Personal information

gene therapy
Australia

Activities

Education and qualifications (5)

Human Genetics Society of Australasia: Sydney, NSW, AU

1994 | HGSA Certified Clinical Geneticist
Education
Source: Self-asserted source
Ian E Alexander

University of New South Wales: Sydney, NSW, AU

1991 | PhD (Garvan Institute)
Education
Source: Self-asserted source
Ian E Alexander

Royal Australasian College of Physicians: Sydney, NSW, AU

1989 | FRACP (Paediatrics)
Education
Source: Self-asserted source
Ian E Alexander

University of New South Wales: Sydney, NSW, AU

1982 | MBBS
Education
Source: Self-asserted source
Ian E Alexander

University of New South Wales: Sydney, NSW, AU

1980 | BMedSci
Education
Source: Self-asserted source
Ian E Alexander

Works (50 of 119)

Items per page:
Page 1 of 3

AAV-Mediated Gene Delivery to the Mouse Liver.

Methods in molecular biology (Clifton, N.J.)
2019-01 | Journal article
Contributors: Cunningham SC; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Codon-Optimization of Wild-Type Adeno-Associated Virus Capsid Sequences Enhances DNA Family Shuffling while Conserving Functionality.

Molecular therapy. Methods & clinical development
2018-11 | Journal article
Contributors: Cabanes-Creus M; Ginn SL; Amaya AK; Liao SHY; Westhaus A; Hallwirth CV; Wilmott P; Ward J; Dilworth KL; Santilli G et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Directed Evolution of Adeno-Associated Virus Vectors in Human Cardiomyocytes for Cardiac Gene Therapy.

Heart, lung & circulation
2018-11 | Journal article
Contributors: Kok CY; Alexander I; Lisowski L; Kizana E
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Age-Related Seroprevalence of Antibodies Against AAV-LK03 in a UK Population Cohort.

Human gene therapy
2018-10 | Journal article
Contributors: Perocheau DP; Cunningham S; Lee J; Antinao Diaz J; Waddington SN; Gilmour K; Eaglestone S; Lisowski L; Thrasher AJ; Alexander IE et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction.

JCI insight
2018-08 | Journal article
Contributors: Paul-Heng M; Leong M; Cunningham E; Bunker DLJ; Bremner K; Wang Z; Wang C; Tay SS; McGuffog C; Logan GJ et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Blockade of HMGB1 Attenuates Diabetic Nephropathy in Mice.

Scientific reports
2018-05 | Journal article
Contributors: Chen X; Ma J; Kwan T; Stribos EGD; Messchendorp AL; Loh YW; Wang X; Paul M; Cunningham EC; Habib M et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy clinical trials worldwide to 2017: An update.

The journal of gene medicine
2018-04 | Journal article
Contributors: Ginn SL; Amaya AK; Alexander IE; Edelstein M; Abedi MR
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Partial pancreatic transdifferentiation of primary human hepatocytes in the livers of a humanised mouse model.

The journal of gene medicine
2018-04 | Journal article
Contributors: Ren B; La QT; O'Brien BA; Nassif NT; Tan Y; Gerace D; Martiniello-Wilks R; Torpy F; Dane AP; Alexander IE et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization.

Angiogenesis
2018-01 | Journal article
Contributors: Tu L; Wang JH; Barathi VA; Prea SM; He Z; Lee JH; Bender J; King AE; Logan GJ; Alexander IE et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity.

Molecular therapy : the journal of the American Society of Gene Therapy
2018-01 | Journal article
Contributors: Paulk NK; Pekrun K; Zhu E; Nygaard S; Li B; Xu J; Chu K; Leborgne C; Dane AP; Haft A et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Clinical Trial of MGMT(P140K) gene therapy in the treatment of paediatric patients with brain tumours.

Human gene therapy
2018-01 | Journal article
Contributors: Kramer B; Singh R; Wischusen J; Velickovic R; Rush A; Middlemiss S; Ching YW; Alexander IE; McCowage GB
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

Heart, lung & circulation
2018-01 | Journal article
Contributors: Kanthan A; Fahmy P; Rao R; Pouliopoulos J; Alexander IE; Thomas SP; Kizana E
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy for monogenic liver diseases: clinical successes, current challenges and future prospects

Journal of Inherited Metabolic Disease
2017 | Journal article
EID:

2-s2.0-85020105413

Contributors: Baruteau, J.; Waddington, S.N.; Alexander, I.E.; Gissen, P.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Identification of liver-specific enhancer-promoter activity in the 3′ untranslated region of the wild-type AAV2 genome

Nature Genetics
2017 | Journal article
EID:

2-s2.0-85026396371

Contributors: Logan, G.J.; Dane, A.P.; Hallwirth, C.V.; Smyth, C.M.; Wilkie, E.E.; Amaya, A.K.; Zhu, E.; Khandekar, N.; Ginn, S.L.; Liao, S.H.Y. et al.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Limiting Thymic Precursor Supply Increases the Risk of Lymphoid Malignancy in Murine X-Linked Severe Combined Immunodeficiency

Molecular Therapy - Nucleic Acids
2017 | Journal article
EID:

2-s2.0-85015650406

Contributors: Ginn, S.L.; Hallwirth, C.V.; Liao, S.H.Y.; Teber, E.T.; Arthur, J.W.; Wu, J.; Lee, H.C.; Tay, S.S.; Hu, M.; Reddel, R.R. et al.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Ub-ISAP: A streamlined UNIX pipeline for mining unique viral vector integration sites from next generation sequencing data

BMC Bioinformatics
2017 | Journal article
EID:

2-s2.0-85027564501

Contributors: Kamboj, A.; Hallwirth, C.V.; Alexander, I.E.; McCowage, G.B.; Kramer, B.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Delivering efficient liver-directed AAV-mediated gene therapy.

Gene therapy
2017-05 | Journal article
Contributors: Baruteau J; Waddington SN; Alexander IE; Gissen P
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy.

Gene therapy
2016-10 | Journal article
Contributors: Baoutina A; Bhat S; Zheng M; Partis L; Dobeson M; Alexander IE; Emslie KR
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.

Scientific reports
2016-07 | Journal article
Contributors: Smith RH; Hallwirth CV; Westerman M; Hetherington NA; Tseng YS; Cecchini S; Virag T; Ziegler ML; Rogozin IB; Koonin EV et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Coherence analysis discriminates between retroviral integration patterns in CD34(+) cells transduced under differing clinical trial conditions.

Molecular therapy. Methods & clinical development
2015 | Journal article
Contributors: Hallwirth CV; Garg G; Peters TJ; Kramer BA; Malani NV; Hyman J; Ruan X; Ginn SL; Hetherington NA; Veeravalli L et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs

Cell Stem Cell
2015 | Journal article
EID:

2-s2.0-84926200105

Contributors: Menon, T.; Firth, A.L.; Scripture-Adams, D.D.; Galic, Z.; Qualls, S.J.; Gilmore, W.B.; Ke, E.; Singer, O.; Anderson, L.S.; Bornzin, A.R. et al.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

The tryptophan "damage" signal and indoleamine 2, 3-dioxygenase

Indoleamines: Sources, Role in Biological Processes and Health Effects
2015 | Book
EID:

2-s2.0-84955745817

Contributors: Earl, J.W.; Nath, C.E.; Hanlon, M.G.; Leach, W.C.; Dale, R.C.; Logan, G.J.; Alexander, I.E.; Bishop, G.A.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Methyl-Guanine-Methyl-Transferase Transgenic Bone Marrow Transplantation Allows N,N-bis(2-chloroethyl)-Nitrosourea Driven Donor Mixed-Chimerism Without Graft-Versus-Host Disease, and With Donor-Specific Allograft Tolerance.

Transplantation
2015-12 | Journal article
Contributors: Hu M; Kramer B; Zhang GY; Wang YM; Watson D; Howden B; McCowage G; Alexander IE; Gunning P; Alexander SI
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus.

Gene therapy
2015-11 | Journal article
Contributors: Dane AP; Cunningham SC; Kok CY; Logan GJ; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Adeno-associated virus serotypes for gene therapeutics.

Current opinion in pharmacology
2015-10 | Journal article
Contributors: Lisowski L; Tay SS; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice.

Molecular therapy : the journal of the American Society of Gene Therapy
2015-09 | Journal article
Contributors: Mak KY; Chin R; Cunningham SC; Habib MR; Torresi J; Sharland AF; Alexander IE; Angus PW; Herath CB
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system.

Hepatology (Baltimore, Md.)
2015-08 | Journal article
Contributors: Cunningham SC; Siew SM; Hallwirth CV; Bolitho C; Sasaki N; Garg G; Michael IP; Hetherington NA; Carpenter K; de Alencastro G et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

A novel intronic splice site deletion of the IL-2 receptor common gamma chain results in expression of a dysfunctional protein and T-cell-positive X-linked Severe combined immunodeficiency.

International journal of immunogenetics
2015-02 | Journal article
Contributors: Gray PE; Logan GJ; Alexander IE; Poulton S; Roscioli T; Ziegler J
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

A genome-wide map of adeno-associated virus-mediated human gene targeting

Nature Nanotechnology
2014 | Journal article
EID:

2-s2.0-84909947100

Contributors: Deyle, D.R.; Hansen, R.S.; Cornea, A.M.; Li, L.B.; Burt, A.A.; Alexander, I.E.; Sandstrom, R.S.; Stamatoyannopoulos, J.A.; Wei, C.-L.; Russell, D.W.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Exploiting the unique regenerative capacity of the liver to underpin cell and gene therapy strategies for genetic and acquired liver disease

International Journal of Biochemistry and Cell Biology
2014 | Journal article
EID:

2-s2.0-84911469487

Contributors: Logan, G.J.; De Alencastro, G.; Alexander, I.E.; Yeoh, G.C.
Source: Self-asserted source
Ian E Alexander via Scopus - Elsevier

Impact of next-generation sequencing error on analysis of barcoded plasmid libraries of known complexity and sequence.

Nucleic acids research
2014 | Journal article
Contributors: Deakin CT; Deakin JJ; Ginn SL; Young P; Humphreys D; Suter CM; Alexander IE; Hallwirth CV
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

The Molecular Bases of Phenylketonuria (PKU) in New South Wales, Australia: Mutation Profile and Correlation with Tetrahydrobiopterin (BH4) Responsiveness.

JIMD reports
2014 | Journal article
Contributors: Ho G; Alexander I; Bhattacharya K; Dennison B; Ellaway C; Thompson S; Wilcken B; Christodoulou J
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Intrahepatic activation of naive CD4+ T cells by liver-resident phagocytic cells.

Journal of immunology (Baltimore, Md. : 1950)
2014-09 | Journal article
Contributors: Tay SS; Wong YC; Roediger B; Sierro F; Lu B; McDonald DM; McGuffog CM; Meyer NJ; Alexander IE; Parish IA et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses.

Proceedings of the National Academy of Sciences of the United States of America
2014-06 | Journal article
Contributors: Tay SS; Wong YC; McDonald DM; Wood NA; Roediger B; Sierro F; Mcguffog C; Alexander IE; Bishop GA; Gamble JR et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Selection and evaluation of clinically relevant AAV variants in a xenograft liver model.

Nature
2014-02 | Journal article
Contributors: Lisowski L; Dane AP; Chu K; Zhang Y; Cunningham SC; Wilson EM; Nygaard S; Grompe M; Alexander IE; Kay MA
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

Cell stem cell
2014-01 | Journal article
Contributors: Kojima Y; Kaufman-Francis K; Studdert JB; Steiner KA; Power MD; Loebel DA; Jones V; Hor A; de Alencastro G; Logan GJ et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

AAV-encoded OTC activity persisting to adulthood following delivery to newborn spf(ash) mice is insufficient to prevent shRNA-induced hyperammonaemia.

Gene therapy
2013-12 | Journal article
Contributors: Cunningham SC; Kok CY; Spinoulas A; Carpenter KH; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Adeno-associated virus-mediated rescue of neonatal lethality in argininosuccinate synthetase-deficient mice.

Molecular therapy : the journal of the American Society of Gene Therapy
2013-10 | Journal article
Contributors: Kok CY; Cunningham SC; Carpenter KH; Dane AP; Siew SM; Logan GJ; Kuchel PW; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Pancreatic transdifferentiation in porcine liver following lentiviral delivery of human furin-cleavable insulin.

Transplantation proceedings
2013-06 | Journal article
Contributors: Gerace D; Ren B; Hawthorne WJ; Byrne MR; Phillips PM; O'Brien BA; Nassif N; Alexander IE; Simpson AM
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes.

Gene therapy
2013-04 | Journal article
Contributors: Dane AP; Wowro SJ; Cunningham SC; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy researchers' assessments of risks and perceptions of risk acceptability in clinical trials.

Molecular Therapy
2013-04 | Journal article
Contributors: Deakin CT; Alexander IE; Hooker CA; Kerridge IH
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy clinical trials worldwide to 2012 - an update.

The journal of gene medicine
2013-02 | Journal article
Contributors: Ginn SL; Alexander IE; Edelstein ML; Abedi MR; Wixon J
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts.

Transplantation
2013-01 | Journal article
Contributors: Cunningham EC; Tay SS; Wang C; Rtshiladze M; Wang ZZ; McGuffog C; Cubitt J; McCaughan GW; Alexander IE; Bertolino P et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Mitochondrial respiratory chain hepatopathies: role of liver transplantation. A case series of five patients.

JIMD reports
2012 | Journal article
Contributors: De Greef E; Christodoulou J; Alexander IE; Shun A; O'Loughlin EV; Thorburn DR; Jermyn V; Stormon MO
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia.

Journal of Inherited Metabolic Disease
2012-11 | Journal article
Contributors: Michot C; Hubert L; Romero NB; Gouda A; Mamoune A; Mathew S; Kirk E; Viollet L; Rahman S; Bekri S et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Adeno-associated virus vectors: immunobiology and potential use for immune modulation.

Current gene therapy
2012-08 | Journal article
Contributors: Logan GJ; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy for metabolic disorders: an overview with a focus on urea cycle disorders.

Journal of Inherited Metabolic Disease
2012-07 | Journal article
Contributors: Alexander IE; Kok C; Dane AP; Cunningham SC
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Gene therapy: progress in childhood disease.

Journal of paediatrics and child health
2012-06 | Journal article
Contributors: Ginn SL; Alexander IE
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2012-01 | Journal article
Contributors: El-Hoss J; Sullivan K; Cheng T; Yu NY; Bobyn JD; Peacock L; Mikulec K; Baldock P; Alexander IE; Schindeler A et al.
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central

Human induced pluripotent stem cells derived under feeder-free conditions display unique cell cycle and DNA replication gene profiles.

Stem cells and development
2012-01 | Journal article
Contributors: Chung HC; Lin RC; Logan GJ; Alexander IE; Sachdev PS; Sidhu KS
Source: Self-asserted source
Ian E Alexander via Europe PubMed Central
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