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Works (4)

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors

Journal for ImmunoTherapy of Cancer
2022-07 | Journal article
DOI: 10.1136/jitc-2022-005054
Contributors: Sophia Stock; Mohamed-Reda Benmebarek; Anna-Kristina Kluever; Diana Darowski; Christian Jost; Kay-Gunnar Stubenrauch; Joerg Benz; Anne Freimoser-Grundschober; Ekkehard Moessner; Pablo Umana et al.
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CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

mAbs
2020-01-01 | Journal article
DOI: 10.1080/19420862.2020.1840709
Contributors: Christian Jost; Diana Darowski; John Challier; Vesna Pulko; Lydia J Hanisch; Wei Xu; Ekkehard Mössner; Alexander Bujotzek; Stefan Klostermann; Pablo Umana et al.
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P329G-CAR-J: a novel Jurkat-NFAT-based CAR-T reporter system recognizing the P329G Fc mutation

Protein Engineering, Design and Selection
2019-09-03 | Journal article
DOI: 10.1093/protein/gzz027
Contributors: Diana Darowski; Christian Jost; Kay Stubenrauch; Uwe Wessels; Jörg Benz; Andreas Ehler; Anne Freimoser-Grundschober; Peter Brünker; Ekkehard Mössner; Pablo Umaña et al.
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Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells

mAbs
2019-05-19 | Journal article
DOI: 10.1080/19420862.2019.1596511
Contributors: Diana Darowski; Sebastian Kobold; Christian Jost; Christian Klein
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