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Universitat Bern: Bern, Bern, CH

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University of Bern

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Mouse models for bacterial enteropathogen infections: insights into the role of colonization resistance

Gut Microbes
2023 | Journal article
Contributors: Herzog, Mathias K. -M.; Cazzaniga, Monica; Peters, Audrey; Shayya, Nizar; Beldi, Luca; Hapfelmeier, Siegfried; Heimesaat, Markus M. M.; Bereswill, Stefan; Frankel, Gad; Gahan, Cormac G. M. et al.
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The stationary phase-specific sRNA FimR2 is a multifunctional regulator of bacterial motility, biofilm formation and virulence

Nucleic Acids Research
2022-11-11 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Nicole Raad; Disha Tandon; Siegfried Hapfelmeier; Norbert Polacek
Source: Self-asserted source
Siegfried Hapfelmeier
grade
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A protocol for generating germ-free<i> Heligmosomoides</i><i> polygyrus</i><i> bakeri</i> larvae for gnotobiotic helminth infection studies

STAR Protocols
2021 | Journal article
Contributors: Russell, Gabriel A.; Peng, Garrie; Faubert, Cynthia; Verdu, Elena F.; Hapfelmeier, Siegfried; King, Irah L.
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Plant chemistry and food web health

New Phytologist
2021 | Journal article
Contributors: Schlaeppi, Klaus; Gross, Josef J.; Hapfelmeier, Siegfried; Erb, Matthias
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Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactions

Nature Communications
2021 | Journal article
Contributors: Romoli, Ottavia; Schonbeck, Johan Claes; Hapfelmeier, Siegfried; Gendrin, Mathilde
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Robust microbe immune recognition in the intestinal mucosa

Genes and Immunity
2021 | Journal article
Contributors: Scharen, Olivier P.; Hapfelmeier, Siegfried
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Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity (vol 11, 1978, 2020)

Nature Communications
2021 | Journal article
Contributors: Pfister, Simona P.; Scharen, Olivier P.; Beldi, Luca; Printz, Andrea; Notter, Matheus D.; Mukherjee, Mohana; Li, Hai; Limenitakis, Julien P.; Werren, Joel P.; Tandon, Disha et al.
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Biogeography of microbial bile acid transformations along the murine gut

Journal of Lipid Research
2020 | Journal article
Contributors: Marion, Solenne; Desharnais, Lyne; Studer, Nicolas; Dong, Yuan; Notter, Matheus D.; Poudel, Suresh; Menin, Laure; Janowczyk, Andrew; Hettich, Robert L.; Hapfelmeier, Siegfried et al.
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Engineering bacterial symbionts of nematodes improves biocontrol potential of the western corn rootworm

Nature Biotechnology
2020 | Journal article
Contributors: Machado, Ricardo A. R.; Thonen, Lisa; Arce, Carla C. M.; Theepan, Vanitha; Prada, Fausto; Wuthrich, Daniel; Robert, Christelle A. M.; Vogiatzaki, Evangelia; Shi, Yi-Ming; Schaeren, Olivier P. et al.
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Engineering bacterial symbionts of nematodes improves their biocontrol potential to counter the western corn rootworm (Feb, 10.1038/s41587-020-0419-1, 2020)

Nature Biotechnology
2020 | Journal article
Contributors: Machado, Ricardo A. R.; Thoenen, Lisa; Arce, Carla C. M.; Theepan, Vanitha; Prada, Fausto; Wuethrich, Daniel; Robert, Christelle A. M.; Vogiatzaki, Evangelia; Shi, Yi-Ming; Schaeren, Olivier P. et al.
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Memory CD8(+) T Cells Balance Pro- and Anti-inflammatory Activity by Reprogramming Cellular Acetate Handling at Sites of Infection

Cell Metabolism
2020 | Journal article
Contributors: Balmer, Maria L.; Ma, Eric H.; Thompson, Andrew J.; Epple, Raja; Unterstab, Gunhild; Loetscher, Jonas; Dehio, Philippe; Schuerch, Christian M.; Warncke, Jan D.; Perrin, Gaelle et al.
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Mucosal or systemic microbiota exposures shape the B cell repertoire

Nature
2020 | Journal article
Contributors: Li, Hai; Limenitakis, Julien P.; Greiff, Victor; Yilmaz, Bahtiyar; Scharen, Olivier; Urbaniak, Camilla; Zund, Mirjam; Lawson, Melissa A. E.; Young, Ian D.; Rupp, Sandra et al.
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Paneth cells promote angiogenesis and regulate portal hypertension in response to microbial signals

Journal of Hepatology
2020 | Journal article
Contributors: Hassan, Mohsin; Moghadamrad, Sheida; Sorribas, Marcel; Muntet, Sergi G.; Kellmann, Philipp; Trentesaux, Coralie; Fraudeau, Marie; Nanni, Paolo; Wolski, Witold; Keller, Irene et al.
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Respiratory tissue-associated commensal bacteria offer therapeutic potential against pneumococcal colonization

eLife
2020 | Journal article
Contributors: Yildiz, Soner; Lopes, Joao P. Pereira Bonifacio; Berge, Matthieu; Gonzalez-Ruiz, Victor; Baud, Damian; Kloehn, Joachim; Boal-Carvalho, Ines; Schaeren, Olivier P.; Schotsaert, Michael; Hathaway, Lucy J. et al.
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Uncoupling of invasive bacterial mucosal immunogenicity from pathogenicity

Nature Communications
2020 | Journal article
Contributors: Pfister, Simona P.; Scharen, Olivier P.; Beldi, Luca; Printz, Andrea; Notter, Matheus D.; Mukherjee, Mohana; Li, Hai; Limenitakis, Julien P.; Werren, Joel P.; Tandon, Disha et al.
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Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactions

BioRxiv
2019 | Journal article
Contributors: Ottavia Romoli; Johan Claes Schönbeck; Siegfried Hapfelmeier; Mathilde Gendrin
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Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

bioRxiv
2019-09-19 | Preprint
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Siegfried Hapfelmeier
grade
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Outrunning Salmonella - the role of endogenous Enterobacteriaceae in variable colonization resistance.

Lab animal
2019-07-01 | Journal article
Source: Self-asserted source
Siegfried Hapfelmeier
grade
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Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response

Immunity
2018 | Journal article
WOSUID:

WOS:000444909600020

Contributors: Uchimura, Yasuhiro; Fuhrer, Tobias; Li, Hai; Lawson, Melissa A.; Zimmermann, Michael; Yilmaz, Bahtiyar; Zindel, Joel; Ronchi, Francesca; Sorribas, Marcel; Hapfelmeier, Siegfried et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
Preferred source (of 2)‎

In vitro and in vivo characterization of Clostridium scindens bile acid transformations.

Gut microbes
2018-12-27 | Journal article
Source: Self-asserted source
Siegfried Hapfelmeier
grade
Preferred source (of 3)‎

Innate immunity restricts Citrobacter rodentium A/E pathogenesis initiation to an early window of opportunity

Plos Pathogens
2017 | Journal article
WOSUID:

WOS:000404511700055

Contributors: Buschor, Stefanie; Cuenca, Miguelangel; Uster, Stephanie S.; Scharen, Olivier P.; Balmer, Maria L.; Terrazos, Miguel A.; Schurch, Christian M.; Hapfelmeier, Siegfried
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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The ESRP1-GPR137 axis contributes to intestinal pathogenesis

Elife
2017 | Journal article
WOSUID:

WOS:000414136200001

Contributors: Mager, Lukas Franz; Koelzer, Viktor Hendrik; Stuber, Regula; Thoo, Lester; Keller, Irene; Koeck, Ivonne; Langenegger, Maya; Simillion, Cedric; Pfister, Simona P.; Faderl, Martin et al.
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Siegfried Hapfelmeier via ResearcherID
grade
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D-Alanine-Controlled Transient Intestinal Mono-Colonization with Non-Laboratory-Adapted Commensal E. coli Strain HS

PLoS One
2016 | Journal article
Contributors: Cuenca, M.; Pfister, S. P.; Buschor, S.; Bayramova, F.; Hernandez, S. B.; Cava, F.; Kuru, E.; Van Nieuwenhze, M. S.; Brun, Y. V.; Coelho, F. M. et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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Functional Intestinal Bile Acid 7 alpha-Dehydroxylation by Clostridium scindens Associated with Protection from Clostridium difficile Infection in a Gnotobiotic Mouse Model

Frontiers in Cellular and Infection Microbiology
2016 | Journal article
WOSUID:

WOS:000390065500001

Contributors: Studer, Nicolas; Deshamais, Lyne; Beutler, Markus; Brugiroux, Sandrine; Terrazos, Miguel A.; Menin, Laure; Schurch, Christian M.; McCoy, Kathy D.; Kuehne, Sarah A.; Minton, Nigel P. et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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Memory CD8(+) T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

Immunity
2016 | Journal article
WOSUID:

WOS:000378341200011

Contributors: Balmer, Maria L.; Ma, Eric H.; Bantug, Glenn R.; Grahlert, Jasmin; Pfister, Simona; Glatter, Timo; Jauch, Annaise; Dimeloe, Sarah; Slack, Emma; Dehio, Philippe et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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Peracetic Acid Treatment Generates Potent Inactivated Oral Vaccines from a Broad Range of Culturable Bacterial Species

Frontiers in Immunology
2016 | Journal article
WOSUID:

WOS:000369979100001

Contributors: Moor, Kathrin; Wotzka, Sandra Y.; Toska, Albulena; Diard, Mederic; Hapfelmeier, Siegfried; Slack, Emma
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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The maternal microbiota drives early postnatal innate immune development

Science
2016 | Journal article
Contributors: de Agueero, Mercedes Gomez; Ganal-Vonarburg, Stephanie C.; Fuhrer, Tobias; Rupp, Sandra; Uchimura, Yasuhiro; Li, Hai; Steinert, Anna; Heikenwalder, Mathias; Hapfelmeier, Siegfried; Sauer, Uwe et al.
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The role of immune system maturation in development of normal behavior in mice

Brain, Behavior, and Immunity
2016 | Journal article
Contributors: Philip, V.; Lu, J.; Galipeau, H. J.; Verdu, E. F.; McCoy, K. D.; Macpherson, A. J.; Hapfelmeier, S.; De Palma, G.; Surette, M. G.; Collins, S. M. et al.
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Gut Microbiota Orchestrates Energy Homeostasis during Cold

Cell
2015 | Journal article
Contributors: Chevalier, C.; Stojanović, O.; Colin, D. J.; Suarez-Zamorano, N.; Tarallo, V.; Veyrat-Durebex, C.; Rigo, D.; Fabbiano, S.; Stevanović, A.; Hagemann, S. et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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Microbiota depletion promotes browning of white adipose tissue and reduces obesity

Nature Medicine
2015 | Journal article
WOSUID:

WOS:000366008700021

Contributors: Suarez-Zamorano, Nicolas; Fabbiano, Salvatore; Chevalier, Claire; Stojanovic, Ozren; Colin, Didier J.; Stevanovic, Ana; Veyrat-Durebex, Christelle; Tarallo, Valentina; Rigo, Dorothee; Germain, Stephane et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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Microbiota-Derived Compounds Drive Steady-State Granulopoiesis via MyD88/TICAM Signaling

Journal of Immunology
2014 | Journal article
WOSUID:

WOS:000345023400055

Contributors: Balmer, Maria L.; Schuerch, Christian M.; Saito, Yasuyuki; Geuking, Markus B.; Li, Hai; Cuenca, Miguelangel; Kovtonyuk, Larisa V.; Mccoy, Kathy D.; Hapfemeier, Siegfried; Ochsenbein, Adrian F. et al.
Source: Self-asserted source
Siegfried Hapfelmeier via ResearcherID
grade
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The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

Science Translational Medicine
2014 | Journal article
Contributors: Balmer, Maria L.; Slack, Emma; de Gottardi, Andrea; Lawson, Melissa A. E.; Hapfelmeier, Siegfried; Miele, Luca; Grieco, Antonio; Van Vlierberghe, Hans; Fahrner, Rene; Patuto, Nicola et al.
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Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

Nature
2012 | Journal article
SOURCE-WORK-ID:

7749

Contributors: Fritz, Jörg H; Rojas, Olga Lucia; Simard, Nathalie; McCarthy, Douglas D; Hapfelmeier, Siegfried Hektor; Rubino, Stephen; Robertson, Susan J; Larijani, Mani; Gosselin, Jean; Ivanov, Ivaylo I et al.
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University of Bern
grade
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Functional flexibility of intestinal IgA - broadening the fine line

Frontiers in immunology
2012 | Journal article
SOURCE-WORK-ID:

16027

Contributors: Slack, Emma; Balmer, Maria Luisa; Fritz, Jörg H; Hapfelmeier, Siegfried Hektor
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University of Bern
grade
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The habitat, double life, citizenship, and forgetfulness of IgA

Immunological reviews
2012 | Journal article
SOURCE-WORK-ID:

16028

Contributors: Macpherson, Andrew; Geuking, Markus; Slack, Emma; Hapfelmeier, Siegfried Hektor; McCoy, Kathleen
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University of Bern
grade
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Intestinal bacterial colonization induces mutualistic regulatory T cell responses

Immunity
2011 | Journal article
SOURCE-WORK-ID:

7755

Contributors: Geuking, Markus; Cahenzli, Julia; Lawson, Melissa A E; Ng, Derek C K; Slack, Emma; Hapfelmeier, Siegfried Hektor; McCoy, Kathleen; Macpherson, Andrew
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University of Bern
grade
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In remembrance of commensal intestinal microbes

Communicative & integrative biology
2010 | Journal article
SOURCE-WORK-ID:

1721

Contributors: Hapfelmeier, Siegfried Hektor; Macpherson, Andrew
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University of Bern
grade
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Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria

PLoS pathogens
2010 | Journal article
SOURCE-WORK-ID:

1484

Contributors: Stecher, Bärbel; Chaffron, Samuel; Käppeli, Rina; Hapfelmeier, Siegfried Hektor; Freedrich, Susanne; Weber, Thomas C; Kirundi, Jorum; Suar, Mrutyunjay; McCoy, Kathy D; von Mering, Christian et al.
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University of Bern
grade
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Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses

Science
2010 | Journal article
SOURCE-WORK-ID:

836

Contributors: Hapfelmeier, Siegfried Hektor; Lawson, Melissa A E; Slack, Emma; Kirundi, Jorum K; Stoel, Maaike; Heikenwalder, Mathias; Cahenzli, Julia; Velykoredko, Yuliya; Balmer, Maria L; Endt, Kathrin et al.
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University of Bern
grade
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Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism

Science
2009 | Journal article
SOURCE-WORK-ID:

29612

Contributors: Slack, Emma; Hapfelmeier, Siegfried Hektor; Stecher, Bärbel; Velykoredko, Yuliya; Stoel, Maaike; Lawson, Melissa A E; Geuking, Markus B; Beutler, Bruce; Tedder, Thomas F; Hardt, Wolf-Dietrich et al.
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University of Bern
grade
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Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent step in DeltainvG S. Typhimurium colitis.

The Journal of experimental medicine
2008 | Journal article
SOURCE-WORK-ID:

67829

Contributors: Hapfelmeier, Siegfried Hektor; Müller, Andreas J; Stecher, Bärbel; Kaiser, Patrick; Barthel, Manja; Endt, Kathrin; Eberhard, Matthias; Robbiani, Riccardo; Jacobi, Christoph A; Heikenwalder, Mathias et al.
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University of Bern
grade
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The armed truce between the intestinal microflora and host mucosal immunity.

Seminars in immunology
2007 | Journal article
SOURCE-WORK-ID:

67830

Contributors: Macpherson, Andrew J; Hapfelmeier, Siegfried Hektor; McCoy, Kathy D
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University of Bern
grade
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Virulence of broad- and narrow-host-range Salmonella enterica serovars in the streptomycin-pretreated mouse model.

Infection and immunity
2006 | Journal article
SOURCE-WORK-ID:

67831

Contributors: Suar, Mrutyunjay; Jantsch, Jonathan; Hapfelmeier, Siegfried Hektor; Kremer, Marcus; Stallmach, Thomas; Barrow, Paul A; Hardt, Wolf-Dietrich
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University of Bern
grade
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A mouse model for S. typhimurium-induced enterocolitis.

Trends in microbiology
2005 | Journal article
SOURCE-WORK-ID:

67832

Contributors: Hapfelmeier, Siegfried Hektor; Hardt, Wolf-Dietrich
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University of Bern
grade
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Comparison of Salmonella enterica serovar Typhimurium colitis in germfree mice and mice pretreated with streptomycin.

Infection and immunity
2005 | Journal article
SOURCE-WORK-ID:

67833

Contributors: Stecher, Bärbel; Macpherson, Andrew J; Hapfelmeier, Siegfried Hektor; Kremer, Marcus; Stallmach, Thomas; Hardt, Wolf-Dietrich
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University of Bern
grade
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The salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow <i>Salmonella</i> serovar <i>typhimurium</i> to trigger colitis via MyD88-dependent and MyD88-independent mechanisms

The Journal of Immunology
2005 | Journal article
Contributors: Hapfelmeier, S; Stecher, B; Barthel, M; Kremer, M; Müller, AJ; Heikenwalder, M; Stallmach, T; Hensel, M; Pfeffer, K; Akira, S et al.
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The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms.

Journal of immunology
2005 | Journal article
SOURCE-WORK-ID:

67834

Contributors: Hapfelmeier, Siegfried Hektor; Stecher, Bärbel; Barthel, Manja; Kremer, Marcus; Müller, Andreas J; Heikenwalder, Mathias; Stallmach, Thomas; Hensel, Michael; Pfeffer, Klaus; Akira, Shizuo et al.
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University of Bern

Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice.

Infection and immunity
2004 | Journal article
SOURCE-WORK-ID:

67835

Contributors: Stecher, Bärbel; Hapfelmeier, Siegfried Hektor; Müller, Catherine; Kremer, Marcus; Stallmach, Thomas; Hardt, Wolf-Dietrich
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University of Bern
grade
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InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium.

Journal of bacteriology
2004 | Journal article
SOURCE-WORK-ID:

67836

Contributors: Ehrbar, Kristin; Hapfelmeier, Siegfried Hektor; Stecher, Bärbel; Hardt, Wolf-Dietrich
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University of Bern
grade
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Role of the Salmonella pathogenicity island 1 effector proteins SipA, SopB, SopE, and SopE2 in Salmonella enterica subspecies 1 serovar Typhimurium colitis in streptomycin-pretreated mice.

Infection and immunity
2004 | Journal article
SOURCE-WORK-ID:

67837

Contributors: Hapfelmeier, Siegfried Hektor; Ehrbar, Kristin; Stecher, Bärbel; Barthel, Manja; Kremer, Marcus; Hardt, Wolf-Dietrich
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University of Bern
grade
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Peer review (4 reviews for 4 publications/grants)

Review activity for BMC immunology (1)
Review activity for Microbiome (1)
Review activity for Nature communications (1)
Review activity for PLoS biology. (1)