Personal information

Verified email domains

membrane biophysics
Argentina

Biography

Dr. Fanani graduated from Biochemistry in 1996 at FCQ-UNC and began her doctoral studies under the direction of Dr. Bruno Maggio under the theme “Supramolecular modulation of the activity of sphingomyelinase in biointerphases”, which ended in 2001 and for which he received the Dr. Agustin Marenzzi Prize, 2000/2001 awarded by the Faculty of Pharmacy and Biochemistry, Univ. Buenos Aires. She also developed a brief postdoctoral work following this subject in Dr. Maggio. During 2003-2005, she developed studied on “Lipid Modulation of the Diacylglycerol Kinase Activity of α – and γ -Isoforms” under the supervision of Dr. Richard Epand at McMaster University (Canada). After her return, she obtained a position as Assistant researched (2005) and then as Associate Researcher of CONICET (2008) at CIQUIBIC, focusing her studies on the interfacial restructuring suffering by lipid membranes when they are subjected to the action of lipolytic enzymes. In this way, she deepened in the study of the structural (domain formation), rheological and thermodynamic properties of model lipid membranes (mainly lipid monolayers), in particular those containing simple sphingolipids such as ceramide and sphingomyelin. Currently she holds the position of Associate Professor and Independent CONICET Researcher at CIQUIBC, focusing her research on the interaction of amphiphiles of pharmacological interest with model lipid membranes, and how such interaction depends on both the drugs properties and the biophysical properties of the target membrane She has published over forty papers in international scientific journals, of which eight are reviews and has received more than 735 citations (index h 17). Dr. Fanani has received numerous trainees in her laboratory primarily interested in visualizing lipid monolayers by Brewster angle microscopy, which has led to collaborations with the National Univ. South Univ. of Habana, the Univ. of Sao Paulo, Brazil and the Univ. of the Basque Country. She has participated in the Bio-Nano-Science network of the center of the country PAE 22642 “Self-organization of bio-nanostructures for transmitting information in neurobiology and molecular biological processes” 2006-2009 and the Ibero-American Network Science and Technology Program for Development (CYTED) “Toxins of interest to biomedicine” 2012-2015. She is an active member of the Soc. Argentina Biophysics (SAB) and Soc. Arg. Research in Biochemistry and Cell Biology (SAIB).
Dr. Fanani has developed teaching activities since 1997 (1997- 2011 as Teacher Assistant and from 2011 to date as Associated Professor) on the fields of Molecular Biophysics in the School of Chemical Sciences, UNC. Beginning in 2018, Dr. Fanani will be in charge of the course Laboratory IV, mandatory for all the careers of our School. She also collaborate in the teaching of topics in Biological Chemistry related to enzymes and enzymatic activity for undergraduate courses. Since 2006 she collaborate in the teaching of the Graduate course “Molecular Biophysics of Biomembranes” in the Department of Biological Chemistry. Up to date she has supervised three theses of degree and two doctoral theses. She has an active participation in conferences and postgraduate thesis committees.

Activities

Employment (2)

Universidad Nacional de Córdoba: Cordoba, Córdoba, AR

2018-03-01 to present | Full Professor (Facultad de Ciencias Quimicas)
Employment
Source: Self-asserted source
Maria Laura Fanani

CONICET Cordoba: Cordoba, Córdoba, AR

2005-01-01 to present | Senior Researcher (CIQUIBIC)
Employment
Source: Self-asserted source
Maria Laura Fanani

Education and qualifications (2)

Universidad Nacional de Córdoba: Cordoba, AR

1996-05-01 to 2001-10-17 | PhD (Facultad de Ciencias Quimicas)
Education
Source: Self-asserted source
Maria Laura Fanani

Universidad Nacional de Córdoba: Cordoba, Córdoba, AR

1991-01-20 to 1996-03-01 | Biochemist (Facultad de Ciencias Quimicas)
Education
Source: Self-asserted source
Maria Laura Fanani

Professional activities (1)

McMaster University: Hamilton, Ontario, CA

2002 to 2004 | Posdoctoral fellow
Invited position
Source: Self-asserted source
Maria Laura Fanani

Funding (2)

Ramnolípidos bioinspirados: nuevos anfifílos para el control de plagas de cultivos

2021 to present | Grant
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Cordoba, Cordoba, AR)
GRANT_NUMBER:

PICT 2019_02331

Source: Self-asserted source
Maria Laura Fanani

Interacción de fármacos anfífilicos con membranas lipídicas; implicancia en la permeabilidad dérmica potenciada

2019 to present | Grant
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (Cordoba, Cordoba, AR)
GRANT_NUMBER:

PICT 2017-0332

Source: Self-asserted source
Maria Laura Fanani

Works (50 of 60)

Items per page:
Page 1 of 2

The role of biophysical properties in defining the functional applications of alkyl esters of L-ascorbic acid

Biochemical and Biophysical Research Communications
2025-02 | Journal article
Contributors: Milagro Mottola; Jessica Aye Valdivia Pérez; María Laura Fanani
Source: check_circle
Crossref

Membrane-targeted mechanism for amphiphilic vitamin C compounds as methicillin-resistant Staphylococcus aureus biofilm eradicating agents

Chemistry and Physics of Lipids
2024-10 | Journal article
Part of ISSN: 0009-3084
Contributors: Jessica A. Valdivia Pérez; Natalia E. Nocelli; Jeremías Bustos; María Laura Antonio; Andrea Smania; Raquel V. Vico; María Laura Fanani
Source: Self-asserted source
Maria Laura Fanani

Understanding the effects of omega-3 fatty acid supplementation on the physical properties of brain lipid membranes

iScience
2024-07 | Journal article
Part of ISSN: 2589-0042
Contributors: María L. Longarzo; Romina F. Vázquez; María J. Bellini; Ricardo A. Zamora; Lorena Redondo-Morata; Marina I. Giannotti; Osvaldo N. Oliveira Jr; María L. Fanani; Sabina M. Maté
Source: Self-asserted source
Maria Laura Fanani

Multidimensional Spectral Phasors of LAURDAN’s Excitation–Emission Matrices: The Ultimate Sensor for Lipid Phases?

Journal of the American Chemical Society
2024-06-26 | Journal article
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Socas, L.B.P.; Jessica A. Valdivia-Pérez; María L. Fanani; Ernesto E. Ambroggio
Source: Self-asserted source
Maria Laura Fanani

Nanoemulsions of synthetic rhamnolipids act as plant resistance inducers without damaging plant tissues or affecting soil microbiota

Frontiers in Plant Science
2023-08-22 | Journal article
Part of ISSN: 1664-462X
Contributors: Milagro Mottola; María C. Bertolino; Lucille Tihomirova Kourdova; Jessica Aye Valdivia Pérez; María Florencia Bogino; Natalia E. Nocelli; Ludovic Chaveriat; Patrick Martin; Raquel V. Vico; Georgina Fabro et al.
Source: Self-asserted source
Maria Laura Fanani

Arginine-based surfactants alter the rheological and in-plane structural properties of stratum corneum model membranes

Journal of Colloid and Interface Science
2023-02 | Journal article
Part of ISSN: 0021-9797
Contributors: Melisa Hermet; Yanis Ricardo Espinosa; María Elisa Fait; Yenisleidy de las M. Zulueta Díaz; Susana Morcelle; Laura S. Bakás; H. Ariel Ariel Alvarez; María Laura Fanani
Source: Self-asserted source
Maria Laura Fanani

Phospholipases and Membrane Curvature: What Is Happening at the Surface?

Membranes
2023-02-03 | Journal article
Contributors: María Laura Fanani; Ernesto Esteban Ambroggio
Source: check_circle
Crossref

The Important Role of Membrane Fluidity on the Lytic Mechanism of the α-Pore-Forming Toxin Sticholysin I

Toxins
2023-01-16 | Journal article
Contributors: Lohans Pedrera; Uris Ros; Maria Laura Fanani; María E. Lanio; Richard M. Epand; Ana J. García-Sáez; Carlos Álvarez
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

What can we learn about amphiphile-membrane interaction from model lipid membranes?

Biochimica et Biophysica Acta (BBA) - Biomembranes
2022-02 | Journal article
Part of ISSN: 0005-2736
Contributors: Maria Laura Fanani; Natalia E. Nocelli; Yenisleidy de las Mercedes Zulueta Díaz
Source: Self-asserted source
Maria Laura Fanani

Self-assembled nanostructures of L-ascorbic acid alkyl esters support monomeric amphotericin B

Heliyon
2021-01 | Journal article | Author
Part of ISSN: 2405-8440
Contributors: Natalia E. Nocelli; Yenisleidy de las Mercedes Zulueta Díaz; Marine Millot; María Luz Colazo; Raquel V. Vico; Maria Laura Fanani
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 2)‎

Exploring the Toxicity, Lung Distribution, and Cellular Uptake of Rifampicin and Ascorbic Acid-Loaded Alginate Nanoparticles as Therapeutic Treatment of Lung Intracellular Infections

Molecular Pharmaceutics
2020-12-24 | Journal article
Part of ISSN: 1543-8384
Part of ISSN: 1543-8392
Source: Self-asserted source
Maria Laura Fanani

Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties

Biochimica et Biophysica Acta (BBA) - Biomembranes
2020-07 | Journal article
Part of ISSN: 0005-2736
Source: Self-asserted source
Maria Laura Fanani

Somuncurins: Bioactive Peptides from the Skin of the Endangered Endemic Patagonian Frog Pleurodema somuncurense

Journal of Natural Products
2020-03-05 | Journal article
Part of ISSN: 0163-3864
Part of ISSN: 1520-6025
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 3)‎

l-Ascorbic acid alkyl esters action on stratum corneum model membranes: An insight into the mechanism for enhanced skin permeation

Colloids and Surfaces B: Biointerfaces
2020-01 | Journal article
Part of ISSN: 0927-7765
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 3)‎

Impact of sphingomyelin acyl chain (16:0 vs 24:1) on the interfacial properties of Langmuir monolayers: A PM-IRRAS study

Colloids and Surfaces B: Biointerfaces
2019-01 | Journal article
Part of ISSN: 0927-7765
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 3)‎

Membrane Restructuring Events during the Enzymatic Generation of Ceramides with Very Long-Chain Polyunsaturated Fatty Acids

Langmuir
2018 | Journal article
EID:

2-s2.0-85045184063

Contributors: Penalva, D.A.; Antollini, S.S.; Ambroggio, E.E.; AveldanÌo, M.I.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier
grade
Preferred source (of 2)‎

Regulation of phase boundaries and phase-segregated patterns in model membranes

Biochimica et Biophysica Acta - Biomembranes
2018 | Journal article
EID:

2-s2.0-85043467494

Contributors: Fanani, M.L.; Wilke, N.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Psychosine remodels model lipid membranes at neutral pH

Biochimica et Biophysica Acta (BBA) - Biomembranes
2018-12 | Journal article
Part of ISSN: 0005-2736
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 2)‎

Clearly Detectable, Kinetically Restricted Solid–Solid Phase Transition in cis-Ceramide Monolayers

Langmuir
2018-10-02 | Journal article
Part of ISSN: 0743-7463
Part of ISSN: 1520-5827
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 3)‎

Mechanical Stability of Lipid Membranes Decorated with Dextran Sulfate

ACS Omega
2018-09-30 | Journal article
Part of ISSN: 2470-1343
Part of ISSN: 2470-1343
Source: Self-asserted source
Maria Laura Fanani
grade
Preferred source (of 3)‎

Alkyl esters of L-ascorbic acid: From synthesis to applications

Ascorbic Acid: Properties, Synthesis and Applications
2017 | Book
EID:

2-s2.0-85021968710

Contributors: Fanani, M.L.; Vico, R.V.; Benedini, L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Crossregulation between the insertion of Hexadecylphosphocholine (miltefosine) into lipid membranes and their rheology and lateral structure

Biochimica et Biophysica Acta - Biomembranes
2017 | Journal article
EID:

2-s2.0-85021691502

Contributors: Zulueta Díaz, Y.D.L.M.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The insertion of Polybia-MP1 peptide into phospholipid monolayers is regulated by its anionic nature and phase state

Chemistry and Physics of Lipids
2017 | Journal article
EID:

2-s2.0-85027415102

Contributors: Alvares, D.S.; Wilke, N.; Ruggiero Neto, J.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The many faces (and phases) of ceramide and sphingomyelin I – single lipids

Biophysical Reviews
2017 | Journal article
EID:

2-s2.0-85032185225

Contributors: Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The many faces (and phases) of ceramide and sphingomyelin II – binary mixtures

Biophysical Reviews
2017 | Journal article
EID:

2-s2.0-85032208861

Contributors: Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Development of a nonionic azobenzene amphiphile for remote photocontrol of a model biomembrane

Journal of Physical Chemistry B
2016 | Journal article
EID:

2-s2.0-84969504987

Contributors: Benedini, L.A.; Sequeira, M.A.; Fanani, M.L.; Maggio, B.; Dodero, V.I.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The amphiphilic alkyl ester derivatives of L-ascorbic acid induce reorganization of phospholipid vesicles

Biochimica et Biophysica Acta - Biomembranes
2016 | Journal article
EID:

2-s2.0-84976551617

Contributors: Giudice, F.; Ambroggio, E.E.; Mottola, M.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The interfacial properties of the peptide Polybia-MP1 and its interaction with DPPC are modulated by lateral electrostatic attractions

Biochimica et Biophysica Acta - Biomembranes
2016 | Journal article
EID:

2-s2.0-84949595510

Contributors: Alvares, D.S.; Fanani, M.L.; Ruggiero Neto, J.; Wilke, N.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The Rheological Properties of Lipid Monolayers Modulate the Incorporation of l -Ascorbic Acid Alkyl Esters

Langmuir
2016 | Journal article
EID:

2-s2.0-84955458035

Contributors: Zulueta Díaz, Y.D.L.M.; Mottola, M.; Vico, R.V.; Wilke, N.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Alkyl esters of l-ascorbic acid: Stability, surface behaviour and interaction with phospholipid monolayers

Journal of Colloid and Interface Science
2015 | Journal article
EID:

2-s2.0-84937134125

Contributors: Mottola, M.; Vico, R.V.; Villanueva, M.E.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The Presence of Sterols Favors Sticholysin I-Membrane Association and Pore Formation Regardless of Their Ability to Form Laterally Segregated Domains

Langmuir
2015 | Journal article
EID:

2-s2.0-84941662529

Contributors: Pedrera, L.; Gomide, A.B.; Sánchez, R.E.; Ros, U.; Wilke, N.; Pazos, F.; Lanio, M.E.; Itri, R.; Fanani, M.L.; Alvarez, C.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Atypical surface behavior of ceramides with nonhydroxy and 2-hydroxy very long-chain (C28-C32) PUFAs

Biochimica et Biophysica Acta - Biomembranes
2014 | Journal article
EID:

2-s2.0-84891506625

Contributors: Peñalva, D.A.; Oresti, G.M.; Dupuy, F.; Antollini, S.S.; Maggio, B.; Aveldaño, M.I.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Boundary region between coexisting lipid phases as initial binding sites for Escherichia coli alpha-hemolysin: A real-time study

Biochimica et Biophysica Acta - Biomembranes
2014 | Journal article
EID:

2-s2.0-84899038670

Contributors: Maté, S.M.; Vázquez, R.F.; Herlax, V.S.; Daza Millone, M.A.; Fanani, M.L.; Maggio, B.; Vela, M.E.; Bakás, L.S.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Sticholysin I-membrane interaction: An interplay between the presence of sphingomyelin and membrane fluidity

Biochimica et Biophysica Acta - Biomembranes
2014 | Journal article
EID:

2-s2.0-84899041891

Contributors: Pedrera, L.; Fanani, M.L.; Ros, U.; Lanio, M.E.; Maggio, B.; Álvarez, C.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Study of the influence of ascorbyl palmitate and amiodarone in the stability of unilamellar liposomes

Molecular Membrane Biology
2014 | Journal article
EID:

2-s2.0-84899439803

Contributors: Benedini, L.; Antollini, S.; Fanani, M.L.; Palma, S.; Messina, P.; Schulz, P.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Surface behavior of sphingomyelins with very long chain polyunsaturated fatty acids and effects of their conversion to ceramides

Langmuir
2014 | Journal article
EID:

2-s2.0-84899455895

Contributors: Peñalva, D.A.; Wilke, N.; Maggio, B.; Aveldaño, M.I.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Ascorbyl palmitate interaction with phospholipid monolayers: Electrostatic and rheological preponderancy

Biochimica et Biophysica Acta - Biomembranes
2013 | Journal article
EID:

2-s2.0-84882608457

Contributors: Mottola, M.; Wilke, N.; Benedini, L.; Oliveira, R.G.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Surface mixing of products and substrate of PLA<inf>2</inf> in enzyme-free mixed monolayers reproduces enzyme-driven structural topography

Biochimica et Biophysica Acta - Biomembranes
2013 | Journal article
EID:

2-s2.0-84879219549

Contributors: De Tullio, L.; Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Ordered-disordered domain coexistence in ternary lipid monolayers activates sphingomyelinase by clearing ceramide from the active phase

Biochimica et Biophysica Acta - Biomembranes
2012 | Journal article
EID:

2-s2.0-84865271182

Contributors: Ale, E.C.; Maggio, B.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Ceramide N-acyl chain length: A determinant of bidimensional transitions, condensed domain morphology, and interfacial thickness

Langmuir
2011 | Journal article
EID:

2-s2.0-79953238160

Contributors: Dupuy, F.; Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Liquid-liquid domain miscibility driven by composition and domain thickness mismatch in ternary lipid monolayers

Journal of Physical Chemistry B
2011 | Journal article
EID:

2-s2.0-78651260433

Contributors: Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Surface phase behavior and domain topography of ascorbyl palmitate monolayers

Langmuir
2011 | Journal article
EID:

2-s2.0-80052254286

Contributors: Benedini, L.; Fanani, M.L.; Maggio, B.; Wilke, N.; Messina, P.; Palma, S.; Schulz, P.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Phase state and surface topography of palmitoyl-ceramide monolayers

Chemistry and Physics of Lipids
2010 | Journal article
EID:

2-s2.0-77954196656

Contributors: Fanani, M.L.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The action of sphingomyelinase in lipid monolayers as revealed by microscopic image analysis

Biochimica et Biophysica Acta - Biomembranes
2010 | Journal article
EID:

2-s2.0-77954731500

Contributors: Fanani, M.L.; Hartel, S.; Maggio, B.; De Tullio, L.; Jara, J.; Olmos, F.; Oliveira, R.G.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Coexistence of immiscible mixtures of palmitoylsphingomyelin and palmitoylceramide in monolayers and bilayers

Biophysical Journal
2009 | Journal article
EID:

2-s2.0-72149090172

Contributors: Busto, J.V.; Fanani, M.L.; De Tullio, L.; Sot, J.; Maggio, B.; Goñi, F.M.; Alonso, A.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Sphingomyelinase-induced domain shape relaxation driven by out-of-equilibrium changes of composition

Biophysical Journal
2009 | Journal article
EID:

2-s2.0-58849111812

Contributors: Fanani, M.L.; De Tullio, L.; Hartel, S.; Jara, J.; Maggio, B.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Composition-driven surface domain structuring mediated by sphingolipids and membrane-active proteins: Above the nano- but under the micro-scale: Mesoscopic biochemical/structural cross-talk in biomembranes

Cell Biochemistry and Biophysics
2008 | Journal article
EID:

2-s2.0-42949172451

Contributors: Maggio, B.; Borioli, G.A.; Del Boca, M.; De Tullio, L.; Fanani, M.L.; Oliveira, R.G.; Rosetti, C.M.; Wilke, N.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Sphingomyelinase acts by an area-activated mechanism on the liquid-expanded phase of sphingomyelin monolayers

Journal of Lipid Research
2008 | Journal article
EID:

2-s2.0-58149204198

Contributors: De Tullio, L.; Maggio, B.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

The initial surface composition and topography modulate sphingomyelinase-driven sphingomyelin to ceramide conversion in lipid monolayers

Cell Biochemistry and Biophysics
2007 | Journal article
EID:

2-s2.0-34548308613

Contributors: De Tullio, L.; Maggio, B.; Hartel, S.; Jara, J.; Fanani, M.L.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier

Biophysics of sphingolipids II. Glycosphingolipids: An assortment of multiple structural information transducers at the membrane surface

Biochimica et Biophysica Acta - Biomembranes
2006 | Journal article
EID:

2-s2.0-33845326747

Contributors: Maggio, B.; Fanani, M.L.; Rosetti, C.M.; Wilke, N.
Source: Self-asserted source
Maria Laura Fanani via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (10 reviews for 4 publications/grants)

Review activity for Biochimica et biophysica acta. (2)
Review activity for Langmuir : (3)
Review activity for Molecular pharmaceutics. (3)
Review activity for The journal of physical chemistry. (2)