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Employment (1)

Carnegie Mellon University: Pittsburgh, US

2017-09-01 to present | Lane Postdoctoral Fellow (Computational Biology)
Employment
Source: Self-asserted source
Irene Kaplow

Education and qualifications (3)

Stanford University: Stanford, CA, US

2010-09-20 to 2014-01-09 | M.S. (Computer Science)
Education
Source: Self-asserted source
Irene Kaplow

Stanford University: Stanford, CH

2010-09-20 to 2010-09-28 | Ph.D. (Computer Science)
Education
Source: Self-asserted source
Irene Kaplow

Massachusetts Institute of Technology: Cambridge, US

2006-09-06 to 2010-06-04 | B.S. (Mathematics)
Education
Source: Self-asserted source
Irene Kaplow

Professional activities (1)

International Society for Computational Biology: La Jolla, CA, US

2013 to present
Membership
Source: Self-asserted source
Irene Kaplow

Research resources (1)

Identifying Open Chromatin Regions Associated with Mammalian Phenotypes that Have Evolved through Gene Expression

Works (18)

Evolutionary constraint and innovation across hundreds of placental mammals

Science
2023-04-28 | Journal article
Contributors: Matthew J. Christmas; Irene M. Kaplow; Diane P. Genereux; Michael X. Dong; Graham M. Hughes; Xue Li; Patrick F. Sullivan; Allyson G. Hindle; Gregory Andrews; Joel C. Armstrong et al.
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Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

Science
2023-04-28 | Journal article
Contributors: Irene M. Kaplow; Alyssa J. Lawler; Daniel E. Schäffer; Chaitanya Srinivasan; Heather H. Sestili; Morgan E. Wirthlin; BaDoi N. Phan; Kavya Prasad; Ashley R. Brown; Xiaomeng Zhang et al.
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Crossref

Vocal learning-associated convergent evolution in mammalian proteins and regulatory elements

2022-12-18 | Preprint
Contributors: Morgan E. Wirthlin; Tobias A. Schmid; Julie E. Elie; Xiaomeng Zhang; Varvara A. Shvareva; Ashley Rakuljic; Maria B. Ji; Ninad S. Bhat; Irene M. Kaplow; Daniel E. Schäffer et al.
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Crossref

Anin vivomassively parallel platform for deciphering tissue-specific regulatory function

2022-11-25 | Preprint
Contributors: Ashley R. Brown; Grant A. Fox; Irene M. Kaplow; Alyssa J. Lawler; BaDoi N. Phan; Morgan E. Wirthlin; Easwaran Ramamurthy; Gemma E. May; Ziheng Chen; Qiao Su et al.
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Crossref

Relating enhancer genetic variation across mammals to complex phenotypes using machine learning

2022-08-26 | Preprint
Contributors: Irene M. Kaplow; Alyssa J. Lawler; Daniel E. Schäffer; Chaitanya Srinivasan; Morgan E. Wirthlin; BaDoi N. Phan; Xiaomeng Zhang; Kathleen Foley; Kavya Prasad; Ashley R. Brown et al.
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Crossref

Machine learning sequence prioritization for cell type-specific enhancer design

eLife
2022-05-16 | Journal article
Contributors: Alyssa J Lawler; Easwaran Ramamurthy; Ashley R Brown; Naomi Shin; Yeonju Kim; Noelle Toong; Irene M Kaplow; Morgan Wirthlin; Xiaoyu Zhang; BaDoi N Phan et al.
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Crossref

Population-specific neuromodulation prolongs therapeutic benefits of deep brain stimulation

Science
2021-10-08 | Journal article
Contributors: Teresa A. Spix; Shruti Nanivadekar; Noelle Toong; Irene M. Kaplow; Brian R. Isett; Yazel Goksen; Andreas R. Pfenning; Aryn H. Gittis
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Crossref

Neural network modeling of differential binding between wild-type and mutant CTCF reveals putative binding preferences for zinc fingers 1-2

2021-09-24 | Other
Contributors: Irene M. Kaplow; Abhimanyu Banerjee; Chuan Sheng Foo
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Crossref

Machine learning sequence prioritization for cell type-specific enhancer design

2021-04-15 | Preprint
Contributors: Alyssa J Lawler; Easwaran Ramamurthy; Ashley R Brown; Naomi Shin; Yeonju Kim; Noelle Toong; Irene M Kaplow; Morgan Wirthlin; Xiaoyu Zhang; Grant Fox et al.
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Crossref

Inferring mammalian tissue-specific regulatory conservation by predicting tissue-specific differences in open chromatin

2020-12-04 | Other
Contributors: Irene M. Kaplow; Daniel E. Schäffer; Morgan E. Wirthlin; Alyssa J. Lawler; Ashley R. Brown; Michael Kleyman; Andreas R. Pfenning
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Crossref

The Regulatory Evolution of the Primate Fine-Motor System

2020-10-27 | Preprint
Contributors: Morgan Wirthlin; Irene M. Kaplow; Alyssa J. Lawler; Jing He; BaDoi N. Phan; Ashley R. Brown; William R. Stauffer; Andreas R. Pfenning
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Crossref

HALPER facilitates the identification of regulatory element orthologs across species

Bioinformatics
2020-08-01 | Journal article
Contributors: Xiaoyu Zhang; Irene M Kaplow; Morgan Wirthlin; Tae Yoon Park; Andreas R Pfenning; Elofsson Arne
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Crossref

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

Nature Communications
2019-09-06 | Journal article
Part of ISSN: 2041-1723
Contributors: Josh Tycko; Michael Wainberg; Georgi K. Marinov; Oana Ursu; Gaelen T. Hess; Braeden K. Ego; Aradhana; Amy Li; Alisa Truong; Alexandro E. Trevino et al.
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

Fine-mapping cis-regulatory variants in diverse human populations

eLife
2019-01 | Journal article
Part of ISSN: 2050-084X
Contributors: Ashley Tehranchi; Brian Hie; Michael Dacre; Irene Kaplow; Kade Pettie; Peter Combs; Hunter B Fraser
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

A pooling-based approach to mapping genetic variants associated with DNA methylation

Genome Research
2015-04 | Journal article
Part of ISSN: 1088-9051
Contributors: Irene M. Kaplow; Julia L. MacIsaac; Sarah M. Mah; Lisa M. McEwen; Michael S. Kobor; Hunter B. Fraser
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

Two DNA-encoded strategies for increasing expression with opposing effects on promoter dynamics and transcriptional noise

Genome Research
2013-02 | Journal article
Part of ISSN: 1088-9051
Contributors: M. Dadiani; D. van Dijk; B. Segal; Y. Field; G. Ben-Artzi; T. Raveh-Sadka; M. Levo; I. Kaplow; A. Weinberger; E. Segal
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

RNAiCut: automated detection of significant genes from functional genomic screens

Nature Methods
2009-07 | Journal article
Part of ISSN: 1548-7091
Contributors: Irene M Kaplow; Rohit Singh; Adam Friedman; Chris Bakal; Norbert Perrimon; Bonnie Berger
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

A Classifier-based approach to identify genetic similarities between diseases

Bioinformatics
2009-05 | Journal article
Part of ISSN: 1367-4803
Contributors: M. A. Schaub; I. M. Kaplow; M. Sirota; C. B. Do; A. J. Butte; S. Batzoglou
Source: Self-asserted source
Irene Kaplow via Crossref Metadata Search

Peer review (22 reviews for 5 publications/grants)

Review activity for Bioinformatics (4)
Review activity for BMC biology. (1)
Review activity for Genome biology. (1)
Review activity for International journal of molecular sciences. (6)
Review activity for PLoS computational biology. (10)