Personal information

Activities

Employment (1)

INSERM: Paris, ÃŽle-de-France, FR

2001 to present | Researcher
Employment
Source: Self-asserted source
Jerome Fagart

Education and qualifications (2)

Université Paris Diderot: Paris, Île-de-France, FR

2008 to 2008 | accreditation to supervise research
Education
Source: Self-asserted source
Jerome Fagart

Université Pierre et Marie Curie: Paris, Île-de-France, FR

1994 to 1998 | PhD
Education
Source: Self-asserted source
Jerome Fagart

Works (50 of 57)

Items per page:
Page 1 of 2

Binding of human Cdc123 to eIF2γ

Journal of Structural Biology
2023-09 | Journal article
Contributors: Cristina Cardenal Peralta; Paul Vandroux; Lea Neumann-Arnold; Michel Panvert; Jérôme Fagart; Wolfgang Seufert; Yves Mechulam; Emmanuelle Schmitt
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Crossref

Antagonistic effects of finerenone and spironolactone on the aldosterone-regulated transcriptome of human kidney cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2021-02-01 | Journal article
Source: Self-asserted source
Jerome Fagart
grade
Preferred source (of 2)‎

Interaction between accumulated 21-deoxysteroids and mineralocorticoid signaling in 21-hydroxylase deficiency.

American journal of physiology. Endocrinology and metabolism
2019-12-10 | Journal article
Source: Self-asserted source
Jerome Fagart

Corticosteroid receptors adopt distinct cyclical transcriptional signatures

The FASEB Journal
2018-10 | Journal article
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Jerome Fagart
grade
Preferred source (of 2)‎

ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.

Genetics in medicine : official journal of the American College of Medical Genetics
2018-09 | Journal article
Contributors: Delcour C; Amazit L; Patino LC; Magnin F; Fagart J; Delemer B; Young J; Laissue P; Binart N; Beau I
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

RNA-binding protein HuR enhances mineralocorticoid signaling in renal KC3AC1 cells under hypotonicity.

Cellular and molecular life sciences : CMLS
2017-12 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis.

Scientific Reports
2017-07 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Familial Multiplicity of Estrogen Insensitivity Associated With a Loss-of-Function ESR1 Mutation.

The Journal of clinical endocrinology and metabolism
2017-01 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Nestorone® as a Novel Progestin for Nonoral Contraception: Structure-Activity Relationships and Brain Metabolism Studies.

Endocrinology
2017-01 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency.

The Journal of clinical endocrinology and metabolism
2016-12 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Three Novel Heterozygous Point Mutations of NR3C1 Causing Glucocorticoid Resistance.

Human mutation
2016-08 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Anti-Tumoral Effects of Anti-Progestins in a Patient-Derived Breast Cancer Xenograft Model.

Hormones & cancer
2016-04 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Switchable Cardiac L Type Ca2+ Channel Transcript by Mineralocorticoid Pathway

Biophysical Journal
2016-02 | Journal article
Part of ISSN: 0006-3495
Source: Self-asserted source
Jerome Fagart

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2015-09 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1.

The Journal of biological chemistry
2015-09 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors.

The Journal of steroid biochemistry and molecular biology
2014-10 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

A structural explanation of the effects of dissociated glucocorticoids on glucocorticoid receptor transactivation.

Molecular pharmacology
2014-02 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Two families with normosmic congenital hypogonadotropic hypogonadism and biallelic mutations in KISS1R (KISS1 receptor): clinical evaluation and molecular characterization of a novel mutation.

PloS one
2013 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

A new strategy for selective targeting of progesterone receptor with passive antagonists.

Molecular Endocrinology
2013-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Characterization of seven novel mutations on the HEXB gene in French Sandhoff patients.

Gene
2013-01 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Structural determinants of ligand binding to the mineralocorticoid receptor.

Molecular and cellular endocrinology
2012-03 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Adult cases of mitochondrial DNA depletion due to TK2 defect: an expanding spectrum.

Neurology
2012-02 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Normosmic congenital hypogonadotropic hypogonadism due to TAC3/TACR3 mutations: characterization of neuroendocrine phenotypes and novel mutations.

PloS one
2011 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Identification of periplakin as a new target for autoreactivity in idiopathic pulmonary fibrosis.

American journal of respiratory and critical care medicine
2011-03 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Mineralocorticoid receptor mutations differentially affect individual gene expression profiles in pseudohypoaldosteronism type 1.

The Journal of clinical endocrinology and metabolism
2011-03 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

The Journal of biological chemistry
2010-09 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Met909 plays a key role in the activation of the progesterone receptor and also in the high potency of 13-ethyl progestins.

Molecular pharmacology
2009-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Structural basis of spirolactone recognition by the mineralocorticoid receptor.

Molecular pharmacology
2007-09 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

The synthetic androgen methyltrienolone (r1881) acts as a potent antagonist of the mineralocorticoid receptor.

Molecular pharmacology
2007-02 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Mineralocorticoid receptor mutations are the principal cause of renal type 1 pseudohypoaldosteronism.

Human mutation
2007-01 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension.

Nature structural & molecular biology
2005-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

The Met852 residue is a key organizer of the ligand-binding cavity of the human mineralocorticoid receptor.

Molecular pharmacology
2005-05 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor.

Endocrinology
2005-01 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Synergistic signaling by corticotropin-releasing hormone and leukemia inhibitory factor bridged by phosphorylated 3',5'-cyclic adenosine monophosphate response element binding protein at the Nur response element (NurRE)-signal transducers and activators of transcription (STAT) element of the proopiomelanocortin promoter.

Molecular Endocrinology
2004-12 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

New naturally occurring missense mutations of the human mineralocorticoid receptor disclose important residues involved in dynamic interactions with deoxyribonucleic acid, intracellular trafficking, and ligand binding.

Molecular endocrinology (Baltimore, Md.)
2004-09 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

[Agonists and antagonists of mineralocorticoids. The relation between structure and activity]

Annales de cardiologie et d'angeiologie
2004-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Identification of steroid ligands able to inactivate the mineralocorticoid receptor harboring the S810L mutation responsible for a severe form of hypertension.

Molecular and cellular endocrinology
2004-03 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Glucocorticoid metabolism by 11-beta hydroxysteroid dehydrogenase type 2 modulates human mineralocorticoid receptor transactivation activity.

The Journal of steroid biochemistry and molecular biology
2003-02 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.

Endocrinology
2003-02 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

11beta-hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.

Molecular pharmacology
2002-12 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

A single amino acid mutation of ala-773 in the mineralocorticoid receptor confers agonist properties to 11beta-substituted spirolactones.

Molecular pharmacology
2000-10 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor.

Molecular Endocrinology
2000-08 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

A new model for 20-hydroxyecdysone and dibenzoylhydrazine binding: a homology modeling and docking approach.

Protein science : a publication of the Protein Society
2000-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Mechanistic aspects of mineralocorticoid receptor activation.

Kidney international
2000-04 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

[Corticosteroid hormones: mechanisms involved in the recognition of aldosterone by mineralocorticoid receptors]

Journal de la Societe de biologie
1999 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Specific hydroxylations determine selective corticosteroid recognition by human glucocorticoid and mineralocorticoid receptors.

FEBS letters
1999-12 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Properties of polyglutamine expansion in vitro and in a cellular model for Huntington's disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
1999-06 | Journal article
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21.

Biochimica et biophysica acta
1998-10 | Journal article
PMID: 9774704
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Antagonism in the human mineralocorticoid receptor.

The EMBO Journal
1998-06 | Journal article
PMID: 9628869
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central

Folding requirements of the ligand-binding domain of the human mineralocorticoid receptor.

Molecular Endocrinology
1998-06 | Journal article
PMID: 9626661
Source: Self-asserted source
Jerome Fagart via Europe PubMed Central
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