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Works (12)

Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways

npj Systems Biology and Applications
2024-06-03 | Journal article
DOI: 10.1038/s41540-024-00390-0
Contributors: Safal Shrestha; Rahil Taujale; Samiksha Katiyar; Natarajan Kannan
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Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs

Science Advances
2024-02-23 | Journal article
DOI: 10.1126/sciadv.adl1258
Contributors: Mitchell H. Omar; Dominic P. Byrne; Safal Shrestha; Tyler M. Lakey; Kyung-Soon Lee; Sophia M. Lauer; Kerrie B. Collins; Leonard A. Daly; Claire E. Eyers; Geoffrey S. Baird et al.
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Illuminating the functions of the understudied Fructosamine-3-kinase (FN3K) using a multi-omics approach reveals new links to lipid, carbon, and co-factor metabolic pathways

2024-02-16 | Preprint
DOI: 10.21203/rs.3.rs-3934957/v1
Contributors: Natarajan Kannan; Safal Shrestha; Rahil Taujale; Samiksha Katiyar
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Evolutionary and cellular analysis of the dark pseudokinase PSKH2

2022-09-10 | Preprint
DOI: 10.1101/2022.09.10.507278
Contributors: Dominic P Byrne; Safal Shrestha; Leonard A Daly; Vanessa Marensi; Krithika Ramakrishnan; Claire E Eyers; Natarajan Kannan; Patrick A Eyers
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Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

Structure
2020-11 | Journal article
DOI: 10.1016/j.str.2020.07.016
Contributors: Franziska Preuss; Deep Chatterjee; Sebastian Mathea; Safal Shrestha; Jonathan St-Germain; Manipa Saha; Natarajan Kannan; Brian Raught; Robert Rottapel; Stefan Knapp
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Cataloguing the dead: breathing new life into pseudokinase research

The FEBS Journal
2020-10 | Journal article
DOI: 10.1111/febs.15246
Contributors: Safal Shrestha; Dominic P. Byrne; John A. Harris; Natarajan Kannan; Patrick A. Eyers
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A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

2020-07-07 | Other
DOI: 10.26434/chemrxiv.12616178
Contributors: Alfredo Picado; Apirat Chaikuad; Carrow Wells; Safal Shrestha; William Zuercher; Julie E. Pickett; Frank Kwarcinski; Parvathi Sinha; Chandi de Silva; Reena Zutshi et al.
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A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation

2020-07-07 | Other
DOI: 10.26434/chemrxiv.12616178.v1
Contributors: Alfredo Picado; Apirat Chaikuad; Carrow Wells; Safal Shrestha; William Zuercher; Julie E. Pickett; Frank Kwarcinski; Parvathi Sinha; Chandi de Silva; Reena Zutshi et al.
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A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

Science Signaling
2020-07-07 | Journal article
DOI: 10.1126/scisignal.aax6313
Contributors: Safal Shrestha; Samiksha Katiyar; Carlos E. Sanz-Rodriguez; Nolan R. Kemppinen; Hyun W. Kim; Renuka Kadirvelraj; Charalampos Panagos; Neda Keyhaninejad; Maxwell Colonna; Pradeep Chopra et al.
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Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

Science Signaling
2020-07-07 | Journal article
DOI: 10.1126/scisignal.aax2713
Contributors: Dominic P. Byrne; Safal Shrestha; Martin Galler; Min Cao; Leonard A. Daly; Amy E. Campbell; Claire E. Eyers; Elizabeth A. Veal; Natarajan Kannan; Patrick A. Eyers
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A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily

2020-01-14 | Preprint
DOI: 10.1101/2020.01.13.904870
Contributors: Safal Shrestha; Samiksha Katiyar; Carlos E. Sanz-Rodriguez; Nolan R. Kemppinen; Hyun W. Kim; Renuka Kadirvelraj; Charalampos Panagos; Neda Keyhaninejad; Maxwell Colonna; Pradeep Chopra et al.
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Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

Science Signaling
2018-09-25 | Journal article
DOI: 10.1126/scisignal.aat7951
Contributors: Daniel M. Foulkes; Dominic P. Byrne; Wayland Yeung; Safal Shrestha; Fiona P. Bailey; Samantha Ferries; Claire E. Eyers; Karen Keeshan; Carrow Wells; David H. Drewry et al.
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