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cancer, metabolism, liver cancer, endometrial cancer, drug discovery
Australia

Activities

Employment (2)

UNSW Sydney: Sydney, New South Wales, AU

2021-07-01 to present | Senior lecturer (School of Biotechnology & Biomolecular Sciences)
Employment
Source: Self-asserted source
Frances Byrne

UNSW Sydney: Sydney, New South Wales, AU

2014-07 to 2021-06-30 | Lecturer/Postdoctoral Fellow (School of Biotechnology & Biomolecular Sciences)
Employment
Source: Self-asserted source
Frances Byrne

Education and qualifications (2)

University of New South Wales: Sydney, NSW, AU

2008 to 2012 | PhD (Children's Cancer Institute )
Qualification
Source: Self-asserted source
Frances Byrne

Flinders University: Adelaide, South Australia, AU

1999 to 2003 | B.Biotechnology (Hons)
Qualification
Source: Self-asserted source
Frances Byrne

Professional activities (6)

Queensland University of Technology: Brisbane, AU

2022-05 to present | UNSW representative, consortium partner (Bridge Program)
Service
Source: Self-asserted source
Frances Byrne

UNSW Sydney: Sydney, AU

2022-01-01 to present | Chair, Equity, Diversity and Inclusion Committee (School of Biotechnology & Biomolecular Sciences)
Service
Source: Self-asserted source
Frances Byrne

UNSW Sydney: Sydney, AU

2021-01-01 to present | School representative, Equity, Diversity and Inclusion Working Group (Faculty of Science)
Service
Source: Self-asserted source
Frances Byrne

UNSW Sydney: Sydney, AU

2024-07 to 2025-03 | Co-Associate Dean, Equity, Diversity & Inclusion (EDI) (Faculty of Science)
Service
Source: Self-asserted source
Frances Byrne

UNSW Sydney: Sydney, New South Wales, AU

2022-01-01 to 2023-12-31 | Co-chair (Women in Research Network)
Service
Source: Self-asserted source
Frances Byrne

University of New South Wales: Sydney, NSW, AU

2021-01-01 to 2023-12-31 | Faculty of Science representative (Executive Committee, Women in Research Network)
Membership
Source: Self-asserted source
Frances Byrne

Funding (3)

Investigating the potential of a new mitochondrial uncoupler for the treatment of liver cancer

2022-01 to 2024-12 | Salary award
Cancer Institute NSW (NSW, NSW, AU)
GRANT_NUMBER:

2021/CDF1120

Source: Self-asserted source
Frances Byrne

Developing new drugs that selectively kill cancer cells by targeting the Warburg Effect

2018 to 2021 | Grant
Cancer Institute NSW (NSW, NSW, AU)
GRANT_NUMBER:

2018/ECF003

Source: Self-asserted source
Frances Byrne

Reversing Warburg Metabolism to Treat Cancer

2014 to 2017 | Grant
Hope Funds for Cancer Research (RI, RI, US)
GRANT_NUMBER:

HFCR 14-06-04

Source: Self-asserted source
Frances Byrne

Works (50 of 51)

Items per page:
Page 1 of 2

Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine

Cancer & Metabolism
2024-11-13 | Journal article
Part of ISSN: 2049-3002
Contributors: Riya Shrestha; Calum S. Vancuylenburg; Martina Beretta; Mingyan Zhou; Divya P. Shah; Ellen M. Olzomer; Sian L. Richards; Kyle L. Hoehn; Frances L. Byrne
Source: Self-asserted source
Frances Byrne

Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2024-01 | Journal article
Part of ISSN: 0925-4439
Contributors: Sing-Young Chen; Martina Beretta; Ellen M. Olzomer; Stephanie J. Alexopoulos; Divya P. Shah; Frances L. Byrne; Joseph M. Salamoun; Christopher J. Garcia; Greg C. Smith; Mark Larance et al.
Source: Self-asserted source
Frances Byrne

Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice

Diabetes
2023-10-23 | Journal article
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Contributors: Martina Beretta; Yumin Dai; Ellen M. Olzomer; Calum S. Vancuylenburg; José A. Santiago-Rivera; Ashleigh M. Philp; Stefan R. Hargett; Keyong Li; Divya P. Shah; Sing-Young Chen et al.
Source: Self-asserted source
Frances Byrne

Investigation of circular RNA transcriptome in obesity-related endometrial cancer

Gene
2023-03 | Journal article
Part of ISSN: 0378-1119
Contributors: Konii Takenaka; Ellen M. Olzomer; Kyle L. Hoehn; Ashton Curry-Hyde; Bei Jun Chen; Rhonda Farrell; Frances L. Byrne; Michael Janitz
Source: Self-asserted source
Frances Byrne

Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

Molecular Metabolism
2023-03 | Journal article
Part of ISSN: 2212-8778
Contributors: Sing-Young Chen; Martina Beretta; Ellen M. Olzomer; Divya P. Shah; Derek Y.H. Wong; Stephanie J. Alexopoulos; Isabella Aleksovska; Joseph M. Salamoun; Christopher J. Garcia; Blake J. Cochran et al.
Source: Self-asserted source
Frances Byrne

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

eLife
2023-01-19 | Journal article
Part of ISSN: 2050-084X
Contributors: Hudson W. Coates; Isabelle M Capell-Hattam; Ellen M Olzomer; Ximing Du; Rhonda Farrell; Hongyuan Yang; Frances L Byrne; Andrew Brown
Source: Self-asserted source
Frances Byrne

Neuroblastoma Differentiation: The Untapped Potential of Mitochondrial Uncouplers

Cancer Research
2023-01-18 | Journal article | Author
Part of ISSN: 0008-5472
Part of ISSN: 1538-7445
Contributors: Frances Byrne; Jessica Bell
Source: Self-asserted source
Frances Byrne
grade
Preferred source (of 2)‎

Investigation of Transcriptome Patterns in Endometrial Cancers from Obese and Lean Women

International Journal of Molecular Sciences
2022-09 | Journal article | Author
Contributors: Konii Takenaka; Ashton Curry-Hyde; Ellen Olzomer; Rhonda Farrell; Frances Byrne; Michael Janitz
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity

International Journal of Molecular Sciences
2022-08 | Journal article | Author
Contributors: Sing-Young Chen; Ellen Olzomer; Martina Beretta; James Cantley; Craig S. Nunemaker; Kyle Hoehn; Frances Byrne
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase

2022-08-19 | Preprint
Contributors: Hudson W. Coates; Ellen M. Olzomer; Ximing Du; Rhonda Farrell; Hongyuan Yang; Frances L. Byrne; Andrew J. Brown
Source: check_circle
Crossref

Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice

Cancers
2022-04 | Journal article | Author
Contributors: Nadeem O. Kaakoush; Ellen M. Olzomer; Melidya Kosasih; Amy R. Martin; Farokh Fargah; Neil Lambie; Daniella Susic; Kyle Hoehn; rhonda farrell; Frances Byrne
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma

International Journal of Molecular Sciences
2022-04 | Journal article | Author
Contributors: Frances Byrne; Ellen M. Olzomer; Nina Lolies; Kyle Hoehn; Marthe-Susanna Wegner
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Membrane glycome is impacted by the cell culturing mode of neuroblastoma cells with differing migration and invasion potential.

Glycobiology
2022-03-22 | Journal article
Source: Self-asserted source
Frances Byrne

Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells.

Cellular and molecular life sciences : CMLS
2021-10-09 | Journal article
Source: Self-asserted source
Frances Byrne

Exploring the therapeutic potential of mitochondrial uncouplers in cancer

Molecular Metabolism
2021-09 | Journal article
Part of ISSN: 2212-8778
Source: Self-asserted source
Frances Byrne
grade
Preferred source (of 2)‎

The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer.

Cellular signalling
2020-06 | Journal article
Contributors: Caruana BT; Byrne FL
Source: Self-asserted source
Frances Byrne via Europe PubMed Central
grade
Preferred source (of 2)‎

Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis.

Circulation research
2020-06 | Journal article
Contributors: Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ et al.
Source: Self-asserted source
Frances Byrne via Europe PubMed Central

Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis, Antioxidants 2020, 9(3), 195".

Antioxidants (Basel, Switzerland)
2020-05 | Journal article
Contributors: Hegarty KJ; Byrne FL
Source: Self-asserted source
Frances Byrne via Europe PubMed Central
grade
Preferred source (of 2)‎

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice.

Nature communications
2020-05 | Journal article
Contributors: Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM et al.
Source: Self-asserted source
Frances Byrne via Europe PubMed Central
grade
Preferred source (of 2)‎

UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells.

Scientific reports
2020-05 | Journal article
Contributors: Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N et al.
Source: Self-asserted source
Frances Byrne via Europe PubMed Central

The Role of Hyperglycemia in Endometrial Cancer Pathogenesis

Cancers
2020-05-08 | Journal article
Contributors: Frances L. Byrne; Amy R. Martin; Melidya Kosasih; Beth T. Caruana; Rhonda Farrell
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

Redox biology
2019-11 | Journal article
Contributors: Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF et al.
Source: Self-asserted source
Frances Byrne via Europe PubMed Central

UGCG influences glutamine metabolism of breast cancer cells.

Scientific reports
2019-10 | Journal article
Contributors: Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G et al.
Source: Self-asserted source
Frances Byrne via Europe PubMed Central
grade
Preferred source (of 2)‎

Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow–Derived Macrophage Function

The Journal of Immunology
2019-03-15 | Journal article
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Source: Self-asserted source
Frances Byrne
grade
Preferred source (of 2)‎

Delivering bioactive cyclic peptides that target Hsp90 as prodrugs

Journal of Enzyme Inhibition and Medicinal Chemistry
2019-01 | Journal article
Part of ISSN: 1475-6366
Part of ISSN: 1475-6374
Source: Self-asserted source
Frances Byrne
grade
Preferred source (of 2)‎

The effects of polymer topology and chain length on the antimicrobial activity and hemocompatibility of amphiphilic ternary copolymers

Polymer Chemistry
2018 | Journal article
Part of ISSN: 1759-9954
Part of ISSN: 1759-9962
Source: Self-asserted source
Frances Byrne
grade
Preferred source (of 2)‎

Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth

Cancers
2018-09 | Journal article | Author
Contributors: Frances Byrne; Stefan R. Hargett; Sujoy Lahiri; R. Jack Roy; Stuart S. Berr; Stephen H. Caldwell; Kyle Hoehn
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice

American Journal of Physiology-Endocrinology and Metabolism
2018-08 | Journal article
Part of ISSN: 0193-1849
Part of ISSN: 1522-1555
Source: Self-asserted source
Frances Byrne

Analysis of the circular RNA transcriptome in endometrial cancer

Oncotarget
2018-01-19 | Journal article
Part of ISSN: 1949-2553
Source: Self-asserted source
Frances Byrne

Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer

Gynecologic Oncology
2017-12 | Journal article
Part of ISSN: 0090-8258
Source: Self-asserted source
Frances Byrne

STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation

Endocrine
2017-06 | Journal article
Part of ISSN: 1355-008X
Part of ISSN: 1559-0100
Source: Self-asserted source
Frances Byrne

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival

Nature Communications
2017-04 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Frances Byrne

Analyses of tumor burden in vivo and metastasis ex vivo using luciferase-expressing cancer cells in an orthotopic mouse model of neuroblastoma

Methods in Molecular Biology
2016 | Book
EID:

2-s2.0-84946601409

Contributors: Byrne, F.L.; McCarroll, J.A.; Kavallaris, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Dietary sugar intake increases liver tumor incidence in female mice

Scientific Reports
2016 | Journal article
EID:

2-s2.0-84959377648

Contributors: Healy, M.E.; Lahiri, S.; Hargett, S.R.; Chow, J.D.Y.; Byrne, F.L.; Breen, D.S.; Kenwood, B.M.; Taddeo, E.P.; Lackner, C.; Caldwell, S.H. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration

Oncogene
2016 | Journal article
EID:

2-s2.0-84975257265

Contributors: Fife, C.M.; Sagnella, S.M.; Teo, W.S.; Po'uha, S.T.; Byrne, F.L.; Yeap, Y.Y.C.; Ng, D.C.H.; Davis, T.P.; McCarroll, J.A.; Kavallaris, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Subclassification of fatty liver by its pathogenesis: CIEFing is believing

Journal of Pathology
2016 | Journal article
EID:

2-s2.0-84963649696

Contributors: Byrne, F.L.; Hoehn, K.L.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

The emerging role of long non-coding RNAs in endometrial cancer

Cancer Genetics
2016 | Journal article
EID:

2-s2.0-84994144954

Contributors: Takenaka, K.; Chen, B.J.; Modesitt, S.C.; Byrne, F.L.; Hoehn, K.L.; Janitz, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1

Biochemical Journal
2015 | Journal article
EID:

2-s2.0-84943231382

Contributors: Du, X.; Zhang, Y.; Jo, S.R.; Liu, X.; Qi, Y.; Osborne, B.; Byrne, F.L.; Smith, G.C.; Turner, N.; Hoehn, K.L. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine

Journal of Hepatology
2015 | Journal article
EID:

2-s2.0-84922956721

Contributors: Healy, M.E.; Chow, J.D.Y.; Byrne, F.L.; Breen, D.S.; Leitinger, N.; Li, C.; Lackner, C.; Caldwell, S.H.; Hoehn, K.L.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

Molecular Cell
2015 | Journal article
EID:

2-s2.0-84924761433

Contributors: Kashatus, J.A.; Nascimento, A.; Myers, L.J.; Sher, A.; Byrne, F.L.; Hoehn, K.L.; Counter, C.M.; Kashatus, D.F.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

TUBB3/βIII-tubulin acts through the PTEN/AKT signaling axis to promote tumorigenesis and anoikis resistance in non-small cell lung cancer

Cancer Research
2015 | Journal article
EID:

2-s2.0-84920939099

Contributors: McCarroll, J.A.; Gan, P.P.; Erlich, R.B.; Liu, M.; Dwarte, T.; Sagnella, S.S.; Akerfeldt, M.C.; Yang, L.; Parker, A.L.; Chang, M.H. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation

Molecular Metabolism
2014 | Journal article
EID:

2-s2.0-84902306653

Contributors: Chow, J.D.Y.; Lawrence, R.T.; Healy, M.E.; Dominy, J.E.; Liao, J.A.; Breen, D.S.; Byrne, F.L.; Kenwood, B.M.; Lackner, C.; Okutsu, S. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane

Molecular Metabolism
2014 | Journal article
EID:

2-s2.0-84895800631

Contributors: Kenwood, B.M.; Weaver, J.L.; Bajwa, A.; Poon, I.K.; Byrne, F.L.; Murrow, B.A.; Calderone, J.A.; Huang, L.; Divakaruni, A.S.; Tomsig, J.L. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Metabolic vulnerabilities in endometrial cancer

Cancer Research
2014 | Journal article
EID:

2-s2.0-84908125830

Contributors: Byrne, F.L.; Poon, I.K.H.; Modesitt, S.C.; Tomsig, J.L.; Chow, J.D.Y.; Healy, M.E.; Baker, W.D.; Atkins, K.A.; Lancaster, J.M.; Marchion, D.C. et al.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

RNAi-mediated stathmin suppression reduces lung metastasis in an orthotopic neuroblastoma mouse model

Oncogene
2014 | Journal article
EID:

2-s2.0-84894064647

Contributors: Byrne, F.L.; Yang, L.; Phillips, P.A.; Hansford, L.M.; Fletcher, J.I.; Ormandy, C.J.; McCarroll, J.A.; Kavallaris, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Stathmin and cancer

Cytoskeleton and Human Disease
2012 | Book
EID:

2-s2.0-84929913705

Contributors: Ng, D.C.H.; Byrne, F.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Block co-polymer nanoparticles with degradable cross-linked core and low-molecular-weight PEG corona for anti-tumour drug delivery

Journal of Biomaterials Science, Polymer Edition
2011 | Journal article
EID:

2-s2.0-79751504877

Contributors: Abraham, G.; McCarroll, J.; Byrne, F.; Saricilar, S.; Kavallaris, M.; Bulmus, V.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells

PLoS ONE
2011 | Journal article
EID:

2-s2.0-79959649836

Contributors: Gan, P.P.; McCarroll, J.A.; Byrne, F.L.; Garner, J.; Kavallaris, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Acid-labile core cross-linked micelles for pH-triggered release of antitumor drugs

Biomacromolecules
2008 | Journal article
EID:

2-s2.0-48449093298

Contributors: Chan, Y.; Wong, T.; Byrne, F.; Kavallaris, M.; Bulmus, V.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier

Acid-cleavable polymeric core-shell particles for delivery of hydrophobic drugs

Journal of Controlled Release
2006 | Journal article
EID:

2-s2.0-33749540952

Contributors: Chan, Y.; Bulmus, V.; Zareie, M.H.; Byrne, F.L.; Barner, L.; Kavallaris, M.
Source: Self-asserted source
Frances Byrne via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (4 reviews for 3 publications/grants)

Review activity for Cancer & metabolism. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for Genes & diseases. (2)