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Activities

Employment (2)

University of South Australia: Adelaide, SA, AU

Adjunct Associate Professor (Centre for Cancer Biology)
Employment
Source: Self-asserted source
Anna Brown

SA Pathology: Adelaide, SA, AU

2017-04-24 to present | Head of Molecular Oncology (Department of Genetics and Molecular Pathology)
Employment
Source: Self-asserted source
Anna Brown

Education and qualifications (2)

University of Queensland: Brisbane, AU

1999-12-01 | PhD (Medicine (Pathology))
Education
Source: Self-asserted source
Anna Brown

University of Adelaide: Adelaide, SA, AU

1994-11-01 | BSC (Hons) (Biochemistry)
Education
Source: Self-asserted source
Anna Brown

Works (48)

Myeloid neoplasms arising after methotrexate therapy for autoimmune rheumatological diseases do not exhibit poor-risk molecular features

Blood Cancer Journal
2024-07-19 | Journal article
Contributors: Mihir D. Wechalekar; Lin-Pierre Zhao; Monika M. Kutyna; Lih En Hong; Joule Li; Kevin Hung; Hamish S. Scott; Anna Brown; Christopher C. Hahn; Karin Kassahn et al.
Source: check_circle
Crossref

IDH-mutant myeloid neoplasms are associated with seronegative rheumatoid arthritis and innate immune activation

Blood
2024-05-02 | Journal article
Contributors: Lih En Hong; Mihir D. Wechalekar; Monika Kutyna; Annabelle Small; Kelly Lim; Chloe Thompson-Peach; Joule J. Li; Rakchha Chhetri; Hamish S. Scott; Anna Brown et al.
Source: check_circle
Crossref

TP53 mutation variant allele frequency of ≥10% is associated with poor prognosis in therapy-related myeloid neoplasms

Blood Cancer Journal
2023-04-11 | Journal article
Contributors: Mithun Vinod Shah; Elizabeth Ngoc Hoa Tran; Syed Shah; Rakchha Chhetri; Anmol Baranwal; Dariusz Ladon; Carl Shultz; Aref Al-Kali; Anna L. Brown; Dong Chen et al.
Source: check_circle
Crossref

Hereditary platelet disorders associated with germ line variants in RUNX1, ETV6, and ANKRD26

Blood
2023-03-30 | Journal article
Contributors: Claire C. Homan; Hamish S. Scott; Anna L. Brown
Source: check_circle
Crossref

Integrating germline variant assessment into routine clinical practice for myelodysplastic syndrome and acute myeloid leukaemia: current strategies and challenges

British Journal of Haematology
2022-03 | Journal article
Contributors: Kiran Tawana; Anna L. Brown; Jane E. Churpek
Source: check_circle
Crossref

And the germline beat (AML) goes on

Blood
2022-02-24 | Journal article
Contributors: Anna L. Brown
Source: check_circle
Crossref

To T or not to B: germline RUNX1 mutation preferences in pediatric ALL predisposition

Journal of Clinical Investigation
2021-09-01 | Journal article
Contributors: Serine Avagyan; Anna L. Brown
Source: check_circle
Crossref

B-cell acute lymphoblastic leukemia in patients with germline RUNX1 mutations

Blood Advances
2021-08-24 | Journal article
Contributors: Kathryn A. Six; Ulrike Gerdemann; Anna L. Brown; Andrew E. Place; Alan B. Cantor; Matthew A. Kutny; Serine Avagyan
Source: check_circle
Crossref

A synonymous GATA2 variant underlying familial myeloid malignancy with striking intrafamilial phenotypic variability

British Journal of Haematology
2020-09 | Journal article
Contributors: Lucy C. Fox; Michelle Tan; Anna L. Brown; Peer Arts; Ella Thompson; Georgina L. Ryland; Jennifer Lickiss; Hamish S. Scott; Nicola K. Poplawski; Kerry Phillips et al.
Source: check_circle
Crossref

Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)

Blood
2020-07-02 | Journal article
Contributors: Anna L. Brown; Christopher N. Hahn; Hamish S. Scott
Source: check_circle
Crossref

RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.

Blood advances
2020-03-01 | Journal article
Source: Self-asserted source
Anna Brown
grade
Preferred source (of 2)‎

Two monogenic disorders masquerading as one: severe congenital neutropenia with monocytosis and non-syndromic sensorineural hearing loss.

BMC medical genetics
2020-02-17 | Journal article
Source: Self-asserted source
Anna Brown

Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis

Leukemia & Lymphoma
2020-01-02 | Journal article
Contributors: Anna L. Brown; Christopher Hahn; Devendra Hiwase; Lucy A. Godley; Hamish S. Scott
Source: check_circle
Crossref

ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants

Blood Advances
2019-10-22 | Journal article
Contributors: Xi Luo; Simone Feurstein; Shruthi Mohan; Christopher C. Porter; Sarah A. Jackson; Sioban Keel; Michael Chicka; Anna L. Brown; Chimene Kesserwan; Anupriya Agarwal et al.
Source: check_circle
Crossref

The mutational burden of therapy-related myeloid neoplasms is similar to primary myelodysplastic syndrome but has a distinctive distribution.

Leukemia
2019-05-14 | Journal article
Source: Self-asserted source
Anna Brown

Genomic subtyping and therapeutic targeting of acute erythroleukemia.

Nature genetics
2019-03-29 | Journal article
Source: Self-asserted source
Anna Brown

A novel germline SAMD9L mutation in a family with ataxia-pancytopenia syndrome and pediatric acute lymphoblastic leukemia.

Haematologica
2019-03-28 | Journal article
Source: Self-asserted source
Anna Brown

Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease.

Blood
2018-07-02 | Journal article
Source: Self-asserted source
Anna Brown

Rare variants in Fanconi anemia genes are enriched in acute myeloid leukemia.

Blood cancer journal
2018-06-01 | Journal article
Source: Self-asserted source
Anna Brown

A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients.

Leukemia
2017-07-04 | Journal article
Source: Self-asserted source
Anna Brown

Differential effects on gene transcription and hematopoietic differentiation correlate with GATA2 mutant disease phenotypes.

Leukemia
2017-06-23 | Journal article
Source: Self-asserted source
Anna Brown

Myeloid neoplasms with germline DDX41 mutation.

International journal of hematology
2017-05-25 | Journal article
Source: Self-asserted source
Anna Brown

DDX41-related myeloid neoplasia.

Seminars in hematology
2017-04-21 | Journal article
Source: Self-asserted source
Anna Brown

Recognition of familial myeloid neoplasia in adults.

Seminars in hematology
2017-04-18 | Journal article
Source: Self-asserted source
Anna Brown

Conditional knockout mice demonstrate function of Klf5 as a myeloid transcription factor

Blood
2016-07-07 | Journal article
Contributors: Nur Hezrin Shahrin; Sonya Diakiw; Lindsay A. Dent; Anna L. Brown; Richard J. D’Andrea
Source: check_circle
Crossref

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

Nature medicine
2016-06-20 | Journal article
Source: Self-asserted source
Anna Brown

Gaq signaling is required for the maintenance of MLL-AF9-induced acute myeloid leukemia.

Leukemia
2016-02-09 | Journal article
Source: Self-asserted source
Anna Brown

Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.

Blood
2015-12-28 | Journal article
Source: Self-asserted source
Anna Brown
grade
Preferred source (of 2)‎

Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.

Leukemia
2015-04-29 | Journal article
Source: Self-asserted source
Anna Brown

A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone.

Leukemia
2015-03-09 | Journal article
Source: Self-asserted source
Anna Brown

Dynamic evolution of clonal epialleles revealed by methclone.

Genome biology
2014-09-27 | Journal article
Source: Self-asserted source
Anna Brown

The double life of KLF5: Opposing roles in regulation of gene-expression, cellular function, and transformation.

IUBMB life
2013-12-10 | Journal article
Source: Self-asserted source
Anna Brown

An optimized algorithm for detecting and annotating regional differential methylation.

BMC bioinformatics
2013-04-10 | Journal article
Source: Self-asserted source
Anna Brown

Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival.

British journal of haematology
2013-03-25 | Journal article
Source: Self-asserted source
Anna Brown

GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations.

Leukemia
2012-11-28 | Journal article
Source: Self-asserted source
Anna Brown

The preferential occurrence of FLT3-TKD mutations in inv(16) AML and impact on survival outcome: a combined analysis of 1053 core-binding factor AML patients.

British journal of haematology
2012-11-28 | Journal article
Source: Self-asserted source
Anna Brown

Unraveling the "known unknowns": lessons and reflections from the new directions in leukemia research 2012 conference.

Cancer research
2012-06-26 | Journal article
Source: Self-asserted source
Anna Brown

The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia.

Leukemia research
2011-10-11 | Journal article
Source: Self-asserted source
Anna Brown

The GM-CSF receptor utilizes β-catenin and Tcf4 to specify macrophage lineage differentiation.

Differentiation; research in biological diversity
2011-10-08 | Journal article
Source: Self-asserted source
Anna Brown

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.

Nature genetics
2011-09-04 | Journal article
Source: Self-asserted source
Anna Brown

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML.

Leukemia
2010-04-29 | Journal article
Source: Self-asserted source
Anna Brown

Alternative modes of GM-CSF receptor activation revealed using activated mutants of the common beta-subunit.

Blood
2010-02-19 | Journal article
Source: Self-asserted source
Anna Brown

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML.

Blood
2009-10-05 | Journal article
Source: Self-asserted source
Anna Brown

Repression of Gadd45alpha by activated FLT3 and GM-CSF receptor mutants contributes to growth, survival and blocked differentiation.

Leukemia
2009-01-08 | Journal article
Source: Self-asserted source
Anna Brown

Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling.

Journal of leukocyte biology
2006-06-12 | Journal article
Source: Self-asserted source
Anna Brown

Constitutive mutants of the GM-CSF receptor reveal multiple pathways leading to myeloid cell survival, proliferation, and granulocyte-macrophage differentiation.

Blood
2003-09-22 | Journal article
Source: Self-asserted source
Anna Brown

Cooperation of cytokine signaling with chimeric transcription factors in leukemogenesis: PML-retinoic acid receptor alpha blocks growth factor-mediated differentiation.

Molecular and cellular biology
2003-07-01 | Journal article
Source: Self-asserted source
Anna Brown

Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family on the mouse X chromosome.

Human molecular genetics
1999-04-01 | Journal article
Source: Self-asserted source
Anna Brown

Peer review (1 review for 1 publication/grant)

Review activity for Leukemia (1)