Personal information

Activities

Employment (4)

ToxGenSolutions BV: Maastricht, Zuid-Limburg, NL

2015-05-22 to present | Managing Director
Employment
Source: Self-asserted source
Erwin L Roggen

Danish 3R Center : Copenhagen, DK

2013-11-01 to present | Board member
Employment
Source: Self-asserted source
Erwin L Roggen

3Rs Management and Consulting ApS: Kongens Lyngby, STOR KOEBENHAVN, DK

2013-04-01 to present | Managing Director
Employment
Source: Self-asserted source
Erwin L Roggen

SenzaGeb AB: Lund, SE

2015-11-01 to 2019-12-31 | Validation Manager
Employment
Source: Self-asserted source
Erwin L Roggen

Education and qualifications (1)

University of Antwerp: Antwerp, BE

1980-09-01 to 1984-07-01 | PhD (Biochemistry - Enzymology)
Education
Source: Self-asserted source
Erwin L Roggen

Professional activities (6)

Society of Toxicology: Reston, Virginia, US

Member
Membership
Source: Self-asserted source
Erwin L Roggen

EUROTOX: Brussels, Brussels, BE

Individual member
Membership
Source: Self-asserted source
Erwin L Roggen

European Partnership for Alternatives Approaches to Animal Testing: Brussels, BE

2006-03-01 to 2018-12-31 | Work package leader and Board member
Service
Source: Self-asserted source
Erwin L Roggen

European Commission Joint Research Centre Ispra Sector: Ispra, Lombardia, IT

2010-01-01 to 2016-12-31 | Member of the Scientific Advisory Board (ESAC) (EURL-ECVAM)
Invited position
Source: Self-asserted source
Erwin L Roggen

Ghent University: Ghent, BE

1986-09-01 to 1988-08-31 | PostDoc (Molecular Biology)
Invited position
Source: Self-asserted source
Erwin L Roggen

Papanikolaou Cancer Research Center: Athens, GR

1980-09-15 to 1980-12-20 | PostDoc (Biochemistry and Molecular Biology)
Invited position
Source: Self-asserted source
Erwin L Roggen

Funding (17)

microRNA tests for diagnosing preclinical Alzheimeer’s disease and accelerating drug development (proAD).

2021-09 to 2024-09 | Grant
Eurostars (Brussels, BE)
GRANT_NUMBER:

E!115456 - proAD

Source: Self-asserted source
Erwin L Roggen

Ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment

2021-05 to 2026-04 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

963845

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Interreg Vlaanderen-Nederland (Brussels, BE)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Agency for Innovation and Entrepreneurship (VLAIO) (Brussels, BE)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Ministerie van Economische Zaken (Den Haag, NL)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Provincie Limburg (Maastricht, NL)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Provincie Vlaams Brabant (Brussel, BE)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Herinneringen

2018-01 to 2020-12 | Grant
Provincie Antwerpen (Antwerp, BE)
Part of GRANT_NUMBER:

Herinneringen

Source: Self-asserted source
Erwin L Roggen

Evaluation of 3D-skin model-based assays using difficult to test substances

2016-01 to 2017-03 | Grant
European Partnership for Alternative Approaches to Animal Testing (Brussels, BE)
Source: Self-asserted source
Erwin L Roggen

Improving Allergy Risk Assessment Strategy for New Food Proteins

2014-12 to 2018-12 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

COST FA 1402

Source: Self-asserted source
Erwin L Roggen

Developing toxicogenomics- and metabolomics-based in vitro tests to detect potential genotoxicants and carcinogens

2006-11 to 2011-11 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

LSHB-CT-2006-037712

Source: Self-asserted source
Erwin L Roggen

Neutralizing antibodies on Interferon beta in Multiple Sclerosis

2006-01 to 2009-06 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

18926

Source: Self-asserted source
Erwin L Roggen

Novel testing strategies for in vitro assessment of allergens

2005-10 to 2011-03 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

LSHB-CT-2005-018681

Source: Self-asserted source
Erwin L Roggen

Application of phage display technology for generation of large surface displayed antibody repertoires

2004-01 to 2005-12 | Grant
Academy of Technical Science (Copenhagen, DK)
Source: Self-asserted source
Erwin L Roggen

Food allergy risk evaluation based on improved diagnosis, allergens and test methods

2002-01 to 2004-12 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

QLK4-CT-2001-00301

Source: Self-asserted source
Erwin L Roggen

Human cell systems for predicting the allergenicity of genetically engineered proteins.

2001-12 to 2003 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

QLK3-CT-2000-00270

Source: Self-asserted source
Erwin L Roggen

Artificial evolution approach to develop new enzymatic functionalities

2001-08 to 2003-08 | Grant
European Commission (Brussels, BE)
Source: Self-asserted source
Erwin L Roggen

Works (50 of 80)

Items per page:
Page 1 of 2

When animal data no longer translate into benefits for human health, novel approaches might offer solutions.

ELIVA Press
2022-03-19 | Book
Source: Self-asserted source
Erwin L Roggen

Sporadic Alzheimer’s disease and neurotoxicity-related microRNAs affecting KEs of the tau-driven AOP toward memory loss

Journal of Alzheimer's Disease
2022-02-21 | Journal article
Source: Self-asserted source
Erwin L Roggen

Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency

Toxicity Assessment
2021 | Book chapter
Part of ISBN: 9781071610909
Part of ISBN: 9781071610916
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Erwin L Roggen

Safer chemicals using less animals: kick-off of the European ONTOX project

Toxicology
2021-06-28 | Journal article
Part of ISSN: 0300-483X
Source: Self-asserted source
Erwin L Roggen

A Tau-Driven Adverse Outcome Pathway Blueprint Toward Memory Loss in Sporadic (Late-Onset) Alzheimer’s Disease with Plausible Molecular Initiating Event Plug-Ins for Environmental Neurotoxicants

Journal of Alzheimer's Disease
2021-05-18 | Journal article
Source: Self-asserted source
Erwin L Roggen

COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium

Clinical and Translational Allergy
2020-12 | Journal article
Part of ISSN: 2045-7022
Source: Self-asserted source
Erwin L Roggen

An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals

Toxicology in Vitro
2020-08 | Journal article
Part of ISSN: 0887-2333
Source: Self-asserted source
Erwin L Roggen

In vitro RHE skin sensitisation assays: Applicability to challenging substances.

Regulatory toxicology and pharmacology : RTP
2019-09 | Journal article
Contributors: Mehling A; Adriaens E; Casati S; Hubesch B; Irizar A; Klaric M; Letasiova S; Manou I; Müller BP; Roggen E et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Validation of the GARDâ„¢skin Assay for Assessment of Chemical Skin Sensitizers: Ring Trial Results of Predictive Performance and Reproducibility.

Toxicological sciences : an official journal of the Society of Toxicology
2019-08 | Journal article
Contributors: Johansson H; Gradin R; Johansson A; Adriaens E; Edwards A; Zuckerstätter V; Jerre A; Burleson F; Gehrke H; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies

Trends in Food Science & Technology
2019-03 | Journal article
Part of ISSN: 0924-2244
Source: Self-asserted source
Erwin L Roggen

Evaluation of 3D skin model-based assays using difficult to test substances: an EPAA multi-sector project

Toxicology Letters
2018-10 | Journal article
Part of ISSN: 0378-4274
Source: Self-asserted source
Erwin L Roggen

The validation of GARDskin

Toxicology Letters
2018-10 | Journal article
Part of ISSN: 0378-4274
Source: Self-asserted source
Erwin L Roggen

One science-driven approach for the regulatory implementation of alternative methods: A multi-sector perspective.

Regulatory toxicology and pharmacology : RTP
2018-08 | Journal article
Contributors: Dal Negro G; Eskes C; Belz S; Bertein C; Chlebus M; Corvaro M; Corvi R; Dhalluin S; Halder M; Harvey J et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Development of an In Vitro Method to Estimate the Sensitization Induction Level of Contact Allergens.

Current protocols in toxicology
2018-02 | Journal article
Contributors: Galbiati V; Gibbs S; Roggen E; Corsini E
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central
grade
Preferred source (of 3)‎

Activation of Stored Messenger Ribonucleoproteins: Identification and Function of the Proteins Associated with Nonpolysomal Poly(A)-Containing Messenger Ribonucleoproteins of Cryptobiotic Gastrulae of Artemia sp.

Biochemistry and Cell Biology of Artemia
2018-01-18 | Book chapter
Part of ISBN: 9781351070157
Source: Self-asserted source
Erwin L Roggen

Advances in the development of in vitro airway models as innovative tools to identify chemical respiratory sensitizers

Toxicology Letters
2017-10 | Journal article
Part of ISSN: 0378-4274
Source: Self-asserted source
Erwin L Roggen

An adverse outcome pathway for respiratory sensitization by chemicals: The way forward?

Toxicology Letters
2017-10 | Journal article
Part of ISSN: 0378-4274
Source: Self-asserted source
Erwin L Roggen
grade
Preferred source (of 2)‎

An alternative biomarker-based approach for the prediction of proteins known to sensitize the respiratory tract.

Toxicology in vitro : an international journal published in association with BIBRA
2017-10 | Journal article
Contributors: Zeller KS; Johansson H; Lund TØ; Kristensen NN; Roggen EL; Lindstedt M
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Assessment of metal sensitizer potency with the reconstructed human epidermis IL-18 assay.

Toxicology
2017-10 | Journal article
Contributors: Gibbs S; Kosten I; Veldhuizen R; Spiekstra S; Corsini E; Roggen E; Rustemeyer T; Feilzer AJ; Kleverlaan CJ
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins.

Clinical and translational allergy
2017-05 | Journal article
Contributors: van Bilsen JHM; Sienkiewicz-Szłapka E; Lozano-Ojalvo D; Willemsen LEM; Antunes CM; Molina E; Smit JJ; Wróblewska B; Wichers HJ; Knol EF et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Preliminary performance data of the RHE/IL-18 assay performed on SkinEthicâ„¢ RHE for the identification of contact sensitizers.

International journal of cosmetic science
2016-08 | Journal article
Contributors: Andres E; Barry M; Hundt A; Dini C; Corsini E; Gibbs S; Roggen EL; Ferret PJ
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Developing a framework for assessing chemical respiratory sensitization: A workshop report.

Regulatory toxicology and pharmacology : RTP
2016-07 | Journal article
Contributors: North CM; Ezendam J; Hotchkiss JA; Maier C; Aoyama K; Enoch S; Goetz A; Graham C; Kimber I; Karjalainen A et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

ALTEX
2015-01 | Journal article
Contributors: Gordon S; Daneshian M; Bouwstra J; Caloni F; Constant S; Davies DE; Dandekar G; Guzman CA; Fabian E; Haltner E et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Treatment of both native and deamidated gluten peptides with an endo-peptidase from Aspergillus niger prevents stimulation of gut-derived gluten-reactive T cells from either children or adults with celiac disease.

Clinical immunology (Orlando, Fla.)
2014-06 | Journal article
Contributors: Toft-Hansen H; Rasmussen KS; Staal A; Roggen EL; Sollid LM; Lillevang ST; Barington T; Husby S
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

State of the art on alternative methods to animal testing from an industrial point of view: ready for regulation?

ALTEX
2014-05 | Journal article
Contributors: Ashton R; De Wever B; Fuchs HW; Gaca M; Hill E; Krul C; Poth A; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Allergic sensitization: screening methods.

Clinical and translational allergy
2014-04 | Journal article
Contributors: Ladics GS; Fry J; Goodman R; Herouet-Guicheney C; Hoffmann-Sommergruber K; Madsen CB; Penninks A; Pomés A; Roggen EL; Smit J et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

In vitro approaches for detection of chemical sensitization.

Basic & clinical pharmacology & toxicology
2014-02 | Journal article
Contributors: Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.

ALTEX
2014-02 | Journal article
Contributors: Teunis MA; Spiekstra SW; Smits M; Adriaens E; Eltze T; Galbiati V; Krul C; Landsiedel R; Pieters R; Reinders J et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

IgE versus IgG4 epitopes of the peanut allergen Ara h 1 in patients with severe allergy.

Molecular immunology
2013-12 | Journal article
Contributors: Bøgh KL; Nielsen H; Eiwegger T; Madsen CB; Mills EN; Rigby NM; Szépfalusi Z; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Proceedings of the 17th ESTIV congress 2012.

Toxicology in vitro : an international journal published in association with BIBRA
2013-10 | Journal article
Contributors: Vinken M; Scarino ML; Roggen E; Blaauboer BJ
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

An epidermal equivalent assay for identification and ranking potency of contact sensitizers.

Toxicology and applied pharmacology
2013-07 | Journal article
Contributors: Gibbs S; Corsini E; Spiekstra SW; Galbiati V; Fuchs HW; Degeorge G; Troese M; Hayden P; Deng W; Roggen E
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Advanced tests for skin and respiratory sensitization assessment.

ALTEX
2013-01 | Journal article
Contributors: Rovida C; Martin SF; Vivier M; Weltzien HU; Roggen E
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Sens-it-iv: a European Union project to develop novel tools for the identification of skin and respiratory sensitizers.

Toxicology in vitro : an international journal published in association with BIBRA
2013-01 | Journal article
Contributors: Roggen EL; Blaauboer BJ
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Application of the acquired knowledge and implementation of the Sens-it-iv toolbox for identification and classification of skin and respiratory sensitizers.

Toxicology in vitro : an international journal published in association with BIBRA
2012-10 | Journal article
Contributors: Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Potential of in vitro reconstituted 3D human airway epithelia (MucilAirâ„¢) to assess respiratory sensitizers.

Toxicology in vitro : an international journal published in association with BIBRA
2012-10 | Journal article
Contributors: Huang S; Wiszniewski L; Constant S; Roggen E
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.

Toxicology in vitro : an international journal published in association with BIBRA
2012-06 | Journal article
Contributors: Teunis M; Corsini E; Smits M; Madsen CB; Eltze T; Ezendam J; Galbiati V; Gremmer E; Krul C; Landin A et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

IgE epitopes of intact and digested Ara h 1: a comparative study in humans and rats.

Molecular immunology
2012-05 | Journal article
Contributors: Bøgh KL; Nielsen H; Madsen CB; Mills EN; Rigby N; Eiwegger T; Szépfalusi Z; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.

ALTEX
2012-01 | Journal article
Contributors: Basketter DA; Clewell H; Kimber I; Rossi A; Blaauboer B; Burrier R; Daneshian M; Eskes C; Goldberg A; Hasiwa N et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Implementation challenges for designing integrated in vitro testing strategies (ITS) aiming at reducing and replacing animal experimentation.

Toxicology in vitro : an international journal published in association with BIBRA
2012-01 | Journal article
Contributors: De Wever B; Fuchs HW; Gaca M; Krul C; Mikulowski S; Poth A; Roggen EL; Vilà MR
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Respiratory sensitization: advances in assessing the risk of respiratory inflammation and irritation.

Toxicology in vitro : an international journal published in association with BIBRA
2011-05 | Journal article
Contributors: Vandebriel R; Callant Cransveld C; Crommelin D; Diamant Z; Glazenburg B; Joos G; Kuper F; Natsch A; Nijkamp F; Noteborn H et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

In vitro Toxicity Testing in the Twenty-First Century.

Frontiers in pharmacology
2011-02 | Journal article
Contributors: Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Toxicology in the 21st century--working our way towards a visionary reality.

Toxicology in vitro : an international journal published in association with BIBRA
2011-02 | Journal article
Contributors: Berg N; De Wever B; Fuchs HW; Gaca M; Krul C; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".

ALTEX
2011-01 | Journal article
Contributors: Hartung T; Blaauboer BJ; Bosgra S; Carney E; Coenen J; Conolly RB; Corsini E; Green S; Faustman EM; Gaspari A et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Immunotoxicology: opportunities for non-animal test development.

Alternatives to laboratory animals : ATLA
2009-09 | Journal article
Contributors: Corsini E; Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing.

Alternatives to laboratory animals : ATLA
2009-07 | Journal article
Contributors: Casati S; Aeby P; Kimber I; Maxwell G; Ovigne JM; Roggen E; Rovida C; Tosti L; Basketter D
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

The development of novel approaches to the identification of chemical and protein respiratory allergens.

Alternatives to laboratory animals : ATLA
2008-11 | Journal article
Contributors: Roggen E; Aufderheide M; Cetin Y; Dearman RJ; Gibbs S; Hermanns I; Kimber I; Regal JF; Rovida C; Warheit DB et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.

Mutation research
2008-04 | Journal article
Contributors: Vinken M; Doktorova T; Ellinger-Ziegelbauer H; Ahr HJ; Lock E; Carmichael P; Roggen E; van Delft J; Kleinjans J; Castell J et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

B-cell epitope engineering: A matter of recognizing protein features and motives.

Drug discovery today. Technologies
2008-01 | Journal article
Contributors: Roggen EL
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Management of an integrated project (Sens-it-iv) to develop in vitro tests to assess sensitisation.

Alternatives to laboratory animals : ATLA
2007-06 | Journal article
Contributors: Rovida C; Basketter D; Casati S; de Silva O; Hermans H; Kimber I; Manou I; Weltzien HU; Roggen E
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central

Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60.

Alternatives to laboratory animals : ATLA
2007-05 | Journal article
Contributors: Kimber I; Agius R; Basketter DA; Corsini E; Cullinan P; Dearman RJ; Gimenez-Arnau E; Greenwell L; Hartung T; Kuper F et al.
Source: Self-asserted source
Erwin L Roggen via Europe PubMed Central
Items per page:
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