern of functional antibody activity against Haemophilus influenzae type b (Hib) in infants immunized with diphtheria-tetanus-pertussis/Hib Brazilian combination vaccine

Brazilian Journal of Medical and Biological Research
2009 | Journal article
DOI: 10.1590/S0100-879X2009005000039
EID:

2-s2.0-73349101417

Part of ISSN: 1414431X 0100879X
Contributors: Matos, D.C.S.; Silva, A.M.V.; Neves, P.C.C.; Martins, R.M.; Homma, A.; Marcovistz, R.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier

TLR expression and NK cell activation after human yellow fever vaccination

Vaccine
2009 | Journal article
DOI: 10.1016/j.vaccine.2009.07.028
EID:

2-s2.0-68949187833

Part of ISSN: 0264410X
Contributors: da Costa Neves, P.C.; de Souza Matos, D.C.; Marcovistz, R.; Galler, R.
Source: Self-asserted source
Patrícia Cristina da Costa Neves via Scopus - Elsevier
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