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Employment (4)

Toho Daigaku: Ota-ku, Tokyo, JP

2019-10-01 to present | technical staff (Department of Biochemstry)
Employment
Source: Self-asserted source
Sachiko Komazawa-Sakon

Juntendo Daigaku: Bunkyo-ku, Tokyo, JP

2019-04-01 to 2019-09-30 | technical staff (Department of Cellular Molecular Neuropathology)
Employment
Source: Self-asserted source
Sachiko Komazawa-Sakon

Toho Daigaku: Ota-ku, Tokyo, JP

2014-07-01 to 2019-03-31 | Technical staff (Department of Biochemistry)
Employment
Source: Self-asserted source
Sachiko Komazawa-Sakon

Juntendo Daigaku: Bunkyo-ku, Tokyo, JP

1997-05-01 to 2014-06-30 | technical staff (Department of Immunology)
Employment
Source: Self-asserted source
Sachiko Komazawa-Sakon

Funding (1)

Elucidation of the mechanisms underlying tissue homeostasis regulated by Reg3 family proteins

2016-04 to 2017-03 | Grant
Japan Society for the Promotion of Science (Tokyo, TOKYO, JP)
GRANT_NUMBER:

16H00591

Source: Self-asserted source
Sachiko Komazawa-Sakon

Works (24)

A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model

[]
2022-06-19 | Preprint
Source: Self-asserted source
Sachiko Komazawa-Sakon

The scaffold-dependent function of RIPK1 in dendritic cells promotes injury-induced colitis

Mucosal Immunology
2022-01 | Journal article
Part of ISSN: 1933-0219
Part of ISSN: 1935-3456
Source: Self-asserted source
Sachiko Komazawa-Sakon

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPL

Communications Biology
2021-12 | Journal article
Part of ISSN: 2399-3642
Source: Self-asserted source
Sachiko Komazawa-Sakon

Regenerating islet-derived protein (Reg)3β plays a crucial role in attenuation of ileitis and colitis in mice

Biochemistry and Biophysics Reports
2020-03 | Journal article
Part of ISSN: 2405-5808
Source: Self-asserted source
Sachiko Komazawa-Sakon

Necroptosis of Intestinal Epithelial Cells Induces Type 3 Innate Lymphoid Cell-Dependent Lethal Ileitis

iScience
2019-05 | Journal article
Part of ISSN: 2589-0042
Source: Self-asserted source
Sachiko Komazawa-Sakon

Blockade of TNF receptor superfamily 1 (TNFR1)–dependent and TNFR1-independent cell death is crucial for normal epidermal differentiation

Journal of Allergy and Clinical Immunology
2019-01 | Journal article
Part of ISSN: 0091-6749
Source: Self-asserted source
Sachiko Komazawa-Sakon

Depletion of myeloid cells exacerbates hepatitis and induces an aberrant increase in histone H3 in mouse serum

Hepatology
2017-01 | Journal article
Part of ISSN: 0270-9139
Part of ISSN: 1527-3350
Source: Self-asserted source
Sachiko Komazawa-Sakon

Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome

Scientific Reports
2016-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Sachiko Komazawa-Sakon

Cellular FLICE-Inhibitory Protein Regulates Tissue Homeostasis

Current Topics in Microbiology and Immunology
2015 | Book chapter
Part of ISBN: 9783319239125
Part of ISBN: 9783319239132
Part of ISSN: 0070-217X
Part of ISSN: 2196-9965
Source: Self-asserted source
Sachiko Komazawa-Sakon

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

Science Signaling
2012-12-18 | Journal article
Part of ISSN: 1945-0877
Part of ISSN: 1937-9145
Source: Self-asserted source
Sachiko Komazawa-Sakon

Interleukin-11 links oxidative stress and compensatory proliferation.

Science signaling
2012-01-17 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Crucial role for autophagy in degranulation of mast cells

Journal of Allergy and Clinical Immunology
2011-05 | Journal article
Part of ISSN: 0091-6749
Source: Self-asserted source
Sachiko Komazawa-Sakon

Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.

The Journal of biological chemistry
2008-07-30 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.

The EMBO journal
2006-11-16 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Reactive oxygen species mediate crosstalk between NF-κB and JNK

Cell Death & Differentiation
2006-05 | Journal article
Part of ISSN: 1350-9047
Part of ISSN: 1476-5403
Source: Self-asserted source
Sachiko Komazawa-Sakon

Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα

Journal of Biological Chemistry
2005-10-07 | Journal article
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Sachiko Komazawa-Sakon

Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS

Molecular Immunology
2004-07 | Journal article
Part of ISSN: 0161-5890
Source: Self-asserted source
Sachiko Komazawa-Sakon

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death.

The EMBO journal
2003-08-01 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Phosphorylation of serine 276 is essential for p65 NF-κB subunit-dependent cellular responses

Biochemical and Biophysical Research Communications
2003-01 | Journal article
Part of ISSN: 0006-291X
Source: Self-asserted source
Sachiko Komazawa-Sakon

Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death.

The Journal of biological chemistry
2002-05-17 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death.

The Journal of biological chemistry
2001-07-30 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.

Proceedings of the National Academy of Sciences of the United States of America
1999-08-01 | Journal article
Source: Self-asserted source
Sachiko Komazawa-Sakon

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.

Proceedings of the National Academy of Sciences of the United States of America
1998-03-01 | Journal article
PMID: 9520401
Source: Self-asserted source
Sachiko Komazawa-Sakon

Assignment of IkappaB kinase beta (IKBKB) to human chromosome band 8p12-->p11 by in situ hybridization.

Cytogenetics and cell genetics
1998-01-01 | Journal article
PMID: 9763654
Source: Self-asserted source
Sachiko Komazawa-Sakon