Personal information

genome instability, DNA replication, DNA repair, DNA damage, yeast genetics, functional genomics
Canada

Activities

Employment (1)

University of Toronto: Toronto, ON, CA

1999-09 to present | Professor (Biochemistry)
Employment
Source: Self-asserted source
Grant Brown

Education and qualifications (3)

Johns Hopkins University School of Medicine: Baltimore, MD, US

1999-08 | Post-doctoral Fellowship (Molecular Biology and Genetics)
Education
Source: Self-asserted source
Grant Brown

University of California Los Angeles: Los Angeles, CA, US

1993-06 | Ph.D. (Molecular Biology)
Education
Source: Self-asserted source
Grant Brown

University of British Columbia: Vancouver, BC, CA

1987-05 | B.Sc. (Hons.) (Biochemistry)
Education
Source: Self-asserted source
Grant Brown

Works (50 of 164)

Items per page:
Page 1 of 4

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

EMBO Reports
2025-01-27 | Journal article
Contributors: Jung Jennifer Ho; Edith Cheng; Cassandra J Wong; Jonathan R St-Germain; Wade H Dunham; Brian Raught; Anne-Claude Gingras; Grant W Brown
Source: check_circle
Crossref

pSPObooster: A Plasmid System to Improve Sporulation Efficiency of Saccharomyces cerevisiae Lab Strains

Yeast
2024-10 | Journal article
Contributors: Raphael Loll‐Krippleber; Yangyang Kate Jiang; Grant W. Brown
Source: check_circle
Crossref

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences

GENETICS
2024-08-07 | Journal article
Contributors: Grant W Brown; H Merrikh
Source: check_circle
Crossref

The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

2024-04-07 | Preprint
Contributors: Jung Jennifer Ho; Edith Cheng; Cassandra J. Wong; Jonathan R. St-Germain; Wade H. Dunham; Brian Raught; Anne-Claude Gingras; Grant W. Brown
Source: check_circle
Crossref

pSPObooster: a plasmid system to improve sporulation efficiency ofSaccharomyces cerevisiaelab strains

2024-03-20 | Preprint
Contributors: Raphael Loll-Krippleber; Yangyang Kate Jiang; Grant W. Brown
Source: check_circle
Crossref

Genetic screens in Saccharomyces cerevisiae identify a role for 40S ribosome recycling factors Tma20 and Tma22 in nonsense-mediated decay

G3: Genes, Genomes, Genetics
2024-03-06 | Journal article
Contributors: Miguel Pacheco; Karole N D’Orazio; Laura N Lessen; Anthony J Veltri; Zachary Neiman; Raphael Loll-Krippleber; Grant W Brown; Rachel Green; J Hesselberth
Source: check_circle
Crossref

The cytidine deaminase APOBEC3C has unique sequence and genome feature preferences

2024-01-16 | Preprint
Contributors: Grant W. Brown
Source: check_circle
Crossref

Data from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Data from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

Cancer Research Communications
2023-12-21 | Journal article
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 3 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 3 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 4 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 4 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 5 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

FIGURE 5 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S3 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S3 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S4 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Figure S4 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Supplementary Data 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Supplementary Data 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

TABLE 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

TABLE 1 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

TABLE 2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

TABLE 2 from <i>FBXW7</i>-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

2023-12-21 | Preprint
Contributors: Siobhan O'Brien; Tajinder Ubhi; Lucie Wolf; Krishna Gandhi; Sichun Lin; Naz Chaudary; Neesha C. Dhani; Michael Milosevic; Grant W. Brown; Stephane Angers
Source: check_circle
Crossref

Two independent DNA repair pathways cause mutagenesis in template switching deficientSaccharomyces cerevisiae

2023-06-26 | Preprint
Contributors: Yangyang Kate Jiang; Eleanor Medley; Grant W. Brown
Source: check_circle
Crossref

Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics

eLife
2023-06-06 | Journal article
Contributors: Brandon Ho; Ethan J Sanford; Raphael Loll-Krippleber; Nikko P Torres; Marcus B Smolka; Grant W Brown
Source: check_circle
Crossref

Development of a yeast whole-cell biocatalyst for MHET conversion into terephthalic acid and ethylene glycol

2022-10-31 | Preprint
Contributors: Raphael Loll-Krippleber; Victoria Sajtovich; Michael W. Ferguson; Brandon Ho; Brandon J. Payliss; Joseph Bellissimo; Sydney Peters; Haley D. M. Wyatt; Grant W. Brown
Source: check_circle
Crossref

Mec1-Independent Activation of the Rad53 Checkpoint Kinase Revealed by Quantitative Analysis of Protein Localization Dynamics

2022-08-05 | Preprint
Contributors: Brandon Ho; Ethan J. Sanford; Nikko P. Torres; Marcus B. Smolka; Grant W. Brown
Source: check_circle
Crossref

Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes

Genetics
2022-07-30 | Journal article
Contributors: Natalie A Lamb; Jonathan E Bard; Raphael Loll-Krippleber; Grant W Brown; Jennifer A Surtees; J A Nickoloff
Source: check_circle
Crossref

Distinct elongation stalls during translation are linked with distinct pathways for mRNA degradation

eLife
2022-07-27 | Journal article
Contributors: Anthony J Veltri; Karole N D'Orazio; Laura N Lessen; Raphael Loll-Krippleber; Grant W Brown; Rachel Green
Source: check_circle
Crossref

Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG

G3 Genes|Genomes|Genetics
2022-07-06 | Journal article
Contributors: Matthew D Berg; Yanrui Zhu; Raphaël Loll-Krippleber; Bryan-Joseph San Luis; Julie Genereaux; Charles Boone; Judit Villén; Grant W Brown; Christopher J Brandl; C Hoffman
Source: check_circle
Crossref

Phenotypic Heterogeneity in the DNA Replication Stress Response Revealed by Quantitative Protein Dynamics Measurements

2022-06-08 | Preprint
Contributors: Brandon Ho; Raphael Loll-Krippleber; Nikko P. Torres; Andreas P. Cuny; Fabian Rudolf; Grant W. Brown
Source: check_circle
Crossref

Genetic background and mistranslation frequency determine the impact of mistranslating tRNASerUGG

2022-03-24 | Preprint
Contributors: Matthew D. Berg; Yanrui Zhu; Raphaël Loll-Krippleber; Bryan-Joseph San Luis; Julie Genereaux; Charles Boone; Judit Villen; Grant W. Brown; Christopher J. Brandl
Source: check_circle
Crossref

The amino acid substitution affects cellular response to mistranslation

G3 Genes|Genomes|Genetics
2021-09-27 | Journal article
Contributors: Matthew D Berg; Yanrui Zhu; Bianca Y Ruiz; Raphaël Loll-Krippleber; Joshua Isaacson; Bryan-Joseph San Luis; Julie Genereaux; Charles Boone; Judit Villén; Grant W Brown et al.
Source: check_circle
Crossref

Genetic screens identify connections between ribosome recycling and nonsense mediated decay

2021-08-03 | Other
Contributors: Karole N. D’Orazio; Laura N. Lessen; Anthony J. Veltri; Zachary Neiman; Miguel Pacheco; Raphael Loll-Krippleber; Grant W. Brown; Rachel Green
Source: check_circle
Crossref

The amino acid substitution affects cellular response to mistranslation

2021-05-15 | Other
Contributors: Matthew D. Berg; Yanrui Zhu; Bianca Y. Ruiz; Raphaël Loll-Krippleber; Joshua Isaacson; Bryan-Joseph San Luis; Julie Genereaux; Charles Boone; Judit Villén; Grant W. Brown et al.
Source: check_circle
Crossref

Setting molecular traps in yeast for identification of anticancer drug targets

Proceedings of the National Academy of Sciences
2021-05-04 | Journal article
Contributors: Grant W. Brown; Brenda Andrews
Source: check_circle
Crossref

Author Correction: Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma

Nature Cancer
2021-04-19 | Journal article
Contributors: Lukas Tamayo-Orrego; David Gallo; Frédéric Racicot; Amandine Bemmo; Sushmetha Mohan; Brandon Ho; Samer Salameh; Trang Hoang; Andrew P. Jackson; Grant W. Brown et al.
Source: check_circle
Crossref

Chemical-Genetic Interactions with the Proline Analog L-Azetidine-2-Carboxylic Acid in Saccharomyces cerevisiae

G3&amp;#58; Genes|Genomes|Genetics
2020-12 | Journal article
Contributors: Matthew D. Berg; Yanrui Zhu; Joshua Isaacson; Julie Genereaux; Raphaël Loll-Krippleber; Grant W. Brown; Christopher J. Brandl
Source: check_circle
Crossref

Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes

2020-09-17 | Other
Contributors: Jessel Ayra-Plasencia; Cristina Ramos-Pérez; Silvia Santana-Sosa; Oliver Quevedo; Sara Medina-Suarez; Emiliano Matos-Perdomo; Marcos Zamora-Dorta; Grant W Brown; Michael Lisby; Félix Machín
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Crossref
Items per page:
Page 1 of 4

Peer review (10 reviews for 9 publications/grants)

Review activity for Biotechnology advances. (2)
Review activity for Communications biology. (1)
Review activity for EMBO journal. (1)
Review activity for Genome biology. (1)
Review activity for Journal of proteome research. (1)
Review activity for Nature protocols (1)
Review activity for Nature structural & molecular biology. (1)
Review activity for PLOS genetics. (1)
Review activity for Wellcome open research. (1)