Personal information

Immune aging and cancer
United States

Biography

Immune aging and cancer

Activities

Employment (7)

Massachusetts General Hospital: Boston, MA, US

2021-07-01 to present | Postdoctoral Fellow (Center for Cancer Research, Department of Medicine)
Employment
Source: Self-asserted source
Alex C.Y. Chen

Tokyo University of Science: Chiba, JP

2020-04-01 to 2021-05-30 | Visiting Scientist (Division of Molecular Regulation of Inflammation and Immune Diseases (Matsushima Lab))
Employment
Source: Self-asserted source
Alex C.Y. Chen

Tokyo University of Science: Chiba, JP

2018-04-01 to 2020-03-23 | Research Assistant (Division of Molecular Regulation of Inflammation and Immune Diseases (Matsushima Lab))
Employment
Source: Self-asserted source
Alex C.Y. Chen

University of Tokyo: Toyko, JP

2016-10 to 2017-03 | Teaching Assistant (Graduate School of Medicine)
Employment
Source: Self-asserted source
Alex C.Y. Chen

Taipei Medical University: Taipei, TW

2015-08-01 to 2016-03-31 | Research Assistant (School of Medical Laboratory Science and Biotechnology)
Employment
Source: Self-asserted source
Alex C.Y. Chen

Shinyi District Administration: Taipei City, TW

2014-07-15 to 2015-06-30 | Assistant
Employment
Source: Self-asserted source
Alex C.Y. Chen

Taipei Medical University: Taipei, TW

2012-09-01 to 2013-06-30 | Teaching Assistant (School of Medical Laboratory Science and Biotechnology)
Employment
Source: Self-asserted source
Alex C.Y. Chen

Education and qualifications (4)

Tokyo University of Science: Chiba, JP

2018-04 to 2020-03-31 | Visiting PhD student (Research Institute for Biomedical Sciences)
Education
Source: Self-asserted source
Alex C.Y. Chen

The University of Tokyo: Tokyo, JP

2016-04-01 to 2020-03-31 | Graduate (Ph.D program) (Graduate School of Medicine)
Education
Source: Self-asserted source
Alex C.Y. Chen

Taipei Medical University: Taipei, TW

2012-09-01 to 2014-06-30 | Graduate (master program) (School of Medical Laboratory Science and Biotechnology)
Education
Source: Self-asserted source
Alex C.Y. Chen

Taipei Medical University: Taipei, TW

2008-09-01 to 2012-06-30 | Undergraduate (School of Medical Laboratory Science and Biotechnology)
Education
Source: Self-asserted source
Alex C.Y. Chen

Professional activities (4)

Society for Immunotherapy of Cancer: Milwaukee, WI, US

2020-10 to present | Student and Scientist-in-Training Membership
Membership
Source: Self-asserted source
Alex C.Y. Chen

American Association for Cancer Research: Philadelphia, PA, US

2017-11 to present | Associate Member
Service
Source: Self-asserted source
Alex C.Y. Chen

Japanese Association of Cancer Immunology: Toyko, JP

2017-06 to present
Membership
Source: Self-asserted source
Alex C.Y. Chen

Japanese Society for Immunology: Toyko, JP

2015-11 to present
Membership
Source: Self-asserted source
Alex C.Y. Chen

Funding (2)

T32 Research Fellowship (MGH Pathology)

2023-07 to 2025-06 | Award
Massachusetts General Hospital (Boston, US)
Source: Self-asserted source
Alex C.Y. Chen

Fellowship of The University of Tokyo

2016-04 to 2020-03 | Award
University of Tokyo (Tokyo, JP)
Source: Self-asserted source
Alex C.Y. Chen

Works (11)

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

Nature Immunology
2024-10 | Journal article
Contributors: Sarah A. Weiss; Amy Y. Huang; Megan E. Fung; Daniela Martinez; Alex C. Y. Chen; Thomas J. LaSalle; Brian C. Miller; Christopher D. Scharer; Mudra Hegde; Thao H. Nguyen et al.
Source: check_circle
Crossref

Hyperactive Dendritc Cells Redirect Aged Antitumor Immunity

Cancer Research
2024-10-01 | Journal article
Contributors: Alex C.Y. Chen; Debattama R. Sen
Source: check_circle
Crossref

The aged tumor microenvironment limits T cell control of cancer

Nature Immunology
2024-06 | Journal article
Contributors: Alex C. Y. Chen; Sneha Jaiswal; Daniela Martinez; Cansu Yerinde; Keely Ji; Velita Miranda; Megan E. Fung; Sarah A. Weiss; Maria Zschummel; Kazuhiro Taguchi et al.
Source: check_circle
Crossref

TAS-Seq is a robust and sensitive amplification method for bead-based scRNA-seq.

Communications biology
2022-06-27 | Journal article
Contributors: Alex C.Y. Chen
Source: Self-asserted source
Alex C.Y. Chen

Ex Vivo Expanded Circulating Tumor Cells for Clinical Anti-Cancer Drug Prediction in Patients with Head and Neck Cancer

Cancers
2021-12-02 | Journal article
Part of ISSN: 2072-6694
Source: Self-asserted source
Alex C.Y. Chen

Combining an alarmin HMGN1 peptide with PD-L1 blockade results in robust antitumor effects with a concomitant increase of stem-like/progenitor exhausted CD8+ T cells

Cancer Immunology Research
2021-08-03 | Journal article
Part of ISSN: 2326-6066
Part of ISSN: 2326-6074
Source: Self-asserted source
Alex C.Y. Chen

Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers

Frontiers in Oncology
2021-05-07 | Journal article
Source: Self-asserted source
Alex C.Y. Chen

A Combined Systemic Strategy for Overcoming Cisplatin Resistance in Head and Neck Cancer: From Target Identification to Drug Discovery

Cancers
2020-11-23 | Journal article
Part of ISSN: 2072-6694
Source: Self-asserted source
Alex C.Y. Chen

Combined treatment with HMGN1 and anti-CD4 depleting antibody reverses T cell exhaustion and exerts robust anti-tumor effects in mice

Journal for ImmunoTherapy of Cancer
2019 | Journal article
EID:

2-s2.0-85060711237

Contributors: Chen, C.-Y.; Ueha, S.; Ishiwata, Y.; Yokochi, S.; Yang, D.; Oppenheim, J.J.; Ogiwara, H.; Shichino, S.; Deshimaru, S.; Shand, F.H.W. et al.
Source: Self-asserted source
Alex C.Y. Chen via Scopus - Elsevier

Annexin A2-mediated cancer progression and therapeutic resistance in nasopharyngeal carcinoma.

Journal of biomedical science
2018-03 | Journal article
Contributors: Chen CY; Lin YS; Chen CH; Chen YJ
Source: Self-asserted source
Alex C.Y. Chen via Europe PubMed Central
grade
Preferred source (of 2)‎

Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

Oncotarget
2015 | Journal article
EID:

2-s2.0-84944459557

Contributors: Chen, C.-Y.; Lin, Y.-S.; Chen, C.-L.; Chao, P.-Z.; Chiou, J.-F.; Kuo, C.-C.; Lee, F.-P.; Lin, Y.-F.; Sung, Y.-H.; Lin, Y.-T. et al.
Source: Self-asserted source
Alex C.Y. Chen via Scopus - Elsevier