Personal information

Verified email addresses

Verified email domains

Metabolism, Cancer, Obesity, Infection, Aging, Signaling
United States

Biography

Improving obesity- and cancer-related metabolic dysfunctions by investigating and controlling body’s’ signaling pathways and metabolism has been the focus of Eunus S. Ali’s research. Using biochemistry and cell biology, he works at the molecular level to identify how to efficiently restore aberrant cellular signaling in cancer, diabetes, aging and neurological diseases. He has published some significant works in this area in several well-ranked journals including Molecular Cell, Brain, Science Advances, Nature Communications, BBA - Molecular Cell Research, Biochemical Journal and AJP - Cell Physiology. Employing high resolution mass spectrometry, biochemical approaches and genome editing CRISPR, Eunus identified two important mechanisms in cancer metabolism - how cancer cells hijack nucleotide metabolism to boost their cell proliferation compared to normal cells. Both studies have separately been published in Molecular Cell (2020 and 2022). Prior to Postdoc with Dr. Issam Ben-Sahra at Northwestern University, his PhD was completed under the supervision of Dr. Greg Barritt at Flinders University, and MS at Stockholm's Arrhenius Laboratory (a home to 4 Nobel laureates) with Dr. Göran Widmalm.

As an Assistant Professor, Eunus currently directs the EAL-METABO lab – Laboratory for Cellular and Cancer Metabolism in the Department of Toxicology and Cancer Biology, and the Markey Cancer Center. He is also a member of the Center for Cancer and Metabolism in the University of Kentucky College of Medicine. The overview of current research program can be found in the lab website:

www.eal-metabo.com

Eunus’s personal background is also quite diverse. With roots in south Asia, he grew up and lived in the south of Australia, northern Norway, eastern part of Sweden, Chicago north, and now in the center of Lexington. During these experiences, he has been enjoying meeting new friends, discovering different life styles and culture, and continually learning how to do better science.

Activities

Employment (1)

Markey (Comprehensive) Cancer Center: Lexington, KY, US

2024-03 to present | Assistant Professor (Toxicology and Cancer Biology)
Employment
Source: Self-asserted source
Eunus S. Ali

Education and qualifications (3)

Northwestern University: Chicago, US

2024 | Postdoc
Education
Source: Self-asserted source
Eunus S. Ali

Flinders University School of Medicine: Adelaide, AU

2016 | Ph.D.
Education
Source: Self-asserted source
Eunus S. Ali

Stockholm University Arrhenius Laboratory: Stockholm, SE

2010 | M.S.
Education
Source: Self-asserted source
Eunus S. Ali

Works (29)

Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor

Molecular Cancer Therapeutics
2023-12-01 | Journal article
Contributors: Kathryn M. Lemberg; Eunus S. Ali; Marcela Krecmerova; Joanna Marie H. Aguilar; Jesse Alt; Diane E. Peters; Liang Zhao; Ying Wu; Naziba Nuha; John M. Asara et al.
Source: check_circle
Crossref

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

Science Advances
2023-05-19 | Journal article
Contributors: Ella N. Perrault; Jack M. Shireman; Eunus S. Ali; Peiyu Lin; Isabelle Preddy; Cheol Park; Shreya Budhiraja; Shivani Baisiwala; Karan Dixit; C. David James et al.
Source: check_circle
Crossref

Regulation of nucleotide metabolism in cancers and immune disorders.

Trends in cell biology
2023-03-24 | Journal article
Contributors: Ali ES; Ben-Sahra I
Source: Self-asserted source
Eunus S. Ali

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway

Nature Communications
2022-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Eunus S. Ali
grade
Preferred source (of 2)‎

Recent advances and limitations of mTOR inhibitors in the treatment of cancer.

Cancer cell international
2022-09-15 | Journal article
Contributors: Ali ES
Source: Self-asserted source
Eunus S. Ali

The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

Molecular Cell
2022-06 | Journal article
Part of ISSN: 1097-2765
Source: Self-asserted source
Eunus S. Ali

TRPM2 Non-Selective Cation Channels in Liver Injury Mediated by Reactive Oxygen Species

Antioxidants
2021-08 | Journal article | Author
Contributors: Eunus S. Ali; Grigori Y. Rychkov; Greg Barritt
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

Targeting redox signaling and ROS metabolism in cancer treatment

Handbook of oxidative stress and cancer: Mechanistic aspects
2021-07-26 | Book chapter
Contributors: Eunus S. Ali
Source: Self-asserted source
Eunus S. Ali

Impaired Ca<sup>2+</sup> signaling due to steatosis mediates hepatic insulin resistance in Alstrom Syndrome mice that is reversed by GLP-1 analog treatment.

American journal of physiology. Cell physiology
2021-06 | Journal article
Contributors: Ali ES; Girard D; Petrovsky N
Source: Self-asserted source
Eunus S. Ali via Europe PubMed Central
grade
Preferred source (of 3)‎

Effects of nerol on paracetamol-induced liver damage in Wistar albino rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2021-06-12 | Journal article
Source: Self-asserted source
Eunus S. Ali
grade
Preferred source (of 2)‎

De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma

Brain
2021-04-14 | Journal article
Source: Self-asserted source
Eunus S. Ali
grade
Preferred source (of 3)‎

mTORC1 stimulates cell growth through SAM synthesis and m<sup>6</sup>A mRNA-dependent control of protein synthesis.

Molecular cell
2021-03 | Journal article
Contributors: Villa E; Sahu U; O'Hara BP; Ali ES; Helmin KA; Asara JM; Gao P; Singer BD; Ben-Sahra I
Source: Self-asserted source
Eunus S. Ali via Europe PubMed Central
grade
Preferred source (of 2)‎

Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon

Anti-Cancer Agents in Medicinal Chemistry
2020-10-14 | Journal article
Contributors: Muhammad T. Islam; Eunus S. Ali; Ishaq N. Khan; Subrata Shaw; Shaikh Jamal Uddin; Razina Rouf; Shrabanti Dev; Seyed S.S. Saravi; Niranjan Das; Swati Tripathi et al.
Source: check_circle
Crossref

Targeting Ca2+ Signaling in the Initiation, Promotion and Progression of Hepatocellular Carcinoma

Cancers
2020-09-24 | Journal article
Contributors: Eunus S. Ali; Grigori Y. Rychkov; Greg J. Barritt
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

Molecular Cell
2020-06-18 | Journal article
Part of ISSN: 1097-2765
Source: Self-asserted source
Eunus S. Ali
grade
Preferred source (of 2)‎

Calcium Signaling As a Therapeutic Target for Liver Steatosis

Trends in Endocrinology and Metabolism
2019 | Journal article
EID:

2-s2.0-85062343980

Contributors: Ali, E.S.; Petrovsky, N.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Deranged hepatocyte intracellular Ca<sup>2+</sup> homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

Cell Calcium
2019 | Journal article
EID:

2-s2.0-85070222576

Contributors: Ali, E.S.; Rychkov, G.Y.; Barritt, G.J.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier

Effect of Diets, Familial History, and Alternative Therapies on Genomic Instability of Breast Cancer Patients

Applied Biochemistry and Biotechnology
2019 | Journal article
EID:

2-s2.0-85056781313

Contributors: Paz, M.F.C.J.; Gomes Júnior, A.L.; de Alencar, M.V.O.B.; Tabrez, S.; Islam, M.T.; Jabir, N.R.; Oves, M.; Alam, M.Z.; Asghar, M.N.; Ali, E.S. et al.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Cancers
2019-05-17 | Journal article
Contributors: Elodie Villa; Eunus Ali; Umakant Sahu; Issam Ben-Sahra
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

Cancer Letters
2018 | Journal article
EID:

2-s2.0-85041925701

Contributors: Islam, M.T.; Ali, E.S.; Uddin, S.J.; Islam, M.A.; Shaw, S.; Khan, I.N.; Saravi, S.S.S.; Ahmad, S.; Rehman, S.; Gupta, V.K. et al.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Assessment of chemotherapy on various biochemical markers in breast cancer patients

Journal of Cellular Biochemistry
2018 | Journal article
EID:

2-s2.0-85037348952

Contributors: Paz, M.F.C.J.; Gomes, A.L.; Islam, M.T.; Tabrez, S.; Jabir, N.R.; Alam, M.Z.; Machado, K.C.; de Alencar, M.V.O.B.; Machado, K.C.; Ali, E.S. et al.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Correlations between risk factors for breast cancer and genetic instability in cancer patients-A clinical perspective study

Frontiers in Genetics
2018 | Journal article
EID:

2-s2.0-85042564287

Contributors: Paz, M.F.C.J.; de Alencar, M.V.O.B.; Junior, A.L.G.; Machado, K.C.; Islam, M.T.; Ali, E.S.; Shill, M.C.; Ahmed, M.I.; Uddin, S.J.; da Mata, A.M.O.F. et al.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Evidence for the interaction of peroxiredoxin-4 with the store-operated calcium channel activator STIM1 in liver cells

Cell Calcium
2018 | Journal article
EID:

2-s2.0-85047395820

Contributors: Tam, K.C.; Ali, E.; Hua, J.; Chataway, T.; Barritt, G.J.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Metabolic disorders and cancer: Hepatocyte store-operated Ca<sup>2+</sup> channels in nonalcoholic fatty liver disease

Advances in Experimental Medicine and Biology
2017 | Book
EID:

2-s2.0-85029574176

Contributors: Ali, E.S.; Rychkov, G.Y.; Barritt, G.J.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Norovirus drug candidates that inhibit viral capsid attachment to human histo-blood group antigens

Antiviral Research
2016 | Journal article
EID:

2-s2.0-84978646169

Contributors: Ali, E.S.; Rajapaksha, H.; Lundborg, M.; Carr, J.M.; Petrovsky, N.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca<sup>2 +</sup> signalling in steatotic hepatocytes

Biochimica et Biophysica Acta - Molecular Cell Research
2016 | Journal article
EID:

2-s2.0-84989934412

Contributors: Ali, E.S.; Hua, J.; Wilson, C.H.; Tallis, G.A.; Zhou, F.H.; Rychkov, G.Y.; Barritt, G.J.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Steatosis inhibits liver cell store-operated Ca<sup>2+</sup> entry and reduces ER Ca<sup>2+</sup> through a protein kinase C-dependent mechanism

Biochemical Journal
2015 | Journal article
EID:

2-s2.0-84923253501

Contributors: Wilson, C.H.; Ali, E.S.; Scrimgeour, N.; Martin, A.M.; Hua, J.; Tallis, G.A.; Rychkov, G.Y.; Barritt, G.J.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

An in silico virtual screening study for the design of norovirus inhibitors: Fragment-based molecular docking and binding free energy calculations

Carbohydrate Research
2013 | Journal article
EID:

2-s2.0-84885021976

Contributors: Lundborg, M.; Ali, E.; Widmalm, G.
Source: Self-asserted source
Eunus S. Ali via Scopus - Elsevier
grade
Preferred source (of 2)‎

Associations between Arsenic Exposure and Global Posttranslational Histone Modifications among Adults in Bangladesh

Cancer Epidemiology Biomarkers & Prevention
2012 | Journal article
Contributors: Y. Chervona; M. N. Hall; A. Arita; F. Wu; H. Sun; H.-C. Tseng; E. Ali; M. N. Uddin; X. Liu; M. A. Zoroddu et al.
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 2)‎

Peer review (12 reviews for 9 publications/grants)

Review activity for Biochimica et biophysica acta. (2)
Review activity for Diabetes & metabolism. (1)
Review activity for Frontiers in genetics. (1)
Review activity for Frontiers in oncology. (1)
Review activity for Frontiers in pharmacology. (1)
Review activity for Journal of diabetes. (1)
Review activity for Journal of food biochemistry. (2)
Review activity for Leukemia and lymphoma. (1)
Review activity for Science advances. (2)