Personal information
Biography
Professor Stitt was appointed to the McCauley Chair of Experimental Ophthalmology in 2001. He is internationally known for his research in ophthalmology, particularly in the pathogenesis of diabetic retinopathy and age-related retinal disease. His research efforts established the role of advanced glycation endproducts (AGEs) and their receptors in the progression of retinal vascular diseases and his work has uncovered several inter-related pathways involved in neuroglial and microvascular dysfunction in the diabetic and ageing retina. This research has led to the development and testing of several drugs that have progressed to clinical trials in diabetic retinopathy and diabetic macular oedema.
His research team consists of several PhD students and post-docs conducting several ongoing projects involving multiple funding streams and local/national/international collaborators:
1. Harnessing ECFCs to repair choriocapillaris during geographic atrophy
2. The role of the placental growth factor pathway in age-related retinal disease
3. Metabolic plasticity of retinal cells in ischaemia and the potential to regulate physiological angiogenesis
4. Identifying key molecular mechanisms underpinning ECFC dysfunction in diabetic microvascular disease.
5. Development of vascular stem cell therapy for ischaemic retinopathy
6. Combinatorial cell therapy for reversing tissue ischaemia
7. The potential of iPS cell technology to understand mechanisms underpinning patient responsiveness to anti-VEGF agents for diabetic macular oedema
Professor Stitt is a member of the Royal Irish Academy (RIA) and a Fellow of the Association for Research in Vision & Ophthalmology (ARVO). He has also earned significant prizes including a Royal Society Merit Award, the Sir Jules Thorn Biomedical Science Award, the JDRF Mary Jane Kugel Award and the 5th Fincham Medal in recognition of research on diabetic retinopathy and neovascular events in diabetes. He contributes significantly to the international academic community by serving on advisory boards, grant panels. These include Chair of the grant award panel for Fight for Sight and membership of Diabetes UK research committee and various MRC panels including DPFS. He also regularly presents guest lectures at meetings and conferences across the world.
He is the Editor-in-Chief for Progress in Retinal & Eye Research (#1 ranked journal in ophthalmology). He is also an editorial board member for several other ophthalmology and vascular biology journals.
As current Dean of Innovation and Impact within the Faculty of Medicine, Health and Life Sciences (MHLS) Prof Stitt promotes academic-commercialization partnerships and a culture of entrepreneurship. In this role he leads the MRC Innovation Accelerator Account (IAA) which encompasses Confidence in Concept (CiC) awards to provide seed-corn funding for researchers to develop their ideas for commercialization and industry engagement. Also in this Deans role he leads the development of the Core Technology Units (CTUs), MHLS Technician Commitment and oversees the PG Research programme. He also leads the Wellcome Trust Institutional Strategic Support Fund (ISSF) for QUB which is focused on providing a range of funding streams relating to ophthalmology and respiratory disease. There is also a strong research public engagement aspect which seeks to provide faculty-wide opportunities for researchers to develop broader and deeper impact outcomes for their research.