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Loop profile: 33933

Keywords

noncoding RNA, regulatory RNA, regulatory evolution

Countries

United Kingdom

Biography

Paulo Amaral is an Assistant Professor at INSPER - Institute of Education and Research, based in Sao Paulo, Brazil. Molecular Geneticists with special interest in bioengineering, genome regulation, RNA and epigenetics. Previously, he studied the role of noncoding DNA; the biology of RNAs and their chemical modifications, as well as their implications in physiology and disease. Former Research Scientist and Consultant at Storm Therapeutics, and independent researcher at Milner Therapeutics Institute supported by a Borysiewicz Biomedical Sciences Fellowship (University of Cambridge).

Activities

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Employment (3)

Insper: Sao Paulo, SP, BR

2021-06 to present | Assistant Professor
Employment
Source: Self-asserted source
Paulo de Paiva Amaral

University of Cambridge: Cambridge, Cambridgeshire, GB

2020-01-01 to 2020-12 | Borysiewicz Biomedical Sciences Fellow (Milner Therapeutics Institute)
Employment
Source: Self-asserted source
Paulo de Paiva Amaral

Gurdon Institute: Cambridge, Cambridgeshire, GB

2011 to 2019-12-31 | Research Associate / Visiting Researcher
Employment
Source: Self-asserted source
Paulo de Paiva Amaral

Education and qualifications (3)

University of Queensland Institute for Molecular Bioscience: Brisbane, QLD, AU

2007 to 2011 | PhD in Molecular Genetics
Education
Source: Self-asserted source
Paulo de Paiva Amaral

Universidade de São Paulo Instituto de Química: Sao Paulo, SP, BR

2003 to 2006 | M.Sc. in Biochemistry (Departamento de Bioquímica)
Education
Source: Self-asserted source
Paulo de Paiva Amaral

Universidade de Brasilia Instituto de Ciências Biológicas: Brasilia, DF, BR

2000 to 2003 | B.Sc. in Biological Sciences
Education
Source: Self-asserted source
Paulo de Paiva Amaral

Works (27)

RNA, the Epicenter of Genetic Information

[CRC Press]
2022-08-25 | Book
DOI: 10.1201/9781003109242
ISBN: 9781003109242
Contributors: Paulo de Paiva Amaral; John Mattick
Source: Self-asserted source
Paulo de Paiva Amaral

The evolution of knowledge on genes associated with human diseases

iScience
2022-01 | Journal article
DOI: 10.1016/j.isci.2021.103610
Part of ISSN: 2589-0042
Source: Self-asserted source
Paulo de Paiva Amaral

RNA modifications detection by comparative Nanopore direct RNA sequencing

Nature Communications
2021-12-10 | Journal article
DOI: 10.1038/s41467-021-27393-3
Source: Self-asserted source
Paulo de Paiva Amaral

Long non-coding RNAs associated with infection and vaccine-induced immunity.

Essays in biochemistry
2021-10-01 | Journal article
DOI: 10.1042/ebc20200072
PMID: 34528687
Source: Self-asserted source
Paulo de Paiva Amaral

RNA, Genome Output and Input.

Frontiers in genetics
2020-10-27 | Journal article
DOI: 10.3389/fgene.2020.589413
PMID: 33193726
PMC: PMC7652816
Source: Self-asserted source
Paulo de Paiva Amaral

Long noncoding RNAs are involved in multiple immunological pathways in response to vaccination.

Proceedings of the National Academy of Sciences of the United States of America
2019-08-09 | Journal article
DOI: 10.1073/pnas.1822046116
PMID: 31399544
PMC: PMC6708379
Source: Self-asserted source
Paulo de Paiva Amaral

Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells.

Experimental cell research
2019-05-09 | Journal article
DOI: 10.1016/j.yexcr.2019.05.006
PMID: 31077711
PMC: PMC6994247
Source: Self-asserted source
Paulo de Paiva Amaral

A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation.

eLife
2017-08 | Journal article
DOI: 10.7554/elife.23468
PMID: 28820723
PMC: PMC5562443
Source: Self-asserted source
Paulo de Paiva Amaral via Europe PubMed Central

The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation.

2016 | Journal article
DOI: 10.1038/srep26657
PMID: 27226347
Contributors: Bell CC; Amaral PP; Kalsbeek A; Magor GW; Gillinder KR; Tangermann P; di Lisio L; Cheetham SW; Gruhl F; Frith J et al.
Source: Self-asserted source
Paulo de Paiva Amaral via Europe PubMed Central

Genomic positional conservation identifies topological anchor point (tap)RNAs linked to developmental loci

2016-04-29 | Preprint
DOI: 10.1101/051052
Contributors: Paulo P. Amaral; Tommaso Leonardi; Namshik Han; Emmanuelle Viré; Dennis K. Gascoigne; Raúl Arias-Carrasco; Magdalena Büscher; Anda Zhang; Stefano Pluchino; Vinicius Maracaja-Coutinho et al.
Source: check_circle
Crossref

Re-place your BETs: the dynamics of super enhancers.

Mol Cell
2014 | Journal article
DOI: 10.1016/j.molcel.2014.10.008
Source: Self-asserted source
Paulo de Paiva Amaral

Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective.

Brief Funct Genomics
2013 | Journal article
DOI: 10.1093/bfgp/elt016
Source: Self-asserted source
Paulo de Paiva Amaral

The non-coding snRNA 7SK controls transcriptional termination, poising, and bidirectionality in embryonic stem cells.

Genome Biol
2013 | Journal article
DOI: 10.1186/gb-2013-14-9-r98
Source: Self-asserted source
Paulo de Paiva Amaral

Pinstripe: a suite of programs for integrating transcriptomic and proteomic datasets identifies novel proteins and improves differentiation of protein-coding and non-coding genes.

Bioinformatics
2012 | Journal article
DOI: 10.1093/bioinformatics/bts582
Source: Self-asserted source
Paulo de Paiva Amaral

LncRNAdb: A reference database for long noncoding RNAs

Nucleic Acids Research
2011 | Journal article
DOI: 10.1093/nar/gkq1138
Source: Self-asserted source
Paulo de Paiva Amaral

The Reality of Pervasive Transcription

PLOS BIOLOGY
2011 | Journal article
DOI: 10.1371/journal.pbio.1000625
Source: Self-asserted source
Paulo de Paiva Amaral

Complex architecture and regulated expression of the Sox2ot locus during vertebrate development.

RNA
2009 | Journal article
DOI: 10.1261/rna.1705309
Source: Self-asserted source
Paulo de Paiva Amaral

Men ε/β nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles

Genome Research
2009 | Journal article
DOI: 10.1101/gr.087775.108
Source: Self-asserted source
Paulo de Paiva Amaral

Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications.

Brief Funct Genomic Proteomic
2009 | Journal article
DOI: 10.1093/bfgp/elp038
Source: Self-asserted source
Paulo de Paiva Amaral

RNA regulation of epigenetic processes.

Bioessays
2009 | Journal article
DOI: 10.1002/bies.080099
Source: Self-asserted source
Paulo de Paiva Amaral

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation.

Genome Res
2008 | Journal article
DOI: 10.1101/gr.078378.108
Source: Self-asserted source
Paulo de Paiva Amaral

Noncoding RNA in development.

Mamm Genome
2008 | Journal article
DOI: 10.1007/s00335-008-9136-7
Source: Self-asserted source
Paulo de Paiva Amaral

The eukaryotic genome as an RNA machine.

Science
2008 | Journal article
DOI: 10.1126/science.1155472
Source: Self-asserted source
Paulo de Paiva Amaral

Androgen responsive intronic non-coding RNAs.

BMC Biol
2007 | Journal article
DOI: 10.1186/1741-7007-5-4
Source: Self-asserted source
Paulo de Paiva Amaral

Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription.

Genome Biol
2007 | Journal article
DOI: 10.1186/gb-2007-8-3-r43
Source: Self-asserted source
Paulo de Paiva Amaral

Identification and characterization of a resistance gene analog (RGA) from the Caricaceae Dumort family

Revista Brasileira de Fruticultura
2006 | Journal article
Source: Self-asserted source
Paulo de Paiva Amaral

Papaya lethal yellowing virus (PLYV) infects Vasconcellea cauliflora

Fitopatologia Brasileira
2006 | Journal article
DOI: 10.1590/S0100-41582006000500014
Source: Self-asserted source
Paulo de Paiva Amaral
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