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Basuraj SK
Switzerland, India

Biography

I am a biochemist specializing in understanding the molecular mechanisms of membrane proteins involved in transmembrane signaling and host-pathogen interactions. My research integrates biochemistry, structural biology, and functional studies to unravel complex cellular signaling pathways and their modulation by biological toxins. By advancing our understanding of these systems, I aim to tackle key challenges in cell biology and contribute to the development of toxin-inspired tools for therapeutic and biotechnological applications.

Activities

Employment (4)

Paul Scherrer Institute: Villigen, CH, CH

2023-02-01 to present | Staff Scientist / Engineer (Center for Life Sciences )
Employment
Source: Self-asserted source
Basavraj Khanppnavar

ETH Zurich: Zurich, AG, CH

2019-05-02 to 2023-01-31 | Postdoctoral Fellow (Department of Biology)
Employment
Source: Self-asserted source
Basavraj Khanppnavar

Indian Institute of Chemical Biology: Kolkata, IN

2016-01-07 to 2019-04-26 | Senior Research Fellow (Structural Biology and Biotechnology)
Employment
Source: Self-asserted source
Basavraj Khanppnavar

Indian Institute of Chemical Biology: Kolkata, IN

2014-01-07 to 2016-01-06 | Junior Research Fellow (Structural Biology and Biotechnology)
Employment
Source: Self-asserted source
Basavraj Khanppnavar

Education and qualifications (3)

Academy of Scientific and Innovative Research: Ghaziabad, IN

2014-01-07 to 2019-01-14 | Doctorate of Philosophy (Biosciences)
Education
Source: Self-asserted source
Basavraj Khanppnavar

Tezpur University: Napaam, Assam, IN

2011-07 to 2013-05 | Masters in Molecular Biology and Biotechnology (Molecular Biology and Biotechnology)
Education
Source: Self-asserted source
Basavraj Khanppnavar

Goa University: Taleigao, Goa, IN

2008-07 to 2011-04 | Bachelor of Science in Biotechnology
Education
Source: Self-asserted source
Basavraj Khanppnavar

Professional activities (6)

Life Science Switzerland (LS2): Bern, CH

2023 to present | Regular
Membership
Source: Self-asserted source
Basavraj Khanppnavar

American Society for Biochemistry and Molecular Biology: Rockville, US

2022 to present | Regular
Membership
Source: Self-asserted source
Basavraj Khanppnavar

University Grants Commission: New Delhi, IN

2013 | UGC Fellowship for Doctoral Studies: Awarded based on top performance in the national-level competitive examination, Joint CSIR-UGC NET Examination.
Distinction
Source: Self-asserted source
Basavraj Khanppnavar

Ministry of Human Resource Development: Delhi, IN

2013 | GATE Fellowship for Doctoral Studies: Awarded for top performance in the national-level competitive examination, the Graduate Aptitude Test in Engineering (GATE).
Distinction
Source: Self-asserted source
Basavraj Khanppnavar

Department of Biotechnology: New Delhi, IN

2013 | DBT Fellowship for Doctoral Studies: Awarded based on top performance in the national-level competitive examination, Biotechnology Eligibility Test
Distinction
Source: Self-asserted source
Basavraj Khanppnavar

Department of Biotechnology: New Delhi, IN

2011 | DBT Fellowship for Master's Studies: Awarded based on top performance in the national-level competitive examination, Combined Biotechnology Entrance Examination
Distinction
Source: Self-asserted source
Basavraj Khanppnavar

Funding (2)

UGC Fellowship for Doctoral Research

2014-01 to 2015-12 | Award
UGC (New Delhi, IN)
Source: Self-asserted source
Basavraj Khanppnavar

DBT Fellowship for Master's Studies

2011-06 to 2013-04 | Award
Department of Biotechnology (New Delhi, IN)
Source: Self-asserted source
Basavraj Khanppnavar

Works (24)

Cryo-EM structure of the botulinum neurotoxin A/SV2B complex and its implications for translocation

Nature Communications
2025-02-11 | Journal article | Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing - review & editing
Part of ISSN: 2041-1723
Contributors: Basavraj Khanppnavar; Oneda Leka; Sushant Kumar Pal; Volodymyr Korkhov; Richard Kammerer
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase

Nature Chemistry
2024-09 | Journal article | Investigation, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing - review & editing
Part of ISSN: 1755-4330
Part of ISSN: 1755-4349
Contributors: Basavraj Khanppnavar; Joel P. S. Choo; Peter-Leon Hagedoorn; Grigory Smolentsev; Sasa Stefanic; Selvapravin Kumaran; Dirk Tischler; Fritz K. Winkler; Volodymyr Korkhov; Zhi Li et al.
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor

Cell
2024-08 | Journal article | Investigation, Methodology, Data curation, Formal analysis, Visualization, Writing - review & editing
Part of ISSN: 0092-8674
Contributors: Shirsha Saha; Basavraj Khanppnavar; Jagannath Maharana; Heeryung Kim; Carlo Marion C. Carino; Carole Daly; Shane Houston; Saloni Sharma; Nashrah Zaidi; Annu Dalal et al.
Source: Self-asserted source
Basavraj Khanppnavar

Structural basis of activation and inhibition of Calcium/Calmodulin sensitive membrane adenylyl cyclase 8

Gordon Research Conference - Calcium Signaling
2024-06-30 | Conference poster
Contributors: Basavraj Khanppnavar
Source: Self-asserted source
Basavraj Khanppnavar

Structural basis of connexin-36 gap junction channel inhibition

Cell Discovery
2024-06-18 | Journal article | Investigation, Methodology, Supervision
Part of ISSN: 2056-5968
Contributors: Xinyue Ding; Simone Aureli; Anand Vaithia; Pia Lavriha; Dina Schuster; Basavraj Khanppnavar; Xiaodan Li; Thorsten B. Blum; Paola Picotti; Francesco L. Gervasio et al.
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Systematic identification of structure-specific protein–protein interactions

Molecular Systems Biology
2024-05-03 | Journal article | Investigation, Methodology
Part of ISSN: 1744-4292
Contributors: Aleš Holfeld; Dina Schuster; Fabian Sesterhenn; Alison Kate Gillingham; Patrick Stalder; Walther Hänseler; Inigo Barrio-Hernandez; DHIMAN GHOSH; Jane Vowles; Sally Cowley et al.
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Advances, challenges, and opportunities in structural biology

Trends in Biochemical Sciences
2024-02 | Review | Conceptualization, Writing - original draft
Part of ISSN: 0968-0004
Contributors: Basavraj Khanppnavar; Rachel A. North; Salvador Ventura; Yanhui Xu
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling

Trends in Biochemical Sciences
2024-02 | Review | Conceptualization, Visualization, Writing - original draft
Part of ISSN: 0968-0004
Contributors: Dina Schuster; Basavraj Khanppnavar; Ilayda Kantarci; Ved Mehta; Volodymyr Korkhov
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Regulatory sites of CaM-sensitive adenylyl cyclase AC8 revealed by cryo-EM and structural proteomics

EMBO Reports
2024-02-13 | Journal article | Conceptualization, Investigation, Data curation, Formal analysis, Methodology, Visualization, Validation, Writing - original draft
Part of ISSN: 1469-3178
Contributors: Basavraj Khanppnavar; Dina Schuster; Pia Lavriha; Federico Uliana; Merve Özel; Ved Mehta; Alexander Leitner; Paola Picotti; Volodymyr Korkhov
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 6)‎

Structural basis of inhibition of organic cation transporter 3

The Brain in Flux – MSCA NeuroTrans Joint Satellite Meeting
2023-08-12 | Conference poster
Contributors: Basavraj Khanppnavar
Source: Self-asserted source
Basavraj Khanppnavar

Structure of the human Duffy antigen receptor

2023-07-10 | Preprint | Investigation, Methodology, Formal analysis, Visualization, Writing - review & editing
Contributors: Shirsha Saha; Basavraj Khanppnavar; Jagannath Maharana; Heeryung Kim; Carlo Marion C. Carino; Carole Daly; Shane Houston; Poonam Kumari; Prem N. Yadav; Bianca Plouffe et al.
Source: Self-asserted source
Basavraj Khanppnavar

Structural basis of activation and inhibition of Ca2+/Calmodulin sensitive membrane adenylyl cyclase AC8

Biophysics of the Brain Conference
2022 | Conference poster
Contributors: Basavraj Khanppnavar
Source: Self-asserted source
Basavraj Khanppnavar

Structural basis of inhibition of organic cation transporter 3

Murnau Conference on Structural Biology
2022 | Conference poster
Contributors: Basavraj Khanppnavar
Source: Self-asserted source
Basavraj Khanppnavar

Structural basis of organic cation transporter-3 inhibition

Nature Communications
2022-11-07 | Journal article | Conceptualization, Investigation, Data curation, Formal analysis, Methodology, Visualization, Validation, Writing - original draft
Part of ISSN: 2041-1723
Contributors: Basavraj Khanppnavar; Julian Maier; Freja Herborg; Ralph Gradisch; Erika Lazzarin; Dino Luethi; Jae-Won Yang; chao qi; Marion Holy; Kathrin Jäntsch et al.
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 4)‎

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases

eLife
2022-08-18 | Journal article | Investigation, Data curation, Formal analysis, Methodology, Visualization, Supervision, Writing - review & editing
Part of ISSN: 2050-084X
Contributors: Ved Mehta; Basavraj Khanppnavar; Dina Schuster; Ilayda Kantarci; Irene Vercellino; Angela Kosturanova; Tarun Iype; Sasa Stefanic; Paola Picotti; Volodymyr Korkhov
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Crystallographic and biophysical analyses of Pseudomonas aeruginosa ketopantoate reductase: Implications of ligand induced conformational changes in cofactor recognition

Biochimie
2022-02 | Supervised student publication | Conceptualization, Investigation, Supervision, Methodology, Writing - review & editing, Formal analysis
Part of ISSN: 0300-9084
Contributors: Arkaprabha Choudhury; Basavraj Khanppnavar; Saumen Datta
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Structural basis of adenylyl cyclase 9 activation

Nature Communications
2022-02-24 | Journal article | Investigation, Methodology
Part of ISSN: 2041-1723
Contributors: chao qi; Pia Lavriha; Ved Mehta; Basavraj Khanppnavar; Inayathulla Mohammed; Yong Li; Michalis Lazaratos; Jonas V. Schaefer; Birgit Dreier; Andreas Plückthun et al.
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding in type-III protein secretion

International Journal of Biological Macromolecules
2020-09 | Journal article | Conceptualization, Investigation, Formal analysis, Data curation, Methodology, Writing - original draft, Project administration
Part of ISSN: 0141-8130
Contributors: Basavraj Khanppnavar; Anupam Roy; Kausik Chandra; Vladimir N. Uversky; Nakul Chandra Maiti; Saumen Datta
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Structure and function of adenylyl cyclases, key enzymes in cellular signaling

Current Opinion in Structural Biology
2020-08 | Review | Conceptualization, Visualization, Writing - original draft
Part of ISSN: 0959-440X
Contributors: Basavraj Khanppnavar; Ved Mehta; Chao Qi; Volodymyr Korkhov
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Role of structural flexibility of effectors in bacterial T3SS mediated secretion.

Annual Meeting of the Indian Biophysical Society
2019 | Conference poster
Contributors: Basavraj Khanppnavar
Source: Self-asserted source
Basavraj Khanppnavar

Genome-wide survey and crystallographic analysis suggests a role for both horizontal gene transfer and duplication in pantothenate biosynthesis pathways

Biochimica et Biophysica Acta (BBA) - General Subjects
2019-05-25 | Journal article | Conceptualization, Investigation, Data curation, Formal analysis, Supervision, Visualization, Methodology, Writing - original draft, Project administration
Part of ISSN: 0304-4165
Contributors: Basavraj Khanppnavar; Rakesh Chatterjee; Gourab Basu Choudhury; Saumen Datta
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Deciphering the structural intricacy in virulence effectors for proton-motive force mediated unfolding and type-III protein secretion

2019-02-21 | Preprint | Author, Conceptualization, Investigation, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing - original draft, Project administration
Contributors: Basavraj Khanppnavar; Anupam Roy; kousik chandra; Nakul Maiti; Saumen Datta
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 2)‎

Crystal structure and substrate specificity of ExoY, a unique T3SS mediated secreted nucleotidyl cyclase toxin from Pseudomonas aeruginosa

Biochimica et Biophysica Acta (BBA) - General Subjects
2018-09 | Journal article | Conceptualization, Investigation, Data curation, Formal analysis, Methodology, Visualization, Writing - original draft, Project administration
Part of ISSN: 0304-4165
Contributors: Basavraj Khanppnavar; Saumen Datta
Source: Self-asserted source
Basavraj Khanppnavar
grade
Preferred source (of 3)‎

TALE: an emerging tool for genome editing and genetic engineering

Current Science
2013 | Journal article
Contributors: Khanppnavar, Basavraj; Baruah, Shashi; Ray, Suvendra Kumar
Source: check_circle
Web of Science Researcher Profile Sync

Peer review (5 reviews for 4 publications/grants)

Review activity for Applied biochemistry and biotechnology. (1)
Review activity for Applied biochemistry and biotechnology. (1)
Review activity for JoVE. (1)
Review activity for Nature communications (2)