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Biography
I have graduated at the Rennes 1 university in France in Cellular and Molecular Biology and Health Science, and obtained a PhD at the INRA department Fish Physiology in Rennes in 1992. During my post doc with Dr John Crowe at UC Davis (California), I explored the behavior of sperm plasma membrane during freeze-thawing. I have then been hired at INRA to work on sperm cryopreservation in fish where I aimed to understand how the cellular damages induced by cryopreservation were affecting sperm ability to fertilize the eggs and to produce healthy offspring. I am presently deputy director of the Fish Physiology and Genomics department of INRAE (former INRA), and head of the research group MaRĂ© (fish spermatogenesis, germ cell cryopreservation and fish regeneration from cryopreserved material). My most recent research is devoted to explore how the reproductive biotechnologies can affect the epigenetic profile of fish cells (sperm and somatic cells), and the consequences on embryo development. This includes the epigenetic reprogramming of somatic cells used for reconstruction by nuclear transfer, and the epigenetic alteration induced by cryopreservation. Most of the research projects I am involved in deal with genetic resources cryobanking and control of alterations that may affect offspring development.