Yu-Chen Fan (0000-0002-9126-679X)

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Biography

Dr. Yu-Chen Fan is the professor in the Department of Hepatology, Qilu Hospital of Shandong University. He was trained as an attending physician in Qilu Hospital of Shandong University (Jinan, China) and finished his graduate studies and obtained the Medical Doctor’s degree in Shandong University Cheeloo College of Medicine. The major interest of Dr. Yu-Chen Fan’s studies is the immune mechanism of hepatitis B virus associated liver diseases, including negative immune regulation of liver failure and hepatitis B, immune molecular biomarkers for the prognosis of liver failure, and DNA methylation in the clinical science of hepatitis B. Currently, Dr. Yu-Chen Fan is the associate editor of Hepatitis Monthly, Clinical and Translational Hepatology, and Frontiers in Molecular Bioscience: Molecular Diagnostics and Therapeutics, in addtion with an editor in Canadian Journal of Gastroenterology and Hepatology. He has also been invited as the reviewer for about more than 30 professional journals, such as Gut, Hepatology, Alimentary Pharmacology & Therapeutics, Liver International, Ebiomedicine, Journal of Viral Hepatitis, and so on. Dr Yu-Chen Fan has published about more than 100 professional papers in the research field of hepatitis B, liver failure and hepatocellular carcinoma.

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Qilu Hospital of Shandong University: Jinan, Shandong, CN

2020-11-30 to present | Professor, Duty Director(Chair) (Department of Hepatology)

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Yu-Chen Fan

https://orcid.org/0000-0002-9126-679X

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Employment (7)

Qilu Hospital of Shandong University: Jinan, Shandong, CN

Shandong University: Jinan, Shandong, CN

Qilu Hospital of Shandong University: Jinan, Shandong, CN

Qilu Hospital of Shandong University: Jinan, Shandong, CN

Shandong University Qilu Hospital: Jinan, Shandong, CN

Shandong University Qilu Hospital: Jinan, Shandong, CN

Shandong University Qilu Hospital: Jinan, Shandong, CN

Education and qualifications (5)

Shandong University - Baotuquan Campus: Jinan, Shandong, CN

Shandong University - Baotuquan Campus: Jinan, Shandong, CN

Shandong University Qilu Hospital: Jinan, Shandong, CN

Shandong University - Baotuquan Campus: Jinan, Shandong, CN

Qingdao University Medical College: Qingdao, Shandong, CN

Funding (12)

Principle Investigator, The role and mechanism of DNA methylation regulating CD8 + T cell immune response in HBV infection

Shandong University multidisciplinary research and innovation team of young scholars

Study on the key technology of methylation regulating the immune tolerance of CD4 + T cells in chronic HBV infection

表观遗传学分子标志物在乙型病毒性肝炎早期筛查、预警及综合防治中的关键技术研究

DNA甲基化在HBV感染患者CD4+T细胞分化中的作用及机制研究

用于早期诊断肝癌的IGFBP7和XPO4基因甲基化检测试剂盒关键技术研究

干扰素与阿德福韦酯联合治疗HBeAg阳性慢性乙肝HBsAg阴转率的研究

新型免疫负调控分子TIPE2调控CD4+T细胞的功能及在HBV感染中的作用研究

Bart蛋白调节Th17细胞分化的机制及其在慢性HBV感染中的作用研究

GSTP1、GSTM3启动子甲基化标志物在乙型病毒性肝炎预警预测中的研究

白细胞介素22在慢性乙型肝炎中的发病机制研究

慢性乙型病毒性肝炎IL-22基因型-表型交互作用研究

Works (50 of 145)

Dual-antenna@reactor with active “hot spots” for full-spectrum driven CO2 cycloaddition studied at single-particle level

Global, Regional, and National Burdens of Hepatitis E From 1990 to 2021 and Predicted 2030 Incidence: Results From the Global Burden of Disease Study 2021

A Model to Identify Grey-Zone Patients with Chronic Hepatitis B Requiring Antiviral Therapy: A Multicentre, Retrospective Study

Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis.

Dose-dependent Relationship between Alcohol Consumption and the Risks of Hepatitis B Virus-associated Cirrhosis and Hepatocellular Carcinoma: A Meta-analysis and Systematic Review

Comparisons of efficacy and safety of 400 or 800 ml bacterial count fecal microbiota transplantation in the treatment of recurrent hepatic encephalopathy: a multicenter prospective randomized controlled trial in China.

DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication.

Probiotics and their metabolite spermidine enhance IFN-γ&lt;sup&gt;+&lt;/sup&gt;CD4&lt;sup&gt;+&lt;/sup&gt; T cell immunity to inhibit hepatitis B virus.

Palmitoylation of TIM-3 promotes immune exhaustion and restrains antitumor immunity

acFibroMASH Index for the Diagnosis of Fibrotic MASH and Prediction of Liver-related Events: An International Multicenter Study.

Hypermethylation of the glutathione peroxidase 4 gene promoter is associated with the occurrence of immune tolerance phase in chronic hepatitis B.

Prognostic value of genome-wide methylation in acute-on-chronic hepatitis B liver failure.

ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury.

Coupling Benzylamine Oxidation with CO<sub>2</sub> Photoconversion to Ethanol over a Black Phosphorus and Bismuth Tungstate S-Scheme Heterojunction.

Fabrication of Hematite Photoanode Consisting of (110)-Oriented Single Crystals.

IL-22-producing CD3 + CD8- T cells increase in immune clearance stage of chronic HBV infection and correlate with the response of Peg-interferon treatment.

Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma.

Superoxide dismutase 2 as a predictor in patients with hepatitis B virus-associated acute-on-chronic liver failure.

Synergistic Effect between CO<sub>2</sub> Chemisorption Using Amino-Modified Carbon Nitride and Epoxide Activation by High-Energy Electrons for Plasmon-Assisted Synthesis of Cyclic Carbonates.

Acute hepatitis of unknown origin in children: A combination of factors.

Risk Factors of Chronic Kidney Disease in Chronic Hepatitis B: A Hospital-based Case-control Study from China

Editorial: Acute-On-Chronic Liver Failure: Natural History, Mechanism, and Treatment.

5-Aza-2'-deoxycytidine may enhance the frequency of T regulatory cells from CD4<sup>+</sup> naïve T cells isolated from the peripheral blood of patients with chronic HBV infection.

Hypermethylation of secreted frizzled related protein 2 gene promoter serves as a noninvasive biomarker for HBV-associated hepatocellular carcinoma.

Surface Fluorination Engineering of NiFe Prussian Blue Analogue Derivatives for Highly Efficient Oxygen Evolution Reaction.

Diagnostic Value of the Hypomethylation of the WISP1 Promoter in Patients with Hepatocellular Carcinoma Associated with Hepatitis B Virus.

Dynamic profiles of SARS-Cov-2 infection from five Chinese family clusters in the early stage of the COVID-19 pandemic.

Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma.

Biomarkers for hepatitis B virus replication: an overview and a look to the future

Combined use of murine double minute-2 promoter methylation and serum AFP improves diagnostic efficiency in hepatitis B virus-related hepatocellular carcinoma.

Radiofrequency ablation versus microwave ablation for early stage hepatocellular carcinoma: A PRISMA-compliant systematic review and meta-analysis.

ACE2: A Linkage for the Interplay Between COVID-19 and Decompensated Cirrhosis.

Hypomethylation of the cyclin D1 promoter in hepatitis B virus-associated hepatocellular carcinoma.

Methylation status of the T-cadherin gene promotor in peripheral blood mononuclear cells is associated with HBV-related hepatocellular carcinoma progression.

Glucocorticoid Regulates NLRP3 in Acute-On-Chronic Hepatitis B Liver Failure

Receptor-Interacting Protein Kinase 3 (RIPK3) mRNA Levels Are Elevated in Blood Mononuclear Cells of Patients with Poor Prognosis of Acute-on-Chronic Hepatitis B Liver Failure

TIPE2 as a potential therapeutic target in chronic viral hepatitis

Tumor necrosis factor-α-induced protein 8-like 2 mRNA in peripheral blood mononuclear cells is associated with the disease progression of chronic hepatitis B virus infection

Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis.

Plasma diamine oxidase level predicts 6-month readmission for patients with hepatitis B virus-related decompensated cirrhosis.

LncRNA SNHG3 Promotes Hepatocellular Tumorigenesis by Targeting miR-326.

Diagnostic value of NKG2D promoter methylation in hepatitis B virus-associated hepatocellular carcinoma.

Progranulin Is Positively Associated with Intervertebral Disc Degeneration by Interaction with IL-10 and IL-17 Through TNF Pathways

Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B.

Probiotics and their metabolite spermidine enhance IFN-γ<sup>+</sup>CD4<sup>+</sup> T cell immunity to inhibit hepatitis B virus.