Personal information

Dendritic cells, Langerhans cells, Humoral and Cellular Immune Responses
United States

Biography

My lab has a major interest in understanding dendritic cell (DC) biology and in developing DC-based immunotherapeutics for cancer, infectious diseases, and organ transplant.

Activities

Employment (4)

Thomas Jefferson University: Philadelphia, Pennsylvania, US

2020 to present | Associate Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Botond Igyártó

Baylor Scott & White Research Institute: Dallas, TX, US

2015 to 2019 | Assistant Investigator (BIIR)
Employment
Source: Self-asserted source
Botond Igyártó

University of Minnesota: Minneapolis, Minnesota, US

2012 to 2015 | Research Assistant Professor (Dermatology)
Employment
Source: Self-asserted source
Botond Igyártó

University of Minnesota: Minneapolis, Minnesota, US

2010 to 2012 | Research Associate (Dermatology)
Employment
Source: Self-asserted source
Botond Igyártó

Education and qualifications (3)

University of Minnesota: Minneapolis, Minnesota, US

2007 to 2010 | Post-doc (Dermatology/Center for Immunology)
Qualification
Source: Self-asserted source
Botond Igyártó

Semmelweis University: Budapest, HU

2002 to 2007 | Ph.D.
Education
Source: Self-asserted source
Botond Igyártó

Universitatea Babeș-Bolyai: Cluj, RO

1998 to 2002 | B.S./M.S. (Biology)
Education
Source: Self-asserted source
Botond Igyártó

Professional activities (4)

Society For Investigative Dermatology: Cleveland, Ohio, US

2013 to present
Membership
Source: Self-asserted source
Botond Igyártó

The American Association of Immunologists: Rockville, Maryland, US

2012 to present
Membership
Source: Self-asserted source
Botond Igyártó

American Skin Association: New York, NY, US

2014 |  Research Scholar Award
Distinction
Source: Self-asserted source
Botond Igyártó

Dermatology Foundation: Evanston, Illinois, US

2011 | Career Development Award
Distinction
Source: Self-asserted source
Botond Igyártó

Funding (2)

DC-subset-tailored vaccines

2020-06-17 to 2025-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI146420
Source: Self-asserted source
Botond Igyártó via DimensionsWizard

Development of Universal Influenza Virus Vaccines Using Nucleoside-Modified Messenger RNA

2019-08 to 2024-07 | Award
National Institute of Allergy and Infectious Diseases (Md., Md., US)
Part of GRANT_NUMBER:

R01AI146101

Source: Self-asserted source
Botond Igyártó

Works (46)

Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells

Science Immunology
2022-11-25 | Journal article
Contributors: Sarah K. Whitley; Mushi Li; Sakeen W. Kashem; Toshiro Hirai; Botond Z. Igyártó; Kelley Knizner; Jonhan Ho; Laura K. Ferris; Casey T. Weaver; Daniel J. Cua et al.
Source: check_circle
Crossref

Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion

PLOS Pathogens
2022-09-02 | Journal article
Contributors: Zhen Qin; Sabra L. Klein; Aurélie Bouteau; Christopher Herbst; Botond Z. Igyártó
Source: check_circle
Crossref

“Don’t Look Up” Your Science—Herd Immunity or Herd Mentality?

Microorganisms
2022-07-20 | Journal article
Contributors: Botond Z. Igyártó
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Antibody-Mediated Targeting of a Hybrid-Insulin-Peptide Towards Neonatal Thymic Langerin+ Cells Enhances T Cell Central Tolerance and Delays Autoimmune Diabetes

Diabetes
2022-05-27 | Journal article
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Botond Igyártó

Single-cell suspension preparation from murine organs following <i>in vivo</i> mRNA-LNP exposure.

STAR protocols
2022-05-18 | Journal article
Source: Self-asserted source
Botond Igyártó

Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responses.

PLoS pathogens
2022-01-24 | Journal article
Source: Self-asserted source
Botond Igyártó

Anti-CD40 Antibody Fused to CD40 Ligand Is a Superagonist Platform for Adjuvant Intrinsic DC-Targeting Vaccines.

Frontiers in immunology
2022-01-13 | Journal article
Source: Self-asserted source
Botond Igyártó

The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory.

iScience
2021-11-20 | Journal article
Source: Self-asserted source
Botond Igyártó

Anti-CD40 Antibodies Fused to CD40 Ligand Have Superagonist Properties.

Journal of immunology (Baltimore, Md. : 1950)
2021-09-22 | Journal article
Source: Self-asserted source
Botond Igyártó

Targeting human langerin promotes HIV-1 specific humoral immune responses.

PLoS pathogens
2021-07-29 | Journal article
Source: Self-asserted source
Botond Igyártó

Future Considerations for the mRNA–Lipid Nanoparticle Vaccine Platform

2020-12-24 | Other
Contributors: Botond Igyártó; Sonya Jacobsen; Sonia Ndeupen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Future Considerations for the mRNA–Lipid Nanoparticle Vaccine Platform

2020-12-21 | Other
Contributors: Botond Igyártó; Sonya Jacobsen; Sonia Ndeupen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

PLOS ONE
2020-01-10 | Journal article
Contributors: Qingtai Su; Irina Budunova; Aurélie Bouteau; Jacob Cardenas; Balaji Uthra; Yuanyaun Wang; Cynthia Smitherman; Jinghua Gu; Botond Z. Igyártó
Source: check_circle
Crossref

DC subsets regulate humoral immune responses by supporting the differentiation of distinct TFH cells

Frontiers in Immunology
2019 | Journal article
EID:

2-s2.0-85068131296

Contributors: Bouteau, A.; Kervevan, J.; Su, Q.; Zurawski, S.M.; Contreras, V.; Dereuddre-Bosquet, N.; Le Grand, R.; Zurawski, G.; Cardinaud, S.; Levy, Y. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Keratinocytes Share Gene Expression Fingerprint with Epidermal Langerhans Cells via mRNA Transfer

Journal of Investigative Dermatology
2019 | Journal article
EID:

2-s2.0-85070666666

Contributors: Su, Q.; Igyártó, B.Z.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

2019-11-16 | Other
Contributors: Qingtai Su; Aurélie Bouteau; Jacob Cardenas; Balaji Uthra; Yuanyaun Wang; Cynthia Smitherman; Jinghua Gu; Botond Z. Igyártó
Source: check_circle
Crossref

Immune cell-specific Cre reporter mouse labels a subset of CNS neurons

2019-11-06 | Other
Contributors: Aurélie Bouteau; Botond Z. Igyártó
Source: check_circle
Crossref

Erratum: Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo (Proceedings of the National Academy of Sciences of the United States of America (2012) 109 (E889-E897) (DOI:10.1073/pnas.1117674109))

Proceedings of the National Academy of Sciences of the United States of America
2016 | Journal article
EID:

2-s2.0-84962740922

Contributors: Gaiser, M.R.; Lämmermann, T.; Feng, X.; Igyarto, B.Z.; Kaplan, D.H.; Tessarollo, L.; Germain, R.N.; Udey, M.C.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β

Nature Immunology
2016 | Journal article
EID:

2-s2.0-84959105586

Contributors: Mohammed, J.; Beura, L.K.; Bobr, A.; Astry, B.; Chicoine, B.; Kashem, S.W.; Welty, N.E.; Igyártó, B.Z.; Wijeyesinghe, S.; Thompson, E.A. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Candida albicans morphology and dendritic cell subsets determine T helper cell differentiation

Immunity
2015 | Journal article
EID:

2-s2.0-84923000491

Contributors: Kashem, S.W.; Igyártó, B.Z.; Gerami-Nejad, M.; Kumamoto, Y.; Mohammed, J.; Jarrett, E.; Drummond, R.A.; Zurawski, S.M.; Zurawski, G.; Berman, J. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Quantifying memory CD8 T cells reveals regionalization of immunosurveillance

Cell
2015 | Journal article
EID:

2-s2.0-84928904487

Contributors: Steinert, E.M.; Schenkel, J.M.; Fraser, K.A.; Beura, L.K.; Manlove, L.S.; Igyártó, B.Z.; Southern, P.J.; Masopust, D.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Skin dendritic cells induce follicular helper T cells and protective humoral immune responses

Journal of Allergy and Clinical Immunology
2015 | Journal article
EID:

2-s2.0-84928958293

Contributors: Yao, C.; Zurawski, S.M.; Jarrett, E.S.; Chicoine, B.; Crabtree, J.; Peterson, E.J.; Zurawski, G.; Kaplan, D.H.; Igyártó, B.Z.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Antigen presentation by Langerhans cells

Current Opinion in Immunology
2013 | Journal article
EID:

2-s2.0-84875240088

Contributors: Igyártó, B.Z.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism

Journal of Experimental Medicine
2013 | Journal article
EID:

2-s2.0-84885447087

Contributors: Welty, N.E.; Staley, C.; Ghilardi, N.; Sadowsky, M.J.; Igyártó, B.Z.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
EID:

2-s2.0-84862987203

Contributors: Bobr, A.; Igyarto, B.Z.; Haley, K.M.; Li, M.O.; Flavell, R.A.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Cancer-associated epithelial cell adhesion molecule (EpCAM; CD326) enables epidermal Langerhans cell motility and migration in vivo

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
EID:

2-s2.0-84859575185

Contributors: Gaiser, M.R.; Lämmermann, T.; Feng, X.; Igyarto, B.Z.; Kaplan, D.H.; Tessarollo, L.; Germain, R.N.; Udey, M.C.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Early immune events in the induction of allergic contact dermatitis

Nature Reviews Immunology
2012 | Journal article
EID:

2-s2.0-84856234422

Contributors: Kaplan, D.H.; Igyártó, B.Z.; Gaspari, A.A.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

Journal of Allergy and Clinical Immunology
2012 | Journal article
EID:

2-s2.0-84859158015

Contributors: Nakajima, S.; Igyártó, B.Z.; Honda, T.; Egawa, G.; Otsuka, A.; Hara-Chikuma, M.; Watanabe, N.; Ziegler, S.F.; Tomura, M.; Inaba, K. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Langerhans cells require MyD88-dependent signals for Candida albicans response but not for contact hypersensitivity or migration

Journal of Immunology
2012 | Journal article
EID:

2-s2.0-84860318542

Contributors: Haley, K.; Igyártó, B.Z.; Ortner, D.; Bobr, A.; Kashem, S.; Schenten, D.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

Immunity
2011 | Journal article
EID:

2-s2.0-80755172184

Contributors: Pepper, M.; Pagán, A.; Igyártó, B.; Taylor, J.; Jenkins, M.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets

Journal of Clinical Investigation
2011 | Journal article
EID:

2-s2.0-79955505656

Contributors: Kastenmüller, K.; Wille-Reece, U.; Lindsay, R.W.B.; Trager, L.R.; Darrah, P.A.; Flynn, B.J.; Becker, M.R.; Udey, M.C.; Clausen, B.E.; Igyarto, B.Z. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses

Immunity
2011 | Journal article
EID:

2-s2.0-80051906942

Contributors: Igyártó, B.; Haley, K.; Ortner, D.; Bobr, A.; Gerami-Nejad, M.; Edelson, B.; Zurawski, S.; Malissen, B.; Zurawski, G.; Berman, J. et al.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Acute ablation of Langerhans cells enhances skin immune responses

Journal of Immunology
2010 | Journal article
EID:

2-s2.0-78049488909

Contributors: Bobr, A.; Olvera-Gomez, I.; Igyarto, B.Z.; Haley, K.M.; Hogquist, K.A.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Decreasing the proportion of apoptotic cells in the endometrium in early period of involution in hyperketonaemic cows,Az apoptikus sejtek arányának csökkenése hyperketonaemiás tehenek endometriumában az involú ció korai idoszakában

Magyar Allatorvosok Lapja
2010 | Journal article
EID:

2-s2.0-78649601784

Contributors: Mónika, D.; Botond, Í.; Anna, P.; Gábor, M.; József, F.; Margit, K.; Gyula, H.; Zsuzsanna, N.; Péter, G.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

The evolving function of Langerhans cells in adaptive skin immunity

Immunology and Cell Biology
2010 | Journal article
EID:

2-s2.0-77952242565

Contributors: Igyarto, B.Z.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10

Journal of Immunology
2009 | Journal article
EID:

2-s2.0-77349125610

Contributors: Igyarto, B.Z.; Jenison, M.C.; Dudda, J.C.; Roers, A.; Müller, W.; Koni, P.A.; Campbell, D.J.; Shlomchik, M.J.; Kaplan, D.H.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Novel monoclonal antibodies recognise guinea fowl thrombocytes

Acta Veterinaria Hungarica
2009 | Journal article
EID:

2-s2.0-68249154983

Contributors: Bódi, I.; Nagy, N.; Sinka, L.; Igyártó, B.-Z.; Oláh, I.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Caveolin-1 is transported to multi-vesicular bodies after albumin-induced endocytosis of caveolae in HepG2 cells

Journal of Cellular and Molecular Medicine
2008 | Journal article
EID:

2-s2.0-54049090763

Contributors: Botos, E.; Klumperman, J.; Oorschot, V.; Ígyártó, B.; Magyar, A.; Oláh, M.; Kiss, A.L.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Identification of the avian B-cell-specific Bu-1 alloantigen by a novel monoclonal antibody

Poultry Science
2008 | Journal article
EID:

2-s2.0-38849202566

Contributors: Igyártó, B.Z.; Nagy, N.; Magyar, A.; Oláh, I.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Identification of a novel population of Langerin <sup>+</sup> dendritic cells

Journal of Experimental Medicine
2007 | Journal article
EID:

2-s2.0-37549051226

Contributors: Bursch, L.S.; Wang, L.; Igyarto, B.; Kissenpfennig, A.; Malissen, B.; Kaplan, D.H.; Hogquist, K.A.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Origin of follicular dendritic cell in the chicken spleen

Cell and Tissue Research
2007 | Journal article
EID:

2-s2.0-33751516951

Contributors: Igyártó, B.-Z.; Magyar, A.; Oláh, I.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Three different coping styles in police dogs exposed to a short-term challenge

Hormones and Behavior
2007 | Journal article
EID:

2-s2.0-36048931398

Contributors: Horváth, Z.; Igyártó, B.-Z.; Magyar, A.; Miklósi, Á.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Characterization of chicken epidermal dendritic cells

Immunology
2006 | Journal article
EID:

2-s2.0-33748742509

Contributors: Igyártó, B.-Z.; Lackó, E.; Oláh, I.; Magyar, A.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Impact of heterophil granulocyte depletion caused by 5-fluorouracil on infectious bursal disease virus infection in specific pathogen free chickens

Avian Pathology
2006 | Journal article
EID:

2-s2.0-33746603140

Contributors: Kabell, S.; Igyártó, B.-Z.; Magyar, A.; Hajdú, Z.; Biró, E.; Bisgaard, M.; Oláh, I.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

In ovo vitelline duct ligation results in transient changes of bursal microenvironments

Immunology
2005 | Journal article
EID:

2-s2.0-25444510658

Contributors: Felföldi, B.; Imre, G.; Igyártó, B.; Iván, J.; Mihalik, R.; Lackó, E.; Oláh, I.; Magyar, A.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Oesophageal tonsil of the chicken

Acta Veterinaria Hungarica
2005 | Journal article
EID:

2-s2.0-19944362872

Contributors: Nagy, N.; Igyártó, B.; Magyar, A.; Gazdag, E.; Palya, V.; Oláh, I.
Source: Self-asserted source
Botond Igyártó via Scopus - Elsevier

Peer review (2 reviews for 1 publication/grant)

Review activity for Nature communications (2)