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Works (23)

Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment

Hypertension
2023-10 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.123.21392
Contributors: Zachary S. Clayton; Matthew J. Rossman; Sophia A. Mahoney; Ravinandan Venkatasubramanian; Grace S. Maurer; David A. Hutton; Nicholas S. VanDongen; Nathan T. Greenberg; Abigail G. Longtine; Katelyn R. Ludwig et al.
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Initiation of 3,3‐dimethyl‐1‐butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice

The Journal of Physiology
2022-11 | Journal article
DOI: 10.1113/JP283581
Contributors: Abigail G. Casso; Nicholas S. VanDongen; Rachel A. Gioscia‐Ryan; Zachary S. Clayton; Nathan T. Greenberg; Brian P. Ziemba; David A. Hutton; Andrew P. Neilson; Kevin P. Davy; Douglas R. Seals et al.
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Crossref

Cellular Senescence and the Associated Secretome Contribute to Age‐Related Vascular Dysfunction

Experimental Biology 2022
2022-05-13 | Conference abstract
DOI: 10.1096/fasebj.2022.36.s1.r2053
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

Age-related Aortic Stiffness Can Be Transferred and Ameliorated via Fecal Microbiota Transplant in Mice

The GSA 2021 Annual Scientific Meeting
2021-12-17 | Conference abstract
DOI: 10.1093/geroni/igab046.3017
Part of ISSN: 2399-5300
Source: Self-asserted source
David A Hutton

The Protective Effects of Apigenin on Cognitive Function and The Brain Transcriptome in Old Mice

The GSA 2021 Annual Scientific Meeting
2021-12-17 | Conference abstract
DOI: 10.1093/geroni/igab046.2562
Part of ISSN: 2399-5300
Source: Self-asserted source
David A Hutton

Lifelong physical activity attenuates age- and Western-style diet-related declines in physical function and adverse changes in skeletal muscle mass and inflammation

Experimental Gerontology
2021-11 | Journal article
DOI: 10.1016/j.exger.2021.111632
Part of ISSN: 0531-5565
PMID: 34822971
Source: Self-asserted source
David A Hutton

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Hypertension
2021-08 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.120.16895
PMID: 33966451
Source: Self-asserted source
David A Hutton
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Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging

American Journal of Physiology-Heart and Circulatory Physiology
2021-07-01 | Journal article
DOI: 10.1152/ajpheart.00118.2021
Part of ISSN: 0363-6135
Part of ISSN: 1522-1539
PMID: 34114892
Source: Self-asserted source
David A Hutton
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Anthracycline chemotherapy‐mediated vascular dysfunction as a model of accelerated vascular aging

Aging and Cancer
2021-06 | Journal article
DOI: 10.1002/aac2.12033
Part of ISSN: 2643-8909
Part of ISSN: 2643-8909
PMID: 34212156
Source: Self-asserted source
David A Hutton

Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin.

Experimental Gerontology
2021-06-18 | Journal article
DOI: 10.1016/j.exger.2021.111451
PMID: 34147619
Source: Self-asserted source
David A Hutton

Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin

Hypertension
2021-05 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.120.16759
PMID: 33719511
Source: Self-asserted source
David A Hutton
grade
Preferred source (of 2)‎

Apigenin restores endothelial function by ameliorating oxidative stress, prevents foam cell formation, reverses aortic stiffening, and mitigates vascular inflammation with aging

Experimental Biology 2021
2021-05-14 | Conference abstract
DOI: 10.1096/fasebj.2021.35.s1.02221
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton
grade
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Cellular senescence mediates doxorubicin‐induced arterial dysfunction via activation of mitochondrial oxidative stress and the mammalian target of rapamycin

Experimental Biology 2021
2021-05-14 | Conference abstract
DOI: 10.1096/fasebj.2021.35.s1.00283
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

Late‐Life Treatment with the Senolytic ABT‐263 Reverses Aortic Stiffening and Improves Endothelial Function with Aging

Experimental Biology 2021
2021-05-14 | Conference abstract
DOI: 10.1096/fasebj.2021.35.s1.02642
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

The Gut Microbiome Targeted Compound 3,3‐Dimethyl‐1‐butanol Attenuates In Vivo Aortic Stiffening with Aging

Experimental Biology 2021
2021-05-14 | Conference abstract
DOI: 10.1096/fasebj.2021.35.s1.05374
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice

The Journal of Physiology
2021-02 | Journal article
DOI: 10.1113/jp280607
Part of ISSN: 0022-3751
Part of ISSN: 1469-7793
PMID: 33103241
Source: Self-asserted source
David A Hutton

Doxorubicin-Induced Oxidative Stress and Endothelial Dysfunction in Conduit Arteries Is Prevented by Mitochondrial-Specific Antioxidant Treatment

JACC: CardioOncology
2020-09 | Journal article
DOI: 10.1016/j.jaccao.2020.06.010
Part of ISSN: 2666-0873
PMID: 33073250
Source: Self-asserted source
David A Hutton

Cerebrovascular reactivity: a new frontier for measuring cognitive health in models of accelerated ageing?

The Journal of Physiology
2020-06-12 | Journal article
DOI: 10.1113/jp279949
PMID: 32468584
Source: Self-asserted source
David A Hutton

Increased Large Elastic Artery Stiffening with The Anthracycline Chemotherapy Drug Doxorubicin: Potential Role of Excess Mitochondrial Superoxide

Experimental Biology 2020
2020-04-19 | Conference abstract
DOI: 10.1096/fasebj.2020.34.s1.04407
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton
grade
Preferred source (of 2)‎

The commonly‐used anthracycline chemotherapy drug Doxorubicin impairs vascular endothelial function via stimulation of mitochondrial superoxide

Experimental Biology 2020
2020-04-19 | Conference abstract
DOI: 10.1096/fasebj.2020.34.s1.02708
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

Vascular Endothelial Dysfunction Induced by a Western‐Style Diet Can Be Transferred via Fecal Microbiota Transplant in Mice

Experimental Biology 2020
2020-04-19 | Conference abstract
DOI: 10.1096/fasebj.2020.34.s1.07405
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
David A Hutton

Anthracycline Chemotherapy-Associated Cardiotoxicity: Lifestyle Interventions to Reduce Cardiovascular Disease Risk

SCAN's Pulse
2020-01-06 | Newsletter article
Part of ISSN: 1528-5707
Source: Self-asserted source
David A Hutton

Physical activity‐related suppression of cancer growth: is a transient increase in cytokine production required for tumour angiogenesis?

The Journal of Physiology
2019-08 | Journal article
DOI: 10.1113/JP278347
PMID: 31298739
Source: Self-asserted source
David A Hutton
grade
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