Personal information

Keywords

structural biology, protein science, drug design, medicinal chemistry, DNA repair and replication, chemical carcinogenesis, pharmaceutical industry, drug discovery and development, oncology, infectious diseases, neuroscience, immunology

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Education and qualifications (2)

New York University: New York, NY, US

2003
Education
Source: Self-asserted source
S. Frank Yan

Fudan University: Shanghai, Shanghai, CN

1998
Education
Source: Self-asserted source
S. Frank Yan

Works (20)

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors.

2017-04 | Journal article
DOI: 10.1021/acs.jmedchem.7b00083
PMID: 28339215
Contributors: Qiu Z; Lin X; Zhang W; Zhou M; Guo L; Kocer B; Wu G; Zhang Z; Liu H; Shi H et al.
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Past, Current, and Future Developments of Therapeutic Agents for Treatment of Chronic Hepatitis B Virus Infection.

2017-04 | Journal article
DOI: 10.1021/acs.jmedchem.6b01442
PMID: 28383274
Contributors: Pei YM; Wang C; Yan SF; Liu G
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels.

2017-02 | Journal article
DOI: 10.1007/s13238-017-0372-z
PMID: 28150151
Contributors: Huang W; Liu M; Yan SF; Yan N
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.

2015-07 | Journal article
DOI: 10.1126/science.aab1091
PMID: 26160948
PMC: PMC4704858
Contributors: Ren R; Zhou X; He Y; Ke M; Wu J; Liu X; Yan C; Wu Y; Gong X; Lei X et al.
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP-TEAD Protein-Protein Interaction.

2014-09 | Journal article
DOI: 10.1021/ml500160m
PMID: 25221655
PMC: PMC4160762
Contributors: Zhang Z; Lin Z; Zhou Z; Shen HC; Yan SF; Mayweg AV; Xu Z; Qin N; Wong JC; Zhang Z et al.
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.

2013-01 | Journal article
DOI: 10.1124/dmd.112.048264
PMID: 23033255
Contributors: Ren S; Zeng J; Mei Y; Zhang JZ; Yan SF; Fei J; Chen L
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

AMP-activated protein kinase undergoes nucleotide-dependent conformational changes.

2012-07 | Journal article
DOI: 10.1038/nsmb.2319
PMID: 22659875
Contributors: Chen L; Wang J; Zhang YY; Yan SF; Neumann D; Schlattner U; Wang ZX; Wu JW
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

In silico discovery of transcription regulatory elements in Plasmodium falciparum.

2008-02 | Journal article
DOI: 10.1186/1471-2164-9-70
PMID: 18257930
PMC: PMC2268928
Contributors: Young JA; Johnson JR; Benner C; Yan SF; Chen K; Le Roch KG; Zhou Y; Winzeler EA
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Large-scale annotation of small-molecule libraries using public databases.

2007 | Journal article
DOI: 10.1021/ci700092v
PMID: 17608408
Contributors: Zhou Y; Zhou B; Chen K; Yan SF; King FJ; Jiang S; Winzeler EA
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

A probability-based approach for the analysis of large-scale RNAi screens.

2007-10 | Journal article
DOI: 10.1038/nmeth1089
PMID: 17828270
Contributors: König R; Chiang CY; Tu BP; Yan SF; DeJesus PD; Romero A; Bergauer T; Orth A; Krueger U; Zhou Y et al.
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Profiling the kinome for drug discovery.

2006 | Journal article
DOI: 10.1016/j.ddtec.2006.09.012
PMID: 24980528
Contributors: Yan SF; King FJ; Zhou Y; Warmuth M; Xia G
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

An efficient rapid system for profiling the cellular activities of molecular libraries.

2006-02 | Journal article
DOI: 10.1073/pnas.0511292103
PMID: 16492761
PMC: PMC1413928
Contributors: Melnick JS; Janes J; Kim S; Chang JY; Sipes DG; Gunderson D; Jarnes L; Matzen JT; Garcia ME; Hood TL et al.
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Novel statistical approach for primary high-throughput screening hit selection.

2005 | Journal article
DOI: 10.1021/ci0502808
PMID: 16309285
Contributors: Yan SF; Asatryan H; Li J; Zhou Y
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Conformational searches elucidate effects of stereochemistry on structures of deoxyadenosine covalently bound to tumorigenic metabolites of benzo[C] phenanthrene.

2004-09 | Journal article
DOI: 10.2741/1438
PMID: 15353316
PMC: PMC4697942
Contributors: Wu M; Yan SF; Tan J; Patel DJ; Geacintov NE; Broyde S
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Altering DNA polymerase incorporation fidelity by distorting the dNTP binding pocket with a bulky carcinogen-damaged template.

2004-06 | Journal article
DOI: 10.1021/bi0499516
PMID: 15196018
Contributors: Yan SF; Wu M; Geacintov NE; Broyde S
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Simulating structural and thermodynamic properties of carcinogen-damaged DNA.

2003-04 | Journal article
DOI: 10.1016/s0006-3495(03)75020-6
PMID: 12668423
PMC: PMC1302781
Contributors: Yan S; Wu M; Patel DJ; Geacintov NE; Broyde S
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Role of base sequence context in conformational equilibria and nucleotide excision repair of benzo[a]pyrene diol epoxide-adenine adducts.

2003-03 | Journal article
DOI: 10.1021/bi0270081
PMID: 12600201
Contributors: Yan S; Wu M; Buterin T; Naegeli H; Geacintov NE; Broyde S
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Comparative mutagenesis of the C8-guanine adducts of 1-nitropyrene and 1,6- and 1,8-dinitropyrene in a CpG repeat sequence. A slipped frameshift intermediate model for dinucleotide deletion.

2002-11 | Journal article
DOI: 10.1074/jbc.m208103200
PMID: 12239219
Contributors: Hilario P; Yan S; Hingerty BE; Broyde S; Basu AK
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery.

2002-11 | Journal article
DOI: 10.1002/bip.10239
PMID: 12228925
Contributors: Geacintov NE; Broyde S; Buterin T; Naegeli H; Wu M; Yan S; Patel DJ
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability.

2002-08 | Journal article
DOI: 10.1093/nar/gkf427
PMID: 12140327
PMC: PMC137070
Contributors: Wu M; Yan S; Patel DJ; Geacintov NE; Broyde S
Source: Self-asserted source
S. Frank Yan via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for ACS infectious diseases. (1)
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