Personal information

Activities

Employment (1)

Showa Yakka Daigaku: Machida, Tokyo, JP

2010-04 to present | Professor (Laboratory of Biochemistry)
Employment
Source: Self-asserted source
Susumu Itoh

Education and qualifications (1)

Osaka Daigaku: Suita, Osaka, JP

1987-04-01 to 1990-03-31 | PhD (Faculty of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Susumu Itoh

Funding (13)

The search for new drug discovery seeds latent in the Himalayan region

2014-04-01 to 2017-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 26305006
Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Smad-mediated spliceosome assembly and alternative splicing

2013-04-01 to 2015-03-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 25670168
Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Progress of anti-angiogenic therapy for brain tumors : new modality and resolution of the resistance

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Tumorigenicity by TGF-βsignaling

2009-01-01 to 2011-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 21590328
Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Regulation of endothelial cell activation by TGF-β family signaling

2005-01-01 to 2006-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 17390073
Source: Self-asserted source
Susumu Itoh via DimensionsWizard

... About the application ... vitamin D synthesis enzyme to the analysis and gene diagnosis of calcium deficiency disease-related gene

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Structural and functional analysis of the enzyme genes that regulate the in vivo active form of vitamin D amount

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Elucidation of Parkinson's disease: identification and cDNA cloning of the enzyme system responsible for the metabolism of MPTP and its similar compounds in the brain

Production of the drug-metabolizing enzyme-deficient mice using the Gene targeting method

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Cause of the specific appearance of autoimmune antibodies fulminant hepatitis occur? Hepatitis spontaneous (LEC) rat as a model

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

System for the regulation of in vivo drug concentration ; Analyzes of genetic polymorphisms of drug metabolizing enzymes

Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Cytochrome - role in the regulation of research over endogenous bioactive peptide relates to a new physiological significance of the non-P over 450 over

Basic study for dunction and gene regulation of human fetal liver P-450

1990-01-01 to 1991-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
GRANT_NUMBER: 02454482
Source: Self-asserted source
Susumu Itoh via DimensionsWizard

Works (50 of 113)

Items per page:
Page 1 of 3

PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor-β (TGF-β) signaling

Journal of Biological Chemistry
2019-03 | Journal article
Contributors: Souichi Ikeno; Naoko Nakano; Keigo Sano; Takashi Minowa; Wataru Sato; Ryosuke Akatsu; Nobuo Sakata; Nobutaka Hanagata; Makiko Fujii; Fumiko Itoh et al.
Source: check_circle
Crossref

Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules

Molecular Pharmacology
2017 | Journal article
EID:

2-s2.0-85012096156

Contributors: Okuhira, K.; Shoda, T.; Omura, R.; Ohoka, N.; Hattori, T.; Shibata, N.; Demizu, Y.; Sugihara, R.; Ichino, A.; Kawahara, H. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

TMED10 protein interferes with transforming growth factor (TGF)-β signaling by disrupting TGF-β receptor complex formation

Journal of Biological Chemistry
2017 | Journal article
EID:

2-s2.0-85015087193

Contributors: Nakano, N.; Tsuchiya, Y.; Kako, K.; Umezaki, K.; Sano, K.; Ikeno, S.; Otsuka, E.; Shigeta, M.; Nakagawa, A.; Sakata, N. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Science Signaling
2017-07-04 | Journal article
Contributors: Anahita Hamidi; Jie Song; Noopur Thakur; Susumu Itoh; Anders Marcusson; Anders Bergh; Carl-Henrik Heldin; Maréne Landström
Source: check_circle
Crossref

Regulation of the TMEPAI promoter by TCF7L2: The C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene

Journal of Biochemistry
2016 | Journal article
EID:

2-s2.0-84965025961

Contributors: Nakano, N.; Kato, M.; Itoh, S.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling

Nature Communications
2015 | Journal article
EID:

2-s2.0-84938634250

Contributors: Hongu, T.; Funakoshi, Y.; Fukuhara, S.; Suzuki, T.; Sakimoto, S.; Takakura, N.; Ema, M.; Takahashi, S.; Itoh, S.; Kato, M. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Transforming growth factor-β signaling enhancement by long-term exposure to hypoxia in a tumor microenvironment composed of Lewis lung carcinoma cells

Cancer Science
2015 | Journal article
EID:

2-s2.0-84983095270

Contributors: Furuta, C.; Miyamoto, T.; Takagi, T.; Noguchi, Y.; Kaneko, J.; Itoh, S.; Watanabe, T.; Itoh, F.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Active TGF-β signaling in hypoxic area

Cancer Science
2015-11 | Journal article
Contributors: Chiaki Furuta; Tatsuki Miyamoto; Takahiro Takagi; Yuri Noguchi; Jyunya Kaneko; Susumu Itoh; Takuya Watanabe; Fumiko Itoh
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search

C18 orf1, a novel negative regulator of transforming growth factor-β signaling

Journal of Biological Chemistry
2014 | Journal article
EID:

2-s2.0-84899757024

Contributors: Nakano, N.; Maeyama, K.; Sakata, N.; Itoh, F.; Akatsu, R.; Nakata, M.; Katsu, Y.; Ikeno, S.; Togawa, Y.; Vo Nguyen, T.T. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

TGF-β signaling cooperates with at motif-binding factor-1 for repression of the α-fetoprotein promoter

Journal of Signal Transduction
2014 | Journal article
EID:

2-s2.0-84941570358

Contributors: Sakata, N.; Kaneko, S.; Ikeno, S.; Miura, Y.; Nakabayashi, H.; Dong, X.-Y.; Dong, J.-T.; Tamaoki, T.; Nakano, N.; Itoh, S.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier
grade
Preferred source (of 2)‎

TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells

Cancer Science
2014 | Journal article
EID:

2-s2.0-84895560608

Contributors: Vo Nguyen, T.T.; Watanabe, Y.; Shiba, A.; Noguchi, M.; Itoh, S.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice

Journal of Biochemistry
2012 | Journal article
EID:

2-s2.0-84870901483

Contributors: Oishi, H.; Itoh, S.; Matsumoto, K.; Ishitobi, H.; Suzuki, R.; Ema, M.; Kojima, T.; Uchida, K.; Kato, M.; Miyata, T. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Implication of TGF-β as a survival factor during tumour development

Journal of Biochemistry
2012 | Journal article
EID:

2-s2.0-84862270307

Contributors: Itoh, S.; Itoh, F.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

Blood
2012 | Journal article
EID:

2-s2.0-84861810420

Contributors: Itoh, F.; Itoh, S.; Adachi, T.; Ichikawa, K.; Matsumura, Y.; Takagi, T.; Festing, M.; Watanabe, T.; Weinstein, M.; Karlsson, S. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2

Cancer Science
2011 | Journal article
EID:

2-s2.0-84862908142

Contributors: Yang, W.; Itoh, F.; Ohya, H.; Kishimoto, F.; Tanaka, A.; Nakano, N.; Itoh, S.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Inhibitory machinery for the TGF-β family signaling pathway

Growth Factors
2011-09 | Journal article
Contributors: Susumu Itoh; Fumiko Itoh
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Flk1-GFP BAC Tg mice: An animal model for the study of blood vessel development

Experimental Animals
2010 | Journal article
EID:

2-s2.0-78149429024

Contributors: Ishitobi, H.; Matsumoto, K.; Azami, T.; Itoh, F.; Itoh, S.; Takahashi, S.; Ema, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis

Blood
2010 | Journal article
EID:

2-s2.0-77953266252

Contributors: Tanaka, A.; Itoh, F.; Nishiyama, K.; Takezawa, T.; Kurihara, H.; Itoh, S.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-78649661063

Contributors: Nakano, N.; Itoh, S.; Watanabe, Y.; Maeyama, K.; Itoh, F.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling

Molecular Cell
2010 | Journal article
EID:

2-s2.0-73649085521

Contributors: Watanabe, Y.; Itoh, S.; Goto, T.; Ohnishi, E.; Inamitsu, M.; Itoh, F.; Satoh, K.; Wiercinska, E.; Yang, W.; Shi, L. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Poor vessel formation in embryos from knock-in mice expressing ALK5 with L45 loop mutation defective in Smad activation

Laboratory Investigation
2009 | Journal article
EID:

2-s2.0-67649877882

Contributors: Itoh, F.; Itoh, S.; Carvalho, R.L.C.; Adachi, T.; Ema, M.; Goumans, M.-J.; Larsson, J.; Karlsson, S.; Takahashi, S.; Mummery, C.L. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity

Journal of Biochemistry
2009 | Journal article
EID:

2-s2.0-59449090378

Contributors: Tanaka, A.; Itoh, F.; Itoh, S.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Ephrin-A1 promotes the malignant progression of intestinal tumors in Apcmin/+ mice

Oncogene
2008 | Journal article
EID:

2-s2.0-44349089921

Contributors: Shi, L.; Itoh, F.; Itoh, S.; Takahashi, S.; Yamamoto, M.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Compensatory signalling induced in the yolk sac vasculature by deletion of TGFβ receptors in mice

Journal of Cell Science
2007 | Journal article
EID:

2-s2.0-38349008641

Contributors: Carvalho, R.L.C.; Itoh, F.; Goumans, M.-J.; Lebrin, F.; Kato, M.; Takahashi, S.; Ema, M.; Itoh, S.; van Rooijen, M.; Bertolino, P. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Negative regulation of TGF-β receptor/Smad signal transduction

Current Opinion in Cell Biology
2007 | Journal article
EID:

2-s2.0-33847716712

Contributors: Itoh, S.; ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-β/Smad-induced growth arrest of prostate cells

Oncogene
2006 | Journal article
EID:

2-s2.0-33748659836

Contributors: Noda, D.; Itoh, S.; Watanabe, Y.; Inamitsu, M.; Dennler, S.; Itoh, F.; Koike, S.; Danielpour, D.; Ten Dijke, P.; Kato, M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

BMC Cell Biology
2006 | Journal article
EID:

2-s2.0-33745188200

Contributors: Valdimarsdottir, G.; Goumans, M.-J.; Itoh, F.; Itoh, S.; Heldin, C.-H.; ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Methylation of Smad6 by protein arginineN-methyltransferase 1

FEBS Letters
2006-11 | Journal article
Contributors: Masako Inamitsu; Susumu Itoh; Ulf Hellman; Peter ten Dijke; Mitsuyasu Kato
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Vascular deficiency in ALK5 knock-in mice

Vascular Pharmacology
2006-09 | Journal article
Contributors: Fumiko Itoh; Susumu Itoh; Masatsugu Ema; Marie-Jose Goumans; Christine L. Mummery; Satoru Takahashi; Peter ten Dijke; Mitsuyasu Kato
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells

EMBO Journal
2004 | Journal article
EID:

2-s2.0-10744231139

Contributors: Itoh, F.; Itoh, S.; Goumans, M.J.; Valdimarsdottir, G.; Iso, T.; Dotto, G.P.; Hamamori, Y.; Kedes, L.; Kato, M.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFβ/ALK5 signaling

Molecular Cell
2003 | Journal article
EID:

2-s2.0-0242330126

Contributors: Goumans, M.-J.; Valdimarsdottir, G.; Itoh, S.; Lebrin, F.; Larsson, J.; Mummery, C.; Karlsson, S.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses

Journal of Biological Chemistry
2003 | Journal article
EID:

2-s2.0-0037423374

Contributors: Itoh, S.; Thorikay, M.; Kowanetz, M.; Moustakas, A.; Itoh, F.; Heldin, C.-H.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

SARA and Hgs attenuate susceptibility to TGF-β1-mediated T cell suppression

FASEB Journal
2003 | Journal article
EID:

2-s2.0-0037310851

Contributors: Kunzmann, S.; Wohlfahrt, J.G.; Itoh, S.; Asao, H.; Komada, M.; Akdis, C.A.; Blaser, K.; Schmidt-Weber, C.B.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Synthetic triterpenoids enhance transforming growth factor β/Smad signaling

Cancer Research
2003 | Journal article
EID:

2-s2.0-0037444161

Contributors: Suh, N.; Roberts, A.B.; Reffey, S.B.; Miyazono, K.; Itoh, S.; Ten Dijke, P.; Heiss, E.H.; Place, A.E.; Risingsong, R.; Williams, C.R. et al.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Balancing the activation state of the endothelium via two distinct TGF-β type I receptors

EMBO Journal
2002 | Journal article
EID:

2-s2.0-0037007226

Contributors: Goumans, M.-J.; Valdimarsdottir, G.; Itoh, S.; Rosendahl, A.; Sideras, P.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells

Circulation
2002 | Journal article
EID:

2-s2.0-0037159280

Contributors: Valdimarsdottir, G.; Goumans, M.-J.; Rosendahl, A.; Brugman, M.; Itoh, S.; Lebrin, F.; Sideras, P.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

The FYVE domain in Smad anchor for receptor activation (SARA) is sufficient for localization of SARA in early endosomes and regulates TGF-β/Smad signalling

Genes to Cells
2002 | Journal article
EID:

2-s2.0-0036201871

Contributors: Itoh, F.; Divecha, N.; Brocks, L.; Oomen, L.; Janssen, H.; Calafat, J.; Itoh, S.; Dijke, P.T.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Regulation of cell proliferation by Smad proteins

Journal of Cellular Physiology
2002-03 | Journal article
Contributors: Peter Ten Dijke; Marie-Jos� Goumans; Fumiko Itoh; Susumu Itoh
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads

EMBO Journal
2001 | Journal article
EID:

2-s2.0-0035422199

Contributors: Itoh, F.; Asao, H.; Sugamura, K.; Heldin, C.-H.; Ten Dijke, P.; Itoh, S.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

Oncogene
2000 | Journal article
EID:

2-s2.0-0034618406

Contributors: Morén, A.; Itoh, S.; Moustakas, A.; Ten Dijke, P.; Heldin, C.-H.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs

Molecular Cell
2000 | Journal article
EID:

2-s2.0-0343967010

Contributors: Tanimoto, H.; Itoh, S.; Ten Dijke, P.; Tabata, T.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Molecular cloning and characterization of a novel human STE20-like kinase, hSLK

Biochimica et Biophysica Acta - Molecular Cell Research
2000 | Journal article
EID:

2-s2.0-0033961586

Contributors: Yamada, E.; Tsujikawa, K.; Itoh, S.; Kameda, Y.-I.; Kohama, Y.; Yamamoto, H.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Signaling of transforming growth factor-β family members through Smad proteins

European Journal of Biochemistry
2000 | Journal article
Contributors: Susumu Itoh; Fumiko Itoh; Marie-José Goumans; Peter ten Dijke
Source: Self-asserted source
Susumu Itoh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Smad and AML proteins synergistically confer transforming growth factor β1 responsiveness to human germ-line IgA genes

Journal of Biological Chemistry
2000 | Journal article
EID:

2-s2.0-0034603004

Contributors: Pardali, E.; Xie, X.-Q.; Tsapogas, P.; Itoh, S.; Arvanitidis, K.; Heldin, C.-H.; Ten Dijke, P.; Grundström, T.; Sideras, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Smad7 mediates apoptosis induced by transforming growth factor β in prostatic carcinoma cells

Current Biology
2000 | Journal article
EID:

2-s2.0-0034193758

Contributors: Landström, M.; Heldin, N.-E.; Bu, S.; Hermansson, A.; Itoh, S.; Ten Dijke, P.; Heldin, C.-H.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling

Nucleic Acids Research
2000 | Journal article
EID:

2-s2.0-0034326828

Contributors: Itoh, S.; Ericsson, J.; Nishikawa, J.-I.; Heldin, C.-H.; Ten Dijke, P.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Xenopus Smad4β is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes

Developmental Biology
1999 | Journal article
EID:

2-s2.0-0033568923

Contributors: Howell, M.; Itoh, F.; Pierreux, C.E.; Valgeirsdottir, S.; Itoh, S.; Ten Dijke, P.T.; Hill, C.S.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

EMBO Journal
1998 | Journal article
EID:

2-s2.0-0032101178

Contributors: Dennler, S.; Itoh, S.; Vivien, D.; Dijke, P.T.; Huet, S.; Gauthier, J.-M.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Effect of 26,26,26,27,27,27-hexafluoro-1,25-dihydroxyvitamin D<inf>3</inf> on the expression of vitamin-D-responsive genes in vitamin-D-deficient mice

Pharmacology
1998 | Journal article
EID:

2-s2.0-0031796026

Contributors: Yoshimura, T.; Itoh, S.; Tsujikawa, K.; Yamada, E.; Ishii, T.; Iemura, O.; Kameda, Y.; Mimura, T.; Kohama, Y.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier

Expression and characterization of dog CYP2D15 using baculovirus expression system

Journal of Biochemistry
1998 | Journal article
EID:

2-s2.0-0031891642

Contributors: Tasaki, T.; Nakamura, A.; Itoh, S.; Ohashi, K.; Yamamoto, Y.; Masuda, M.; Iwata, H.; Kazusaka, A.; Kamataki, T.; Fujita, S.
Source: Self-asserted source
Susumu Itoh via Scopus - Elsevier
Items per page:
Page 1 of 3

Peer review (5 reviews for 4 publications/grants)

Review activity for Biochimica et biophysica acta. Molecular cell research (1)
Review activity for Cell death and differentiation. (2)
Review activity for Oncogene. (1)
Review activity for Signal transduction and targeted therapy. (1)