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Employment (1)

Georgetown University: Washington, DC, US

2012 to present | Research Associate Professor (Lombardi Comprehensive Cancer Center)
Employment
Source: Self-asserted source
Chen-Yong Lin

Education and qualifications (1)

Georgetown University: Washington, DC, US

1990 to 1995 | PhD (Cell Biology)
Education
Source: Self-asserted source
Chen-Yong Lin

Works (9)

SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation

Human Molecular Genetics
2024-04-18 | Journal article
DOI: 10.1093/hmg/ddae005
Contributors: Nanxi Huang; Qiaochu Wang; Robert B Bernard; Chao-Yang Chen; Je-Ming Hu; Jehng-Kang Wang; Khee-Siang Chan; Michael D Johnson; Chen-Yong Lin
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Crossref

HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes

Human Cell
2023-04-19 | Journal article
DOI: 10.1007/s13577-023-00906-6
Contributors: Dajun D. Lu; Nanxi Huang; Sheng-Wen A. Li; Jessica R. Fang; Chih-Hsin Lai; Jehng-Kang Wang; Khee-Siang Chan; Michael D. Johnson; Chen-Yong Lin
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Crossref

N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity

Glycobiology
2023-04-19 | Journal article
DOI: 10.1093/glycob/cwad002
Contributors: Nanxi Huang; Qiaochu Wang; Chao-Yang Chen; Je-Ming Hu; Jehng-Kang Wang; Ping-Ying Chang; Michael D Johnson; Chen-Yong Lin
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Crossref

Targeted deletion of HAI-1 increases prostasin proteolysis but decreases matriptase proteolysis in human keratinocytes

Human Cell
2021-05-24 | Journal article
DOI: 10.1007/s13577-021-00488-1
Contributors: Dajun D. Lu; Yayun Gu; Sheng-Wen A. Li; Robert J. Barndt; Shih-Ming Huang; Jehng-Kang Wang; Hui Chen Su; Michael D. Johnson; Chen-Yong Lin
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Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation

Human Cell
2020-10-10 | Journal article
DOI: 10.1007/s13577-020-00410-1
Contributors: Bailing Jia; Hamishi A. Thompson; Robert B. Barndt; Yi-Lin Chiu; Mon-Juan Lee; See-Chi Lee; Jehng-Kang Wang; Hung-Jen Tang; Chen-Yong Lin; Michael D. Johnson
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The spatiotemporal control of human matriptase action on its physiological substrates: a case against a direct role for matriptase proteolytic activity in profilaggrin processing and desquamation

Human Cell
2020-07-18 | Journal article
DOI: 10.1007/s13577-020-00361-7
Contributors: Chen-Yong Lin; Jehng-Kang Wang; Michael D. Johnson
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Crossref

The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane

PLOS ONE
2020-02-12 | Journal article
DOI: 10.1371/journal.pone.0228874
Contributors: Chun-Che Tseng; Qing-Xiang Amy Sang; Bailing Jia; Robert B. Barndt; Yang-Hong Dai; Yu Hsin Chen; Po-Wen A. Du; Jehng-Kang Wang; Hung-Jen Tang; Chen-Yong Lin et al.
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Crossref

Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity

PLOS ONE
2017-08-22 | Journal article
DOI: 10.1371/journal.pone.0183507
Contributors: Chun-Che Tseng; Eugene A. Permyakov; Bailing Jia; Robert Barndt; Yayun Gu; Chien-Yu Chen; I-Chu Tseng; Sheng-Fang Su; Jehng-Kang Wang; Michael D. Johnson et al.
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Crossref

Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2

PLOS ONE
2017-01-26 | Journal article
DOI: 10.1371/journal.pone.0170944
Contributors: Frank Shiao; Qing-Xiang Amy Sang; Li-Ching O. Liu; Nanxi Huang; Ying-Jung J. Lai; Robert J. Barndt; Chun-Che Tseng; Jehng-Kang Wang; Bailing Jia; Michael D. Johnson et al.
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Crossref

Peer review (1 review for 1 publication/grant)

Review activity for Cancer metastasis reviews. (1)
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