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Biography
Improving obesity- and cancer-related metabolic dysfunctions by investigating and controlling body’s’ signaling pathways and metabolism has been the focus of Eunus S. Ali’s research. Using biochemistry and cell biology, he works at the molecular level to identify how to efficiently restore aberrant cellular signaling in cancer, diabetes, aging and neurological diseases. He has published some significant works in this area in several well-ranked journals including Molecular Cell, Brain, Science Advances, Nature Communications, BBA - Molecular Cell Research, Biochemical Journal and AJP - Cell Physiology. Employing high resolution mass spectrometry, biochemical approaches and genome editing CRISPR, Eunus identified two important mechanisms in cancer metabolism - how cancer cells hijack nucleotide metabolism to boost their cell proliferation compared to normal cells. Both studies have separately been published in Molecular Cell (2020 and 2022). Prior to Postdoc with Dr. Issam Ben-Sahra at Northwestern University, his PhD was completed under the supervision of Dr. Greg Barritt at Flinders University, and MS at Stockholm's Arrhenius Laboratory (a home to 4 Nobel laureates) with Dr. Göran Widmalm.
As an Assistant Professor, Eunus currently directs the EAL-METABO lab – Laboratory for Cellular and Cancer Metabolism in the Department of Toxicology and Cancer Biology, and the Markey Cancer Center. He is also a member of the Center for Cancer and Metabolism in the University of Kentucky College of Medicine. The overview of current research program can be found in the lab website:
www.eal-metabo.com
Eunus’s personal background is also quite diverse. With roots in south Asia, he grew up and lived in the south of Australia, northern Norway, eastern part of Sweden, Chicago north, and now in the center of Lexington. During these experiences, he has been enjoying meeting new friends, discovering different life styles and culture, and continually learning how to do better science.
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Works (29)
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