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Intervertebral Disc, Hydrogels, Catabolisim, Network modelling

Activities

Employment (1)

Universität Bern: Bern, Bern, CH

2021-02-01 to 2024-12-31 | Marie Skłodowska-Curie Actions ITN fellow - Disc4all (Department of BioMedical Research)
Employment
Source: Self-asserted source
Paola Bermudez-Lekerika

Education and qualifications (6)

University of Bern: Bern, CH

2021-02-01 to 2024-12-31 | PhD candidate (Department of BioMedical Research)
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

Universität Bern: Bern, Bern, CH

2020-03-01 to 2020-12-01 | Master’s Degree Project (Membrane Transport Discovery Lab, Department of Nephrology and Hypertension, University Hospital Bern Inselspital)
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

University of Navarra: Pamplona, Navarra, ES

2019-09-01 to 2020-09-15 | Master’s degree in Biomedical Research, Regenerative Medicine and Advanced Therapies speciality (School of Science)
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

University of Navarra: Pamplona, Navarra, ES

2013-09-01 to 2019-05-15 | Bachelor in Biochemistry (Department of Biochemistry and Genetics, University of Navarra School of Sciences)
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

University of Tromsø - The Arctic University of Norway: Tromsø, NO

2017-08-01 to 2018-06-15 | Bachelor in Biochemistry - Exchange programme
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

University of Navarra: Pamplona, Navarra, ES

2013-09-01 to 2017-05-15 | Bachelor in Chemistry (Organic Chemistry Department)
Education
Source: Self-asserted source
Paola Bermudez-Lekerika

Professional activities (2)

Tissue Engineering and Regenerative Medicine Society: Columbus, Ohio, US

2023-01-01 to 2023-12-31 | Student membership
Membership
Source: Self-asserted source
Paola Bermudez-Lekerika

Orthopaedic Research Society: Rosemont, US

2022 to 2023 | Student member (Spine Section)
Membership
Source: Self-asserted source
Paola Bermudez-Lekerika

Works (16)

In-silico proteomic analysis of IL-4 and IL-10 role in IVD degeneration: Protein-protein interaction networks for candidate prioritization

Computational and Structural Biotechnology Journal (Under Review)
2025 | Journal article
Contributors: Paola Bermudez-Lekerika
Source: Self-asserted source
Paola Bermudez-Lekerika

Ex Vivo and In Vitro Proteomic Approach to Elucidate the Relevance of IL‐4 and IL‐10 in Intervertebral Disc Pathophysiology

JOR SPINE
2025-03 | Journal article
Contributors: Paola Bermudez‐Lekerika; Sofia Tseranidou; Exarchos Kanelis; Andrea Nüesch; Katherine B. Crump; Leonidas G. Alexopoulos; Karin Wuertz‐Kozak; Jérôme Noailly; Christine L. Le Maitre; Benjamin Gantenbein
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Sulfated Hydrogels as Primary Intervertebral Disc Cell Culture Systems

Gels
2024-05-14 | Journal article
Contributors: Paola Bermudez-Lekerika; Katherine B. Crump; Karin Wuertz-Kozak; Christine L. Le Maitre; Benjamin Gantenbein
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The bone morphogenetic protein 2 analogue L51P enhances spinal fusion in combination with BMP2 in an in vivo rat tail model

Acta Biomaterialia
2024-03 | Journal article
Part of ISSN: 1742-7061
Contributors: Benjamin Gantenbein; Katharina A.C. Oswald; Georg F. Erbach; Andreas Shaun Croft; Paola Bermudez-Lekerika; Franziska Silvia Strunz; Sebastian F. Bigdon; Christoph E. Albers
Source: Self-asserted source
Paola Bermudez-Lekerika

THE METABOLIC ROLE OF IL-4 AND IL-10 IN INTERVERTEBRAL DISC DEGENERATION

Orthopaedic Proceedings
2024-01-02 | Conference presentation
Part of ISSN: 1358-992X
Part of ISSN: 2049-4416
Contributors: P. Bermudez-Lekerika; S. Tseranidou; E. Kanelis; K.B. Crump; C. Le Maitre; K. Wuertz-Kozak; L.G. Alexopoulos; J. Noailly; B. Gantenbein
Source: Self-asserted source
Paola Bermudez-Lekerika

Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research

JOR SPINE
2023-12 | Journal article
Contributors: Katherine B. Crump; Ahmad Alminnawi; Paola Bermudez‐Lekerika; Roger Compte; Francesco Gualdi; Terence McSweeney; Estefano Muñoz‐Moya; Andrea Nüesch; Liesbet Geris; Stefan Dudli et al.
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TERMIS 2023 – European Chapter Manchester Central Conference Centre Manchester, UK March 28–31, 2023

Tissue Engineering Part A
2023-06-30 | Conference output
Part of ISSN: 1937-3341
Part of ISSN: 1937-335X
Source: Self-asserted source
Paola Bermudez-Lekerika

Modulating intervertebral disc catabolism in in vitro and ex vivo systems: IL-4 and IL-10 metabolic role in intervertebral disc degeneration

The Human Digital Twin Summer School
2023-06-03 | Conference presentation
Contributors: Paola Bermudez-Lekerika
Source: Self-asserted source
Paola Bermudez-Lekerika

Inhibition of the extracellular signal‐regulated kinase pathway reduces the inflammatory component in nucleus pulposus cells

Journal of Orthopaedic Research
2022-10 | Journal article
Contributors: Adel Tekari; Alessandro Marazza; Katherine Crump; Paola Bermudez‐Lekerika; Benjamin Gantenbein
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Crossref

Immuno-Modulatory Effects of Intervertebral Disc Cells

Frontiers in Cell and Developmental Biology
2022-06-29 | Journal article
Part of ISSN: 2296-634X
Contributors: Paola Bermudez-Lekerika; Katherine B. Crump; Sofia Tseranidou; Andrea Nüesch; Exarchos Kanelis; Ahmad Alminnawi; Laura Baumgartner; Estefano Muñoz-Moya; Roger Compte; Francesco Gualdi et al.
Source: Self-asserted source
Paola Bermudez-Lekerika

Should Degenerated Intervertebral Discs of Patients with Modic Type 1 Changes Be Treated with Mesenchymal Stem Cells?

International Journal of Molecular Sciences
2022-02-28 | Journal article
Contributors: Nick Herger; Paola Bermudez-Lekerika; Mazda Farshad; Christoph E. Albers; Oliver Distler; Benjamin Gantenbein; Stefan Dudli
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Inhibition of histone deacetylase 6 by tubastatin A as an experimental therapeutic strategy against glioblastoma

Glioma
2021 | Journal article
Part of ISSN: 2589-6113
Source: Self-asserted source
Paola Bermudez-Lekerika

In Situ Cell Signalling of the Hippo-YAP/TAZ Pathway in Reaction to Complex Dynamic Loading in an Intervertebral Disc Organ Culture

International Journal of Molecular Sciences
2021-12-20 | Journal article
Contributors: Andreas S. Croft; Ysaline Roth; Katharina A. C. Oswald; Slavko Ćorluka; Paola Bermudez-Lekerika; Benjamin Gantenbein
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Sulfated Hydrogels in Intervertebral Disc and Cartilage Research

Cells
2021-12-17 | Journal article
Contributors: Emily Lazarus; Paola Bermudez-Lekerika; Daniel Farchione; Taylor Schofield; Sloan Howard; Iskender Mambetkadyrov; Mikkael Lamoca; Iris V. Rivero; Benjamin Gantenbein; Christopher L. Lewis et al.
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Establishment of a Novel Method for Spinal Discectomy Surgery in Elderly Rats in an In Vivo Spinal Fusion Model.

Methods and protocols
2021-11-02 | Journal article
Source: Self-asserted source
Paola Bermudez-Lekerika

EGR2, IGF1 and IL6 Expression Are Elevated in the Intervertebral Disc of Patients Suffering from Diffuse Idiopathic Skeletal Hyperostosis (DISH) Compared to Degenerative or Trauma Discs

Applied Sciences
2021-04-29 | Journal article
Contributors: Benjamin Gantenbein; Rahel D. May; Paola Bermudez-Lekerika; Katharina A. C. Oswald; Lorin M. Benneker; Christoph E. Albers
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