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Scopus Author ID: 16205206000

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Works (25)

Interplay between genetics and epigenetics in lung fibrosis

The International Journal of Biochemistry & Cell Biology
2025-03 | Journal article
DOI: 10.1016/j.biocel.2025.106739
Contributors: Anita Valand; Poojitha Rajasekar; Louise V. Wain; Rachel L. Clifford
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Crossref

Accelerated epigenetic aging worsens survival and mediates environmental stressors in fibrotic interstitial lung disease

European Respiratory Journal
2025-01-30 | Journal article
DOI: 10.1183/13993003.01618-2024
Contributors: Gillian C. Goobie; Daniel-Costin Marinescu; Ayodeji Adegunsoye; Jean Bourbeau; Christopher Carlsten; Rachel L. Clifford; Dany Doiron; Qingling Duan; Kevin F. Gibson; Amanda Grant-Orser et al.
Source: check_circle
Crossref

The effects of inhaled corticosteroids on healthy airways

Allergy
2024-07 | Journal article
DOI: 10.1111/all.16146
Contributors: Emanuele Marchi; Timothy S. C. Hinks; Matthew Richardson; Latifa Khalfaoui; Fiona A. Symon; Poojitha Rajasekar; Rachel Clifford; Beverley Hargadon; Cary D. Austin; Julia L. MacIsaac et al.
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Crossref

Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma

American Journal of Respiratory and Critical Care Medicine
2024-05-15 | Journal article
DOI: 10.1164/rccm.202308-1477LE
Contributors: Kamini Rakkar; Yik L. Pang; Poojitha Rajasekar; Michael A. Portelli; Robert J. Hall; Rachel L. Clifford; Dominick Shaw; Ian Sayers
Source: check_circle
Crossref

Greater than the sum of its parts: Integrating multiple data sets to decipher cigarette smoking effects on airway epithelium

American Journal of Respiratory Cell and Molecular Biology
2021 | Journal article
DOI: 10.1165/rcmb.2021-0207ED
EID:

2-s2.0-85116548550

Part of ISSN: 15354989 10441549
Contributors: Clifford, R.L.; Jones, M.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Predominant DNMT and TET mediate effects of allergen on the human bronchial epithelium in a controlled air pollution exposure study

Journal of Allergy and Clinical Immunology
2021 | Journal article
DOI: 10.1016/j.jaci.2020.08.044
EID:

2-s2.0-85095942697

Part of ISSN: 10976825 00916749
Contributors: Li, H.; Ryu, M.H.; Rider, C.F.; Tse, W.; Clifford, R.L.; Aristizabal, M.J.; Wen, W.; Carlsten, C.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

DNA Methylation of Fibroblast Phenotypes and Contributions to Lung Fibrosis

Cells
2021-08-03 | Journal article
DOI: 10.3390/cells10081977
Contributors: Poojitha Rajasekar; Jamie Patel; Rachel L. Clifford
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Crossref
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Preferred source (of 3)‎

TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma

Clinical Epigenetics
2020-12 | Journal article
DOI: 10.1186/s13148-020-00931-4
Contributors: Rachel L. Clifford; Chen Xi Yang; Nick Fishbane; Jamie Patel; Julia L. MacIsaac; Lisa M. McEwen; Sean T. May; Marcos Castellanos-Uribe; Parameswaran Nair; Ma’en Obeidat et al.
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Crossref
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Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma

Chest
2019 | Journal article
DOI: 10.1016/j.chest.2018.10.038
EID:

2-s2.0-85061936264

Part of ISSN: 19313543 00123692
Contributors: Kaczmarek, K.A.; Clifford, R.L.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation

Scientific Reports
2019-10-08 | Journal article
DOI: 10.1038/s41598-019-50873-y
Contributors: Rachel L. Clifford; Jamie Patel; Julia L. MacIsaac; Lisa M. McEwen; Simon R. Johnson; Dominick Shaw; Alan J. Knox; Tillie-Louise Hackett; Michael S. Kobor
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Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Clinical Epigenetics
2018 | Journal article
DOI: 10.1186/s13148-018-0464-5
EID:

2-s2.0-85043316864

Part of ISSN: 18687083 18687075
Contributors: Clifford, R.L.; Fishbane, N.; Patel, J.; MacIsaac, J.L.; McEwen, L.M.; Fisher, A.J.; Brandsma, C.-A.; Nair, P.; Kobor, M.S.; Hackett, T.-L. et al.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation

Journal of Allergy and Clinical Immunology
2017 | Journal article
DOI: 10.1016/j.jaci.2016.03.046
EID:

2-s2.0-85008173544

Part of ISSN: 10976825 00916749
Contributors: Clifford, R.L.; Jones, M.J.; MacIsaac, J.L.; McEwen, L.M.; Goodman, S.J.; Mostafavi, S.; Kobor, M.S.; Carlsten, C.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Amplification of TGFβ induced ITGB6 gene transcription may promote pulmonary fibrosis

PLoS ONE
2016 | Journal article
DOI: 10.1371/journal.pone.0158047
EID:

2-s2.0-84983316519

Part of ISSN: 19326203
Contributors: Tatler, A.L.; Goodwin, A.T.; Gbolahan, O.; Saini, G.; Porte, J.; John, A.E.; Clifford, R.L.; Violette, S.M.; Weinreb, P.H.; Parfrey, H. et al.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

Biochemical and Biophysical Research Communications
2016 | Journal article
DOI: 10.1016/j.bbrc.2016.05.140
EID:

2-s2.0-84976869594

Part of ISSN: 10902104 0006291X
Contributors: Poghosyan, A.; Patel, J.K.; Clifford, R.L.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: Regulation by BET

American Journal of Physiology - Lung Cellular and Molecular Physiology
2015 | Journal article
DOI: 10.1152/ajplung.00021.2015
EID:

2-s2.0-84929682949

Part of ISSN: 15221504 10400605
Contributors: Clifford, R.L.; Patel, J.K.; John, A.E.; Tatler, A.L.; Mazengarb, L.; Brightling, C.E.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and function

Pulmonary Pharmacology and Therapeutics
2013 | Journal article
DOI: 10.1016/j.pupt.2012.07.002
EID:

2-s2.0-84873189092

Part of ISSN: 10945539 15229629
Contributors: Clifford, R.L.; Singer, C.A.; John, A.E.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Pro-inflammatory and immunomodulatory functions of airway smooth muscle: Emerging concepts

Pulmonary Pharmacology and Therapeutics
2013 | Journal article
DOI: 10.1016/j.pupt.2012.05.006
EID:

2-s2.0-84873160340

Part of ISSN: 10945539 15229629
Contributors: Xia, Y.C.; Redhu, N.S.; Moir, L.M.; Koziol-White, C.; Ammit, A.J.; Al-Alwan, L.; Camoretti-Mercado, B.; Clifford, R.L.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma

Journal of Immunology
2012 | Journal article
DOI: 10.4049/jimmunol.1103641
EID:

2-s2.0-84863611382

Part of ISSN: 00221767 15506606
Contributors: Clifford, R.L.; John, A.E.; Brightling, C.E.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Ciclesonide inhibits TNFα- and IL-1β-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells

American Journal of Physiology - Lung Cellular and Molecular Physiology
2012 | Journal article
DOI: 10.1152/ajplung.00257.2011
EID:

2-s2.0-84859778814

Part of ISSN: 10400605 15221504
Contributors: Patel, J.K.; Clifford, R.L.; Deacon, K.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Future bronchodilator therapy: A bitter pill to swallow?

American Journal of Physiology - Lung Cellular and Molecular Physiology
2012 | Journal article
DOI: 10.1152/ajplung.00303.2012
EID:

2-s2.0-84870928342

Part of ISSN: 10400605 15221504
Contributors: Clifford, R.L.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Transcriptional regulation of inflammatory Genes associated with severe Asthma

Current Pharmaceutical Design
2011 | Journal article
DOI: 10.2174/138161211795429000
EID:

2-s2.0-79954552603

Part of ISSN: 13816128
Contributors: Clifford, R.L.; Coward, W.R.; Knox, A.J.; John, A.E.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein

Journal of Biological Chemistry
2010 | Journal article
DOI: 10.1074/jbc.M109.099952
EID:

2-s2.0-77956547990

Part of ISSN: 1083351X 00219258
Contributors: Clarke, D.L.; Clifford, R.L.; Jindarat, S.; Proud, D.; Pang, L.; Belvisi, M.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Vitamin D - A new treatment for airway remodelling in asthma?

British Journal of Pharmacology
2009 | Journal article
DOI: 10.1111/j.1476-5381.2009.00429.x
EID:

2-s2.0-70350539101

Part of ISSN: 00071188 14765381
Contributors: Clifford, R.L.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor β<sub>1</sub>: Requirement for Smads, β-catenin, and GSK3β

Journal of Biological Chemistry
2008 | Journal article
DOI: 10.1074/jbc.M803342200
EID:

2-s2.0-58149100136

Part of ISSN: 00219258 1083351X
Contributors: Clifford, R.L.; Deacon, K.; Knox, A.J.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Blanching the airways: Steroid effects in asthma

Thorax
2007 | Journal article
DOI: 10.1136/thx.2006.073221
EID:

2-s2.0-34147218539

Part of ISSN: 00406376
Contributors: Knox, A.J.; Deacon, K.; Clifford, R.
Source: Self-asserted source
Rachel Clifford via Scopus - Elsevier

Peer review (4 reviews for 4 publications/grants)

Review activity for EMBO journal. (1)
Review activity for Heliyon. (1)
Review activity for Pharmacology & therapeutics. (1)
Review activity for UK Research and Innovation (1)
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