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Charité Universitätsmedizin Berlin - Campus Virchow-Klinikum: Berlin, Berlin, DE

2020-09-01 to present | Bioinformatician (Department of Hepatology and Gastroenterology)
Employment
Source: Self-asserted source
Hilmar Berger

Christian-Albrechts-Universität zu Kiel: Kiel, Schleswig-Holstein, DE

2020-09-03 to 2022-08-31 | Bioinformatician (Infection Oncology)
Employment
Source: Self-asserted source
Hilmar Berger

Works (31)

C-C chemokine receptor type 7 (CCR7) regulates hepatic CD8 + T cell homeostasis and response to acute liver injury.

Hepatology
2024 | Journal article | Author
DOI: 10.1097/HEP.0000000000000757
PMID: 38231043
Part of ISSN: 0270-9139
Contributors: Niemietz P; Moritz Peiseler; Marlene Kohlhepp; Paul Horn; Kylie P Matchett; Wang Y; Haas L; Zhang T; Alix Bruneau; Adrien Guillot et al.
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FACTScience - Charité Universitätsmedizin Berlin

Long-term impact of scheduled regular endoscopic interventions for patients with primary sclerosing cholangitis.

Hepatol Communications
2024 | Journal article
DOI: 10.1097/HC9.0000000000000494
PMC: PMC11371311
PMID: 39225697
Part of ISSN:

HEPATOL_COMMUN
Contributors: Özdirik B; Veltzke-Schlieker W; Nicklaus JM; Berger H; Schmidt D; Leonhardt S; Penndorf V; Adler A; Müller T; Wree A et al.
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FACTScience - Charité Universitätsmedizin Berlin

p53 terminates the regenerative fetal-like state after colitis-associated injury.

Science Advances
2024 | Journal article | Author
DOI: 10.1126/sciadv.adp8783
PMC: PMC11506124
PMID: 39453996
Part of ISSN:

SCI_ADV
Contributors: Kimberly Hartl; Bayram Ş; Wetzel A; Harnack C; Lin M; Fischer AS; Lichao liu; Giulia Beccaceci; Guido Mastrobuoni; Sabrina Yasmin Geisberger et al.
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FACTScience - Charité Universitätsmedizin Berlin

Expression of Cyclin E1 in hepatic stellate cells is critical for the induction and progression of liver fibrosis and hepatocellular carcinoma in mice.

Cell Death and Disease
2023 | Journal article
DOI: 10.1038/s41419-023-06077-4
PMC: PMC10449804
PMID: 37620309
Part of ISSN:

CELL_DEATH_DIS
Contributors: Otto J; Anna Verwaayen; Christian Penners; Hundertmark J; Lin C; Kallen C; Paffen D; Tobias Otto; Berger H; Tacke F et al.
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FACTScience - Charité Universitätsmedizin Berlin

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression.

Hepatology
2023 | Journal article
DOI: 10.1097/HEP.0000000000000270
PMID: 36630995
Part of ISSN: 0270-9139
Contributors: Guillot A; Winkler M; Silva Afonso M; Aggarwal A; Lopez D; Berger H; Kohlhepp MS; Liu H; Özdirik B; Eschrich J et al.
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FACTScience - Charité Universitätsmedizin Berlin
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Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis.

Gut Microbes
2023 | Journal article
DOI: 10.1080/19490976.2023.2233689
PMC: PMC10334853
PMID: 37427832
Part of ISSN:

GUT_MICROBES
Contributors: Harnack C; Berger H; Liu L; Mollenkopf HJ; Strowig T; Sigal M
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FACTScience - Charité Universitätsmedizin Berlin

Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis.

JHEP Rep
2023 | Journal article
DOI: 10.1016/j.jhepr.2023.100883
PMC: PMC10582775
PMID: 37860052
Part of ISSN: 2589-5559
Contributors: Bai Q; Hong X; Lin H; He X; Li R; Hassan M; Berger H; Tacke F; Engelmann C; Hu T
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FACTScience - Charité Universitätsmedizin Berlin

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids.

Frontiers in Immunology
2023 | Journal article
DOI: 10.3389/fimmu.2023.1281646
PMC: PMC10711208
PMID: 38090581
Part of ISSN:

FRONT_IMMUNOL
Contributors: Dong J; Holthaus D; Peters C; Koster S; Ehsani M; Quevedo-Olmos A; Berger H; Zarobkiewicz M; Mangler M; Gurumurthy RK et al.
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FACTScience - Charité Universitätsmedizin Berlin

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

2023-07-26 | Preprint
DOI: 10.1101/2023.07.25.550464
Contributors: Junxue Dong; David Holthaus; Christian Peters; Stefanie Koster; Marzieh Ehsani; Alvaro Quevedo-Olmos; Hilmar Berger; Michal Zarobkiewicz; Mandy Mangler; Rajendra Kumar Gurumurthy et al.
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Crossref

Establishment of gastrointestinal assembloids to study the interplay between epithelial crypts and their mesenchymal niche

Nature Communications
2023-05-25 | Journal article
DOI: 10.1038/s41467-023-38780-3
Contributors: Manqiang Lin; Kimberly Hartl; Julian Heuberger; Giulia Beccaceci; Hilmar Berger; Hao Li; Lichao Liu; Stefanie Müllerke; Thomas Conrad; Felix Heymann et al.
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Crossref

BMP feed-forward loop promotes terminal differentiation in gastric glands and is interrupted by H. pylori-driven inflammation.

Nature Communications
2022 | Journal article | Author
DOI: 10.1038/s41467-022-29176-w
PMC: PMC8948225
PMID: 35332152
Part of ISSN: 2041-1723
Contributors: Kapalczynska M; Lin M; Maertzdorf J; Julian Heuberger; Muellerke S; Xiangsheng Zuo; Vidal R; Imad Shureiqi; Fischer AS; Sascha Sauer et al.
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FACTScience - Charité Universitätsmedizin Berlin

DNA methylation in human gastric epithelial cells defines regional identity without restricting lineage plasticity.

Clinical Epigenetics
2022 | Journal article
DOI: 10.1186/s13148-022-01406-4
PMC: PMC9801550
PMID: 36585699
Part of ISSN: 1868-7083
Contributors: Fritsche K; Boccellato F; Schlaermann P; Koeppel M; Denecke C; Link A; Malfertheiner P; Gut I; Meyer TF; Berger H
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FACTScience - Charité Universitätsmedizin Berlin

Gastric stem cells promote inflammation and gland remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.

EMBO Journal
2022 | Journal article
DOI: 10.15252/embj.2021109996
PMID: 35767364
Part of ISSN: 0261-4189
Contributors: Jonas Wizenty; Müllerke S; Kolesnichenko M; Julian Heuberger; Lin M; Fischer AS; Mollenkopf HJ; Berger H; Frank Tacke; Michael Sigal
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FACTScience - Charité Universitätsmedizin Berlin

R-spondin/YAP axis promotes gastric oxyntic gland regeneration and Helicobacter pylori-associated metaplasia in mice.

Journal of Clinical Investigation
2022 | Journal article
DOI: 10.1172/JCI151363
PMC: PMC9621134
PMID: 36099044
Part of ISSN: 1558-8238
Contributors: Fischer AS; Müllerke S; Arnold A; Heuberger J; Berger H; Lin M; Mollenkopf HJ; Wizenty J; Horst D; Tacke F et al.
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FACTScience - Charité Universitätsmedizin Berlin

Single Cell RNA Sequencing in NASH

2022 | Book chapter
DOI: 10.1007/978-1-0716-2128-8_15
Contributors: Jana Hundertmark; Hilmar Berger; Frank Tacke
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Crossref

DNA methylation in human gastric epithelial cells allows cell type-related plasticity and defines regional identity

2022-03-29 | Preprint
DOI: 10.1101/2022.03.29.486203
Contributors: Kristin Fritsche; Francesco Boccellato; Philipp Schlaermann; Max Koeppel; Christian Denecke; Ivo Gut; Thomas F. Meyer; Hilmar Berger
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Crossref

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

Nature Communications
2022-02-24 | Journal article
DOI: 10.1038/s41467-022-28569-1
Contributors: Stefanie Koster; Rajendra Kumar Gurumurthy; Naveen Kumar; Pon Ganish Prakash; Jayabhuvaneshwari Dhanraj; Sofia Bayer; Hilmar Berger; Shilpa Mary Kurian; Marina Drabkina; Hans-Joachim Mollenkopf et al.
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Crossref

Mechanistic dissection unmasks colibactin as a prevalent mutagenic driver of cancer.

Cancer Cell
2021 | Journal article
DOI: 10.1016/j.ccell.2021.10.010
PMID: 34752751
Part of ISSN: 1535-6108
Contributors: Berger H; Meyer TF
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FACTScience - Charité Universitätsmedizin Berlin

Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

2021-04-15 | Preprint
DOI: 10.1101/2021.04.15.439996
Contributors: Stefanie Koster; Rajendra Kumar Gurumurthy; Hilmar Berger; Marina Drabkina; Hans-Joachim Mollenkopf; Christian Goosmann; Volker Brinkmann; Zachary Nagel; Mandy Mangler; Thomas F Meyer et al.
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Crossref

Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia

Nature Cell Biology
2021-02 | Journal article
DOI: 10.1038/s41556-020-00619-0
Contributors: Cindrilla Chumduri; Rajendra Kumar Gurumurthy; Hilmar Berger; Oliver Dietrich; Naveen Kumar; Stefanie Koster; Volker Brinkmann; Kirstin Hoffmann; Marina Drabkina; Panagiota Arampatzi et al.
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Crossref

Genomic aberrations after short-term exposure to colibactin-producing E. coli transform primary colon epithelial cells

Nature Communications
2021-02-12 | Journal article
DOI: 10.1038/s41467-021-21162-y
Contributors: Amina Iftekhar; Hilmar Berger; Nassim Bouznad; Julian Heuberger; Francesco Boccellato; Ulrich Dobrindt; Heiko Hermeking; Michael Sigal; Thomas F. Meyer
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Crossref

Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment.

EMBO Journal
2020 | Journal article
DOI: 10.15252/embj.2019104013
PMC: PMC7073464
PMID: 32009247
Part of ISSN: 0261-4189
Contributors: Hoffmann K; Berger H; Kulbe H; Thillainadarasan S; Mollenkopf HJ; Zemojtel T; Taube E; Darb-Esfahani S; Mangler M; Sehouli J et al.
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FACTScience - Charité Universitätsmedizin Berlin

Genotoxic Effect of Salmonella Paratyphi A Infection on Human Primary Gallbladder Cells

mBio
2020-10-27 | Journal article
DOI: 10.1128/mBio.01911-20
Contributors: Ludovico P. Sepe; Kimberly Hartl; Amina Iftekhar; Hilmar Berger; Naveen Kumar; Christian Goosmann; Sascha Chopra; Sven Christian Schmidt; Rajendra Kumar Gurumurthy; Thomas F. Meyer et al.
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Crossref

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer

Nature Medicine
2020-07 | Journal article
DOI: 10.1038/s41591-020-0908-2
Contributors: Paulina J. Dziubańska-Kusibab; Hilmar Berger; Federica Battistini; Britta A. M. Bouwman; Amina Iftekhar; Riku Katainen; Tatiana Cajuso; Nicola Crosetto; Modesto Orozco; Lauri A. Aaltonen et al.
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Crossref

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation.

Nature Communications
2019 | Journal article | Author
DOI: 10.1038/s41467-019-09144-7
PMC: PMC6423033
PMID: 30886143
Part of ISSN: 2041-1723
Contributors: Kessler M; Hoffmann K; Fritsche K; Volker Brinkmann; Mollenkopf HJ; Thieck O; Teixeira da Costa AR; Braicu EI; Sehouli J; Mangler M et al.
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FACTScience - Charité Universitätsmedizin Berlin

Integrated Phosphoproteome and Transcriptome Analysis Reveals Chlamydia-Induced Epithelial-to-Mesenchymal Transition in Host Cells.

Cell Reports
2019 | Journal article
DOI: 10.1016/j.celrep.2019.01.006
PMID: 30699355
Part of ISSN: 2211-1247
Contributors: Zadora PK; Chumduri C; Imami K; Berger H; Mi Y; Selbach M; Meyer TF; Gurumurthy RK
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FACTScience - Charité Universitätsmedizin Berlin

Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection.

Gut
2019 | Journal article
DOI: 10.1136/gutjnl-2017-314540
PMC: PMC6580761
PMID: 29467166
Part of ISSN: 0017-5749
Contributors: Boccellato F; Woelffling S; Imai-Matsushima A; Sanchez G; Goosmann C; Schmid M; Berger H; Morey P; Denecke C; Ordemann J et al.
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FACTScience - Charité Universitätsmedizin Berlin

R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon

Nature Communications
2019-09-25 | Journal article
DOI: 10.1038/s41467-019-12349-5
Contributors: Christine Harnack; Hilmar Berger; Agne Antanaviciute; Ramon Vidal; Sascha Sauer; Alison Simmons; Thomas F. Meyer; Michael Sigal
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Crossref

R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach

Nature Cell Biology
2019-07 | Journal article
DOI: 10.1038/s41556-019-0339-9
Contributors: Michael Sigal; Maria del Mar Reinés; Stefanie Müllerke; Cornelius Fischer; Marta Kapalczynska; Hilmar Berger; Elvira R. M. Bakker; Hans-Joachim Mollenkopf; Michael E. Rothenberg; Bertram Wiedenmann et al.
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Crossref

Long-Term Culture of Distal Airway Epithelial Cells Allows Differentiation Towards Alveolar Epithelial Cells Suited for Influenza Virus Studies.

EBioMedicine
2018 | Journal article
DOI: 10.1016/j.ebiom.2018.05.032
PMC: PMC6085545
PMID: 29937069
Part of ISSN: 2352-3964
Contributors: Imai-Matsushima A; Martin-Sancho L; Karlas A; Imai S; Zoranovic T; Hocke AC; Mollenkopf HJ; Berger H; Meyer TF
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FACTScience - Charité Universitätsmedizin Berlin

Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.

Nature
2017 | Journal article
DOI: 10.1038/nature23642
PMID: 28813421
Part of ISSN: 1476-4687
Contributors: Sigal M; Logan CY; Kapalczynska M; Mollenkopf HJ; Berger H; Wiedenmann B; Nusse R; Amieva MR; Meyer TF
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FACTScience - Charité Universitätsmedizin Berlin
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