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Our research group has two main aims - to utilise new imaging techniques to understand cardiac biology, and to use our understanding of cardiac biology to develop new imaging techniques. We use high field NMR imaging and spectroscopy, and PET and SPECT imaging to characterise the biochemistry of the heart during health and disease. We then use traditional biochemical assays (and less traditional ones like immunogold electron microscopy) to provide biochemical context to the data that our imaging techniques provide. We also employ the process in reverse, for example utilising isolated hearts and NMR spectroscopy to help validate and characterise the novel PET and SPECT imaging agents that our department is developing. Our current projects focus on the development of PET and SPECT imaging agents for the identification, stratification and study of chronic cardiovascular syndomes including non-compensated hypertophy, diabetic cardiomyopathy, heart failure with preserved ejection fraction, coronary microvascular disease and off-target cardiac injury caused by cancer radiotherapy and chemotherapy.