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Employment (1)

McLean Hospital / Harvard Medical School: Belmont, MA, US

2006-06-01 to present | Assistant Professor (Neuroregeneration Institute)
Employment
Source: Self-asserted source
Penelope Hallett

Works (50 of 52)

Items per page:
Page 1 of 2

Upstream lipid and metabolic systems are potential causes of Alzheimer's disease, Parkinson's disease and dementias

The FEBS Journal
2024-02 | Journal article
Contributors: Oliver Cooper; Penny Hallett; Ole Isacson
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Crossref

Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Cells
2023-11-02 | Journal article
Contributors: Kyle J. Connolly; Juliette Margaria; Erika Di Biase; Oliver Cooper; Penelope J. Hallett; Ole Isacson
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Crossref
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Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease

Glycoconjugate Journal
2022-02 | Journal article
Contributors: Kerri-Lee Wallom; María E. Fernández-Suárez; David A. Priestman; Danielle te Vruchte; Mylene Huebecker; Penelope J. Hallett; Ole Isacson; Frances M. Platt
Source: check_circle
Crossref

Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2.

Molecular brain
2021-01-19 | Journal article
Source: Self-asserted source
Penelope Hallett

Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance.

Proceedings of the National Academy of Sciences of the United States of America
2020-10-15 | Journal article
Source: Self-asserted source
Penelope Hallett

Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity.

Acta neuropathologica communications
2020-08-06 | Journal article
Source: Self-asserted source
Penelope Hallett

Experimental studies of mitochondrial and lysosomal function in in vitro and in vivo models relevant to Parkinson's disease genetic risk.

International review of neurobiology
2020-07-10 | Journal article
Source: Self-asserted source
Penelope Hallett

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice.

Molecular therapy. Nucleic acids
2020-06-27 | Journal article
Source: Self-asserted source
Penelope Hallett

Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients.

Frontiers in cellular neuroscience
2020-04-03 | Journal article
Source: Self-asserted source
Penelope Hallett

Neurite Collapse and Altered ER Ca <sup>2+</sup> Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

Stem Cell Reports
2019 | Journal article
EID:

2-s2.0-85059641451

Contributors: Korecka, J.A.; Talbot, S.; Osborn, T.M.; de Leeuw, S.M.; Levy, S.A.; Ferrari, E.J.; Moskites, A.; Atkinson, E.; Jodelka, F.M.; Hinrich, A.J. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier
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Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.

Molecular neurodegeneration
2019-11-08 | Journal article
Source: Self-asserted source
Penelope Hallett

Novel Results and Concepts Emerging From Lipid Cell Biology Relevant to Degenerative Brain Aging and Disease.

Frontiers in neurology
2019-10-09 | Journal article
Source: Self-asserted source
Penelope Hallett

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts.

Human molecular genetics
2019-07 | Journal article
Contributors: Korecka JA; Thomas R; Christensen DP; Hinrich AJ; Ferrari EJ; Levy SA; Hastings ML; Hallett PJ; Isacson O
Source: Self-asserted source
Penelope Hallett via Europe PubMed Central

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain

Neurobiology of Aging
2018 | Journal article
EID:

2-s2.0-85045651182

Contributors: Hallett, P.J.; Huebecker, M.; Brekk, O.R.; Moloney, E.B.; Rocha, E.M.; Priestman, D.A.; Platt, F.M.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

Scientific Reports
2018 | Journal article
EID:

2-s2.0-85054898559

Contributors: Brekk, O.R.; Moskites, A.; Isacson, O.; Hallett, P.J.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress

Neurobiology of Disease
2018-12 | Journal article
Contributors: Elizabeth B. Moloney; Alyssa Moskites; Eliza J. Ferrari; Ole Isacson; Penelope J. Hallett
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Crossref
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Seq-ing Markers of Midbrain Dopamine Neurons

Cell Stem Cell
2017-01 | Journal article
Part of ISSN: 1934-5909
Contributors: Teresia Osborn; Penelope J. Hallett
Source: Self-asserted source
Penelope Hallett via Crossref Metadata Search
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Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition

Molecular Neurobiology
2016 | Journal article
EID:

2-s2.0-84944708009

Contributors: Smith, G.A.; Jansson, J.; Rocha, E.M.; Osborn, T.; Hallett, P.J.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

A Nurr1 agonist causes neuroprotection in a parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C)

PLoS ONE
2015 | Journal article
EID:

2-s2.0-84926325705

Contributors: Smith, G.A.; Rocha, E.M.; Rooney, T.; Barneoud, P.; McLean, J.R.; Beagan, J.; Osborn, T.; Coimbra, M.; Luo, Y.; Hallett, P.J. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons

Neurobiology of Disease
2015 | Journal article
EID:

2-s2.0-84947037583

Contributors: Rocha, E.M.; Smith, G.A.; Park, E.; Cao, H.; Brown, E.; Hayes, M.A.; Beagan, J.; McLean, J.R.; Izen, S.C.; Perez-Torres, E. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease

Cell Stem Cell
2015 | Journal article
EID:

2-s2.0-84924339474

Contributors: Hallett, P.J.; Deleidi, M.; Astradsson, A.; Smith, G.A.; Cooper, O.; Osborn, T.M.; Sundberg, M.; Moore, M.A.; Perez-Torres, E.; Brownell, A.-L. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice

Antioxidants and Redox Signaling
2015 | Journal article
EID:

2-s2.0-84939795706

Contributors: Rocha, E.M.; Smith, G.A.; Park, E.; Cao, H.; Graham, A.-R.; Brown, E.; McLean, J.R.; Hayes, M.A.; Beagan, J.; Izen, S.C. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Annals of Clinical and Translational Neurology
2015-02 | Journal article
Contributors: Rocha EM; Smith GA; Park E; Cao H; Brown E; Hallett P; Isacson O
Source: Self-asserted source
Penelope Hallett via Europe PubMed Central

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress

Experimental Neurology
2014 | Journal article
EID:

2-s2.0-84905457858

Contributors: McLean, J.R.; Smith, G.A.; Rocha, E.M.; Osborn, T.M.; Dib, S.; Hayes, M.A.; Beagan, J.A.; Brown, T.B.; Lawson, T.F.S.; Hallett, P.J. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease

Neurobiology of Disease
2014 | Journal article
EID:

2-s2.0-84892456555

Contributors: Davies, S.E.; Hallett, P.J.; Moens, T.; Smith, G.; Mangano, E.; Kim, H.T.; Goldberg, A.L.; Liu, J.-L.; Isacson, O.; Tofaris, G.K.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Long-Term Health of Dopaminergic Neuron Transplants in Parkinson's Disease Patients

Cell Reports
2014 | Journal article
EID:

2-s2.0-84903385146

Contributors: Hallett, P.; Cooper, O.; Sadi, D.; Robertson, H.; Mendez, I.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

Human Molecular Genetics
2014 | Journal article
EID:

2-s2.0-84905667224

Contributors: Smith, G.A.; Rocha, E.M.; McLean, J.R.; Hayes, M.A.; Izen, S.C.; Isacson, O.; Hallett, P.J.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection

Neuroscience Letters
2014 | Journal article
EID:

2-s2.0-84902602985

Contributors: McLean, J.R.; Smith, G.A.; Rocha, E.M.; Hayes, M.A.; Beagan, J.A.; Hallett, P.J.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons

Stem Cells
2013 | Journal article
EID:

2-s2.0-84883431348

Contributors: Sundberg, M.; Bogetofte, H.; Lawson, T.; Jansson, J.; Smith, G.; Astradsson, A.; Moore, M.; Osborn, T.; Cooper, O.; Spealman, R. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

Neurobiology of Disease
2012 | Journal article
EID:

2-s2.0-84861706581

Contributors: Hallett, P.J.; McLean, J.R.; Kartunen, A.; Langston, J.W.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Neurotransplantation in the treatment of Parkinson’s disease

Parkinson's Disease, Second Edition
2012 | Book chapter
Part of DOI: 10.1201/b12948
EID:

2-s2.0-85055826317

Contributors: Hallett, P.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression

Molecular and Cellular Neuroscience
2012 | Journal article
EID:

2-s2.0-84855809551

Contributors: McLean, J.R.; Hallett, P.J.; Cooper, O.; Stanley, M.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Using stem cells and iPS cells to discover new treatments for Parkinson's disease

Parkinsonism and Related Disorders
2012 | Journal article
EID:

2-s2.0-84858627916

Contributors: Cooper, O.; Hallett, P.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Development of histocompatible primate-induced pluripotent stem cells for neural transplantation

Stem Cells
2011 | Journal article
EID:

2-s2.0-79960083404

Contributors: Deleidi, M.; Hargus, G.; Hallett, P.; Osborn, T.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Proceedings of the National Academy of Sciences of the United States of America
2010 | Journal article
EID:

2-s2.0-77957670482

Contributors: Hargus, G.; Cooper, O.; Deleidi, M.; Levy, A.; Lee, K.; Marlow, E.; Yow, A.; Soldner, F.; Hockemeyer, D.; Hallett, P.J. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Synaptic recruitment of AMPA glutamate receptor subunits in levodopa-induced dyskinesia in the mptp-lesioned nonhuman primate

Synapse
2010 | Journal article
EID:

2-s2.0-72449160194

Contributors: Silverdale, M.A.; Kobylecki, C.; Hallett, P.J.; Li, Q.; Dunah, A.W.; Ravenscroft, P.; Bezard, E.; Brotchie, J.M.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

The toll-like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration

Journal of Neuroscience
2010 | Journal article
EID:

2-s2.0-78649745833

Contributors: Deleidi, M.; Hallett, P.J.; Koprich, J.B.; Chung, C.-Y.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
EID:

2-s2.0-76049093950

Contributors: Chung, C.Y.; Koprich, J.B.; Hallett, P.J.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

Neuroscience
2009 | Journal article
EID:

2-s2.0-60349091628

Contributors: Spoelgen, R.; Adams, K.W.; Koker, M.; Thomas, A.V.; Andersen, O.M.; Hallett, P.J.; Bercury, K.K.; Joyner, D.F.; Deng, M.; Stoothoff, W.H. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients

Journal of Neurology
2009 | Journal article
EID:

2-s2.0-69549113043

Contributors: Cooper, O.; Astradsson, A.; Hallett, P.; Robertson, H.; Mendez, I.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

No evidence for disease-like processes in fetal transplants

Proceedings of the National Academy of Sciences of the United States of America
2009 | Journal article
EID:

2-s2.0-70349459252

Contributors: Hallett, P.J.; Cooper, O.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

PSD-95 uncouples dopamine-glutamate interaction in the D <inf>1</inf>/PSD-95/NMDA receptor complex

Journal of Neuroscience
2009 | Journal article
EID:

2-s2.0-63849111775

Contributors: Zhang, J.; Xu, T.-X.; Hallett, P.J.; Watanabe, M.; Grant, S.G.N.; Isacson, O.; Yao, W.-D.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates-Evidence from in vivo neuroimaging studies

Neurobiology of Disease
2009 | Journal article
EID:

2-s2.0-68149156534

Contributors: Astradsson, A.; Jenkins, B.G.; Choi, J.-K.; Hallett, P.J.; Levesque, M.A.; McDowell, J.S.; Brownell, A.-L.; Spealman, R.D.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Biochemical fractionation of brain tissue for studies of receptor distribution and trafficking

Current Protocols in Neuroscience
2008 | Journal article
EID:

2-s2.0-44049087656

Contributors: Hallett, P.J.; Collins, T.L.; Standaert, D.G.; Dunah, A.W.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Nature Medicine
2008 | Journal article
EID:

2-s2.0-43249085326

Contributors: Mendez, I.; VÄ©uela, A.; Astradsson, A.; Mukhida, K.; Hallett, P.; Robertson, H.; Tierney, T.; Holness, R.; Dagher, A.; Trojanowski, J.Q. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Implanted reuptake-deficient or wild-type dopaminergic neurons improve on L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease

Brain
2008 | Journal article
EID:

2-s2.0-58149119564

Contributors: Vinuela, A.; Hallett, P.J.; Reske-Nielsen, C.; Patterson, M.; Sotnikova, T.D.; Caron, M.G.; Gainetdinov, R.R.; Isacson, O.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Striatal histone modifications in models of levodopa-induced dyskinesia

Journal of Neurochemistry
2008 | Journal article
EID:

2-s2.0-45249099791

Contributors: Nicholas, A.P.; Lubin, F.D.; Hallett, P.J.; Vattem, P.; Ravenscroft, P.; Bezard, E.; Zhou, S.; Fox, S.H.; Brotchie, J.M.; Sweatt, J.D. et al.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Inhibition of the dopamine D1 receptor signaling by PSD-95

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-34447502447

Contributors: Zhang, J.; Vinuela, A.; Neely, M.H.; Hallett, P.J.; Grant, S.G.N.; Miller, G.M.; Isacson, O.; Caron, M.G.; Yao, W.-D.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Striatal delta opioid receptor binding in experimental models of Parkinson's disease and dyskinesia

Movement Disorders
2007 | Journal article
EID:

2-s2.0-33847766506

Contributors: Hallett, P.J.; Brotchie, J.M.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier

Dopamine D<inf>1</inf> activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking

Journal of Neuroscience
2006 | Journal article
EID:

2-s2.0-33646824867

Contributors: Hallett, P.J.; Spoelgen, R.; Hyman, B.T.; Standaert, D.G.; Dunah, A.W.
Source: Self-asserted source
Penelope Hallett via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (3 reviews for 3 publications/grants)

Review activity for Acta neuropathologica. (1)
Review activity for Nature communications (1)
Review activity for NPJ Parkinson's disease. (1)