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Biography

Educational background: I earned my Chemical Engineering degree (2005-10) and Master's in Industrial Processes Engineering (2011) from UCM. I completed lab technician training at Repsol YPF, specifically on wastewater treatment. I earned an International Mention Ph.D. in Molecular Biosciences with a Summa Cum Laude distinction from UAM in 2016.
Scientific contributions, societal impact, and contributions to professional research: In 2012, I initiated my Ph.D. thesis at HGUGM under the guidance of Drs. MA. Muñoz-Fernández and JL. Jiménez. During my pre- and postdoctoral positions at HGUGM (2012-18), I focused on developing innovative nanocompounds for topical vaginal microbicides to prevent HIV and other sexually transmitted infections (HSV-2, HCV). My research enhanced the comprehension of diverse aspects of molecular biology related to various viruses. It explored genetic, molecular, and immunological features underlying virus/host interactions. Moreover, with my granted patent, I emphasized my commitment to translating research into tangible societal benefits through collaborations with industries and public institutions.
My international scientific-technical career spans prestigious institutions like CBMSO, CNB-CSIC, and CQM of the University of Madeira (CQM-UMa), totaling 16 months. In Dr. Domingo's CBMSO group, I gained expertise in hepatoma cell culture, HCV infection systems, virus titration, RNA extraction, and RT-PCR quantification. It exposed me to advanced virology research, emphasizing RNA virus genetic variability. In Dr. Gastaminza's CNB-CSIC group, I assessed the impact of novel nanoparticles on HCV infection and pathogenesis by conducting compound library screening. These stints provided invaluable insights into HCV biology, immune response, and treatment strategies. Learning from prominent figures in virology expanded my knowledge and expertise, enriched my network, and established a foundation for future contributions. Under Dr. Rodrigues' guidance at CQM-UMa, I prepared and characterized novel molecular materials, focusing on metallic and non-metallic dendritic hyperbranched and polymeric systems to enhance biomedical properties. Applying cutting-edge techniques in structural chemistry has advanced my skills in this specialized area of research.
In 2018, I secured a postdoctoral contract at ULe in Dr. Balaña-Fouce's group through a competitive, merit-based contract as a Ph.D. researcher funded by JCyL/FEDER. This transition redirected my focus to drug discovery for neglected tropical diseases caused by human-threatening parasites, including gastrointestinal helminths. This experience allowed me to develop epidemiology and molecular biology skills, further enhancing my profile as an independent and versatile researcher.
In 2019, I received the ONCE Foundation scholarship 'Opportunity for Talent,' securing it for two consecutive years for a research stay at CNM-ISCIII. In 2021, I obtained a Sara Borrell contract to investigate the impact of HCV elimination in HIV/HCV coinfected patients, assessing neutralizing antibodies against HCV and biomarkers linked to severe liver disease and HCV clearance during anti-HCV therapy. I collaborated in various scientific networks (RIS, CIBERINFEC) and actively participated in the group's research areas (HIV, COVID-19). In 2023, I led a project funded by ISCIII, serving as the principal investigator, shifting my focus to novel dendritic nanosystems for diagnosing HCV and other emerging viruses like dengue. In 2024, I obtained a Miguel Servet contract to investigate highly sensitive immunoassays based on magnetic nanoparticles to detect West Nile virus NS1 protein early. It reflects my versatility in addressing real-world health challenges and underscores my growing leadership role.
My numerous first-author publications in high-rated journals and a substantial citation index focusing on global health priorities reflect the impact and recognition of my work. Besides, open-access publications, outreach, and collaboration with industry have extended my research's reach, easing access to the global scientific community. I have played a crucial role in mentoring young researchers, proving my dedication to fostering the next generation of scientists. Beyond teaching and ANECA accreditation, editorial roles in reputable journals and participation in external scientific committees highlight my commitment to educational aspects and the evaluation and development of research activities.
Others: The collaborative nature of my career and expertise gained from diverse institutions have contributed to scientific research in biomedical sciences. It positions me as a non-conventional chemical engineer, excelling in translational and interdisciplinary research. Despite having a hearing disability, I have shown resilience in diverse teams and multicultural settings, showcasing essential soft skills vital for successful collaboration in the sci

Activities

Employment (8)

Instituto de Salud Carlos III: Madrid, ES

2024-07-16 to present | Miguel Servet Postdoctoral Researcher (Viral Infection and Immunity Unit)
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Instituto de Salud Carlos III Campus de Majadahonda: Majadahonda, Comunidad de Madrid, ES

2021-07-12 to 2024-07-11 | Sara Borrell Postdoctoral Researcher (Viral Infection and Immunity Unit)
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Fundación SEIMC-GESIDA: Madrid, Madrid, ES

2020 to 2021 | Postdoctoral Researcher (Stay at Carlos III Health Institute)
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

University of Leon: León, ES

2016 to 2018 | Postdoctoral Researcher (Department of Biomedical Sciences )
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Hospital General Universitario Gregorio Marañón: Madrid, ES

2016 to 2018 | Postdoctoral Researcher (Molecular ImmunoBiology laboratory)
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Hospital General Universitario Gregorio Marañón: Madrid, ES

2012 to 2016 | Postdoctoral Researcher (Molecular ImmunoBiology laboratory)
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Repsol: Madrid, Madrid, ES

2010 to 2010 | Laboratory Technician
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Complutense University of Madrid: Madrid, ES

2005 to 2009 | Laboratory Analyst
Employment
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Education and qualifications (3)

Autonomous University of Madrid: Madrid, ES

2012 to 2016 | Ph.D
Qualification
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Complutense University of Madrid: Madrid, ES

2010 to 2011 | M.Eng.
Qualification
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Complutense University of Madrid: Madrid, ES

2005 to 2010 | B.Ch.E.
Qualification
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Professional activities (2)

Fundación ONCE: Madrid, ES

2020 | ONCE Foundation Scholarship Program "Opportunity for Talent" (Viral Infection and Immunity Unit )
Distinction
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Fundación ONCE: Madrid, ES

2019 | ONCE Foundation Scholarship Program "Opportunity for Talent" (Viral Infection and Immunity Unit )
Distinction
Source: Self-asserted source
Daniel Sepúlveda-Crespo

Funding (1)

Dendritic nanosystems applied to the diagnosis of viral infections

2024 to 2027 | Grant
Fondo de Investigaciones Sanitarias. Instituto de Salud Carlos III. Cofinanciado con fondos FEDER. (Madrid, ES)
GRANT_NUMBER:

PI23CIII/00018

Source: Self-asserted source
Daniel Sepúlveda-Crespo