Personal information

Neuroimmunology, Pain, Osteoarthritis, Neuropathic Pain, Angiotensin, Obesity, Neuropharmacology, TRP Channels, Macrophages, Reactive Oxygen Species, Oxidative Stress
United States, United Kingdom

Biography

I received my Bachelors’ degree in Molecular Cell Biology in 2003 from the University of Manchester Institute of Science and Technology in the UK.

I received my PhD in Neuroimmunomodulation in 2006 at the nearby University of Manchester – where I investigated the impact of sensory innervation and neuropeptide release in a rodent model of allergic inflammation. Following a brief postdoc in the same institution studying folate metabolism in the development of hydrocephalus, I relocated to the newly-established lab of Durga ‘DP’ Mohapatra in the Department of Pharmacology at the University of Iowa in 2008. During this time, I developed an interest in G-protein coupled receptor-based modulation of ion channel activity in the central and peripheral nervous system, particularly in relation to pain associated with bone-metastasized prostate cancer.

Since becoming a research-track faculty member of the Department of Anesthesiology at Washington University in St. Louis in 2015, I have developed research related to macrophage involvement in chronic inflammatory and neuropathic pain. In particular, I am currently focusing on the pain-promoting effects of obesity and the renin-angiotensin system in the exacerbation of such pain states.

Activities

Employment (5)

The University of Texas MD Anderson Cancer Center: Houston, Texas, US

2018-12-18 to present | Assistant Professor (Symptom Research)
Employment
Source: Self-asserted source
Andrew Shepherd

Washington University in Saint Louis: Saint Louis, MO, US

2015-01-01 to 2018-11-30 | Instructor (Anesthesiology)
Employment
Source: Self-asserted source
Andrew Shepherd

University of Iowa: Iowa City, IA, US

2014-07-01 to 2014-12-31 | Assistant Research Scientist (Pharmacology)
Employment
Source: Self-asserted source
Andrew Shepherd

University of Iowa: Iowa City, IA, US

2008-04-01 to 2014-06-30 | Postdoctoral Research Scholar (Pharmacology)
Employment
Source: Self-asserted source
Andrew Shepherd

University of Manchester: Manchester, Greater Manchester, GB

2006-12-01 to 2007-11-30 | Postdoctoral Research Scholar (Faculty of Life Sciences)
Employment
Source: Self-asserted source
Andrew Shepherd

Education and qualifications (2)

University of Manchester: Manchester, Greater Manchester, GB

2003-09-01 to 2006-11-30 | PhD Student (Faculty of Life Sciences)
Qualification
Source: Self-asserted source
Andrew Shepherd

University of Manchester: Manchester, Greater Manchester, GB

2000-09-01 to 2003-07-15 | Undergraduate (Biomedical Sciences)
Qualification
Source: Self-asserted source
Andrew Shepherd

Professional activities (4)

International Association for the Study of Pain: Seattle, WA, US

2018-01-01 to present
Membership
Source: Self-asserted source
Andrew Shepherd

American Pain Society: Chicago, Illinois, US

2013-01-01 to present
Membership
Source: Self-asserted source
Andrew Shepherd

American Heart Association: TX, TX, US

2010-01-01 to present
Membership
Source: Self-asserted source
Andrew Shepherd

Society for Neuroscience: Washington, DC, US

2009-01-01 to present
Membership
Source: Self-asserted source
Andrew Shepherd

Funding (9)

Targeting Angiotensin-Based Neuroimmune Cross Talk for Treatment of Neuromuscular Trauma

2021-04-01 to 2023-03-31 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-21-1-0197

Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Targeting STAT3 Signaling to Promote Recovery from Neuropathic Pain

2020-10-01 to 2021-09-01 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-22-1-0685

Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Validation of Fibroblast-Derived PI16 as a Novel Target for pain Treatment

2020-09-30 to 2024-08-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: R01NS116704
Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Neuro-Immuno Modulating Analgesic (NiMA) Nanomedicine Platform for Treatment of Diabetic Neuropathy

2020-07-01 to 2022-06-30 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
GRANT_NUMBER:

W81XWH-20-1-0277

Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Non-addictive Angiotensin AT2 inhibitors for neuropathic pain relief

2020-06-01 to 2025-05-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: UH3NS116929
Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Non-addictive Angiotensin AT2 inhibitors for neuropathic pain relief

2020-06-01 to 2021-05-31 | Grant
National Institute of Neurological Disorders and Stroke (Bethesda, US)
GRANT_NUMBER: UG3NS116929
Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

PQ12 Targeting HDAC6 for Chemotherapy-Induced Neuropathy and Chemobrain

2018-05-22 to 2024-04-30 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R01CA227064
Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Angiotensin Links Osteoarthritis Pain to Obesity via Macrophages and TRPA1

2017-10 to 2018-09 | Award
Washington University Nutrition Obesity Research Center (St. Louis, Missouri, US)
GRANT_NUMBER: P30DK056341
Source: Self-asserted source
Andrew Shepherd

Mesenchymal Stem Cells to Repair Chemobrain

2016-09-01 to 2022-08-31 | Grant
National Cancer Institute (Bethesda, US)
GRANT_NUMBER: R01CA208371
Source: Self-asserted source
Andrew Shepherd via DimensionsWizard

Works (38)

Intrinsic adaptive plasticity in mouse and human sensory neurons

Journal of General Physiology
2025-01-06 | Journal article
Contributors: Lisa A. McIlvried; John Smith Del Rosario; Melanie Y. Pullen; Andi Wangzhou; Tayler D. Sheahan; Andrew J. Shepherd; Richard A. Slivicki; John A. Lemen; Theodore J. Price; Bryan A. Copits et al.
Source: check_circle
Crossref

Animal models of neuropathic pain

2024 | Book chapter
Contributors: Angela M. Casaril; Caitlyn M. Gaffney; Andrew J. Shepherd
Source: check_circle
Crossref

Single-cell analysis of age-related changes in leukocytes of diabetic mouse hindpaws

Cellular and Molecular Life Sciences
2024-12 | Journal article
Contributors: James M. Nichols; Hoang Vu Pham; Eric F. Lee; Rajasekaran Mahalingam; Andrew J. Shepherd
Source: check_circle
Crossref

Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons

2023-06-14 | Preprint
Contributors: Lisa A. McIlvried; John Smith Del Rosario; Melanie Y. Pullen; Andi Wangzhou; Tayler D. Sheahan; Andrew J. Shepherd; Richard A. Slivicki; John A. Lemen; Theodore J. Price; Bryan A. Copits et al.
Source: check_circle
Crossref

Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1

European Journal of Pain
2022-10 | Journal article
Contributors: Gabriella L. Robilotto; Durga P. Mohapatra; Andrew J. Shepherd; Aaron D. Mickle
Source: check_circle
Crossref

Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine

Antioxidants & Redox Signaling
2022-01-01 | Journal article
Contributors: Mihály Balogh; Jelena M. Janjic; Andrew J. Shepherd
Source: check_circle
Crossref

Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy

Journal of Neuroinflammation
2021-12-23 | Journal article
Contributors: James M. Nichols; Caitlin V. Crelli; Lu Liu; Hoang Vu Pham; Jelena M. Janjic; Andrew J. Shepherd
Source: check_circle
Crossref

Drug targeting to sites of oxidative stress using the Baeyer-Villiger reaction

2021-09-06 | Other
Contributors: Thomas D Avery; Jiahe Li; Dion J. L. Turner; Fisher R. Cherry; Mohd S. Ur Rasheed; Clarissa Aguilar; Andrew J. Shepherd; Jingxian Yu; Peter M Grace; Andrew D Abell
Source: check_circle
Crossref

Tracking Macrophages in Diabetic Neuropathy With Two-Color Nanoemulsions for Near-Infrared Fluorescent Imaging and Microscopy

2021-08-31 | Preprint
Contributors: James M. Nichols; Caitlin V. Crelli; Lu Liu; Hoang Vu Pham; Jelena M. Janjic; Andrew J Shepherd
Source: check_circle
Crossref

Astrocytes improve neuronal health after cisplatin treatment through mitochondrial transfer

2019-12-18 | Preprint
Contributors: Krystal English; Andrew Shepherd; Ndidi-Ese Nzor; Ronnie Trinh; Annemieke Kavelaars; Cobi J. Heijnen
Source: check_circle
Crossref

Attenuation of Unevoked Mechanical and Cold Pain Hypersensitivities Associated With Experimental Neuropathy in Mice by Angiotensin II Type-2 Receptor Antagonism.

Anesthesia and analgesia
2018-10 | Journal article
Contributors: Shepherd AJ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Macrophage angiotensin II type 2 receptor triggers neuropathic pain.

Proceedings of the National Academy of Sciences of the United States of America
2018-08 | Journal article
Contributors: Shepherd AJ; Mickle AD; Golden JP; Mack MR; Halabi CM; de Kloet AD; Samineni VK; Kim BS; Krause EG; Gereau RW et al.
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain

The Journal of Neuroscience
2018-08-08 | Journal article
Contributors: Andrew J. Shepherd; Bryan A. Copits; Aaron D. Mickle; Páll Karlsson; Suraj Kadunganattil; Simon Haroutounian; Satya M. Tadinada; Annette D. de Kloet; Manouela V. Valtcheva; Lisa A. McIlvried et al.
Source: check_circle
Crossref

Deficits in Burrowing Behaviors Are Associated With Mouse Models of Neuropathic but Not Inflammatory Pain or Migraine.

Frontiers in behavioral neuroscience
2018-06 | Journal article
Contributors: Shepherd AJ; Cloud ME; Cao YQ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons.

European journal of pain (London, England)
2018-06 | Journal article
Contributors: Shepherd AJ; Mickle AD; McIlvried LA; Gereau RW; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Parathyroid Hormone-Related Peptide Elicits Peripheral TRPV1-dependent Mechanical Hypersensitivity.

Frontiers in cellular neuroscience
2018-02 | Journal article
Contributors: Shepherd AJ; Mickle AD; Kadunganattil S; Hu H; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice.

Neuropharmacology
2017-11 | Journal article
Contributors: Shepherd AJ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain.

Neurobiology of pain (Elsevier)
2017-08 | Journal article
Contributors: Sheahan TD; Siuda ER; Bruchas MR; Shepherd AJ; Mohapatra DP; Gereau RW; Golden JP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Macrophage-to-sensory neuron crosstalk mediated by Angiotensin II type-2 receptor elicits neuropathic pain

2017-08 | Other
OTHER-ID:

PPR25494

Contributors: Shepherd AJ; Mickle AD; Copits BA; Karlsson P; Kadunganattil S; Golden JP; Tadinada SM; Mack MR; Haroutounian S; de Kloet AD et al.
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Neuropathic Pain: Central vs. Peripheral Mechanisms

Current Pain and Headache Reports
2017-06 | Journal article
Contributors: Kathleen Meacham; Andrew Shepherd; Durga P. Mohapatra; Simon Haroutounian
Source: check_circle
Crossref

Nociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain Pathologies.

Pharmaceuticals (Basel, Switzerland)
2016-11 | Journal article
Contributors: Mickle AD; Shepherd AJ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2016-05 | Journal article
Contributors: Shutov LP; Warwick CA; Shi X; Gnanasekaran A; Shepherd AJ; Mohapatra DP; Woodruff TM; Clark JD; Usachev YM
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.

Neuropharmacology
2015-10 | Journal article
Contributors: Gupte RP; Kadunganattil S; Shepherd AJ; Merrill R; Planer W; Bruchas MR; Strack S; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking.

Pain
2015-09 | Journal article
Contributors: Mickle AD; Shepherd AJ; Loo L; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Sensory TRP channels: the key transducers of nociception and pain.

Progress in molecular biology and translational science
2015-02 | Journal article
Contributors: Mickle AD; Shepherd AJ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Localization and expression of CaBP1/caldendrin in the mouse brain.

Neuroscience
2014-03 | Journal article
Contributors: Kim KY; Scholl ES; Liu X; Shepherd A; Haeseleer F; Lee A
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

PloS one
2013-09 | Journal article
Contributors: Shepherd AJ; Loo L; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Competition between α-actinin and Ca²⁺-calmodulin controls surface retention of the L-type Ca²⁺ channel Ca(V)1.2.

Neuron
2013-05 | Journal article
Contributors: Hall DD; Dai S; Tseng PY; Malik Z; Nguyen M; Matt L; Schnizler K; Shephard A; Mohapatra DP; Tsuruta F et al.
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction.

Molecular psychiatry
2013-05 | Journal article
Contributors: Sowers LP; Loo L; Wu Y; Campbell E; Ulrich JD; Wu S; Paemka L; Wassink T; Meyer K; Bing X et al.
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2012-12 | Journal article
Contributors: Shepherd AJ; Loo L; Gupte RP; Mickle AD; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2012-08 | Journal article
Contributors: Loo L; Shepherd AJ; Mickle AD; Lorca RA; Shutov LP; Usachev YM; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Immunostaining of Voltage-Gated Ion Channels in Cell Lines and Neurons – Key Concepts and Potential Pitfalls

Applications of Immunocytochemistry
2012-03-09 | Book chapter
Source: Self-asserted source
Andrew Shepherd

Tissue preparation and immunostaining of mouse sensory nerve fibers innervating skin and limb bones.

Journal of visualized experiments : JoVE
2012-01 | Journal article
Contributors: Shepherd AJ; Mohapatra DP
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.

The Journal of biological chemistry
2011-12 | Journal article
Contributors: Maity B; Stewart A; Yang J; Loo L; Sheff D; Shepherd AJ; Mohapatra DP; Fisher RA
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

RGS6, a modulator of parasympathetic activation in heart.

Circulation research
2010-09 | Journal article
Contributors: Yang J; Huang J; Maity B; Gao Z; Lorca RA; Gudmundsson H; Li J; Stewart A; Swaminathan PD; Ibeawuchi SR et al.
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Addressing a folate imbalance in fetal cerebrospinal fluid can decrease the incidence of congenital hydrocephalus.

Journal of neuropathology and experimental neurology
2009-04 | Journal article
Contributors: Cains S; Shepherd A; Nabiuni M; Owen-Lynch PJ; Miyan J
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Without nerves, immunology remains incomplete -in vivo veritas.

Immunology
2005-10 | Journal article
Contributors: Shepherd AJ; Downing JE; Miyan JA
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Mobilisation of specific T cells from lymph nodes in contact sensitivity requires substance P.

Journal of neuroimmunology
2005-07 | Journal article
Contributors: Shepherd AJ; Beresford LJ; Bell EB; Miyan JA
Source: Self-asserted source
Andrew Shepherd via Europe PubMed Central

Peer review (6 reviews for 5 publications/grants)

Review activity for ACS omega. (1)
Review activity for Brain, behavior, and immunity. (1)
Review activity for Journal of neuroimmune pharmacology. (1)
Review activity for Nature communications (1)
Review activity for The journal of pain (2)