Personal information

Brazil

Biography

Junior Postdoctoral Researcher (CNPq) at the Federal University of Minas Gerais (UFMG). PhD in Microbiology (2023) from UFMG. He was a postdoctoral abroad (PDE/CNPq, 2024) and PhD visitor (CAPES/PrInt, 2022), both at the University of California San Diego (UCSD). Biomedical Scientist with major in clinical analysis (2017) and Master's in Microbiology (2020), both from UFMG. He was a scientific advisor at the company ECO Diagnóstica LTDA, focusing on COVID-19 diagnosis (2020). He was also a technical fellow in the coordination of the Technological Platforms Network (RPT) of the René Rachou Institute (IRR) - FIOCRUZ Minas (2020). Currently is an affiliated member of the Center for Discovery and Innovation in Parasitic Diseases (CDIPD) at UCSD. He has experience in molecular modeling, structural biology, and medicinal chemistry, in addition to biological evaluations of compounds in viruses, bacteria, and mammalian cells, as well as enzyme activity inhibition assays. He demonstrates interest in the discovery and development of antimicrobial drug candidates, in addition to the mechanisms of action and associated resistance profiles. Works employing computational simulations to the design and discovery of bioactive molecules and their experimental validation in vitro, as in the search for antiviral candidates against flaviviruses and coronaviruses.

Activities

Employment (6)

Federal University of Minas Gerais: Belo Horizonte, BR

2024-10-03 to present | Junior Postdoctoral Researcher (Microbiology)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

University of California, San Diego: San Diego, US

2024-03-15 to 2024-09-30 | Research Scholar / Postdoctoral Researcher (Skaggs School of Pharmacy and Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Universidade Federal de Minas Gerais: Belo Horizonte, Minas Gerais, BR

2023-03-01 to 2024-02-29 | Postdoctoral Researcher (Microbiology)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Universidade Federal de Minas Gerais: Belo Horizonte, Minas Gerais, BR

2021-01-01 to 2023-02-17 | Doctoral Fellow / PhD student / PhD candidate (Microbiology)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Fundação Oswaldo Cruz Instituto René Rachou: Belo Horizonte, Minas Gerais, BR

2020-09-11 to 2020-12-31 | Technical Support / Technical Manager (Technological Platforms)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

ECO DIAGNOSTICA LTDA: Nova Lima, Minas Gerais, BR

2020-01-20 to 2020-07-05 | Scientific Advisor (Clinical Analysis)
Employment
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Education and qualifications (3)

Universidade Federal de Minas Gerais: Belo Horizonte, MG, BR

2021-01-01 to 2023-02-17 | PhD (Microbiology)
Qualification
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Universidade Federal de Minas Gerais: Belo Horizonte, MG, BR

2018-03-05 to 2020-02-18 | Master of Science (Microbiology)
Education
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Universidade Federal de Minas Gerais: Belo Horizonte, Minas Gerais, BR

2013-03-04 to 2017-07-20 | Biomedical Scientist (Clinical and Toxicological Analysis)
Education
Source: Self-asserted source
Mateus Sá Magalhães Serafim

Works (29)

AI is a viable alternative to high throughput screening: a 318-target study

Scientific Reports
2024 | Journal article
EID:

2-s2.0-85191821387

Part of ISSN: 20452322
Contributors: Wallach, I.; Bernard, D.; Nguyen, K.; Ho, G.; Morrison, A.; Stecula, A.; Rosnik, A.; O’Sullivan, A.M.; Davtyan, A.; Samudio, B. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Aminopyrimidine Derivatives as Multiflavivirus Antiviral Compounds Identified from a Consensus Virtual Screening Approach

Journal of Chemical Information and Modeling
2024 | Journal article
EID:

2-s2.0-85182586037

Part of ISSN: 1549960X 15499596
Contributors: Serafim, M.S.M.; Kronenberger, T.; Rocha, R.E.O.; Rosa, A.D.R.A.; Mello, T.L.G.; Poso, A.; Ferreira, R.S.; Abrahão, J.S.; Kroon, E.G.; Mota, B.E.F. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Could giant viruses be considered as a biotechnological tool for preventing and controlling Acanthamoeba infections?

Journal of Applied Microbiology
2024 | Journal article
EID:

2-s2.0-85186384126

Part of ISSN: 13652672 13645072
Contributors: Crispim, A.P.C.; Serafim, M.S.M.; Costa, A.O.; Abrahão, J.S.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Design, development, and validation of multiepitope proteins for serological diagnosis of Zika virus infections and discrimination from dengue virus seropositivity

PLoS Neglected Tropical Diseases
2024 | Journal article
EID:

2-s2.0-85191102834

Part of ISSN: 19352735 19352727
Contributors: Pereira, S.H.; Sá Magalhães Serafim, M.; Moraes, T.F.S.; Zini, N.; Abrahão, J.S.; Nogueira, M.L.; dos Reis, J.G.A.C.; Bagno, F.F.; da Fonseca, F.G.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Machine Learning-Based Virtual Screening of Antibacterial Agents against Methicillin-Susceptible and Resistant Staphylococcus aureus

Journal of Chemical Information and Modeling
2024 | Journal article
EID:

2-s2.0-85186903212

Part of ISSN: 1549960X 15499596
Contributors: Fernandes, P.O.; Dias, A.L.T.; dos Santos Júnior, V.S.; Sá Magalhães Serafim, M.; Sousa, Y.V.; Monteiro, G.C.; Coutinho, I.D.; Valli, M.; Verzola, M.M.S.A.; Ottoni, F.M. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

New anti-SARS-CoV-2 aminoadamantane compounds as antiviral candidates for the treatment of COVID-19

Virus Research
2024 | Journal article
EID:

2-s2.0-85180508333

Part of ISSN: 18727492 01681702
Contributors: de Almeida Marques, D.P.; Andrade, L.A.F.; Reis, E.V.S.; Clarindo, F.A.; Moraes, T.D.F.S.; Lourenço, K.L.; De Barros, W.A.; Costa, N.E.M.; Andrade, L.M.D.; Lopes-Ribeiro, Á. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

The GC% landscape of the Nucleocytoviricota

Research Square
2024 | Other
EID:

2-s2.0-85193305689

Contributors: Witt, A.S.A.; Carvalho, J.V.R.P.; Serafim, M.S.M.; Arias, N.E.C.; Rodrigues, R.A.L.; Abrahão, J.S.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity

Chemistry & Biodiversity
2024-12 | Journal article
Contributors: Daniela Quadros de Azevedo; João Vinícius Viera Nóia; Yasmim Carla M. Ribeiro; Raphael Alves dos Reis; Paulo Henrique Otoni Ribeiro; Gustavo Almeida Moura; Pamela Mendes; Ana Beatriz Barbosa de Souza; Sofia Carpini Mermejo; Mateus Sá Magalhães Serafim et al.
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Structure elucidation, biosynthetic gene cluster distribution, and biological activities of ketomemicin analogs inSalinispora

2024-10-30 | Preprint
Contributors: Gabriel Castro-Falcón; Dulce G. Guillén-Matus; Elany Barbosa Da Silva; Wentao Guo; Alicia Ross; Mateus Sá Magalhães Serafim; Thais Helena Maciel Fernandes; Dean J. Tantillo; Anthony J. O’Donoghue; Paul R. Jensen
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Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system

bioRxiv
2023 | Other
EID:

2-s2.0-85160354227

Part of ISSN: 26928205
Contributors: Røyseth, V.; Hurysz, B.M.; Kaczorowska, A.; Dorawa, S.; Fedøy, A.-E.; Arsin, H.; Serafim, M.; Werbowy, O.; Kaczorowski, T.; Stokke, R. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system

Frontiers in Microbiology
2023 | Journal article
EID:

2-s2.0-85164411966

Part of ISSN: 1664302X
Contributors: Røyseth, V.; Hurysz, B.M.; Kaczorowska, A.-K.; Dorawa, S.; Fedøy, A.-E.; Arsın, H.; Serafim, M.S.á.M.; Myers, S.A.; Werbowy, O.; Kaczorowski, T. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Surface fibrils on the particles of nucleocytoviruses: A review

Experimental Biology and Medicine
2023 | Journal article
EID:

2-s2.0-85176920231

Part of ISSN: 15353699 15353702
Contributors: Aquino, I.L.M.D.; Barcelos, M.G.; Machado, T.B.; Serafim, M.S.M.; Abrahão, J.S.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Synthesis of indole-based ferulic acid derivatives and in vitro evaluation of antiviral activity against SARS-CoV-2

Medicinal Chemistry Research
2023 | Journal article
EID:

2-s2.0-85167339533

Part of ISSN: 15548120 10542523
Contributors: Verzola, M.M.S.A.; de Almeida Marques, D.P.; da Silva, E.B.; Serafim, M.S.M.; Ferreira, R.S.; Fajtová, P.; Kohlhoff, M.; O’Donoghue, A.J.; Maltarollo, V.G.; Coelho-dos-Reis, J.G.A. et al.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Evaluating Known Zika Virus NS2B-NS3 Protease Inhibitor Scaffolds via In Silico Screening and Biochemical Assays

Pharmaceuticals
2023-09-19 | Journal article
Contributors: Lucianna H. Santos; Rafael E. O. Rocha; Diego L. Dias; Beatriz M. R. M. Ribeiro; Mateus Sá M. Serafim; Jônatas S. Abrahão; Rafaela S. Ferreira
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Elaboration and Characterization of Pereskia aculeate Miller Extracts Obtained from Multiple Ultrasound-Assisted Extraction Conditions

Metabolites
2023-05-26 | Journal article
Contributors: Maria Clara Coutinho Macedo; Viviane Dias Medeiros Silva; Mateus Sá Magalhães Serafim; Vinícius Tadeu da Veiga Correia; Débora Tamires Vitor Pereira; Patrícia Regina Amante; Antônio Soares Júnior da Silva; Henrique de Oliveira Prata Mendonça; Rodinei Augusti; Ana Cardoso Clemente Filha Ferreira de Paula et al.
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Development of subunit selective substrates forTrichomonas vaginalisproteasome

2023-04-06 | Preprint
Contributors: Pavla Fajtova; Brianna M Hurysz; Yukiko Miyamoto; Mateus Serafim; Zhenze Jiang; Diego F. Trujillo; Lawrence Liu; Urvashi Somani; Jehad Almaliti; Samuel A. Myers et al.
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Synthetic Curcumin Analogues Present Antiflavivirus Activity In Vitro with Potential Multiflavivirus Activity from a Thiazolylhydrazone Moiety

Future Pharmacology
2023-03-25 | Journal article
Contributors: Mateus Sá Magalhães Serafim; Thales Kronenberger; Renata Barbosa de Oliveira; Erna Geessien Kroon; Jônatas Santos Abrahão; Bruno Eduardo Fernandes Mota; Vinícius Gonçalves Maltarollo
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Ultrastructural analysis of monkeypox virus replication in Vero cells

Journal of Medical Virology
2023-02 | Journal article
Part of ISSN: 0146-6615
Part of ISSN: 1096-9071
Contributors: Amanda Stéphanie Arantes Witt; Giliane de Souza Trindade; Fernanda Gil de Souza; Mateus Sá Magalhães Serafim; Alana Vitor Barbosa da Costa; Marcos Vinícius Ferreira Silva; Felipe Campos de Melo Iani; Rodrigo Araújo Lima Rodrigues; Erna Geessien Kroon; Abrahao, JS
Source: Self-asserted source
Mateus Sá Magalhães Serafim
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Diversity of Surface Fibril Patterns in Mimivirus Isolates

Journal of Virology
2023-02-28 | Journal article
Part of ISSN: 0022-538X
Part of ISSN: 1098-5514
Contributors: Isabella Luiza Martins de Aquino; Mateus Sá Magalhães Serafim; Talita Bastos Machado; Bruna Luiza Azevedo; Denilson Eduardo Silva Cunha; Leila Sabrina Ullmann; João Pessoa Araújo; Abrahao, JS
Source: Self-asserted source
Mateus Sá Magalhães Serafim
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Atherosclerosis fate in the era of tailored functional foods: Evidence-based guidelines elicited from structure- and ligand-based approaches

Trends in Food Science & Technology
2022-10 | Journal article
Contributors: Luciana Azevedo; Mateus Sá M. Serafim; Vinícius G. Maltarollo; Andreas M. Grabrucker; Daniel Granato
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Designing drugs when there is low data availability: one-shot learning and other approaches to face the issues of a long-term concern

Expert Opinion on Drug Discovery
2022-08-30 | Journal article
Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Contributors: Mateus Sá Magalhães Serafim
Source: Self-asserted source
Mateus Sá Magalhães Serafim
grade
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A Brief History of Giant Viruses’ Studies in Brazilian Biomes

Viruses
2022-01-19 | Journal article
Contributors: Paulo Victor M. Boratto; Mateus Sá M. Serafim; Amanda Stéphanie A. Witt; Ana Paula C. Crispim; Bruna Luiza de Azevedo; Gabriel Augusto P. de Souza; Isabella Luiza M. de Aquino; Talita B. Machado; Victória F. Queiroz; Rodrigo A. L. Rodrigues et al.
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Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

Natural Product Research
2021 | Journal article
EID:

2-s2.0-85075455200

Contributors: da Silva, M.L.; Stehmann, J.R.; Serafim, M.S.á.M.; Vale, V.V.; Gontijo, D.C.; Brandão, G.C.; Kroon, E.G.; de Oliveira, A.B.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Machine learning techniques applied to the drug design and discovery of new antivirals: a brief look over the past decade

Expert Opinion on Drug Discovery
2021-09-02 | Journal article
Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Contributors: Mateus Sá Magalhães Serafim
Source: Self-asserted source
Mateus Sá Magalhães Serafim
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Ligand Accessibility Insights to the Dengue Virus NS3‐NS2B Protease Assessed by Long‐Timescale Molecular Dynamics Simulations

ChemMedChem
2021-08-19 | Journal article
Contributors: Thales Kronenberger; Mateus Sá Magalhães Serafim; Arun Kumar Tonduru; Vinícius Gonçalves Maltarollo; Antti Poso
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Knowing and combating the enemy: a brief review on SARS-CoV-2 and computational approaches applied to the discovery of drug candidates

BIOSCIENCE REPORTS
2021-02-24 | Journal article
Source: Self-asserted source
Mateus Sá Magalhães Serafim
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The application of machine learning techniques to innovative antibacterial discovery and development

Expert Opinion on Drug Discovery
2020-06-17 | Journal article
Part of ISSN: 1746-0441
Part of ISSN: 1746-045X
Source: Self-asserted source
Mateus Sá Magalhães Serafim
grade
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Virtual screening of antibacterial compounds by similarity search of Enoyl-ACP reductase (FabI) inhibitors

Future Medicinal Chemistry
2020-01 | Journal article
Part of ISSN: 1756-8919
Part of ISSN: 1756-8927
Source: Self-asserted source
Mateus Sá Magalhães Serafim
grade
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Antibacterial activity of synthetic 1,3-bis(aryloxy)propan-2-amines against Gram-positive bacteria

MicrobiologyOpen
2019 | Journal article
EID:

2-s2.0-85074963873

Contributors: Serafim, M.S.M.; Lavorato, S.N.; Kronenberger, T.; Sousa, Y.V.; Oliveira, G.P.; dos Santos, S.G.; Kroon, E.G.; Maltarollo, V.G.; Alves, R.J.; Mota, B.E.F.
Source: Self-asserted source
Mateus Sá Magalhães Serafim via Scopus - Elsevier

Peer review (9 reviews for 1 publication/grant)

Review activity for Brazilian journal of microbiology. (9)