Personal information

Russia

Activities

Employment (1)

Gause Institute of New Antibiotics : Moscow, RU

Employment
Source: Self-asserted source
Yury Portnoy

Education and qualifications (1)

Mendeleev Moscow Chemical-Technology Institute: Moscow, RU

1965 to 1970
Education
Source: Self-asserted source
Yury Portnoy

Professional activities (1)

Gause Institute of New Antibiotics : Moscow, RU

2001 to present | Senior researcher (Department of Pharmacokinetics&pharmacodynamics)
Invited position
Source: Self-asserted source
Yury Portnoy

Works (50 of 55)

Items per page:
Page 1 of 2

Predicting the Effects of Carbapenem/Carbapenemase Inhibitor Combinations against KPC-Producing Klebsiella pneumoniae in Time-Kill Experiments: Alternative versus Traditional Approaches to MIC Determination

Antibiotics
2021-12-11 | Journal article
Contributors: Alla V. Filimonova; Maria V. Golikova; Elena N. Strukova; Yury A. Portnoy; Anastasiya A. Kuznetsova; Stephen H. Zinner
Source: check_circle
Crossref
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Preferred source (of 2)‎

MPC-Based Prediction of Anti-Mutant Effectiveness of Antibiotic Combinations: In Vitro Model Study with Daptomycin and Gentamicin against Staphylococcus aureus

Antibiotics
2021-09-23 | Journal article
Part of ISSN: 2079-6382
Source: Self-asserted source
Yury Portnoy

Anti-mutant efficacy of antibiotic combinations: in vitro model studies with linezolid and daptomycin

Journal of Antimicrobial Chemotherapy
2021-06-18 | Journal article
Part of ISSN: 0305-7453
Part of ISSN: 1460-2091
Source: Self-asserted source
Yury Portnoy
grade
Preferred source (of 2)‎

Verification of a Novel Approach to Predicting Effects of Antibiotic Combinations: In Vitro Dynamic Model Study with Daptomycin and Gentamicin against Staphylococcus aureus

Antibiotics
2020-08-25 | Journal article
Part of ISSN: 2079-6382
Source: Self-asserted source
Yury Portnoy

Доклиническая фармакокинетика и острая токсичность антрафурана — нового противоопухолевого вещества

Химико-фармацевтический журнал
2020-03-19 | Journal article
Contributors: Юрий Абрамович Портной; Светлана Анатольевна Довженко; Михаил Борисович Кобрин; Элеонора Рафаиловна Переверзева; Михаил Иванович Трещалин; Василиса Антоновна Голибродо; Андрей Егорович Щекотихин; Александр Алексеевич Фирсов
Source: check_circle
Crossref

Доклиническое изучение фармакокинетики нового полусинтетического противогрибкового антибиотика амфамида

Химико-фармацевтический журнал
2020-03-19 | Journal article
Contributors: Юрий Абрамович Портной; Михаил Борисович Кобрин; Светлана Анатольевна Довженко; Анна Николаевна Тевяшова; Михаил Иванович Трещалин; Василиса Антоновна Голибродо; Александр Алексеевич Фирсов
Source: check_circle
Crossref

A novel parameter to predict the effects of antibiotic combinations on the development of Staphylococcus aureus resistance: in vitro model studies at subtherapeutic daptomycin and rifampicin exposures

Journal of Chemotherapy
2019-08-18 | Journal article
Contributors: Maria V. Golikova; Elena N. Strukova; Yury A. Portnoy; Svetlana A. Dovzhenko; Mikhail B. Kobrin; Stephen H. Zinner; Alexander A. Firsov
Source: check_circle
Crossref

Predicting antibiotic combination effects on the selection of resistant Staphylococcus aureus: In vitro model studies with linezolid and gentamicin

International journal of antimicrobial agents
2018 | Journal article
WOSUID:

MEDLINE:30236953

Contributors: Zinner, Stephen H.; Golikova, Maria V.; Strukova, Elena N.; Portnoy, Yury A.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Time inside the mutant selection window as a predictor of staphylococcal resistance to linezolid

Journal of Antibiotics
2018 | Journal article
WOSUID:

WOS:000431131700004

Contributors: Alieva, Kamilla N.; Strukova, Elena N.; Golikova, Maria V.; Portnoy, Yury A.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Pharmacokinetically-based prediction of the effects of antibiotic combinations on resistant Staphylococcus aureus mutants: in vitro model studies with linezolid and rifampicin

Journal of Chemotherapy
2017 | Journal article
WOSUID:

WOS:000404458000003

Contributors: Firsov, Alexander A.; Golikova, Maria V.; Strukova, Elena N.; Portnoy, Yury A.; Dovzhenko, Svetlana A.; Kobrin, Mikhail B.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Pharmacokinetics of Olivamide after Bolus Administration in Rats and Rabbits (a Pilot Study)

Antibiotiki i khimioterapiya
2017 | Journal article
SOURCE-WORK-ID:

1227180811272-47

Contributors: Portnoy, Yu A.; Dovzhenko, S. A.; Kobrin, M. B.; Treshalin, M. I.; Golobrodo, V. A.; Tevyashova, A. N.; Firsov, A. A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Predicting effects of antibiotic combinations using MICs determined at pharmacokinetically derived concentration ratios: in vitro model studies with linezolid- and rifampicin-exposed Staphylococcus aureus

Journal of Chemotherapy
2017 | Journal article
WOSUID:

WOS:000416494200002

Contributors: Golikova, Maria V.; Strukova, Elena N.; Portnoy, Yury A.; Dovzhenko, Svetlana A.; Kobrin, Mikhail B.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Species differences in ciprofloxacin resistance among Gram-negative bacteria: can "anti-mutant" ratios of the area under the concentration-time curve to the MIC be achieved clinically?

Journal of chemotherapy (Florence, Italy)
2017 | Journal article
WOSUID:

MEDLINE:28587559

Contributors: Strukova, Elena N; Portnoy, Yury A; Zinner, Stephen H; Firsov, Alexander A
Source: Self-asserted source
Yury Portnoy via ResearcherID

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to linezolid in an in vitro dynamic model

Journal of Antimicrobial Chemotherapy
2017 | Journal article
WOSUID:

WOS:000413464200018

Contributors: Firsov, Alexander A.; Alieva, Kamilla N.; Strukova, Elena N.; Golikova, Maria V.; Portnoy, Yury A.; Dovzhenko, Svetlana A.; Kobrin, Mikhail B.; Romanov, Andrey V.; Edelstein, Mikhail V.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Predictors of bacterial resistance using in vitro dynamic models: area under the concentration-time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration

Journal of Antimicrobial Chemotherapy
2016 | Journal article
WOSUID:

WOS:000372984200017

Contributors: Strukova, Elena N.; Portnoy, Yury A.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Searching for the Optimal Predictor of Ciprofloxacin Resistance in Klebsiella pneumoniae by Using In Vitro Dynamic Models

Antimicrobial Agents and Chemotherapy
2016 | Journal article
WOSUID:

WOS:000376490800005

Contributors: Strukova, Elena N.; Portnoy, Yury A.; Romanov, Andrey V.; Edelstein, Mikhail V.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

[PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data].

Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]
2015 | Journal article
WOSUID:

MEDLINE:27141633

Contributors: Golikova, M V; Strukova, E N; Portnoy, Y A; Firsov, A A
Source: Self-asserted source
Yury Portnoy via ResearcherID

Bacterial antibiotic resistance studies using in vitro dynamic models: Population analysis vs. susceptibility testing as endpoints of mutant enrichment

International Journal of Antimicrobial Agents
2015 | Journal article
WOSUID:

WOS:000360706000013

Contributors: Firsov, Alexander A.; Strukova, Elena N.; Portnoy, Yury A.; Shlykova, Darya S.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

In Vitro Resistance Studies with Bacteria That Exhibit Low Mutation Frequencies: Prediction of "Antimutant" Linezolid Concentrations Using a Mixed Inoculum Containing both Susceptible and Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy
2015 | Journal article
WOSUID:

WOS:000348610000032

Contributors: Firsov, Alexander A.; Golikova, Maria V.; Strukova, Elena N.; Portnoy, Yury A.; Romanov, Andrey V.; Edelstein, Mikhail V.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Predicting bacterial resistance using the time inside the mutant selection window: Possibilities and limitations

International Journal of Antimicrobial Agents
2014 | Journal article
WOSUID:

WOS:000343109600004

Contributors: Firsov, Alexander A.; Portnoy, Yury A.; Strukova, Elena N.; Shlykova, Darya S.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Bacterial Resistance Studies Using In Vitro Dynamic Models: the Predictive Power of the Mutant Prevention and Minimum Inhibitory Antibiotic Concentrations

Antimicrobial Agents and Chemotherapy
2013 | Journal article
WOSUID:

WOS:000324480300044

Contributors: Firsov, Alexander A.; Strukova, Elena N.; Shlykova, Darya S.; Portnoy, Yury A.; Kozyreva, Varvara K.; Edelstein, Mikhail V.; Dovzhenko, Svetlana A.; Kobrin, Mikhail B.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Concentration-resistance relationships with Pseudomonas aeruginosa exposed to doripenem and ciprofloxacin in an in vitro model

Journal of Antimicrobial Chemotherapy
2013 | Journal article
WOSUID:

WOS:000316841600020

Contributors: Zinner, Stephen H.; Gilbert, Deborah; Greer, Kenneth; Portnoy, Yury K.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative Pharmacodynamics and Antimutant Potentials of Doripenem and Imipenem with Ciprofloxacin-Resistant Pseudomonas aeruginosa in an In Vitro Model

Antimicrobial Agents and Chemotherapy
2012 | Journal article
WOSUID:

WOS:000300623300010

Contributors: Firsov, Alexander A.; Gilbert, Deborah; Greer, Kenneth; Portnoy, Yury A.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

The Antistaphylococcal Pharmacodynamics of Linezolid Alone and in Combination with Doxycycline in an In Vitro Dynamic Model

Journal of Chemotherapy
2011 | Journal article
WOSUID:

WOS:000294584500005

Contributors: Smirnova, M. V.; Strukova, E. N.; Portnoy, Y. A.; Dovzhenko, S. A.; Kobrin, M. B.; Zinner, S. H.; Firsov, A. A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

AntiStaphylococcal Effects of Telavancin and Vancomycin in In Vitro Simulations of the Antibiotic Pharmacokinetics

Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya
2009 | Journal article
SOURCE-WORK-ID:

1227180811274-48

Contributors: Strukova, E. N.; Smirnova, M. V.; Vostrov, S. N.; Portnoy, Y. A.; Dovzhenko, S. A.; Kobrin, M. B.; Firsov, A. A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Linezolid pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model

International Journal of Antimicrobial Agents
2009 | Journal article
WOSUID:

WOS:000263991200011

Contributors: Strukova, Elena N.; Smirnova, Maria V.; Vostrov, Sergey N.; Lubenko, Irene Y.; Firsov, Alexander A.; Zinner, Stephen H.; Portnoy, Yury A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Prediction of Development of Antimicrobial Resistance in Invitro Dynamic Models of Different Dosage Regiments

Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya
2009 | Journal article
SOURCE-WORK-ID:

1227180811274-49

Contributors: Strukova, E. N.; Smirnova, M. V.; Vostrov, S. N.; Portnoy, Yu A.; Firsov, А А
Source: Self-asserted source
Yury Portnoy via ResearcherID

The impact of duration of antibiotic exposure on bacterial resistance predictions using in vitro dynamic models

Journal of Antimicrobial Chemotherapy
2009 | Journal article
WOSUID:

WOS:000270592400024

Contributors: Smirnova, Maria V.; Vostrov, Sergey N.; Strukova, Elena V.; Dovzhenko, Svetlana A.; Kobrin, Michael B.; Portnoy, Yury A.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Enrichment of resistant Staphylococcus aureus at ciprofloxacin concentrations simulated within the mutant selection window: bolus versus continuous infusion

International Journal of Antimicrobial Agents
2008 | Journal article
WOSUID:

WOS:000261744400006

Contributors: Firsov, Alexander A.; Smirnova, Maria V.; Strukova, Elena N.; Vostrov, Sergey N.; Portnoy, Yury A.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Telavancin and vancomycin pharmacodynamics with Staphylococcus aureus in an in vitro dynamic model

Journal of Antimicrobial Chemotherapy
2008 | Journal article
WOSUID:

WOS:000259974700039

Contributors: Lubenko, Irene Yu.; Strukova, Elena V.; Smirnova, Maria V.; Vostrov, Sergey N.; Portnoy, Yury A.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Concentration-response relationships as a basis for choice of the optimal endpoints of the antimicrobial effect: daptomycin and vancomycin pharmacodynamics with staphylococci in an in vitro dynamic model

International Journal of Antimicrobial Agents
2007 | Journal article
WOSUID:

WOS:000244082300007

Contributors: Smirnova, Maria V.; Lubenko, Irene Yu.; Portnoy, Yury A.; Zinner, Stephen H.; Firsov, Alexander A.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Testing the mutant selection window hypothesis with Staphylococcus aureus exposed to daptomycin and vancomycin in an in vitro dynamic model

Journal of Antimicrobial Chemotherapy
2006 | Journal article
WOSUID:

WOS:000242716600012

Contributors: Firsov, Alexander A.; Smirnova, Maria V.; Lubenko, Irene Yu.; Vostrov, Sergey N.; Portnoy, Yury A.; Zinner, Stephen H.
Source: Self-asserted source
Yury Portnoy via ResearcherID

Antistaphylococcal effect related to the area under the curve/MIC ratio in an in vitro dynamic model: Predicted breakpoints versus clinically achievable values for seven fluoroquinolones

Antimicrobial Agents and Chemotherapy
2005 | Journal article
WOSUID:

WOS:000230181800010

Contributors: Firsov, AA; Lubenko, IY; Vostrov, SN; Portnoy, YA; Zinner, SH
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative pharmacodynamics of telithromycin and clarithromycin with Streptococcus pneumoniae and Staphylococcus aureus in an in vitro dynamic model: focus on clinically achievable antibiotic concentrations

International Journal of Antimicrobial Agents
2005 | Journal article
WOSUID:

WOS:000232211600004

Contributors: Alferova, IV; Vostrov, SN; Portnoy, YA; Lubenko, IY; Zinner, SH; Firsov, AA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative pharmacodynamics of the new fluoroquinolone ABT492 and levofloxacin with Streptococcus pneumoniae in an in vitro dynamic model

International Journal of Antimicrobial Agents
2005 | Journal article
WOSUID:

WOS:000229381700008

Contributors: Firsov, AA; Alferova, IV; Smirnova, MV; Lubenko, IY; Portnoy, YA; Zinner, SH
Source: Self-asserted source
Yury Portnoy via ResearcherID

ABT492 and levofloxacin: comparison of their pharmacodynamics and their abilities to prevent the selection of resistant Staphylococcus aureus in an in vitro dynamic model

Journal of Antimicrobial Chemotherapy
2004 | Journal article
WOSUID:

WOS:000222558100030

Contributors: Firsov, AA; Vostrov, SN; Lubenko, IY; Arzamastsev, AP; Portnoy, YA; Zinner, SH
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative pharmacodynamics of the new fluoroquinolone ABT492 and ciprofloxacin with Escherichia coli and Pseudomonas aeruginosa in an in vitro dynamic model

International Journal of Antimicrobial Agents
2004 | Journal article
WOSUID:

WOS:000223648200012

Contributors: Zinner, SH; Vostrov, SN; Alferova, IV; Lubenko, IY; Portnoy, YA; Firsov, AA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Concentration-dependent changes in the susceptibility and killing of Staphylococcus aureus in an in vitro dynamic model that simulates normal and impaired gatifloxacin elimination

International Journal of Antimicrobial Agents
2004 | Journal article
WOSUID:

WOS:000189096900010

Contributors: Firsov, AA; Vostrov, SN; Lubenko, IY; Zinner, SH; Portnoy, YA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Prevention of the selection of resistant Staphylococcus aureus by moxifloxacin plus doxycycline in an in vitro dynamic model: an additive effect of the combination

International Journal of Antimicrobial Agents
2004 | Journal article
WOSUID:

WOS:000221720400005

Contributors: Firsov, AA; Vostrov, SN; Lubenko, IY; Portnoy, YA; Zinner, SH
Source: Self-asserted source
Yury Portnoy via ResearcherID

In vitro pharmacodynamic evaluation of the mutant selection window hypothesis using four fluoroquinolones against Staphylococcus aureus

Antimicrobial Agents and Chemotherapy
2003 | Journal article
WOSUID:

WOS:000183786600018

Contributors: Firsov, AA; Vostrov, SN; Lubenko, IY; Drlica, K; Portnoy, YA; Zinner, SH
Source: Self-asserted source
Yury Portnoy via ResearcherID

AUC/MIC relationships to different endpoints of the antimicrobial effect: multiple-dose in vitro simulations with moxifloxacin and levofloxacin

Journal of Antimicrobial Chemotherapy
2002 | Journal article
WOSUID:

WOS:000178830500013

Contributors: Firsov, AA; Zinner, SH; Vostrov, SN; Portnoy, YA; Lubenko, IY
Source: Self-asserted source
Yury Portnoy via ResearcherID

Bacterial strain-independent AUC/MIC and strain-specific dose-response relationships reflecting comparative fluoroquinolone anti-pseudomonal pharmacodynamics in an in vitro dynamic model

International Journal of Antimicrobial Agents
2002 | Journal article
WOSUID:

WOS:000177691400006

Contributors: Lubenko, IY; Vostrov, SN; Portnoy, YA; Zinner, SH; Firsov, AA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative pharmacodynamics of azithromycin and roxithromycin with S-pyogenes and S-pneumoniae in a model that simulates in vitro pharmacokinetics in human tonsils

Journal of Antimicrobial Chemotherapy
2002 | Journal article
WOSUID:

WOS:000173399300017

Contributors: Firsov, AA; Zinner, SH; Vostrov, SN; Kononenko, OV; Portnoy, YA; Shustova, LV; Kadenatsi, IB
Source: Self-asserted source
Yury Portnoy via ResearcherID

Simulated in vitro quinolone pharmacodynamics at clinically achievable AUC/MIC ratios: advantage of I-E over other integral parameters

Chemotherapy
2002 | Journal article
WOSUID:

WOS:000182370700002

Contributors: Firsov, AA; Zinner, SH; Lubenko, IY; Portnoy, YA; Vostrov, SN
Source: Self-asserted source
Yury Portnoy via ResearcherID

Species-independent pharmacodynamics of gemifloxacin and ciprofloxacin with Haemophilus influenzae and Moraxella catarrhalis in an in vitro dynamic model

International Journal of Antimicrobial Agents
2002 | Journal article
WOSUID:

WOS:000178900900007

Contributors: Portnoy, YA; Vostrov, SN; Lubenko, IY; Zinner, SH; Firsov, AA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative anti-staphylococcal effects of gemifloxacin and trovafloxacin in an in vitro dynamic model in terms of AUC/MIC and dose relationships

Diagnostic Microbiology and Infectious Disease
2001 | Journal article
WOSUID:

WOS:000171323800005

Contributors: Zinner, SH; Vostrov, SN; Lubenko, IY; Portnoy, YA; Cornaglia, G; Firsov, AA
Source: Self-asserted source
Yury Portnoy via ResearcherID

Different integral endpoints of the anti-staphylococcal effect of moxifloxacin & levofloxacin in an in vitro dynamic model

Journal of Antimicrobial Chemotherapy
2001 | Journal article
WOSUID:

WOS:000169382900141

Contributors: Firsov, A; Zinner, S; Lubenko, I; Portnoy, Y; Vostrov, S
Source: Self-asserted source
Yury Portnoy via ResearcherID

Gemifloxacin and ciprofloxacin pharmacodynamics against Haemophilus influenzae and Moraxella catarrhalis

Journal of Antimicrobial Chemotherapy
2001 | Journal article
WOSUID:

WOS:000169382900134

Contributors: Lubenko, I; Vostrov, S; Portnoy, Y; Zinner, S; Firsov, A
Source: Self-asserted source
Yury Portnoy via ResearcherID

Relationships of the area under the curve/MIC ratio to different integral endpoints of the antimicrobial effect: Gemifloxacin pharmacodynamics in an in vitro dynamic model

Antimicrobial Agents and Chemotherapy
2001 | Journal article
WOSUID:

WOS:000167134800045

Contributors: Firsov, AA; Lubenko, IY; Portnoy, YA; Zinner, SH; Vostrov, SN
Source: Self-asserted source
Yury Portnoy via ResearcherID

Comparative pharmacodynamics of moxifloxacin and levofloxacin in an in vitro dynamic model: prediction of the equivalent AUC/MIC breakpoints and equiefficient doses

Journal of Antimicrobial Chemotherapy
2000 | Journal article
WOSUID:

WOS:000165510200010

Contributors: Firsov, AA; Lubenko, IY; Vostrov, SN; Kononenko, OV; Zinner, SH; Portnoy, YA
Source: Self-asserted source
Yury Portnoy via ResearcherID
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