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Other IDs

Scopus Author ID: 37019726200
SciProfiles: 2231962

Keywords

RYBP, MMP-2, Epigenetic, DNA Repair, ribosomal RNA

Countries

United States

Biography

My current research utilizes various pharmacological, biochemical and molecular biology techniques, with emphasis on their applications to study epigenetic in cancer biology, oxidative stress damage to the heart & DNA damage repair. By exploiting the state-of-the-art imaging and structural methods including; live-cell imaging, super-resolution microscopy and NMR spectroscopy, I am working to unravel epigenetic and non-epigenetic roles of RYBP in DNA repair and cancer biology. Knowing that DNA repair is one mechanism allows cancer cell to resist therapy; this theme of my research has potential implications in cancer therapeutics.

The novel epigenetic role of the protease, MMP-2, in ribosomal RNA biogenesis, nucleolus function and gene expression in osteosarcoma is also under active investigation which could open new avenues for the deployment of nuclear MMP-2 inhibitors as anti-metastasis in pediatric oncology.

I published 20 manuscripts in prestigious peer-reviewed journals including Circulation, Cell Reports, FEBS Journal and been invited to give over 15 presentations in both national and international conferences. I served as a reviewer of peer-reviewed journals e.g. British Journal of Pharmacology, Frontiers in Oncology & Journal of Cellular Physiology.

I am also a licensed clinical pharmacist (Alberta College of Pharmacy). My practice focused on providing pharmaceutical care to special populations: pediatrics, older adults, HIV and opioid use disorder patients.

Activities

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Employment (7)

Binghamton University: Binghamton, NY, US

2020-01-02 to present | Assistant Professor (Pharmaceutical Sciences )
Employment
Source: Self-asserted source
Mohammad Ali

Alberta Health Services: Edmonton, AB, CA

2019-06-01 to 2019-12-31 | Part-time Pharmacist (Opioid Response Coordinator Community of Practice)
Employment
Source: Self-asserted source
Mohammad Ali

Red Deer Primary Care Network : Red Deer, Alberta, CA

2018-11-03 to 2019-12-31 | PCN Pharmacist (Pharmacy Department)
Employment
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2018-01-01 to 2019-12-31 | Research Associate (Pharmacology )
Employment
Source: Self-asserted source
Mohammad Ali

RAH Outpatient Pharmacy- Rexall : Edmonton, AB, CA

2018-03-04 to 2018-09-21 | Interim Pharmacy Manager (Outpatient Pharmacy )
Employment
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2013-01-03 to 2017-12-31 | Postdoctoral Fellow (Oncology )
Employment
Source: Self-asserted source
Mohammad Ali

Alexandria University: Alexandria, Alexandria , EG

2002-01-05 to 2006-06-30 | Assistant Lecturer (Pharmacology )
Employment
Source: Self-asserted source
Mohammad Ali

Education and qualifications (6)

Alberta College of Pharmacy: AB, AB, CA

2017-09-01 to present | Pharmacist (Additional Prescribing Authorization )
Qualification
Source: Self-asserted source
Mohammad Ali

Alberta College of Pharmacy: AB, AB, CA

2014-06-01 to present | Pharmacist (Authorized to administer drugs by injection )
Qualification
Source: Self-asserted source
Mohammad Ali

Alberta College of Pharmacy: AB, AB, CA

2013-10-01 to present | Pharmacist (Registered Pharmacist )
Qualification
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2006-08-21 to 2012-11-22 | PhD (Pharmacology )
Education
Source: Self-asserted source
Mohammad Ali

Alexandria University: Alexandria, EG

2002-01-07 to 2006-06-08 | MSc. (Pharmacology )
Education
Source: Self-asserted source
Mohammad Ali

Alexandria University: Alexandria, EG

1994-09-22 to 1999-06-23 | BSc. Pharm (Faculty of Pharmacy )
Education
Source: Self-asserted source
Mohammad Ali

Professional activities (25)

New York State Council of Health-system Pharmacists: Albany, New York , US

2020-01-02 to present
Membership
Source: Self-asserted source
Mohammad Ali

American Association of Colleges of Pharmacy: VA, VA, US

2020-01-02 to present
Membership
Source: Self-asserted source
Mohammad Ali

British Journal of Pharmacology: London, GB

2013-07-05 to present | Reviewer
Service
Source: Self-asserted source
Mohammad Ali

Journal of Cellular Physiology : San Francisco , US

2012-07-06 to present | Reviewer
Service
Source: Self-asserted source
Mohammad Ali

Alberta College of Pharmacy: AB, AB, CA

2010-11-01 to present
Membership
Source: Self-asserted source
Mohammad Ali

Canadian Pharmacists Association: Ottawa, Ontario, CA

2013-12-06 to 2019-12-20
Membership
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2018-07-01 | Med-Star Postdoctoral Fellow Award (Faculty of Medicine & Dentistry- Alberta Health Services )
Distinction
Source: Self-asserted source
Mohammad Ali

Alberta Cancer Foundation: Edmonton, AB, CA

2013-01-01 to 2017-12-31
Membership
Source: Self-asserted source
Mohammad Ali

Cancer Reseaarch Institue of Northern Alberta: Edmonton, AB, CA

2017-11-21 | Highlighted Poster Award
Distinction
Source: Self-asserted source
Mohammad Ali

Signal Transduction Research Group : Edmoton , AB, CA

2015-05-17 | Oral Presentation Award (Department of Cell Biology)
Distinction
Source: Self-asserted source
Mohammad Ali

Alberta Innovates Health Solutions: Edmonton, AB, CA

2013-09-01 | Clinician Fellowship
Distinction
Source: Self-asserted source
Mohammad Ali

Golden Key International Honour Society: GA, GA, US

2008-01-01 to 2013-02-09 | University of Alberta-Chapter
Invited position
Source: Self-asserted source
Mohammad Ali

Alberta Cancer Foundation: Edmonton, AB, CA

2012-12-31 | Postdoctoral Fellowship
Distinction
Source: Self-asserted source
Mohammad Ali

Canadian Society of Pharmacology and Therapeutics: Hamilton, Ontario, CA

2006-12-20 to 2012-12-31
Membership
Source: Self-asserted source
Mohammad Ali

International Society for Heart Research: Columbia, MD, US

2007-01-01 to 2012-12-03
Membership
Source: Self-asserted source
Mohammad Ali

Cardiovascular Research Centre : Edmonton , AB , CA

2011-06-21 | Dr. Francis X. Witkowski Publication Award (University of Alberta )
Distinction
Source: Self-asserted source
Mohammad Ali

Department of Pharmacology-University of Alberta : Edmonton , AB, CA

2011-05-08 | Certificate of Excellence in Research (Pharmacology )
Distinction
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2011-03-01 | Med-Star Graduate Student Award (Faculty of Medicine & Dentistry-Alberta Health Services )
Distinction
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2011-01-01 | Andrew Stewart Memorial Graduate Prize (Faculty of Graduate Studies & Research (FGSR))
Distinction
Source: Self-asserted source
Mohammad Ali

International Society for Heart Research: Columbia, MD, US

2010-06-01 | Travel Award
Distinction
Source: Self-asserted source
Mohammad Ali

Canadian Cardiovascular Society: Ottawa, Ontario, CA

2009-12-09 | Education Award-Best Oral Presentation
Distinction
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2009-07-07 | - The Profiling Albertaā€™s Graduate Student Award (Faculty of Graduate Studies and Research (FGSR))
Distinction
Source: Self-asserted source
Mohammad Ali

Cardiovascular Research Centre : Edmonton, AB, CA

2008-05-03 | The 4th Alberta-wide Cardiovascular Retreat Award
Distinction
Source: Self-asserted source
Mohammad Ali

Alberta Heritage Foundation for Medical Research: AB, AB, CA

2008-01-01 | Doctoral Studentship Award
Distinction
Source: Self-asserted source
Mohammad Ali

University of Alberta: Edmonton, AB, CA

2007-12-13 | 75th Anniversary Graduate Student Award
Distinction
Source: Self-asserted source
Mohammad Ali

Funding (4)

SUNY Startup fund

2020-01 to 2023-12 | Grant
State University of New York (NY, NY, US)
Source: Self-asserted source
Mohammad Ali

Role of non canonical Polycomb Repressive Complex-1, RYBP, in DNA damage response

2013-09 to 2017-01 | Salary award
Alberta Innovates (AB, AB, CA)
Source: Self-asserted source
Mohammad Ali

Polycomb group, PcG, proteins in DNA damage repair

2012-12 to 2015-12 | Salary award
Alberta Cancer Foundation (AB, AB, CA)
Source: Self-asserted source
Mohammad Ali

Intracellular roles of Matrix Metalloproteinase-2; biological mechanisms and novel targets

2008-01 to 2011-01 | Salary award
Alberta Heritage Foundation for Medical Research (AB, AB, CA)
Source: Self-asserted source
Mohammad Ali

Works (26)

MMPā€2 regulates Src activation via repression of the CHK/MATK tumor suppressor in osteosarcoma

Cancer Reports
2024-02 | Journal article
DOI: 10.1002/cnr2.1946
Contributors: Deanna V. Maybee; Christopher R. Cromwell; Basil P. Hubbard; Mohammad A. M. Ali
Source: check_circle
Crossref

MMP-2 regulates Src activation via repression of the CHK/MATK tumor suppressor in Osteosarcoma

2023-06-08 | Preprint
DOI: 10.22541/au.168624020.08576588/v1
Contributors: Deanna Maybee; Christopher Cromwell; Basil Hubbard; Mohammad Ali
Source: check_circle
Crossref

RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity

International Journal of Molecular Sciences
2022-10 | Journal article | Author
DOI: 10.3390/ijms231911764
Contributors: Deanna V. Maybee; Alexandra Maria Psaras; Tracy A. Brooks; Mohammad Ali
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)ā€Ž

Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu

International Journal of Molecular Sciences
2022-08-23 | Journal article
DOI: 10.3390/ijms23179513
Contributors: Deanna V. Maybee; Nicole L. Ink; Mohammad A. M. Ali
Source: check_circle
Crossref
grade
Preferred source (of 2)ā€Ž

Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu

2022-06-22 | Preprint
DOI: 10.20944/preprints202206.0305.v1
Contributors: Deanna V. Maybee; Nicole L. Ink; Mohammad A.M. Ali
Source: check_circle
Crossref
grade
Preferred source (of 2)ā€Ž

Editorial commentary: The platelet in COVID-19: A critical participant or a bystander?

Trends in Cardiovascular Medicine
2022-01 | Journal article
DOI: 10.1016/j.tcm.2021.09.004
Contributors: Mohammad A.M. Ali
Source: check_circle
Crossref

Matrix metalloproteinaseā€2 mediates ribosomal RNA transcription by cleaving nucleolar histones

The FEBS Journal
2021-12 | Journal article
DOI: 10.1111/febs.16061
Contributors: Mohammad A. M. Ali; Javier A. Garciaā€Vilas; Christopher R. Cromwell; Basil P. Hubbard; Michael J. Hendzel; Richard Schulz
Source: check_circle
Crossref

COVID-19 and thrombosis: From bench to bedside

Trends in Cardiovascular Medicine
2021-04 | Journal article
DOI: 10.1016/j.tcm.2020.12.004
Contributors: Mohammad A.M. Ali; Sarah A. Spinler
Source: check_circle
Crossref

Multifunctional Intracellular Matrix Metalloproteinases: Implications in Disease.

The FEBS journal
2021-01-06 | Journal article
DOI: 10.1111/febs.15701
PMID: 33405316
Source: Self-asserted source
Mohammad Ali

Matrix metalloproteinase-2 mediates ribosomal RNA transcription by cleaving nucleolar histones

[]
2020-02-22 | Preprint
DOI: 10.1101/2020.02.21.958280
Source: Self-asserted source
Mohammad Ali

RYBP Is a K63-Ubiquitin-Chain-Binding Protein that Inhibits Homologous Recombination Repair

Cell Reports
2018 | Journal article
DOI: 10.1016/j.celrep.2017.12.047
EID:

2-s2.0-85041205865
Contributors: Ali, M.A.M.; Strickfaden, H.; Lee, B.L.; Spyracopoulos, L.; Hendzel, M.J.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes

American Journal of Physiology - Heart and Circulatory Physiology
2016 | Journal article
DOI: 10.1152/ajpheart.00229.2016
EID:

2-s2.0-84983775208
Contributors: Fan, X.; Hughes, B.G.; Ali, M.A.M.; Chan, B.Y.H.; Launier, K.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Dynamic alterations to Ī±-actinin accompanying sarcomere disassembly and reassembly during cardiomyocyte mitosis

PLoS ONE
2015 | Journal article
DOI: 10.1371/journal.pone.0129176
EID:

2-s2.0-84936857429
Contributors: Fan, X.; Hughes, B.G.; Ali, M.A.M.; Cho, W.J.; Lopez, W.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Postresuscitation administration of doxycycline preserves cardiac contractile function in hypoxia-reoxygenation injury of newborn piglets

Critical Care Medicine
2014 | Journal article
DOI: 10.1097/CCM.0000000000000135
EID:

2-s2.0-84896670112
Contributors: Labossiere, J.R.; Pelletier, J.-S.; Ali, M.A.; Thiesen, A.; Schulz, R.; Bigam, D.L.; Cheung, P.-Y.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Hydrogen peroxide-induced necrotic cell death in cardiomyocytes is independent of matrix metalloproteinase-2

Toxicology in Vitro
2013 | Journal article
DOI: 10.1016/j.tiv.2013.04.013
EID:

2-s2.0-84878357038
Contributors: Ali, M.A.M.; Kandasamy, A.D.; Fan, X.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2

Biochemical Pharmacology
2013 | Journal article
DOI: 10.1016/j.bcp.2013.06.003
EID:

2-s2.0-84884904867
Contributors: Castro, M.M.; Fuah, J.; Ali, M.; Sung, M.; Schulz, J.; Kondo, M.Y.; Fan, X.; Holt, A.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Intracellular matrix remodeling and cardiac function in ischemia-reperfusion injury

Cardiac Remodeling: Molecular Mechanisms
2013 | Book chapter
Part of DOI: 10.1007/978-1-4614-5930-9_26
EID:

2-s2.0-85028507099
Contributors: Fan, X.; Ali, M.A.M.; Hughes, B.G.; Jacob-Ferreira, A.L.B.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity

Biochemical and Biophysical Research Communications
2012 | Journal article
DOI: 10.1016/j.bbrc.2012.05.005
EID:

2-s2.0-84862646766
Contributors: Ali, M.A.M.; Stepanko, A.; Fan, X.; Holt, A.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Mechanisms of cytosolic targeting of matrix metalloproteinase-2

Journal of Cellular Physiology
2012 | Journal article
DOI: 10.1002/jcp.24040
EID:

2-s2.0-84862682540
Contributors: Ali, M.A.; Chow, A.K.; Kandasamy, A.D.; Fan, X.; West, L.J.; Crawford, B.D.; Simmen, T.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Cardiac Sarcomeric Proteins: Novel Intracellular Targets of Matrix Metalloproteinase-2 in Heart Disease

Trends in Cardiovascular Medicine
2011 | Journal article
DOI: 10.1016/j.tcm.2012.03.008
EID:

2-s2.0-84861856192
Contributors: Ali, M.A.M.; Fan, X.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Matrix metalloproteinase-2 and myocardial oxidative stress injury: Beyond the matrix

Cardiovascular Research
2010 | Journal article
DOI: 10.1093/cvr/cvp268
EID:

2-s2.0-74249098410
Contributors: Kandasamy, A.D.; Chow, A.K.; Ali, M.A.M.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Titin is a target of matrix metalloproteinase-2: Implications in myocardial ischemia/reperfusion injury

Circulation
2010 | Journal article
DOI: 10.1161/CIRCULATIONAHA.109.930222
EID:

2-s2.0-78549277458
Contributors: Ali, M.A.M.; Cho, W.J.; Hudson, B.; Kassiri, Z.; Granzier, H.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Activation of MMP-2 as a key event in oxidative stress injury to the heart

Frontiers in Bioscience
2009 | Journal article
DOI: 10.2741/3274
EID:

2-s2.0-63849264551
Contributors: Ali, M.A.M.; Schulz, R.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

PPARĪ±: Essential component to prevent myocardial oxidative stress?

American Journal of Physiology - Heart and Circulatory Physiology
2007 | Journal article
DOI: 10.1152/ajpheart.00345.2007
EID:

2-s2.0-34547100967
Contributors: Schulz, R.; Ali, M.A.M.
Source: Self-asserted source
Mohammad Ali via Scopus - Elsevier

Effect of mastic gum, vitamin E and omeprazole on indomethacin-induced gastric ulcers

Alex J Vet Science 25:263-272.
2007-01-01 | Journal article
Source: Self-asserted source
Mohammad Ali

Effect of mastic gum, vitamin E, and omeprazole on ethanol/HCl-induced gastric ulcers in rats

Ibn Al-Haitham J Sci Tech 1:71-81.
2006-01-01 | Journal article
Source: Self-asserted source
Mohammad Ali

Peer review (3 reviews for 2 publications/grants)

Review activity for Experimental cell research. (2)
Review activity for Signal transduction and targeted therapy. (1)
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