Personal information

ALS, CTE, brain injury, neurodegeneration, TDP-43, Tau, DNAJC7
Canada

Activities

Employment (4)

Fanshawe College: London, ON, CA

2019 to present | Professor-part time (Applied Science and Technology)
Employment
Source: Self-asserted source
Kathryn Volkening

University of Western Ontario Department of Clinical Neurological Sciences: London, ON, CA

2013 to present | Adjunct Research Faculty (Clinical Neurological Sciences)
Employment
Source: Self-asserted source
Kathryn Volkening

University of Western Ontario: London, ON, CA

2007 to present | Senior Research Associate (Molecular Medicine)
Employment
Source: Self-asserted source
Kathryn Volkening

Robarts Research Institute: London, ON, CA

2003 to 2007 | Research Associate (Molecular Medicine)
Employment
Source: Self-asserted source
Kathryn Volkening

Education and qualifications (4)

Robarts Research Institute: London, ON, CA

1999 to 2003 | Postdoctoral Training
Education
Source: Self-asserted source
Kathryn Volkening

University of Wisconsin Madison: Madison, WI, US

1998 to 1999 | Postdoctoral Training (Biological Sciences)
Education
Source: Self-asserted source
Kathryn Volkening

University of Guelph: Guelph, ON, CA

1994 to 1998 | PhD (Biomedical Sciences)
Education
Source: Self-asserted source
Kathryn Volkening

University of Guelph: Guelph, ON, CA

1990 to 1994 | BSc Hon (Biomedical Sciences)
Education
Source: Self-asserted source
Kathryn Volkening

Works (47)

A methodological primer of extracellular vesicles isolation and characterization via different techniques

Biology Methods and Protocols
2024 | Journal article
EID:

2-s2.0-85186396494

Part of ISSN: 23968923
Contributors: Aliakbari, F.; Stocek, N.B.; Cole-Andre, M.; Gomes, J.; Fanchini, G.; Pasternak, S.H.; Christiansen, G.; Morshedi, D.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier
grade
Preferred source (of 2)‎

A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anesthesia

Scientific Reports
2024 | Journal article
EID:

2-s2.0-85186555311

Part of ISSN: 20452322
Contributors: Santandrea, E.; Aliakbari, F.; Truscott, E.; McCaig, L.; Donison, N.S.; Graham, D.; Strong, M.J.; Volkening, K.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Development of Metal-Organic Framework Biocomposites from Chitosan as Drug Delivery Vehicles: In Vitro Evaluation on HeLa and SH-SY5Y Cell Lines

International Journal of Biological Macromolecules
2024 | Journal article
Contributors: Kathryn Volkening; Hafezeh Nabipour; Farhang Aliakbari; Michael J Strong; Sohab Rohani
Source: Self-asserted source
Kathryn Volkening

DNAJC7 expression in rat brain after a single cortical injury and in human ALS-affected brain cortex and hippocampus

Research Square
2024 | Journal article
Contributors: Kathryn Volkening; Neil Donison; Matthew Hintermayer; Jacqueline Palik; Maegha Subramaniam; Martin Duennwald; Michael J Strong
Source: Self-asserted source
Kathryn Volkening

New metal-organic framework coated sodium alginate for the delivery of curcumin as a sustainable drug delivery and cancer therapy system

International Journal of Biological Macromolecules
2024 | Journal article
EID:

2-s2.0-85181947278

Part of ISSN: 18790003 01418130
Contributors: Nabipour, H.; Aliakbari, F.; Volkening, K.; Strong, M.J.; Rohani, S.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

The development of a bio-based metal-organic framework coated with carboxymethyl cellulose with the ability to deliver curcumin with anticancer properties

Materials Today Chemistry
2024 | Journal article
EID:

2-s2.0-85186537542

Part of ISSN: 24685194
Contributors: Nabipour, H.; Aliakbari, F.; Volkening, K.; Strong, M.J.; Rohani, S.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anaesthesia

Research Square
2023 | Other
EID:

2-s2.0-85174130959

Contributors: Strong, M.; Santandrea, E.; Aliakbari, F.; Truscott, E.; McCaig, L.; Donison, N.; Graham, D.; Volkening, K.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Upregulation of LRRK2 following traumatic brain injury does not directly phosphorylate Thr<sup>175</sup> tau

Frontiers in Cellular Neuroscience
2023 | Journal article
EID:

2-s2.0-85178160030

Part of ISSN: 16625102
Contributors: Donison, N.; Hintermayer, M.; Subramaniam, M.; Santandrea, E.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Evidence of synergism among three genetic variants in a patient with LMNA-related lipodystrophy and amyotrophic lateral sclerosis leading to a remarkable nuclear phenotype

Molecular and Cellular Biochemistry
2021-07-04 | Journal article
Contributors: Kathryn Volkening; Sali M. K. Farhan; Jessica Kao; Cheryl Leystra-Lantz; Lee Cyn Ang; Adam McIntyre; Jian Wang; Robert A. Hegele; Michael J. Strong
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Alterations in Tau Metabolism in ALS and ALS-FTSD

Frontiers in Neurology
2020 | Journal article
EID:

2-s2.0-85097447754

Part of ISSN: 16642295
Contributors: Strong, M.J.; Donison, N.S.; Volkening, K.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Neurofilament Immunohistochemistry Followed by Luxol Fast Blue, for Staining Axons and Myelin in the Same Paraffin Section of Spinal Cord

Applied Immunohistochemistry and Molecular Morphology
2020 | Journal article
EID:

2-s2.0-85074494127

Part of ISSN: 15334058 15412016
Contributors: Moszczynski, A.J.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Tau protein phosphorylation at Thr<sup>175</sup> initiates fibril formation via accessibility of the N-terminal phosphatase-activating domain

Journal of Neurochemistry
2020 | Journal article
EID:

2-s2.0-85077980221

Part of ISSN: 14714159 00223042
Contributors: Hintermayer, M.A.; Volkening, K.; Moszczynski, A.J.; Donison, N.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Inclusion Formation and Toxicity of the ALS Protein RGNEF and Its Association with the Microtubule Network

International Journal of Molecular Sciences
2020-08-05 | Journal article
Contributors: Sonja E. Di Gregorio; Kathryn Volkening; Michael J. Strong; Martin L. Duennwald
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization

European Journal of Cell Biology
2019 | Journal article
EID:

2-s2.0-85057066586

Part of ISSN: 16181298 01719335
Contributors: Tavolieri, M.V.; Droppelmann, C.A.; Campos-Melo, D.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Somatic expansion of the C9orf72 hexanucleotide repeat does not occur in ALS spinal cord tissues

Neurology: Genetics
2019 | Journal article
EID:

2-s2.0-85065078438

Part of ISSN: 23767839
Contributors: Ross, J.P.; Leblond, C.S.; Catoire, H.; Volkening, K.; Strong, M.; Zinman, L.; Robertson, J.; Dion, P.A.; Rouleau, G.A.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Synergistic toxicity in an in vivo model of neurodegeneration through the co-expression of human TDP-43<sup>M337V</sup> and tau<sup>T175D</sup> protein

Acta neuropathologica communications
2019 | Journal article
EID:

2-s2.0-85074684987

Part of ISSN: 20515960
Contributors: Moszczynski, A.J.; Harvey, M.; Fulcher, N.; de Oliveira, C.; McCunn, P.; Donison, N.; Bartha, R.; Schmid, S.; Strong, M.J.; Volkening, K.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Reply: TDP-43 mutations increase HNRNP A1-7B through gain of splicing function

Brain
2018 | Journal article
EID:

2-s2.0-85057570055

Part of ISSN: 14602156 00068950
Contributors: Tetreault, M.; Deshaies, J.-E.; Semmler, S.; Sidibe, H.; Shkreta, L.; Volkening, K.; Soreq, H.; Strong, M.J.; Chabot, B.; Velde, C.V.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis

Journal of Proteome Research
2018 | Journal article
EID:

2-s2.0-85045027785

Part of ISSN: 15353907 15353893
Contributors: Volkening, K.; Keller, B.A.; Leystra-Lantz, C.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Somatic gene transfer using a recombinant adenoviral vector (RAAV9) encoding pseudophosphorylated human Thr<sup>175</sup> tau in adult rat hippocampus induces tau pathology

Journal of Neuropathology and Experimental Neurology
2018 | Journal article
EID:

2-s2.0-85055426892

Part of ISSN: 15546578 00223069
Contributors: Moszczynski, A.J.; Gopaul, J.; McCunn, P.; Volkening, K.; Harvey, M.; Bartha, R.; Schmid, S.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis

Brain
2018 | Journal article
EID:

2-s2.0-85047088314

Part of ISSN: 14602156 00068950
Contributors: Deshaies, J.-E.; Shkreta, L.; Moszczynski, A.J.; Sidibé, H.; Semmler, S.; Fouillen, A.; Bennett, E.R.; Bekenstein, U.; Destroismaisons, L.; Toutant, J. et al.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Correction to “RNA and Protein Interactors with TDP-43 in Human Spinal-Cord Lysates in Amyotrophic Lateral Sclerosis”

Journal of Proteome Research
2018-06-01 | Journal article
Contributors: Kathryn Volkening; Brian A. Keller; Cheryl Leystra-Lantz; Michael J. Strong
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

C9orf72 mutations do not influence the tau signature of amyotrophic lateral sclerosis with cognitive impairment (ALSci)

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
2017 | Journal article
EID:

2-s2.0-85020062428

Part of ISSN: 21679223 21678421
Contributors: Volkening, K.; Strong, W.L.; Seaton, S.; Yang, W.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Rho guanine nucleotide exchange factor (RGNEF) is a prosurvival factor under stress conditions

Molecular and Cellular Neuroscience
2017-07 | Journal article
Contributors: Kevin Cheung; Cristian A. Droppelmann; Adam MacLellan; Ian Cameron; Benjamin Withers; Danae Campos-Melo; Kathryn Volkening; Michael J. Strong
Source: check_circle
Crossref
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Preferred source (of 2)‎

Thr<sup>175</sup>-phosphorylated tau induces pathologic fibril formation via GSK3β-mediated phosphorylation of Thr<sup>231</sup> invitro

Neurobiology of Aging
2015 | Journal article
EID:

2-s2.0-84923637155

Part of ISSN: 15581497 01974580
Contributors: Moszczynski, A.J.; Gohar, M.; Volkening, K.; Leystra-Lantz, C.; Strong, W.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Analysis of novel NEFL mRNA targeting microRNAs in amyotrophic lateral sclerosis

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84898606538

Part of ISSN: 19326203
Contributors: Ishtiaq, M.; Campos-Melo, D.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Comprehensive luciferase-based reporter gene assay reveals previously masked up-regulatory effects of miRNAs

International Journal of Molecular Sciences
2014 | Journal article
EID:

2-s2.0-84908331627

Part of ISSN: 14220067 16616596
Contributors: Campos-Melo, D.; Droppelmann, C.A.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Expression and cellular localization of the classical progesterone receptor in healthy and amyotrophic lateral sclerosis affected spinal cord

European Journal of Neurology
2014 | Journal article
EID:

2-s2.0-84892477233

Part of ISSN: 14681331 13515101
Contributors: Gargiulo-Monachelli, G.M.; Campos-Melo, D.; Droppelmann, C.A.; Keller, B.A.; Leystra-Lantz, C.; De Nicola, A.F.; Gonzalez Deniselle, M.C.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

RNA metabolism in ALS: When normal processes become pathological

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
2014 | Journal article
EID:

2-s2.0-84906354951

Part of ISSN: 21679223 21678421
Contributors: Droppelmann, C.A.; Campos-Melo, D.; Ishtiaq, M.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

RNA-binding proteins as molecular links between cancer and neurodegeneration

Biogerontology
2014 | Journal article
EID:

2-s2.0-84916630849

Part of ISSN: 15736768 13895729
Contributors: Campos-Melo, D.; Droppelmann, C.A.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases

Frontiers in Cellular Neuroscience
2014 | Journal article
EID:

2-s2.0-84907219381

Part of ISSN: 16625102
Contributors: Droppelmann, C.A.; Campos-Melo, D.; Volkening, K.; Strong, M.J.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Altered microRNA expression profile in amyotrophic lateral sclerosis: A role in the regulation of NFL mRNA levels

Molecular Brain
2013 | Journal article
EID:

2-s2.0-84878005741

Part of ISSN: 17566606
Contributors: Campos-Melo, D.; Droppelmann, C.A.; He, Z.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Detection of a novel frameshift mutation and regions with homozygosis within ARHGEF28 gene in familial amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
2013 | Journal article
EID:

2-s2.0-84881364742

Part of ISSN: 21678421 21679223
Contributors: Droppelmann, C.A.; Wang, J.; Campos-Melo, D.; Keller, B.; Volkening, K.; Hegele, R.A.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis

Neurobiology of Aging
2013 | Journal article
EID:

2-s2.0-84868137686

Part of ISSN: 01974580 15581497
Contributors: Droppelmann, C.A.; Keller, B.A.; Campos-Melo, D.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Co-aggregation of RNA binding proteins in ALS spinal motor neurons: Evidence of a common pathogenic mechanism

Acta Neuropathologica
2012 | Journal article
EID:

2-s2.0-84870994113

Part of ISSN: 00016322 14320533
Contributors: Keller, B.A.; Volkening, K.; Droppelmann, C.A.; Ang, L.C.; Rademakers, R.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype

Neurobiology of Aging
2012 | Journal article
EID:

2-s2.0-84866760281

Part of ISSN: 15581497 01974580
Contributors: Rutherford, N.J.; Heckman, M.G.; DeJesus-Hernandez, M.; Baker, M.C.; Soto-Ortolaza, A.I.; Rayaprolu, S.; Stewart, H.; Finger, E.; Volkening, K.; Seeley, W.W. et al.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Ataxin-2 repeat-length variation and neurodegeneration

Human Molecular Genetics
2011 | Journal article
EID:

2-s2.0-79960811611

Part of ISSN: 14602083 09646906
Contributors: Ross, O.A.; Rutherford, N.J.; Baker, M.; Soto-Ortolaza, A.I.; Carrasquillo, M.M.; DeJesus-Hernandez, M.; Adamson, J.; Li, M.; Volkening, K.; Finger, E. et al.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

RNA metabolism in neurodegenerative disease

Current Chemical Biology
2011 | Journal article
EID:

2-s2.0-79953792527

Part of ISSN: 18723136
Contributors: Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

TDP-43 and FUS/TLS: Sending a complex message about messenger RNA in amyotrophic lateral sclerosis?

FEBS Journal
2011 | Journal article
EID:

2-s2.0-80052962642

Part of ISSN: 1742464X 17424658
Contributors: Strong, M.J.; Volkening, K.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Human low molecular weight neurofilament (NFL) mRNA interacts with a predicted p190RhoGEF homologue (RGNEF) in humans

Amyotrophic Lateral Sclerosis
2010 | Journal article
EID:

2-s2.0-77649317237

Part of ISSN: 17482968 1471180X
Contributors: Volkening, K.; Leystra-Lantz, C.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL<sup>-/-</sup> mice: Support for a role for TDP-43 in the physiological response to neuronal injury

Brain Research
2009 | Journal article
EID:

2-s2.0-70349292075

Part of ISSN: 00068993
Contributors: Moisse, K.; Mepham, J.; Volkening, K.; Welch, I.; Hill, T.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: Implications for TDP-43 in the physiological response to neuronal injury

Brain Research
2009 | Journal article
EID:

2-s2.0-58049221032

Part of ISSN: 00068993
Contributors: Moisse, K.; Volkening, K.; Leystra-Lantz, C.; Welch, I.; Hill, T.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

Brain Research
2009 | Journal article
EID:

2-s2.0-73949134014

Part of ISSN: 18726240 00068993
Contributors: Volkening, K.; Leystra-Lantz, C.; Yang, W.; Jaffee, H.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Tau phosphorylation at threonine-175 leads to fibril formation and enhanced cell death: Implications for amyotrophic lateral sclerosis with cognitive impairment

Journal of Neurochemistry
2009 | Journal article
EID:

2-s2.0-58149339675

Part of ISSN: 00223042 14714159
Contributors: Gohar, M.; Yang, W.; Strong, W.; Volkening, K.; Leystra-Lantz, C.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

The complement factor C5a receptor is upregulated in NFL-/- mouse motor neurons

Journal of Neuroimmunology
2009 | Journal article
EID:

2-s2.0-67349192161

Part of ISSN: 01655728
Contributors: Humayun, S.; Gohar, M.; Volkening, K.; Moisse, K.; Leystra-Lantz, C.; Mepham, J.; McLean, J.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

Transient middle cerebral artery occlusion induces microglial priming in the lumbar spinal cord: A novel model of neuroinflammation

Journal of Neuroinflammation
2008 | Journal article
EID:

2-s2.0-48249154193

Part of ISSN: 17422094
Contributors: Moisse, K.; Welch, I.; Hill, T.; Volkening, K.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3′ UTR

Molecular and Cellular Neuroscience
2007 | Journal article
EID:

2-s2.0-33845900214

Part of ISSN: 10447431
Contributors: Ge, W.-w.; Volkening, K.; Leystra-Lantz, C.; Jaffe, H.; Strong, M.J.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier

TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein

Molecular and Cellular Neuroscience
2007 | Journal article
EID:

2-s2.0-34249751076

Part of ISSN: 10447431
Contributors: Strong, M.J.; Volkening, K.; Hammond, R.; Yang, W.; Strong, W.; Leystra-Lantz, C.; Shoesmith, C.
Source: Self-asserted source
Kathryn Volkening via Scopus - Elsevier