Personal information

Czech Republic

Activities

Employment (3)

Boston Children's Hospital: Boston, MA, US

2023-10 to present | Postdoc (remote) (Computational Health Informatics Program, Dietlein Lab)
Employment
Source: Self-asserted source
Petr Holý

Lékařská Fakulta v Plzni, Univerzita Karlova: Pilsen, CZ

2018-03 to present | Researcher (Biomedical Center, Laboratory of Pharmacogenomics)
Employment
Source: Self-asserted source
Petr Holý

National Institute of Public Health: Prague, CZ

2017-10 to present | Staff Researcher (Toxicogenomics Unit)
Employment
Source: Self-asserted source
Petr Holý

Education and qualifications (4)

Institute for Postgraduate Medical Education: Prague, CZ

2024 | Professional Competency in Medical Laboratory Methods (accredited qualification course)
Qualification
Source: Self-asserted source
Petr Holý

Charles University: Prague, CZ

2017 to 2023 | PhD - Biomedicine (Third Faculty of Medicine)
Education
Source: Self-asserted source
Petr Holý

Charles University: Prague, CZ

2015 to 2017 | MSc - Biochemistry (Faculty of Science)
Education
Source: Self-asserted source
Petr Holý

Charles University: Prague, CZ

2011 to 2014 | BSc - Biochemistry (Faculty of Science)
Education
Source: Self-asserted source
Petr Holý

Professional activities (4)

Sigma Xi: Durham, North Carolina, US

2023 to present | Full Member
Membership
Source: Self-asserted source
Petr Holý

European Association for Cancer Research: Nottingham, GB

2022 to present | Early Career Member
Membership
Source: Self-asserted source
Petr Holý

European Cooperation in Science and Technology: Prague, CZ

2019 to present | Member
Membership
Source: Self-asserted source
Petr Holý

Czech Society for Biochemistry and Molecular Biology: Prague, CZ

2019 to present | Member
Membership
Source: Self-asserted source
Petr Holý

Works (21)

Targeted DNA sequencing of high‐grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression

International Journal of Cancer
2024-07 | Journal article
Contributors: Petr Holý; Viktor Hlaváč; Karolína Šeborová; Simona Šůsová; Tereza Tesařová; Lukáš Rob; Martin Hruda; Jiří Bouda; Alena Bartáková; Marcela Mrhalová et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

1035 Characterization of ovarian carcinoma molecular profile by integration of transriptomic profile with somatic and germline genetic variability

ESGO 2024 - International Journal of Gynecological Cancer
2024-03-10 | Conference poster
Contributors: Martin Hruda; Karolina Seborova; Viktor Hlavac; Petr Holý; Radka Vaclavikova; Marcela Mrhalova; Alena Bartakova; Jiri Bouda; Vendula Smoligova; Jiri Spacek et al.
Source: Self-asserted source
Petr Holý
grade
Preferred source (of 2)‎

934 Crucial genetic variants associated with sensitivity to therapy in epithelial ovarian carcinoma patients and optimalization of digital PCR for their analysis

ESGO 2024 - International Journal of Gynecological Cancer
2024-03-10 | Conference poster
Contributors: Radka Vaclavikova; Karolina Seborova; Mohammad Al Obeed Allah; Viktor Hlavac; Martin Hruda; Lukas Rob; Marcela Mrhalova; Alena Bartakova; Jiri Bouda; Vendula Smoligova et al.
Source: Self-asserted source
Petr Holý
grade
Preferred source (of 2)‎

Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction

JCO Precision Oncology
2023 | Journal article
Contributors: Hlavac, Viktor; Cervenkova, Lenka; Susova, Simona; Holy, Petr; Liska, Vaclav; Vycital, Ondrej; Sorejs, Ondrej; Fiala, Ondrej; Daum, Ondrej; Soucek, Pavel
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

GERMLINE AND SOMATIC GENETIC PROFILES OF EPITHELIAL OVARIAN CARCINOMA PATIENTS SENSITIVE AND RESISTANT TO PLATINUM DERIVATIVES ESTIMATED BY TARGETED DNA SEQUENCING

International Journal of Gynecological Cancer
2023 | Journal article
Contributors: Rob, Lukas; Hlavac, Viktor; Holy, Petr; Seborova, Karolina; Vaclavikova, Radka; Mrhalova, Marcela; Bartakova, Alena; Bouda, Jiri; Spacek, Jiri; Sedlakova, Iva et al.
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases

Cancer Cell International
2023 | Journal article
Contributors: Heczko, Lucie; Hlavac, Viktor; Holy, Petr; Dvorak, Pavel; Liska, Vaclav; Vycital, Ondrej; Fiala, Ondrej; Soucek, Pavel
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Inhibition of homologous recombination repair by Mirin in ovarian cancer ameliorates carboplatin therapy response in vitro

Mutagenesis
2023-12-14 | Journal article
Contributors: Josef Horak; Dominika Vallusova; Andrea Cumova; Petr Holy; Pavel Vodicka; Alena Opattova
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early‐stage luminal breast cancer

Molecular Oncology
2023-10 | Journal article
Contributors: Petr Holý; Veronika Brynychová; Karolína Šeborová; Vojtěch Haničinec; Renata Koževnikovová; Markéta Trnková; David Vrána; Jiří Gatěk; Kateřina Kopečková; Marcela Mrhalová et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

The Potential of Exome Sequencing of Paired Colorectal Tumors and Synchronous Liver Metastases to Improve Treatment

Pharmacogenomics
2023-08 | Journal article
Contributors: Viktor Hlaváč; Petr Holý; Pavel Souček
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Abstract 5544: Association of circulating markers of gut barrier damage and inflammation with colorectal neoplasia stage

Cancer Research, Proceedings of the American Association for Cancer Research Annual Meeting 2023
2023-04-04 | Conference abstract
Part of ISSN: 1538-7445
Contributors: Flavia Genua; Petr Holý; Pavel Souček; Václav Liška; David J. Hughes
Source: Self-asserted source
Petr Holý
grade
Preferred source (of 2)‎

2022-RA-861-ESGO Transcriptome and genetic profile of epithelial ovarian carcinoma patients sensitive and resistant to platinum derivatives

European Congress on Gynaecological Oncology
2022 | Conference paper
Contributors: Martin Hruda; Viktor Hlaváč; Petr Holý; Karolína Šeborová; Radka Václavíková; Marcela Mrhalová; Petr Černaj; Jiří Bouda; Pavel Souček; Lukáš Rob
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model

Frontiers in Pharmacology
2022 | Journal article
Contributors: Seborova, Karolina; Koucka, Kamila; Spalenkova, Alzbeta; Holy, Petr; Ehrlichova, Marie; Sychra, Tomas; Chen, Lei; Bendale, Hersh; Ojima, Iwao; Sandoval-Acuna, Cristian et al.
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy

Frontiers in Oncology
2022 | Journal article
Contributors: Seborova, Karolina; Hlavac, Viktor; Holy, Petr; Bjorklund, Sunniva S.; Fleischer, Thomas; Rob, Lukas; Hruda, Martin; Bouda, Jiri; Mrhalova, Marcela; Allah, Mohammad Moufaq Khatar Al Obeed et al.
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Integrated molecular profile of platinum resistant epithelial ovarian carcinoma

IGCS 2022 - International Journal of Gynecological Cancer
2022-12 | Conference poster
Contributors: Karolina Seborova; Viktor Hlavac; Petr Holy; Sunniva Bjørklund; Thomas Fleischer; Alzbeta Spalenkova; Lukas Rob; Martin Hruda; Petr Cernaj; Jiri Bouda et al.
Source: Self-asserted source
Petr Holý

Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy

Life Science Alliance
2022-12 | Journal article
Contributors: Viktor Hlaváč; Petr Holý; Radka Václavíková; Lukáš Rob; Martin Hruda; Marcela Mrhalová; Petr Černaj; Jiří Bouda; Pavel Souček
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype.

Biochimie
2022-05-04 | Journal article
Contributors: Petr Holý; Viktor Hlaváč; Pavel Ostašov; Veronika Brynychová; Renata Koževnikovová; Markéta Trnková; Kateřina Kopečková; Soňa Měšťáková; Marcela Mrhalová; Pavel Souček
Source: Self-asserted source
Petr Holý

The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes

International Journal of Molecular Sciences
2021-12-22 | Journal article
Contributors: Karolina Seborova; Alzbeta Kloudova-Spalenkova; Kamila Koucka; Petr Holy; Marie Ehrlichova; Changwei Wang; Iwao Ojima; Iveta Voleska; Petr Daniel; Kamila Balusikova et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Novel Stony Brook taxanes are efficacious in paclitaxel-resistant ovarian cancer models both in vitro and in vivo

International Journal of Gynecological Cancer - ESGO 2021
2021-10 | Conference abstract
Contributors: Petr Holý; Karolína Šeborová; Alžběta Spálenková; Kamila Koucká; Marie Ehrlichová; Changwei Wang; Iwao Ojima; Petr Daniel; Kamila Balušíková; M Jelínek et al.
Source: Self-asserted source
Petr Holý

Oxysterols in cancer management: From therapy to biomarkers

British Journal of Pharmacology
2021-08 | Journal article
Contributors: Alzbeta Kloudova‐Spalenkova; Petr Holy; Pavel Soucek
Source: check_circle
Crossref

Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450

Journal of Personalized Medicine
2020-08-28 | Journal article
Contributors: Viktor Hlaváč; Petr Holý; Pavel Souček
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Importance of genetic background of oxysterol signaling in cancer.

Biochimie
2018-05 | Journal article
Contributors: Holy P; Kloudova A; Soucek P
Source: Self-asserted source
Petr Holý via Europe PubMed Central
grade
Preferred source (of 2)‎

Peer review (7 reviews for 4 publications/grants)

Review activity for British journal of pharmacology. (1)
Review activity for Exploration of targeted anti-tumor therapy. (2)
Review activity for Frontiers in oncology. (1)
Review activity for JCO precision oncology. (3)