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Keywords

Gamma aminobutyric acid receptors, allosteric modulation, protein-ligand interactions, protein struc

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United States

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Employment (2)

Boston Children's Hospital : Boston, Massachusetts, US

2019-09-03 to present | Instructor (Neurology)
Employment
Source: Self-asserted source
Selwyn Jayakar

Harvard Medical School: Boston, MA, US

2014-07-01 to present | Instructor in Neurobiology (Neurobiology)
Employment
Source: Self-asserted source
Selwyn Jayakar

Education and qualifications (3)

Harvard Medical School: Boston, MA, US

2010-04-01 to 2014-06-31 | Postdoctoral research fellow (Neurobiology)
Education
Source: Self-asserted source
Selwyn Jayakar

University of Toledo: Toledo, OH, US

2003-08-27 to 2009-05-29 | PhD (Neurosciences)
Education
Source: Self-asserted source
Selwyn Jayakar

Birla Institute of Technology and Science: Pilani, RJ, IN

1999-08-06 to 2003-06-17 | B.Pharm (Hons.) (Pharmacy)
Education
Source: Self-asserted source
Selwyn Jayakar

Funding (1)

The Alice and Joseph E. Brooks Funds

Award
The Alice and Joseph E. Brooks Funds (Boston, US)
GRANT_NUMBER: The Alice and Joseph E. Brooks Funds
Source: Self-asserted source
Selwyn Jayakar

Works (16)

The oncomodulin receptor ArmC10 enables axon regeneration in mice after nerve injury and neurite outgrowth in human iPSC–derived sensory neurons

Science Translational Medicine
2023-08-09 | Journal article
DOI: 10.1126/scitranslmed.adg6241
Contributors: Lili Xie; Yuqin Yin; Selwyn Jayakar; Riki Kawaguchi; Qing Wang; Sheri Peterson; Caleb Shi; Bruna Lenfers Turnes; Zihe Zhang; Juan Oses-Prieto et al.
Source: check_circle
Crossref

Developing nociceptor-selective treatments for acute and chronic pain

Science Translational Medicine
2021-11-10 | Journal article
DOI: 10.1126/scitranslmed.abj9837
Contributors: Selwyn Jayakar; Jaehoon Shim; Sooyeon Jo; Bruce P. Bean; Ilyas Singeç; Clifford J. Woolf
Source: check_circle
Crossref

Orthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking Cessation.

2015 | Journal article
DOI: 10.3389/fnmol.2015.00071
PMID: 26635524
PMC: PMC4658446
Contributors: Mohamed TS; Jayakar SS; Hamouda AK
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

2015-09 | Journal article
DOI: 10.1074/jbc.m115.672006
PMID: 26229099
PMC: PMC4645599
Contributors: Jayakar SS; Zhou X; Savechenkov PY; Chiara DC; Desai R; Bruzik KS; Miller KW; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

PACAP induces plasticity at autonomic synapses by nAChR-dependent NOS1 activation and AKAP-mediated PKA targeting.

2014-11 | Journal article
DOI: 10.1016/j.mcn.2014.08.007
PMID: 25168001
Contributors: Jayakar SS; Pugh PC; Dale Z; Starr ER; Cole S; Margiotta JF
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

2014-10 | Journal article
DOI: 10.1074/jbc.m114.581728
PMID: 25086038
PMC: PMC4183786
Contributors: Jayakar SS; Zhou X; Chiara DC; Dostalova Z; Savechenkov PY; Bruzik KS; Dailey WP; Miller KW; Eckenhoff RG; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites!

2014-07 | Journal article
DOI: 10.1007/s12031-013-0150-1
PMID: 24158732
Contributors: Hamouda AK; Jayakar SS; Chiara DC; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

2013-07 | Journal article
DOI: 10.1074/jbc.m113.479725
PMID: 23677991
PMC: PMC3707639
Contributors: Chiara DC; Jayakar SS; Zhou X; Zhang X; Savechenkov PY; Bruzik KS; Miller KW; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog.

2013-03 | Journal article
DOI: 10.1074/jbc.m112.435909
PMID: 23300078
PMC: PMC3585054
Contributors: Jayakar SS; Dailey WP; Eckenhoff RG; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

2012-01 | Journal article
DOI: 10.1021/bi201772m
PMID: 22243422
PMC: PMC3274767
Contributors: Chiara DC; Dostalova Z; Jayakar SS; Zhou X; Miller KW; Cohen JB
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Abelson family tyrosine kinases regulate the function of nicotinic acetylcholine receptors and nicotinic synapses on autonomic neurons.

2011-07 | Journal article
DOI: 10.1124/mol.111.071308
PMID: 21502378
PMC: PMC3127535
Contributors: Jayakar SS; Margiotta JF
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses.

2010-02 | Journal article
DOI: 10.1016/j.mcn.2009.11.007
PMID: 19958833
PMC: PMC2818583
Contributors: Pugh PC; Jayakar SS; Margiotta JF
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Depolarization promotes survival of ciliary ganglion neurons by BDNF-dependent and -independent mechanisms.

2006-03 | Journal article
DOI: 10.1016/j.ydbio.2005.12.008
PMID: 16426601
Contributors: Pugh PC; Zhou X; Jayakar SS; Margiotta JF
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

3-Chloro-2-methylphenyl-substituted semicarbazones: synthesis and anticonvulsant activity.

2004-08 | Journal article
DOI: 10.1016/j.ejmech.2004.03.008
PMID: 15276306
Contributors: Yogeeswari P; Thirumurugan R; Kavya R; Samuel JS; Stables J; Sriram D
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

AMPA receptor regulation mechanisms: future target for safer neuroprotective drugs.

2004-06 | Journal article
DOI: 10.1080/00207450490430453
PMID: 15204061
Contributors: Jayakar SS; Dikshit M
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central

Abl family kinases regulate neuronal nicotinic receptors and synapses in chick ciliary ganglion neurons.

Supervised student publication
OTHER-ID:

5001
Contributors: Jayakar SS
Source: Self-asserted source
Selwyn Jayakar via Europe PubMed Central
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