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Inflammation, Cancer, Cyclooxygenase, Immune response, Infection, T. cruzi
Spain

Biography

PROF. Dr. MANUEL FRESNO

Manuel Fresno (1952) is Professor of Microbiology and Head of the research group of immune activation in the CBMSO of the Universidad Autonoma de Madrid (UAM) and CSIC. He was director during four years of this center, which includes more than 70 research groups at 5 departments. After obtaining his Ph.D in Biochemistry in 1977 at the UAM, he moved to the United States where he was Assistant in the Department of Pathology, Harvard University, Boston. He has also been Director of the Institute of Molecular Biology and Department of Molecular Biology both from UAM. In 2010 he found and was Scientific Director of Diomune, an SME Pharma Biotech until 2021.
Research Lines: a) Characterization and regulation of immune response against protozoan parasites (T. cruzi and Leishmania); b) Inflammation and disease; c) Activation of the Immune System Dr. Fresno has extensive experience in the study of both innate and acquired immunity "in vitro" and "in vivo" including molecular and cellular mechanisms. Also he has extensive experience in Parasitology, specifically in the alteration in immune response parasitic protozoa infections "(T. cruzi and Leishmania) and Virology (HIV-1) and its implications for pathogenesis and therapy including the design and evaluation of immunomodulators and description of its mechanism of action as well as in the design of Vaccines He completed his PhD under the direction of Dr. David Vazquez on the synthesis of proteins and ribosomal activity, leading to the discovery of new antibiotics. Noteworthy, the published results of the thesis 40 years ago are still are being cited today Later he moved to the US and where he was appointed Assistant Professor at Harvard Medical School two years later, helped contribute to the characterization of subpopulations of T lymphocytes by cloning them. Upon returning to Spain was the first to bring the Molecular and Cellular Immunology to a basic research center in Spain. More recently, his main scientific contributions are related to the regulation and role of cyclooxygenase-2 and prostaglandins in various inflammatory diseases, including cancer. In a pioneering work, the group described the expression of Cox-2 in T cells and its regulation by NFAT and involvement in cancer. In the last years his research is also focused on a new a complex Transcription factor TCFL5 in the immune system and leukemia. As a consequence of his work he has many exploited patents and created and Spin off DIOMUNE, SL, that is now applying for a clinical trial in humans based on his studies on TLR in inflammation. He has been the principal investigator of more than 78 competitive projects of national or international public and private agencies (EU: 8, Spanish Ministry: FIS, REDES 38, NIH- USA)/ Latin America: 5, Local governments: 13, Private Pharmaceutical companies: 18, Private foundations: 3). Also during his scientific/academic career he has directed a total of 37 doctoral theses and currently directs 5 and many TFGs and Master’s Thesis. Many of them direct already their own groups in Academic and Industry and some are Full Professor or Associate Professor in leading institutions as CNIC or Tufts University He actively participates in the training of students and researchers with an average of 300 hrs/year teaching in undergraduate and postgraduate courses, tutoring of students, participation in Faculty committees, etc.
Doctoral theses directed and presented since 2004: 19 doctoral theses. Total Citations: over 110,000 citations without self citations. Average citations in the last 5 years: approx 450/year (including around 10 citations /year of his PhD publications (1975-1977)) . Publications in D1: 4% and Q1: 60% H Index: 57.
Manuel Fresno is the author of more than 290 scientific articles (71 from January 2009, 26 as senior author) in international journals and 23 book chapters and books in its field. Highlight items are: Nature (1), Nature Immunol (2) Cell (2) J. Exp. Med. (6), EMBO J. (1), Circulation (1), J. Biol. Chem (16), J. Immunol. (20), J. Virol. (5), Eur. J. Immunol. (14), Blood (1), Cancer Res (2), Cardiovascular Res (1), Oncogene (3), AIDS (2), J. Clin. Invest. (2), J Infect Dis (4), Trends Parasitol. (1), Trends Molecular Medicine (2), Immunology Today (1), Progress in Neurobiology (1), PLos Pathogens (1), Oncotarget (3), J. Cell Sci (1), JACI (1), Biochem. J. (2), Cell Reports (1). Sci Transl Med (1), J. Allergy Clin. Immunol (2), Cell Report (1), EMBO Molecular Medicine (1), Front Inmmunol (5), among others.

Activities

Employment (9)

Autonomous University of Madrid: Madrid, ES

2000 to present | Full Professor (Molecular Biology )
Employment
Source: Self-asserted source
Manuel Fresno

Hospital Universitario de La Princesa: Madrid, ES

2010 to 2023 | Head Grupo Investigación 12
Employment
Source: Self-asserted source
Manuel Fresno

Centro de Biología Molecular Severo Ochoa: Madrid, ES

2008 to 2012 | Director
Employment
Source: Self-asserted source
Manuel Fresno

Autonomous University of Madrid: Madrid, ES

2000 to 2004 | Chairman (Biologia Molecular)
Employment
Source: Self-asserted source
Manuel Fresno

Universidad Autónoma de Madrid: Madrid, Madrid, ES

1985 to 1999 | Associate professor of Microbiology (BIOLOGIA MOLECULAR)
Employment
Source: Self-asserted source
Manuel Fresno

Centro de Biología Molecular Severo Ochoa: Madrid, ES

1994 to 1996 | Vice-Director
Employment
Source: Self-asserted source
Manuel Fresno

Autonomous University of Madrid: Madrid, ES

1990 to 1992 | Director (Instituto de Biologia Molecular)
Employment
Source: Self-asserted source
Manuel Fresno

Harvard University: Cambridge, US

1982 to 1984 | Assistant Professor, Department of Pathology, Harvard University and Tumor Immunology Division, Sidney Farber Cancer Institute, Boston, Massachusetts, USA (Pathology)
Employment
Source: Self-asserted source
Manuel Fresno

Harvard University: Cambridge, US

1979 to 1981 | Research Fellow Department of Pathology, Harvard University and Tumor Immunology Division, Sidney Farber Cancer Institute, Boston, Massachusetts, USA (Pathology)
Employment
Source: Self-asserted source
Manuel Fresno

Education and qualifications (2)

Universidad Autonoma de Madrid Facultad de Ciencias: Madrid, ES

1978 | DOCTOR EN CIENCIAS QUÍMICAS (BIOQUÍMICA) (BIOLOGIA MOLECULAR )
Education
Source: Self-asserted source
Manuel Fresno

Universidad Complutense de Madrid: Madrid, Comunidad de Madrid, ES

1975 | LICENCIADO EN CC. QUÍMICAS (Bioquímica y Biología Molecular )
Education
Source: Self-asserted source
Manuel Fresno

Professional activities (2)

Royal Academy of Pharmacy. Spain: Madrid, ES

2003 to present | Elected Academic
Membership
Source: Self-asserted source
Manuel Fresno

Sociedad Cubana de Inmunología: La Habana, CU

2012 | Honorary Member
Distinction
Source: Self-asserted source
Manuel Fresno

Funding (18)

PAPEL DE TCFL5 EN PROCESOS DE DIFERENCIACION, INMUNOSENESCENCIA, INFLAMACION Y TRASTORNOS ASOCIADOS AL ENVEJECIMIENTO

2023-09 to 2026-08 | Grant
Agencia Estatal de Investigación (Madrid, ES)
Source: Self-asserted source
Manuel Fresno

PLATAFORMA Y MODELOS PRECLINICOS PARA EL ABORDAJE MULTIDISCIPLICANAR EN COVID19 Y EN RESPUESTAS A FUTURAS PANDEMIAS

2021-11 to 2023-12 | Grant
EU-COMUNIDAD DE MADRID (MADRID, MADRID, ES)
Source: Self-asserted source
Manuel Fresno

ACE2 como biomarcador con utilidad para identificación de población de alto riesgo para infección por SARS-2 COV y pronóstica de evolución en COVID-19

2021-11 to 2022-11 | Grant
Consejo Superior de Investigaciones Científicas (Madrid, ES)
Source: Self-asserted source
Manuel Fresno

PID2019-104760RB-I00- TCFL5/CHA EN LA DIFERENCIACIÓN Y ACTIVACIÓN DE LINFOCITOS B Y T Y EN LA GENERACIÓN DE LEUCEMIAS.

2020-06 to 2023-05 | Grant
Ministerio de Ciencia, Innovación y Universidades (MADRID, MADRID, ES)
Source: Self-asserted source
Manuel Fresno

DOCTORADOS INDUSTRIALES 2018 -

2019-02 to 2022-02 | Grant
Comunidad de Madrid (Madrid, ES)
Source: Self-asserted source
Manuel Fresno

RTC-2017-6292-1 (FEDER)- VALIDACIÓN DE DIANAS FARMACOLÓGICAS NEUROINFLAMATORIAS PARA EL TRATAMIENTO DEL DOLOR CRÓNICO

2018-11 to 2023-09 | Grant
ESTEVE LABORATORIOS - CSIC - UAM. MINISTERIO DE CIENCIA E INNOVACIÓN (MADRID, MADRID, ES)
Source: Self-asserted source
Manuel Fresno

INFLAMUNE-CM S2017/BMD-3671 NUEVOS MECANISMOS MOLECULARES Y CELULARES IMPLICADOS EN LA FISIOPATOLOGIA INMUNE Y ENFERMEDADES INFLAMATORIAS

2018-01 to 2022-06 | Grant
Comunidad de Madrid (MADRID, MADRID, ES)
Source: Self-asserted source
Manuel Fresno

RED DE INVESTIGACIÓN COLABORATIVA EN ENFERMEDADES TROPICALES – Grupo RICET RD16/0027/0006, IP: Dr. Manuel Fresno Escudero.

2017-01 to 2021-12 | Grant
Instituto de Investigación Sanitaria La Princesa. Instituto de Salud Carlos III (MADRID, MADRID, ES)
Source: Self-asserted source
Manuel Fresno

PAPEL DEL FACTOR DE TRANSCRIPCION TCFL5/CHA EN EL DESARROLLO NORMAL Y PATOLOGICO DE LOS LINFOCITOS T Y B.

2016-12 to 2019-12 | Grant
MINECO (MADRID, ES)
GRANT_NUMBER:

SAF2016-75988-R

Source: Self-asserted source
Manuel Fresno

PROSTANOIDES Y RECEPTORES TIPO TOLL COMO MEDIADORES CLAVE Y POTENCIALES DIANAS TERAPEUTICAS EN ENFERMEDADES INFLAMATORIAS CRONICAS: Cancer y Obesidad

2014 to 2017 | Grant
MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD (MADRID, ES)
GRANT_NUMBER:

SAF2013-42850-R

Source: Self-asserted source
Manuel Fresno

Immunoregulatory molecules as biomarkers predicting response to Biological Therapies and disease severity in Immune-Mediated Inflammatory Disorders

2014 to 2016 | Grant
INSTITUTO DE SALUD CARLOS III (MADRID, ES)
GRANT_NUMBER:

BIOIMID

Source: Self-asserted source
Manuel Fresno

Host-microbe interactions in Health and disease. Interface with the immune system.

2013 to 2017 | Grant
European Union (Brusselas, ES)
GRANT_NUMBER:

HOMIN - 317057 - FP7-PEOPLE-2012-ITN

Source: Self-asserted source
Manuel Fresno

Red de Investigación Colaborativa en Enfermedades Tropicales (RICET)

2013 to 2016 | Grant
INSTITUTO DE SALUD CARLOS III (MADRID, ES)
GRANT_NUMBER:

RD12/0018/0004

Source: Self-asserted source
Manuel Fresno

Identificación de biomarcadores para el seguimiento de pacientes infectados con distintos linajes de Trypanosoma cruzi y sometidos a tratamiento.

2013 to 2014 | Grant
UAM-BANCO DE SANTANDER (MADRID, ES)
Source: Self-asserted source
Manuel Fresno

REDES MOLECULARES Y CELULARES EN ENFERMEDADES INFLAMATORIAS

2012 to 2015 | Grant
COMUNIDAD DE MADRID (MADRID, ES)
GRANT_NUMBER:

S2010/BMD-2332

Source: Self-asserted source
Manuel Fresno

RECEPTORES TOLL-LIKE, PROSTANOIDES Y REDES DE SEÑALIZACION EN ENFERMEDADES INFLAMATORIAS.

2011-10 to 2013-09 | Grant
Agencia Estatal de Investigación (Madrid, ES)
Source: Self-asserted source
Manuel Fresno

INMUNOPATOGENIA DE LA ENFERMEDAD DE CHAGAS: NUEVAS APROXIMACIONES BIOTECNOLÓGICAS.

2011-10 to 2012-12 | Grant
Agencia Estatal de Investigación (Madrid, ES)
Source: Self-asserted source
Manuel Fresno

ENDOTELINA-1 COMO FACTOR INVOLUCRADO EN EL DESARROLLO DE MIOCARDIOPATIA POR ENFERMEDAD DE CHAGAS: REGULACIÓN DE LA EXPRESION DE MEDIADORES INFLAMATORIOS POR LA VIA DE CALCINEURINA/NFAT.

2009-10 to 2010-12 | Grant
Agencia Estatal de Investigación (Madrid, ES)
Source: Self-asserted source
Manuel Fresno