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Education and qualifications (1)

Johns Hopkins University School of Medicine: Baltimore, MD, US

2017-08 to 2022-02 | PhD (Molecular Biology and Genetics)
Education
Source: Self-asserted source
Benjamin Zaepfel

Works (10)

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

Cell Reports
2022-07 | Journal article
DOI: 10.1016/j.celrep.2022.111106
Contributors: Lauren Duan; Benjamin L. Zaepfel; Vasilisa Aksenova; Mary Dasso; Jeffrey D. Rothstein; Petr Kalab; Lindsey R. Hayes
Source: check_circle
Crossref

Nuclear Pore Dysfunction in Neurodegeneration.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2022-07-01 | Journal article
DOI: 10.1007/s13311-022-01293-w
PMID: 36070178
Contributors: Spead O; Zaepfel BL; Jeffrey Rothstein
Source: Self-asserted source
Benjamin Zaepfel

Polyadenylated RNA and RNA-Binding Proteins Exhibit Unique Response to Hyperosmotic Stress.

Frontiers in cell and developmental biology
2021-12-14 | Journal article
DOI: 10.3389/fcell.2021.809859
PMID: 34970554
PMC: PMC8712688
Contributors: Zaepfel BL; Rothstein JD
Source: Self-asserted source
Benjamin Zaepfel

Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS

Science Translational Medicine
2021-07-28 | Journal article
DOI: 10.1126/scitranslmed.abe1923
Contributors: Alyssa N. Coyne; Victoria Baskerville; Benjamin L. Zaepfel; Dennis W. Dickson; Frank Rigo; Frank Bennett; C. Patrick Lusk; Jeffrey D. Rothstein
Source: check_circle
Crossref

RNA Is a Double-Edged Sword in ALS Pathogenesis

Frontiers in Cellular Neuroscience
2021-07-19 | Journal article
DOI: 10.3389/fncel.2021.708181
Part of ISSN: 1662-5102
Source: Self-asserted source
Benjamin Zaepfel

UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction

Cell Reports
2021-03 | Journal article
DOI: 10.1016/j.celrep.2021.108925
Contributors: Benjamin L. Zaepfel; Zhe Zhang; Kirstin Maulding; Alyssa N. Coyne; Weiwei Cheng; Lindsey R. Hayes; Thomas E. Lloyd; Shuying Sun; Jeffrey D. Rothstein
Source: check_circle
Crossref

G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.

Neuron
2020-07-15 | Journal article
DOI: 10.1016/j.neuron.2020.06.027
PMID: 32673563
Source: Self-asserted source
Benjamin Zaepfel

Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS

Cell Reports
2017-10 | Journal article
DOI: 10.1016/j.celrep.2017.09.028
Part of ISSN: 2211-1247
Source: Self-asserted source
Benjamin Zaepfel

Failure to Deliver and Translate—New Insights into RNA Dysregulation in ALS

Frontiers in Cellular Neuroscience
2017-08-17 | Journal article
DOI: 10.3389/fncel.2017.00243
Part of ISSN: 1662-5102
Source: Self-asserted source
Benjamin Zaepfel

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation

Human Molecular Genetics
2015-09-18 | Journal article
DOI: 10.1093/hmg/ddv389
Part of ISSN: 0964-6906
Part of ISSN: 1460-2083
Source: Self-asserted source
Benjamin Zaepfel
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