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Scopus Author ID: 55671067100
ResearcherID: C-6534-2016
Ciência ID: 9F1C-A97D-C3CE

Biography

Recently finished my PhD, which was focused on the pre-clinical validation of molecules that interfere with the p53 pathway in human cells and animal models. Currently working as a postdoctoral research assistant at the MRCPPU University of Dundee, on a project that aims to study the LRRK2 pathway in human samples from patients with Parkinson's disease.

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Education and qualifications (3)

University of Porto Institute for Biomedical Sciences Abel Salazar: Porto, PT

2014 to 2019 | PhD in Molecular and Cellular Biotechnology Applied to Health Sciences
Education
Source: Self-asserted source
Sara Gomes

University of Porto Faculty of Sciences / Institute for Biomedical Sciences Abel Salazar: Porto, PT

2011 to 2013 | MSc in Biochemistry
Education
Source: Self-asserted source
Sara Gomes

University of Porto Faculty of Sciences / Institute for Biomedical Sciences Abel Salazar: Porto, PT

2008 to 2011 | Degree in Biochemistry
Education
Source: Self-asserted source
Sara Gomes

Works (18)

Correlating LRRK2 activation status in peripheral blood to urine BMPs in monogenic and idiopathic Parkinson’s disease

Movement Disorders
2021 | Other | Author
SOURCE-WORK-ID:

933899c3-3800-4d66-9385-68879d33515c
Contributors: Sara Gomes; Alicia Garrido; Francesca Tonelli; Eduardo Tolosa; M. Marti; D. Anderson; Neringa Pratuseviciute; F. Hsieh; T. Bruecke; T. Koenig et al.
Source: check_circle
University of Dundee

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils

Acta Neuropathologica
2021-09 | Journal article | Author
DOI: 10.1007/s00401-021-02325-z
SOURCE-WORK-ID:

950efce8-c17f-4ef9-b9cd-546b5edb9291

EID:

2-s2.0-85107869591

PMID: 34125248
Contributors: Ying Fan; Raja S. Nirujogi; Alicia Garrido; Javier Ruiz-Martínez; Alberto Bergareche-Yarza; Elisabet Mondragón Rezola; Ana Vinagre Aragón; Ioana Croitoru; Ana Gorostidi Pagola; Laura Paternain Markinez et al.
Source: check_circle
University of Dundee

Yeast as a chassis for developing functional assays to study human P53

Journal of Visualized Experiments
2019 | Journal article
DOI: 10.3791/59071
EID:

2-s2.0-85070827874
Contributors: Monti, P.; Bosco, B.; Gomes, S.; Saraiva, L.; Fronza, G.; Inga, A.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier

SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations.

Biochimica et biophysica acta. General subjects
2019-09 | Journal article
DOI: 10.1016/j.bbagen.2019.129440
PMID: 31536751
Contributors: Gomes AS; Ramos H; Gomes S; Loureiro JB; Soares J; Barcherini V; Monti P; Fronza G; Oliveira C; Domingues L et al.
Source: Self-asserted source
Sara Gomes via Europe PubMed Central

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.

Cancers
2019-08 | Journal article
DOI: 10.3390/cancers11081151
PMID: 31405179
PMC: PMC6721528
Contributors: Gomes S; Bosco B; Loureiro JB; Ramos H; Raimundo L; Soares J; Nazareth N; Barcherini V; Domingues L; Oliveira C et al.
Source: Self-asserted source
Sara Gomes via Europe PubMed Central

New inhibitor of the TAp73 interaction with MDM2 and mutant p53 with promising antitumor activity against neuroblastoma

Cancer Letters
2019-04 | Journal article
DOI: 10.1016/j.canlet.2019.01.014
Part of ISSN: 0304-3835
Contributors: Sara Gomes; Liliana Raimundo; Joana Soares; Joana B. Loureiro; Mariana Leão; Helena Ramos; Madalena N. Monteiro; Agostinho Lemos; Joana Moreira; Madalena Pinto et al.
Source: Self-asserted source
Sara Gomes via Crossref Metadata Search
grade
Preferred source (of 3)‎

Biological effects of saponin fractions from Astragalus verrucosus in tumor and non-tumor human cells

Natural Product Communications
2018 | Journal article
EID:

2-s2.0-85053230833
Contributors: Facioni, M.S.; Soares, J.; Adinolfi, B.; Gomes, S.; Raimundo, L.; Contini, A.; Ruffoni, B.; Azzarà, A.; Tavanti, A.; Bertoli, A. et al.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier
grade
Preferred source (of 2)‎

Small Molecules Targeting Mutant P53: A Promising Approach For Cancer Treatment.

Current medicinal chemistry
2018-11 | Journal article
DOI: 10.2174/0929867325666181116124308
PMID: 30444195
Contributors: Lopes EA; Gomes S; Saraiva L; Santos M
Source: Self-asserted source
Sara Gomes via Europe PubMed Central
grade
Preferred source (of 2)‎

The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

International Journal of Molecular Sciences
2018-04 | Journal article
DOI: 10.3390/ijms19041184
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.

2017-03 | Journal article
DOI: 10.1002/1878-0261.12051
PMID: 28296148
Contributors: Soares J; Espadinha M; Raimundo L; Ramos H; Gomes AS; Gomes S; Loureiro JB; Inga A; Reis F; Gomes C et al.
Source: Self-asserted source
Sara Gomes via Europe PubMed Central
grade
Preferred source (of 3)‎

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold

Arabian Journal of Chemistry
2016 | Journal article
DOI: http://dx.doi.org/10.1016/j.arabjc.2016.04.015
Source: Self-asserted source
Sara Gomes
grade
Preferred source (of 4)‎

p53 family interactions and yeast: together in anticancer therapy.

2016-04 | Journal article
DOI: 10.1016/j.drudis.2016.02.007
PMID: 26891980
Contributors: Gomes S; Leão M; Raimundo L; Ramos H; Soares J; Saraiva L
Source: Self-asserted source
Sara Gomes via Europe PubMed Central
grade
Preferred source (of 3)‎

Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.

2016-01 | Journal article
DOI: 10.18632/oncotarget.6775
PMID: 26735173
PMC: PMC4826208
Contributors: Soares J; Raimundo L; Pereira NA; Monteiro Â; Gomes S; Bessa C; Pereira C; Queiroz G; Bisio A; Fernandes J et al.
Source: Self-asserted source
Sara Gomes via Europe PubMed Central
grade
Preferred source (of 3)‎

Studying p53 family proteins in yeast: Induction of autophagic cell death and modulation by interactors and small molecules

Experimental Cell Research
2015 | Journal article
DOI: 10.1016/j.yexcr.2014.09.028
EID:

2-s2.0-84917677533
Contributors: Leão, M.; Gomes, S.; Bessa, C.; Soares, J.; Raimundo, L.; Monti, P.; Fronza, G.; Pereira, C.; Saraiva, L.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier
grade
Preferred source (of 2)‎

Enhanced cytotoxicity of prenylated chalcone against tumour cells via disruption of the p53-MDM2 interaction.

2015-12 | Journal article
DOI: 10.1016/j.lfs.2015.10.015
PMID: 26475964
Contributors: Leão M; Soares J; Gomes S; Raimundo L; Ramos H; Bessa C; Queiroz G; Domingos S; Pinto M; Inga A et al.
Source: Self-asserted source
Sara Gomes via Europe PubMed Central
grade
Preferred source (of 3)‎

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity

FEBS Journal
2013 | Journal article
DOI: 10.1111/febs.12552
EID:

2-s2.0-84889663663
Contributors: Leão, M.; Gomes, S.; Soares, J.; Bessa, C.; MacIel, C.; Ciribilli, Y.; Pereira, C.; Inga, A.; Saraiva, L.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier
grade
Preferred source (of 2)‎

Using yeast to uncover the regulation of protein kinase Cδ by ceramide

FEMS Yeast Research
2013 | Journal article
DOI: 10.1111/1567-1364.12069
EID:

2-s2.0-84886089759
Contributors: Bessa, C.; Pereira, C.; Leão, M.; Maciel, C.; Gomes, S.; Gonçalves, J.; Corte-Real, M.; Costa, V.; Saraiva, L.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier
grade
Preferred source (of 2)‎

α-mangostin and gambogic acid as potential inhibitors of the p53-MDM2 interaction revealed by a yeast approach

Journal of Natural Products
2013 | Journal article
DOI: 10.1021/np400049j
EID:

2-s2.0-84876902872
Contributors: Leão, M.; Gomes, S.; Pedraza-Chaverri, J.; MacHado, N.; Sousa, E.; Pinto, M.; Inga, A.; Pereira, C.; Saraiva, L.
Source: Self-asserted source
Sara Gomes via Scopus - Elsevier
grade
Preferred source (of 2)‎
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